GAMT Gene
protein-coding GIFtS: 65
GCID: GC19M001397
|
|
guanidinoacetate N-methyltransferase
| |
Aliases
for GAMT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Guanidinoacetate N-Methyltransferase1 2 | | PIG21 2 | | TP53I21 2 | | EC 2.1.1.23 8 |
Export aliases for GAMT gene to outside databasesPrevious GC identifers: GC19M001454 GC19M001466 GC19M001337 GC19M001348 GC19M001171 |
Summaries
for GAMT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GAMT:
The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, usingS-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes andmuscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affectedindividuals. Two transcript variants encoding different isoforms have been described for this gene. Pseudogenes ofthis gene are found on chromosomes 2 and 13. (provided by RefSeq, Feb 2012)
Gene Wiki entry for GAMT (Guanidinoacetate N-methyltransferase)
|
Genomic Views
for GAMT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GAMT gene promoter:
SRF GR SRF (504 AA) GR-beta NRSF form 1 NRSF form 2 HEN1 GR-alpha LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GAMT
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAMT |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3GAMT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M001397: view genomic region
(about GC identifiers)
Start:
|
1,397,088 bp from pter |
End:
|
1,401,569 bp from pter |
Size:
|
4,482 bases |
Orientation:
|
minus strand |
|
Proteins
for GAMT gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GAMT_HUMAN, Q14353 (See
protein sequence)Recommended Name: Guanidinoacetate N-methyltransferase Size: 236 amino acids; 26318 Da
Subunit: Monomer (By similarity)
1 PDB 3D structure from  and Proteopedia  for GAMT:3ORH (3D)
Secondary accessions: A8K0A0 Q53Y34 Q8WVJ1Alternative splicing: 2 isoforms: Q14353-1 Q14353-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for GAMT: NX_Q14353
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14353
3 DME Specific Peptides for GAMT (Q14353)
GAMT Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_000147.1 NP_620279.1
ENSEMBL proteins: ENSP00000252288 ENSP00000403536 ENSP00000466341 Reactome Protein details: Q14353
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
GAMT for ontologies About GeneDecksing
GAMT Antibody Products:
Assay Products for GAMT: |
Protein
Domains /
Families
for GAMT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GAMT for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14353ProtoNet protein and cluster: Q14353 UniProtKB/Swiss-Prot: GAMT_HUMAN, Q14353Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase familySimilarity: Contains 1 RMT2 (arginine N-methyltransferase 2-like) domain |
Function
for GAMT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GAMT_HUMAN, Q14353Catalytic activity: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine Genatlas biochemistry entry for GAMT:guanidinoacetate N-methyltransferase,expressed in liver,catalyzing the synthesis of creatine from guanidinoaacetate andS-adenosylmethionine
Enzyme Number (IUBMB): EC 2.1.1.21 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAMT (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAMT (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): GAMT (NM_000156) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GAMT | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAMT |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAMT |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008168 | methyltransferase activity |
TAS | 9325156 | | GO:0008757 | S-adenosylmethionine-dependent methyltransferase activity |
-- | -- | | GO:0030731 | guanidinoacetate N-methyltransferase activity |
IMP | 8651275 | | GO:0042803 | protein homodimerization activity |
-- | -- |
GAMT for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Gamttm1Isb for GAMT
9 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Gamt):
GAMT for phenotypes About GeneDecksing
|
Pathways & Interactions
for GAMT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | Arginine and proline metabolism | | | 3 | Metabolism of amino acids and derivatives | | | 4 | Glycine, serine and threonine metabolism | | | 5 | glycine degradation (creatine biosynthesis) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for GAMT
3 
Reactome Pathways for GAMT
3 
Kegg Pathways (Kegg details for GAMT):
UniProtKB/Swiss-Prot: GAMT_HUMAN, Q14353Pathway: Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 2/2
GAMT for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GAMT
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/13 Interacting proteins for GAMT (Q143533 ENSP000004035364) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
GAMT for ontologies About GeneDecksing
|
Drugs & Compounds
for GAMT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GAMT for compounds About GeneDecksing
 Browse Tocris compounds for GAMT
4 HMDB Compounds for GAMT About this table
4 DrugBank Compounds for GAMT About this table
9 Novoseek chemical compound relationships for GAMT gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| guanidinoacetate |
99 |
153 |
12597058 (4), 12324495 (4), 12701824 (4), 15028668 (3) (see all 65) |
| guanidino |
83.1 |
3 |
15028668 (1), 9322805 (1) |
| creatinine |
77.4 |
143 |
12597058 (3), 15028668 (3), 16941429 (3), 9322805 (3) (see all 53) |
| ornithine |
64.3 |
3 |
11749046 (2), 12701824 (1) |
| phosphocreatine |
64.3 |
2 |
15234333 (2) |
| arginine |
39 |
3 |
11749046 (2), 12701824 (1) |
| s-adenosylmethionine |
23.6 |
2 |
16471489 (1) |
| fatty acid |
0.759 |
4 |
19917247 (1), 19917243 (1), 20404548 (1) |
| hydrogen |
0 |
1 |
19733262 (1) |
Search CenterWatch for drugs/clinical trials and news about GAMT
|
Transcripts
for GAMT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GAMT gene (2 alternative transcripts): NM_000156.5 NM_138924.2 Unigene Cluster for GAMT: Guanidinoacetate N-methyltransferase Hs.81131 [show with all ESTs]Unigene Representative Sequence: NM_1389243 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000252288(uc002lsj.3) ENST00000447102(uc002lsk.3) ENST00000591788
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAMT (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAMT (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): GAMT (NM_000156) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GAMT | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAMT |
Additional cDNA sequence: AF086508.1 AK289465.1 AK297487.1 BC016760.2 BC017936.1 BT007034.1 Z49878.1 9 DOTS entries: DT.415415 DT.100776274 DT.91699555 DT.86847682 DT.121495003 DT.97792868 DT.121495080 DT.100811293 DT.91911056 24/207 AceView cDNA sequences (see all 207): BI821248 F28468 CK818879 BM917186 BM560778 F24913 BM703031 BU553002 CB242422 BX438620 F24553 CR592539 AA192786 BE907355 AW328135 BM552032 CR598497 BM547826 CA438906 BQ678012 CB054088 F26602 BU622961 F30073
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for GAMT About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for GAMT
|
Expression
for GAMT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GAMT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTCCTCCG
About this image
See GAMT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GAMT
SOURCE GeneReport for Unigene cluster: Hs.81131
UniProtKB/Swiss-Prot: GAMT_HUMAN, Q14353Tissue specificity: Expressed in liver
SABiosciences Expression via Pathway-Focused PCR Arrays including GAMT:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAMT
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAMT |
Orthologs
for GAMT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for GAMT gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Gamt1 , 5 |
guanidinoacetate methyltransferase1, 5 |
84.82(n)1
88.09(a)1 |
|
10 (39.72 cM)5
144311 NM_010255.31 NP_034385.11
802581515 |
chicken
(Gallus gallus) |
Aves |
GAMT6 |
Uncharacterized protein |
45(a) |
1 ↔ 1 |
28(2522662-2525002) |
lizard
(Anolis carolinensis) |
Reptilia |
GAMT6 |
-- |
63(a) |
1 ↔ 1 |
AAWZ02037456(6766-14422) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.287822 |
Xenopus laevis transcribed sequence with moderate similarity more |
78.56(n) |
|
48019336 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.284512 |
Danio rerio guanidinoacetate N-methyltransferase mRNA, more |
74.97(n) |
|
AF425745.1 |
ENSEMBL Gene Tree for GAMT (if available)
TreeFam Gene Tree for GAMT (if available) |
Paralogs
for GAMT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GAMT gene
GAMT for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for GAMT
PGOHUM00000248359 PGOHUM00000240553
|
Genomic Variants
for GAMT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GAMT (1397088 - 1401569 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for GAMT
3 CNVs: 7191 4066 5066
Human Gene Mutation Database (HGMD): GAMT
Locus Specific Mutation Databases (LSDB): GAMT
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAMT |
|
Disorders
/ Diseases
for GAMT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GAMT for disorders About GeneDecksing
OMIM gene information: 601240
OMIM disorders: 612736
UniProtKB/Swiss-Prot: GAMT_HUMAN, Q14353
Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency (GAMT deficiency) [MIM:612736].GAMT deficiency is an autosomal recessive disorder characterized by developmental delay/regression, mentalretardation, severe disturbance of expressive and cognitive speech, intractable seizures and movement disturbances,severe depletion of creatine/phosphocreatine in the brain, and accumulation of guanidinoacetic acid (GAA) in brain andbody fluids
11  diseases for GAMT: About MalaCardsguanidinoacetate methyltransferase deficiency hypotonia creatine deficiency syndrome gamt deficiency
agat deficiency spina bifida intellectual disability metabolic disorders
homocysteine cerebritis pancreatitis
3 diseases from the University of Copenhagen DISEASES database for GAMT:AGAT deficiency Intellectual disability Movement disease 5 Novoseek disease relationships for GAMT gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| mental retardation |
75.5 |
5 |
12597058 (1), 17336114 (1), 15108290 (1), 16054853 (1) (see all 5) |
| language delay |
74.6 |
2 |
17186272 (1), 19388150 (1) |
| movement disorders |
72.9 |
7 |
8547310 (1), 12597058 (1), 12701824 (1), 12889668 (1) (see all 7) |
| developmental delay |
65.6 |
2 |
19027335 (1), 11412830 (1) |
| epilepsy |
63.3 |
10 |
12597058 (2), 19388150 (2), 17336114 (1), 15108290 (1) (see all 8) |
Genatlas disease: GAMT muscular hypotonia,severe,progressive extrapyramidal movement disorder,extremely low excretion of creatine andaccumulation of guanidinoacetate in brain
GeneTests: GAMT
Creatine Deficiency Syndromes
Human Genome Epidemiology (HuGE) Navigator: GAMT (3 documents)
Export disorders for GAMT gene to outside databases
|
Publications
for GAMT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GAMT gene, integrated from 9 sources (see all 96):
(articles sorted by number of sources associating them with GAMT) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and sequence analysis of human guanidinoacetate N- methyltransferase cDNA. (PubMed id 8547310)1, 2, 3, 9 Isbrandt D. and von Figura K. (1995)
- The human guanidinoacetate methyltransferase (GAMT) gene maps to a syntenic region on 19p13.3, homologous to band C of mouse chromosome 10, but GAMT is not mutated in jittery mice. (PubMed id 9325156)1, 2, 9 Jenne D.E.... Zimmer M. (1997)
- A prevalent pathogenic GAMT mutation (c.59G>C) in Portugal. (PubMed id 17336114)1, 7, 9 Almeida L.S....Salomons G.S. (2007)
- Guanidinoacetate methyltransferase deficiency: the first inborn error of creatine metabolism in man. (PubMed id 8651275)1, 2, 9 Stoeckler S.... von Figura K. (1996)
- The gene encoding guanidinoacetate methyltransferase (GAMT) maps to human chromosome 19 at band p13.3 and to mouse chromosome 10. (PubMed id 9570966)1, 3, 9 Chae Y.J....Lee H. (1998)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Overexpression of GAMT restores GAMT activity in primary GAMT-deficient fibroblasts. (PubMed id 16899382)1, 9 Almeida L.S....Salomons G.S. (2006)
- Expanded clinical and molecular spectrum of guanidinoacetate methyltransferase (GAMT) deficiency. (PubMed id 19027335)1, 9 Dhar S.U....Wong L.J. (2009)
- Guanidinoacetate methyltransferase (GAMT) deficiency diagnosed by proton NMR spectroscopy of body fluids. (PubMed id 19288536)1, 9 Engelke U.F....Wevers R.A. (2009)
|
External Searches for GAMT gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GAMT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GAMT gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GAMT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GAMT | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GAMT |
|
| | |
About This Section
| Patent Information for GAMT gene:
Search GeneIP for patents involving GAMT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for GAMT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for GAMT | | OriGene shRNA RFP for GAMT | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GAMT | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAMT | | | OriGene Protein Over-expression Lysate for GAMT | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GAMT | | OriGene 3'-UTR Clone for GAMT | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAMT | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAMT | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for GAMT | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GAMT | | OriGene Custom Protein Services for GAMT | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GAMT | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAMT | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAMT | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAMT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAMT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAMT |
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| | | | Search Tocris compounds for GAMT |
| |  |  |  |  | | | | | | Recombinant Protein for GAMT |
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 | | | GAMT Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAMT |
|  |  |  | | | | ThermoFisher Antibodies for GAMT |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAMT |
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