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GALR3 Gene

protein-coding   GIFtS: 62
GCID: GC22P038219

Galanin Receptor 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Galanin Receptor 31 2
GAL3-R2 3
GALR-32 3
Galanin Receptor Type 32
Galanin Receptor, Family Member 32
GALNR33

External Ids:    HGNC: 41341   Entrez Gene: 84842   Ensembl: ENSG000001283107   OMIM: 6036925   UniProtKB: O607553   

Export aliases for GALR3 gene to outside databases

Previous GC identifers: GC22P034833 GC22P036462 GC22P036543 GC22P021186


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GALR3 Gene:
The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain
processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors
that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in
many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts (provided by RefSeq, Jul 2008)

GeneCards Summary for GALR3 Gene:
GALR3 (galanin receptor 3) is a protein-coding gene. GO annotations related to this gene include galanin receptor activity. An important paralog of this gene is SSTR3.

UniProtKB/Swiss-Prot: GALR3_HUMAN, O60755
Function: Receptor for the hormone galanin

summary for GALR3 Gene:
Galanin is widely distributed in the central and peripheral nervous systems and the endocrine system. Three
different galanin receptors (GAL1-3) have been identified which are Gi/o-protein-coupled. They are highly
expressed in hypothalamic nuclei and the brainstem. In addition, they are found in proliferating zones of
the fetal and adult brain and in peripheral tissues including the pancreas, heart, skin and gastrointestinal
tract. Galanin receptors mediate a variety of physiological functions including inhibition of
glucose-induced insulin secretion, stimulation of growth hormone release and modulation of gastrointestinal
motility. These receptors also modulate neuronal functions including memory, nociception, spinal reflexes
and feeding. Disruption of galanin expression or galanin receptor signaling is seen in many multifactoral
conditions, suggesting a role in the development and/or pathology of certain diseases. These include
Alzheimer's disease, epilepsy, diabetes, alcoholism, neuropathic pain and cancer.

Gene Wiki entry for GALR3 (Galanin receptor 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the GALR3 gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   E2F-2   GATA-2   Max   PPAR-gamma1   E2F-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGALR3 promoter sequence
   Search Chromatin IP Primers for GALR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GALR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q113.1

GALR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GALR3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P038219:  view genomic region     (about GC identifiers)

Start:
38,219,389 bp from pter      End:
38,221,502 bp from pter
Size:
2,114 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GALR3_HUMAN, O60755 (See protein sequence)
Recommended Name: Galanin receptor type 3  
Size: 368 amino acids; 39573 Da
Secondary accessions: Q53YJ4

Explore the universe of human proteins at neXtProt for GALR3: NX_O60755

Explore proteomics data for GALR3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn6

  • See GALR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003605.1  
    ENSEMBL proteins: 
     ENSP00000249041  
    Reactome Protein details: O60755

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GALR: GPCR / Class A : Galanin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GAL3 receptor
    Galanin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003908 Galnin_3_rcpt
     IPR000405 Galanin_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O60755

    ProtoNet protein and cluster: O60755

    2 Blocks protein domains:
    IPB000405 Galanin receptor signature
    IPB003908 Galanin 3 receptor signature


    UniProtKB/Swiss-Prot: GALR3_HUMAN, O60755
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with GALR3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GALR3_HUMAN, O60755
    Function: Receptor for the hormone galanin

         Genatlas biochemistry entry for GALR3:
    galanin receptor 3,G protein coupled receptor superfamily,linked to voltage gated calcium channel,expressed in
    testis,adrenal gland,pancreas,predominantly signaling through inhibition of adenylate cyclase

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004966galanin receptor activity IEA--
         
    Find genes that share ontologies with GALR3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GALR3:
     Increased cell number in G1, a 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Galr3):
     homeostasis/metabolism 

    Find genes that share phenotypes with GALR3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Galr3tm1Lex for GALR3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GALR3_HUMAN, O60755: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with GALR3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GALR3 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with GALR3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for GALR3
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for GALR3
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for GALR3):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including GALR3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GALR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GALR3 (ENSP000002490414) via UniProtKB, MINT, STRING, and/or I2D (see all 144)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY6ENSP000003114054STRING: ENSP00000311405
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA--
    GO:0007194negative regulation of adenylate cyclase activity IEA--
    GO:0007218neuropeptide signaling pathway TAS9722565
    GO:0007268synaptic transmission TAS9722565

    Find genes that share ontologies with GALR3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Compounds for GALR3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    M617Selective GAL1 agonist[860790-38-1]
    Galanin (1-29) (rat, mouse) Non-selective galanin receptor agonist[114547-31-8]
    M40 Potent, non-selective galanin receptor antagonist [143896-17-7]
    M 1145Potent and selective GAL2 agonist[1172089-00-7]
    M871Selective GAL2 antagonist[908844-75-7]

    Selected IUPHAR Ligands for GALR3 (GAL3 receptor) (see all 28)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I][Tyr26]galanin (pig)
    AgonistAgonist8.659722565
    [125I][Tyr26]galanin (human)
    AgonistAgonist8.659880084
    galanin
    AgonistFull agonist7.91 - 8.359722565 19467704 21333705 9880084
    SNAP 398299
    AntagonistAntagonist8.2716287967
    M32
    AntagonistAntagonist8.229880084 9722565
    C7
    AntagonistAntagonist8.089880084 9722565
    galanin-like peptide
    AgonistAgonist815944009
    galanin
    AgonistFull agonist7.929832121
    J20 (galanin analogue)
    AgonistAgonist7.8923600864
    M35
    AntagonistAntagonist7.8 - 7.849880084 9722565

    1 Novoseek inferred chemical compound relationship for GALR3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 1 9832121 (1)



    Find genes that share compounds with GALR3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GALR3 gene: 
    NM_003614.1  

    Unigene Cluster for GALR3:

    Galanin receptor 3
    Hs.158353  [show with all ESTs]
    Unigene Representative Sequence: AF073799
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000249041(uc003aub.1)
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    Additional mRNA sequence: 

    AF067733.1 AF073799.1 AY587582.1 

    1 DOTS entry:

    DT.91751733 

    8 AceView cDNA sequences:

    AF073799 AF067733 NM_003614 AY587582 BF512731 BF116239 BQ187252 BX280441 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GALR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCGGTGG
    GALR3 Expression
    About this image


    GALR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Thalamus
             Septum   
    GALR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GALR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.158353
        Pathway & Disease-focused RT2 Profiler PCR Array including GALR3: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GALR3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Galr31 , 5 galanin receptor 31, 5 87.07(n)1
    90.58(a)1
      15 (37.70 cM)5
    144291  NM_015738.21  NP_056553.21 
     790418855 
    chicken
    (Gallus gallus)
    Aves GALR31 galanin receptor 3 67.79(n)
    65.99(a)
      427904  NM_001130585.1  NP_001124057.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    49(a)
    many ↔ many
    5(24039165-24052404)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-52e11.16
    si:ch73-52e11.1
    44(a)
    many ↔ many
    3(43139715-43154799) ENSDARG00000044969
    fruit fly
    (Drosophila melanogaster)
    Insecta AlstR3 G-protein coupled receptor protein
    signaling pathway more
    34(a)   1 3E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea ZK455.33 G-protein coupled receptor 30(a)   X(11363821-11367302)   --


    ENSEMBL Gene Tree for GALR3 (if available)
    TreeFam Gene Tree for GALR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GALR3 gene
    SSTR32  OPRL12  OPRK12  NPBWR12  OPRD12  KISS1R2  GALR12  SSTR42  
    GALR22  SSTR52  MCHR22  SSTR12  SSTR22  MCHR12  OPRM12  NPBWR22  
    10 SIMAP similar genes for GALR3 using alignment to 1 protein entry:     GALR3_HUMAN:
    GALR2    GALR1    OPRM1    SSTR4    KISS1R    NPBWR2
    OPRD1    CYSLTR2    KPG_011    OPRK1

    Find genes that share paralogs with GALR3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GALR3 (see all 121)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs126277921,2
    H--38217481(+) cactgA/Caacct 1 -- us2k10--------
    rs1895132361,2
    --38217692(+) ACCGCA/GCCCAG 1 -- us2k10--------
    rs711950581,2
    C--38217705(+) TTTTT-/TTTGAG 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs622350711,2
    C,F--38217751(+) ATCACC/TTGGGC 1 -- us2k11Minor allele frequency- T:0.04NA 120
    rs1932080871,2
    --38217899(+) GAGACA/GAGGTT 1 -- us2k10--------
    rs1843824741,2
    C--38217912(+) GCCACA/TTTGGC 1 -- us2k10--------
    rs59955021,2
    C,F,A--38217935(+) gaattT/Cctggc 1 -- us2k16Minor allele frequency- C:0.30NA CSA 10
    rs1893137341,2
    C--38218005(+) ATGCCC/TGGCCT 1 -- us2k10--------
    rs1813504901,2
    --38218151(+) AAATCA/GCAGAG 1 -- us2k10--------
    rs1858082961,2
    --38218207(+) AGCAAC/TGCAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GALR3 (38219389 - 38221502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GALR3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4966n71CNV Loss21882294
    nsv915035CNV Loss21882294
    dgv4967n71CNV Loss21882294
    dgv4965n71CNV Loss21882294
    dgv1406e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603692    OMIM disorders: --


    Find genes that share disorders with GALR3           About GenesLikeMe

    2 Novoseek inferred disease relationships for GALR3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pathological processes 44.4 1 18500647 (1)
    alzheimers disease 40.1 3 18500647 (1), 19159918 (1)

    Genetic Association Database (GAD): GALR3
    Human Genome Epidemiology (HuGE) Navigator: GALR3 (4 documents)

    Export disorders for GALR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GALR3 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with GALR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3. (PubMed id 9832121)1, 2, 3, 9 Kolakowski L.F. Jr.... O'Dowd B.F. (J. Neurochem. 1998)
    2. Cloned human and rat galanin GALR3 receptors: pharmacology and activation of G-protein inwardly rectifying K+ channels. (PubMed id 9722565)1, 2, 3 Smith K.E....Jones K.A. (J. Biol. Chem. 1998)
    3. Alcoholism is associated with GALR3 but not two other galanin receptor genes. (PubMed id 17083333)1, 4, 9 Belfer I....Enoch M.A. (Genes Brain Behav. 2007)
    4. Structural organization and chromosomal localization of three human galanin receptor genes. (PubMed id 9928159)1, 2, 9 Iismaa T.P.... Shine J. (Ann. N. Y. Acad. Sci. 1998)
    5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    6. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
    7. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    8. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    9. A polymorphism in the human GALR3 galanin receptor gene (GALNR3). (PubMed id 10441207)1, 9 Lapsys N.M....Iismaa T.P. (Mol. Cell. Probes 1999)
    10. Galanin and its three receptors in human pituitary adenoma. (PubMed id 22889491)1 Tofighi R....Hulting A.L. (Neuropeptides 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8484 HGNC: 4134 AceView: GALR3 Ensembl:ENSG00000128310 euGenes: HUgn8484
    ECgene: GALR3 Kegg: 8484 H-InvDB: GALR3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GALR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GALR3 gene:
    Search GeneIP for patents involving GALR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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