Aliases for GALR3 Gene
External Ids for GALR3 Gene
Previous GeneCards Identifiers for GALR3 Gene
The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts [provided by RefSeq, Jul 2008]
GeneCards Summary for GALR3 Gene
GALR3 (Galanin Receptor 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include galanin receptor activity. An important paralog of this gene is GALR2.
UniProtKB/Swiss-Prot for GALR3 Gene
Receptor for the hormone galanin. Receptor for the hormone spexin-1 (PubMed:24517231).
Galanin is widely distributed in the central and peripheral nervous systems and the endocrine system. Three different galanin receptors (GAL1-3) have been identified which are Gi/o-protein-coupled. They are highly expressed in hypothalamic nuclei and the brainstem. In addition, they are found in proliferating zones of the fetal and adult brain and in peripheral tissues including the pancreas, heart, skin and gastrointestinal tract. Galanin receptors mediate a variety of physiological functions including inhibition of glucose-induced insulin secretion, stimulation of growth hormone release and modulation of gastrointestinal motility. These receptors also modulate neuronal functions including memory, nociception, spinal reflexes and feeding. Disruption of galanin expression or galanin receptor signaling is seen in many multifactoral conditions, suggesting a role in the development and/or pathology of certain diseases. These include Alzheimer's disease, epilepsy, diabetes, alcoholism, neuropathic pain and cancer.