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Aliases for GALR3 Gene

Aliases for GALR3 Gene

  • Galanin Receptor 3 2 3 5
  • GAL3-R 3 4
  • GALR-3 3 4
  • Galanin Receptor, Family Member 3 3
  • GALNR3 4

External Ids for GALR3 Gene

Previous GeneCards Identifiers for GALR3 Gene

  • GC22P034833
  • GC22P036462
  • GC22P036543
  • GC22P038219
  • GC22P021186

Summaries for GALR3 Gene

Entrez Gene Summary for GALR3 Gene

  • The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts [provided by RefSeq, Jul 2008]

GeneCards Summary for GALR3 Gene

GALR3 (Galanin Receptor 3) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and galanin receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for GALR3 Gene

  • Receptor for the hormone galanin (PubMed:25691535). Receptor for the hormone spexin-1 (PubMed:24517231).

Tocris Summary for GALR3 Gene

  • Galanin is widely distributed in the central and peripheral nervous systems and the endocrine system. Three different galanin receptors (GAL1-3) have been identified. Disruption of galanin expression or galanin receptor signaling is seen in many multifactoral conditions.

Gene Wiki entry for GALR3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALR3 Gene

Genomics for GALR3 Gene

Regulatory Elements for GALR3 Gene

Enhancers for GALR3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GALR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GALR3 Gene

Chromosome:
22
Start:
37,822,009 bp from pter
End:
37,825,865 bp from pter
Size:
3,857 bases
Orientation:
Plus strand

Genomic View for GALR3 Gene

Genes around GALR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GALR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GALR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALR3 Gene

Proteins for GALR3 Gene

  • Protein details for GALR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60755-GALR3_HUMAN
    Recommended name:
    Galanin receptor type 3
    Protein Accession:
    O60755
    Secondary Accessions:
    • Q53YJ4

    Protein attributes for GALR3 Gene

    Size:
    368 amino acids
    Molecular mass:
    39573 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GALR3 Gene

Proteomics data for GALR3 Gene at MOPED

Post-translational modifications for GALR3 Gene

  • Glycosylation at Asn 6
  • Modification sites at PhosphoSitePlus

Other Protein References for GALR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GALR3 Gene

Domains & Families for GALR3 Gene

Gene Families for GALR3 Gene

Suggested Antigen Peptide Sequences for GALR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60755

UniProtKB/Swiss-Prot:

GALR3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GALR3: view

Function for GALR3 Gene

Molecular function for GALR3 Gene

GENATLAS Biochemistry:
galanin receptor 3,G protein coupled receptor superfamily,linked to voltage gated calcium channel,expressed in testis,adrenal gland,pancreas,predominantly signaling through inhibition of adenylate cyclase
UniProtKB/Swiss-Prot Function:
Receptor for the hormone galanin (PubMed:25691535). Receptor for the hormone spexin-1 (PubMed:24517231).

Gene Ontology (GO) - Molecular Function for GALR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004966 galanin receptor activity IDA 24517231
genes like me logo Genes that share ontologies with GALR3: view
genes like me logo Genes that share phenotypes with GALR3: view

Animal Models for GALR3 Gene

MGI Knock Outs for GALR3:

Animal Model Products

  • Taconic Biosciences Mouse Models for GALR3

miRNA for GALR3 Gene

miRTarBase miRNAs that target GALR3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GALR3 Gene

Localization for GALR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GALR3 Gene COMPARTMENTS Subcellular localization image for GALR3 gene
Compartment Confidence
plasma membrane 5
extracellular 2

No data available for Gene Ontology (GO) - Cellular Components for GALR3 Gene

Pathways & Interactions for GALR3 Gene

genes like me logo Genes that share pathways with GALR3: view

Interacting Proteins for GALR3 Gene

Gene Ontology (GO) - Biological Process for GALR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA --
GO:0007218 neuropeptide signaling pathway TAS 9722565
GO:0007631 feeding behavior TAS 9722565
genes like me logo Genes that share ontologies with GALR3: view

No data available for SIGNOR curated interactions for GALR3 Gene

Drugs & Compounds for GALR3 Gene

(28) Drugs for GALR3 Gene - From: DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>125</sup>I][Tyr<sup>26</sup>]galanin (human) Pharma Agonist 0
[<sup>125</sup>I][Tyr<sup>26</sup>]galanin (pig) Pharma Agonist 0
C7 Pharma Antagonist 0
galanin Pharma Full agonist, Agonist 0
galanin(1-16) (rat/mouse/pig) Pharma Agonist 0

(4) Additional Compounds for GALR3 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Galanin (1-15) (porcine, rat)
112747-70-3
Galanin (1-29) (rat, mouse)
114547-31-8
Galanin (1-30) (human)
119418-04-1
Galanin (2-29) (rat)
141696-11-9

(5) Tocris Compounds for GALR3 Gene

Compound Action Cas Number
Galanin (1-15) (porcine, rat) Galanin receptor agonist peptide 112747-70-3
Galanin (1-29) (rat, mouse) Non-selective galanin receptor agonist 114547-31-8
Galanin (1-30) (human) Endogenous galanin receptor agonist 119418-04-1
Galanin (2-29) (rat) Selective GAL2 peptide agonist 141696-11-9
Galnon Non-selective galanin receptor agonist 475115-35-6
genes like me logo Genes that share compounds with GALR3: view

Transcripts for GALR3 Gene

mRNA/cDNA for GALR3 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GALR3 Gene

Galanin receptor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GALR3 Gene

No ASD Table

Relevant External Links for GALR3 Gene

GeneLoc Exon Structure for
GALR3
ECgene alternative splicing isoforms for
GALR3

Expression for GALR3 Gene

mRNA expression in normal human tissues for GALR3 Gene

mRNA differential expression in normal tissues according to GTEx for GALR3 Gene

This gene is overexpressed in Brain - Cerebellum (x5.3), Brain - Cerebellar Hemisphere (x5.2), Pancreas (x4.9), and Testis (x4.6).

Protein differential expression in normal tissues from HIPED for GALR3 Gene

This gene is overexpressed in Plasma (41.2) and Heart (27.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GALR3 Gene



SOURCE GeneReport for Unigene cluster for GALR3 Gene Hs.158353

genes like me logo Genes that share expression patterns with GALR3: view

Protein tissue co-expression partners for GALR3 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GALR3 Gene

Orthologs for GALR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALR3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GALR3 35
  • 92.75 (n)
  • 97.23 (a)
GALR3 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GALR3 35
  • 91.67 (n)
  • 94.94 (a)
GALR3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Galr3 35
  • 87.07 (n)
  • 90.58 (a)
Galr3 16
chimpanzee
(Pan troglodytes)
Mammalia GALR3 35
  • 99 (n)
  • 99.46 (a)
GALR3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Galr3 35
  • 86.41 (n)
  • 90.78 (a)
oppossum
(Monodelphis domestica)
Mammalia GALR3 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
ManyToMany
chicken
(Gallus gallus)
Aves GALR3 35
  • 67.79 (n)
  • 65.99 (a)
GALR3 36
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch73-52e11.1 36
  • 44 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta AlstR 37
  • 34 (a)
AlstR 36
  • 26 (a)
ManyToMany
AR-2 36
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ZK455.3 37
  • 30 (a)
npr-9 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for GALR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GALR3 Gene

ENSEMBL:
Gene Tree for GALR3 (if available)
TreeFam:
Gene Tree for GALR3 (if available)

Paralogs for GALR3 Gene

(10) SIMAP similar genes for GALR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GALR3: view

Variants for GALR3 Gene

Sequence variations from dbSNP and Humsavar for GALR3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs8137541 - 37,825,387(+) GCGGG(A/G)GGCTG reference, missense
rs8137553 - 37,825,409(+) CGGCC(A/G)GGGCC reference, missense
rs2284057 -- 37,825,596(+) GACTT(A/G)TCCCC downstream-variant-500B, utr-variant-3-prime
rs2284058 -- 37,825,651(+) ATATG(A/G)ACAGC downstream-variant-500B, utr-variant-3-prime
rs7290156 -- 37,822,630(+) ACAGG(C/T)AGTAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GALR3 Gene

Variant ID Type Subtype PubMed ID
dgv4965n71 CNV Loss 21882294
nsv915035 CNV Loss 21882294
dgv1406e1 CNV Complex 17122850
dgv4966n71 CNV Loss 21882294
dgv4967n71 CNV Loss 21882294

Variation tolerance for GALR3 Gene

Gene Damage Index Score: 3.22; 52.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GALR3 Gene

Disorders for GALR3 Gene

Relevant External Links for GALR3

Genetic Association Database (GAD)
GALR3
Human Genome Epidemiology (HuGE) Navigator
GALR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GALR3

No disorders were found for GALR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GALR3 Gene

Publications for GALR3 Gene

  1. Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3. (PMID: 9832121) Kolakowski L.F. Jr. … O'Dowd B.F. (J. Neurochem. 1998) 2 3 4 23 67
  2. Alcoholism is associated with GALR3 but not two other galanin receptor genes. (PMID: 17083333) Belfer I. … Enoch M.A. (Genes Brain Behav. 2007) 3 23
  3. A polymorphism in the human GALR3 galanin receptor gene (GALNR3). (PMID: 10441207) Lapsys N.M. … Iismaa T.P. (Mol. Cell. Probes 1999) 3 23
  4. Cloned human and rat galanin GALR3 receptors: pharmacology and activation of G-protein inwardly rectifying K+ channels. (PMID: 9722565) Smith K.E. … Jones K.A. (J. Biol. Chem. 1998) 2 3
  5. Structural organization and chromosomal localization of three human galanin receptor genes. (PMID: 9928159) Iismaa T.P. … Shine J. (Ann. N. Y. Acad. Sci. 1998) 3 23

Products for GALR3 Gene

Sources for GALR3 Gene

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