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GALR1 Gene

protein-coding   GIFtS: 65
GCID: GC18P074962

Galanin Receptor 1


(Previous symbols: GALNR1, GALNR)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Galanin Receptor 11 2
GALNR1 2 3 5
GALNR11 2 3 5
GAL1-R2 3
GALR-12 3
Galanin Receptor Type 12

External Ids:    HGNC: 41321   Entrez Gene: 25872   Ensembl: ENSG000001665737   OMIM: 6003775   UniProtKB: P472113   

Export aliases for GALR1 gene to outside databases

Previous GC identifers: GC18M074531 GC18P075110 GC18P074724 GC18P073088 GC18P073090 GC18P071642


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GALR1 Gene:
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled
receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular
second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely
expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.
(provided by RefSeq, Jul 2008)

GeneCards Summary for GALR1 Gene:
GALR1 (galanin receptor 1) is a protein-coding gene. GO annotations related to this gene include galanin receptor activity and neuropeptide binding. An important paralog of this gene is SSTR3.

UniProtKB/Swiss-Prot: GALR1_HUMAN, P47211
Function: Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit
adenylate cyclase activity

summary for GALR1 Gene:
Galanin is widely distributed in the central and peripheral nervous systems and the endocrine system. Three
different galanin receptors (GAL1-3) have been identified which are Gi/o-protein-coupled. They are highly
expressed in hypothalamic nuclei and the brainstem. In addition, they are found in proliferating zones of
the fetal and adult brain and in peripheral tissues including the pancreas, heart, skin and gastrointestinal
tract. Galanin receptors mediate a variety of physiological functions including inhibition of
glucose-induced insulin secretion, stimulation of growth hormone release and modulation of gastrointestinal
motility. These receptors also modulate neuronal functions including memory, nociception, spinal reflexes
and feeding. Disruption of galanin expression or galanin receptor signaling is seen in many multifactoral
conditions, suggesting a role in the development and/or pathology of certain diseases. These include
Alzheimer's disease, epilepsy, diabetes, alcoholism, neuropathic pain and cancer.

Gene Wiki entry for GALR1 (Galanin receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the GALR1 gene promoter:
         Bach1   AhR   FOXD3   S8   PPAR-gamma1   POU2F1   POU2F1a   Msx-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGALR1 promoter sequence
   Search Chromatin IP Primers for GALR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GALR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q23   Ensembl cytogenetic band:  18q23   HGNC cytogenetic band: 18q23

GALR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GALR1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P074962:  view genomic region     (about GC identifiers)

Start:
74,962,008 bp from pter      End:
74,982,098 bp from pter
Size:
20,091 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GALR1_HUMAN, P47211 (See protein sequence)
Recommended Name: Galanin receptor type 1  
Size: 349 amino acids; 38953 Da
Secondary accessions: Q4VBL7

Explore the universe of human proteins at neXtProt for GALR1: NX_P47211

Explore proteomics data for GALR1 at MOPED

Post-translational modifications: 

  • Palmitoylated on at least one of the three cysteine residues present in the C-terminal part1
  • Glycosylation2 at Asn7, Asn12, Asn183
  • Modification sites at PhosphoSitePlus

  • See GALR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001471.2  
    ENSEMBL proteins: 
     ENSP00000299727  
    Reactome Protein details: P47211

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GALR: GPCR / Class A : Galanin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GAL1 receptor
    Galanin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003906 GAL1_rcpt
     IPR000405 Galanin_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P47211

    ProtoNet protein and cluster: P47211

    2 Blocks protein domains:
    IPB000405 Galanin receptor signature
    IPB003906 Galanin 1 receptor signature


    UniProtKB/Swiss-Prot: GALR1_HUMAN, P47211
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with GALR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GALR1_HUMAN, P47211
    Function: Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit
    adenylate cyclase activity

         Genatlas biochemistry entry for GALR1:
    galanin receptor 1,G protein coupled receptor superfamily,linked to voltage gated calcium channel,expressed in
    brain,also coexpressed with GALN in ciliary epithelium predominantly signaling through inhibition of adenylate
    cyclase

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004966galanin receptor activity IEA--
    GO:0005515protein binding IPI--
    GO:0042923neuropeptide binding IEA--
         
    Find genes that share ontologies with GALR1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GALR1:
     Increased HPV18 LCR reporter a 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Galr1):
     behavior/neurological  normal 

    Find genes that share phenotypes with GALR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Galr1tm1Tpi for GALR1

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    SwitchGear 3'UTR luciferase reporter plasmidGALR1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GALR1_HUMAN, P47211: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with GALR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GALR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with GALR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for GALR1
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for GALR1
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for GALR1):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GALR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GALR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GALR1 (P472111, 3 ENSP000002997274) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GALP224661, 3, ENSP000002656434EBI-6624741,EBI-6624800 I2D: score=1 STRING: ENSP00000265643
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY9ENSP000002940164STRING: ENSP00000294016
    ADORA1ENSP000003085494STRING: ENSP00000308549
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007194negative regulation of adenylate cyclase activity IEA--
    GO:0007204positive regulation of cytosolic calcium ion concentration IEA--
    GO:0007218neuropeptide signaling pathway TAS7524088

    Find genes that share ontologies with GALR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Compounds for GALR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    M617Selective GAL1 agonist[860790-38-1]
    Galanin (1-29) (rat, mouse) Non-selective galanin receptor agonist[114547-31-8]
    M40 Potent, non-selective galanin receptor antagonist [143896-17-7]
    M 1145Potent and selective GAL2 agonist[1172089-00-7]
    M871Selective GAL2 antagonist[908844-75-7]

    Selected IUPHAR Ligands for GALR1 (GAL1 receptor) (see all 52)    About this table
    LigandTypeActionAffinityPubmed IDs
    M35
    AntagonistAntagonist10.49168941
    galanin
    AgonistFull agonist9.57 - 9.8911481429 9685625 9168941
    galanin
    AgonistFull agonist9.899685625
    M32
    AntagonistAntagonist9.59 - 9.7411600206 9880084
    M617
    AgonistAgonist9.64--
    M242
    AgonistAgonist9.611600206
    galanin(1-19) (human)
    AgonistAgonist9.479168941
    Gal-(K)4
    AgonistAgonist9.419199479
    [Sar1, D-Ala12]galanin(1-16)
    AgonistAgonist9.411491429
    Gal-B2-MPEG4
    AgonistAgonist9.319199479

    3 Novoseek inferred chemical compound relationships for GALR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    galp 76.8 1 15944009 (1)
    adenylate 34.3 3 17982695 (2), 9832121 (1)
    calcium 0 2 9832121 (1), 11567049 (1)



    Find genes that share compounds with GALR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GALR1 gene: 
    NM_001480.3  

    Unigene Cluster for GALR1:

    Galanin receptor 1
    Hs.272191  [show with all ESTs]
    Unigene Representative Sequence: NM_001480
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299727(uc002lms.4) ENST00000582943
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    Additional mRNA sequence: 

    AY541036.1 BC095530.1 L34339.1 U23854.1 U53511.1 

    1 DOTS entry:

    DT.75139260 

    10 AceView cDNA sequences:

    BF445747 U23854 BX282079 NM_001480 U53511 BV198993 CF147813 AA952998 
    AY541036 L34339 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GALR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATATTAA
    GALR1 Expression
    About this image


    GALR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             Olfactory Bulb   
    GALR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GALR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.272191
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GALR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GALR1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Galr11 , 5 galanin receptor 11, 5 87.64(n)1
    92.24(a)1
      18 (55.78 cM)5
    144271  NM_008082.21  NP_032108.11 
     823924965 
    chicken
    (Gallus gallus)
    Aves GALR11 galanin receptor 1 85.39(n)
    89.2(a)
      428512  NM_001128062.1  NP_001121534.1 
    lizard
    (Anolis carolinensis)
    Reptilia GALR16
    Uncharacterized protein
    78(a)
    1 ↔ 1
    4(51161839-51195455)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia galr11 galanin receptor 1 75.78(n)
    85.4(a)
      100135180  NM_001113883.1  NP_001107355.1 
    zebrafish
    (Danio rerio)
    Actinopterygii galr11 galanin receptor 1 70.28(n)
    74.61(a)
      567820  XM_691123.2  XP_696215.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AlstR3 G-protein coupled receptor protein
    signaling pathway more
    39(a)
    (best of 2)
      1 3E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea ZK455.33
    CELE_Y54E2A.11
    G-protein coupled receptor3
    CELE_Y54E2A.11
    30(a)3
    43.13(n)1
    34.77(a)1
      X(11363821-11367302)3
    1751311  NM_064656.51  NP_497057.21 


    ENSEMBL Gene Tree for GALR1 (if available)
    TreeFam Gene Tree for GALR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GALR1 gene
    SSTR32  OPRL12  OPRK12  NPBWR12  OPRD12  KISS1R2  SSTR42  GALR22  
    SSTR52  MCHR22  SSTR12  GALR32  SSTR22  MCHR12  OPRM12  NPBWR22  
    Selected SIMAP similar genes for GALR1 using alignment to 1 protein entry:     GALR1_HUMAN(see all similar genes):
    GALR2    CMKLR1    GPR18    GALR3    OPRD1    PRLHR
    SSTR2    SSTR3    BRS3    CHRM2    OPRK1    SSTR1
    OPRM1    QRFPR    CCR5    NPY2R    KISS1R    LTB4R

    Find genes that share paralogs with GALR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for GALR1 (see all 647)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1821296221,2
    --74812044(+) GTTAGC/TAATAA 1 -- us2k10--------
    rs1880591201,2
    C--74812175(+) AGGAAA/GGCTGT 1 -- us2k10--------
    rs782994441,2
    --74812273(+) CAAAAC/TATGTA 1 -- us2k10--------
    rs1415903051,2
    C--74812346(+) ATATA-/TTAT  
            
    TTAAG
    1 -- us2k10--------
    rs1910327001,2
    C--74812425(+) GAGATA/TGTGGG 1 -- us2k10--------
    rs1391513851,2
    C--74812429(+) TAGTG-/GGAGAGGT 1 -- us2k10--------
    rs1471538601,2
    C--74812740(+) AGGTCA/G/TGGGCA 1 -- us2k10--------
    rs1831411991,2
    --74812847(+) CCTTGC/TAAGGA 1 -- us2k10--------
    rs1883276101,2
    --74812873(+) ATGTAC/GATAAA 1 -- us2k10--------
    rs1403447251,2
    C--74813037(+) ACTGCA/GTCCGC 1 -- us2k10--------
    rs1441924501,2
    --74813040(+) GCGTCC/GGCGCA 1 -- us2k10--------
    rs1474393881,2
    --74813052(+) AATGGA/GCAGTC 1 -- us2k10--------
    rs46210621,2
    C,F,A,H--74813067(-) CATTCA/TCCATC 1 -- us2k112Minor allele frequency- T:0.37EA NS NA CSA WA 682
    rs129654791,2
    C,F--74813314(+) AATACA/GAGGCA 1 -- us2k1 tfbs37Minor allele frequency- G:0.06NA CSA WA EA 366
    rs729786911,2
    C--74813351(+) AACAGC/ACTTCC 1 -- us2k15Minor allele frequency- A:0.38NA CSA WA EA 362
    rs1930360361,2
    --74813394(+) CACGCA/GGCCCT 1 -- us2k10--------
    rs1848546631,2
    --74813414(+) CACTTC/GTCTCC 1 -- us2k10--------
    rs116620101,2
    C,F,A,H--74813428(+) GTAGCA/GGGCCG 1 -- us2k119Minor allele frequency- G:0.39NS EA NA CSA WA 2344
    rs72429191,2
    C,F,A,H--74813666(+) TGGCCC/GGCGGC 1 -- us2k16Minor allele frequency- G:0.44NA WA 248
    rs2018397281,2
    --74813666(+) TGGCC-/CGCGGCA 1 -- us2k10--------
    rs1484753881,2
    --74813699(+) CCGCCC/GGGCAG 1 -- us2k10--------
    rs111510141,2
    C,F,A,H--74813706(+) GCAGGT/GCCGCA 1 -- us2k16Minor allele frequency- G:0.38NA CSA WA EA 366
    rs111510151,2
    C,F,A,H--74813718(+) TCCGCA/GGAGGC 1 -- us2k18Minor allele frequency- G:0.36NA CSA WA EA 370
    rs1164293131,2
    F--74813734(+) CGCTCC/TGGTTC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs750083301,2
    C,F--74813735(+) GCTCCG/AGTTCC 1 -- us2k11Minor allele frequency- A:0.12EA 120
    rs801311131,2
    C,F--74814017(+) GAGCCT/CTCTCT 1 -- us2k12Minor allele frequency- C:0.07NA EA 240
    rs350611751,2
    C,F--74814033(+) AGCCGC/TACAGT 1 -- us2k16Minor allele frequency- T:0.08NA CSA EA 247
    rs53711,2
    C--74814114(+) CGCAGC/GCCCTC 1 -- ut51 ese35Minor allele frequency- G:0.18MN NA WA 504
    rs53721,2
    C,F--74814116(+) CAGCCG/CCTCCG 1 -- ut51 ese38Minor allele frequency- C:0.46MN NA WA EA 628
    rs133063741,2
    C,F,H--74814255(+) CCGGGA/CAGGGG 1 -- ut51 trp317Minor allele frequency- C:0.38NS EA NA CSA WA 2338
    rs53731,2
    C,F,H--74814342(+) AGGTCC/GCGGCG 1 -- ut51 ese310Minor allele frequency- G:0.47MN EA NS NA CSA WA 742
    rs133063751,2
    C,F--74814478(+) CGCCTA/GCTATC 1 -- ut51 ese34Minor allele frequency- G:0.40NA WA 242
    rs1426604601,2
    C--74814505(+) CGCGCA/CCCGCC 1 -- ut510--------
    rs2014619491,2
    C--74814557(+) GGAACC/TTCAGC 2 L F mis10--------
    rs2004739441,2
    C--74814594(+) CCCCGA/CCCCGG 2 D A mis10--------
    rs53741,2
    C,F,H--74814676(+) CTGGGC/TGTGCT 2 G syn125Minor allele frequency- T:0.43MN NS EA NA CSA WA EU 8002
    rs1880679601,2
    --74814738(+) GCGGAA/GCACCA 2 N S mis10--------
    rs1913097791,2
    C--74814773(+) GCATCA/GCCGAC 2 T A mis10--------
    rs1402168811,2
    C,F--74814825(+) GTACGC/TGCTGC 2 A V mis11Minor allele frequency- T:0.00NA 4544
    rs53751,2
    C,F,H--74814841(+) TGGGTG/TCTGGG 2 V syn1 ese322Minor allele frequency- T:0.07MN NS EA NA CSA WA EU 8418
    rs2019009691,2
    C--74814916(+) CTGGCA/C/TGCGAT 3 A syn10--------
    rs1410654711,2
    C,F--74814983(+) TGTCCC/GGCAAC 2 R G mis11Minor allele frequency- G:0.00NA 4494
    rs1492938131,2
    C,F--74815039(+) GCCTCG/ACCCGT 2 /S syn11Minor allele frequency- A:0.00NA 4500
    rs1509874481,2
    C--74815047(+) CGTGGC/TCTACC 2 A V mis10--------
    rs1445639981,2
    C--74815118(+) ACCCTC/TGCCAC 2 R C mis11Minor allele frequency- T:0.00NA 4520
    rs44161011,2
    C,F,H--74815217(-) GGCCCC/AGCGAC 1 -- int15Minor allele frequency- A:0.08NS NA WA 618
    rs753932751,2
    C,F--74815258(+) GGGGGC/TCCTGG 1 -- int13Minor allele frequency- T:0.07CSA WA EA 240
    rs780651211,2
    C,F--74815409(+) GTTACT/CTGGAG 1 -- int11Minor allele frequency- C:0.07EA 120
    rs802035691,2
    C--74815564(+) TTCCCG/CGTACA 1 -- int14Minor allele frequency- C:0.10CSA WA NA EA 360
    rs744774061,2
    C,F--74815578(+) AACCCC/TGCTCG 1 -- int11Minor allele frequency- T:0.08WA 118
    rs726185571,2
    C--74815583(+) CGCTCG/CGTTCC 1 -- int13Minor allele frequency- C:0.27WA NA EA 242
    rs1895043081,2
    C--74815626(+) AGGTTA/GCCGCC 1 -- int10--------
    rs745852281,2
    C,F--74815664(+) CTGGTG/AGTCAC 1 -- int11Minor allele frequency- A:0.05EA 120
    rs348432081,2
    C,F--74815796(+) CGCTCC/GGAAGG 1 -- int13Minor allele frequency- G:0.33NA 6
    rs734862041,2
    C--74815834(+) CGCTGC/GTCCCG 1 -- int13Minor allele frequency- G:0.22WA EA 240
    rs1147233571,2
    F--74815848(+) ACAGAG/ACCTCG 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1854243581,2
    --74815854(+) CCTCGA/GATTTT 1 -- int10--------
    rs1900761901,2
    --74815877(+) AGCTTA/GGCTTT 1 -- int10--------
    rs1131560721,2
    C,F--74815901(+) CAAAAG/AGGTGT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs734862051,2
    C,F--74816033(+) GGCGGG/ATCTTC 1 -- int15Minor allele frequency- A:0.21WA CSA EA 244
    rs1863848231,2
    --74816101(+) ACAGCC/TGGGCA 1 -- int10--------
    rs1408092321,2
    C--74816134(+) TTCTCA/CTTAAG 1 -- int10--------
    rs1443005441,2
    C--74816164(+) TTTATA/GCTGAT 1 -- int10--------
    rs1886466121,2
    --74816283(+) TCCTCA/GCTCCA 1 -- int10--------
    rs129538281,2
    C,F,H--74816374(+) TGACTA/GTACGA 1 -- int120Minor allele frequency- G:0.05NS EA NA CSA WA 2345
    rs129615471,2
    C,F--74816526(+) AATAAT/CATTGC 1 -- int18Minor allele frequency- C:0.07NA CSA WA EA 368
    rs1810748381,2
    --74816600(+) GAGGCC/TGAGGT 1 -- int10--------
    rs19445461,2
    C--74816625(-) ATTCCT/CGACCT 1 -- int14Minor allele frequency- C:0.12NA WA CSA 8
    rs1852370781,2
    C--74816703(+) GGTGGA/CGGGCC 1 -- int10--------
    rs1134648771,2
    C--74816728(+) TACTCT/CGGAGG 1 -- int12Minor allele frequency- C:0.25WA CSA 4
    rs1449714711,2
    C--74816743(+) GACAGA/GAGAAT 1 -- int10--------
    rs1165998351,2
    C,F--74816775(+) GGGTGC/TAGTGA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1140024251,2
    F--74816787(+) CCGAAA/CTCGTG 1 -- int11Minor allele frequency- C:0.14WA 118
    rs50033881,2
    F--74816892(-) tggtgG/Atggtg 1 -- int12Minor allele frequency- A:0.50NA 4
    rs1911821951,2
    --74817060(+) AAATGG/TCTGGT 1 -- int10--------
    rs1834553841,2
    --74817163(+) CTCTGC/TGGCTT 1 -- int10--------
    rs1490131101,2
    C--74817203(+) ATTATA/TTAAGG 1 -- int10--------
    rs1164160281,2
    C,F--74817217(+) AAGAGC/ATTTGG 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1437956561,2
    --74817397(+) AGAACG/TGAAGC 1 -- int10--------
    rs1872541181,2
    --74817406(+) GCACAC/TGCTTC 1 -- int10--------
    rs285386301,2
    F--74817545(+) CATGGA/GTAGGT 1 -- int10--------
    rs797298031,2
    C,F--74817592(+) TCAGGC/AATTAG 1 -- int11Minor allele frequency- A:0.01EA 120
    rs116641161,2
    C,F,A,H--74817765(+) GCATTC/GCAGAG 1 -- int17Minor allele frequency- G:0.19NA CSA WA EA 366
    rs557525781,2
    C,F--74817797(+) TCACAA/GGTTTG 1 -- int17Minor allele frequency- G:0.35WA NA EA 366
    rs284020931,2
    C--74817807(+) GTAAGC/GGAGCA 1 -- int10--------
    rs1146585551,2
    C,F--74817813(+) GAGCAG/ATCTTT 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1439892741,2
    C--74817865(+) GGGAGA/GATGAG 1 -- int10--------
    rs129619091,2
    C,A--74817967(+) CCTTAG/AAGTGA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1471771311,2
    --74818028(+) CCACTA/CGACTA 1 -- int10--------
    rs72367531,2
    C,F,H--74818126(+) ACTCAG/CCAAGA 1 -- int14Minor allele frequency- C:0.25EA NS WA 408
    rs1387124931,2
    --74818167(+) TAAACA/GTCGTC 1 -- int10--------
    rs48909211,2
    C,F,A,H--74818195(+) CTACAT/CTCTTC 1 -- int1 trp310Minor allele frequency- C:0.18EA NS NA WA CSA 546
    rs72415641,2
    C,F--74818199(+) ATTCTT/CCCTCC 1 -- int1 trp37Minor allele frequency- C:0.16NA CSA WA EA 366
    rs48909221,2
    C,F,A--74818213(+) GCTGCT/CGAGAC 1 -- int110Minor allele frequency- C:0.28NA WA CSA EA 372
    rs1834904851,2
    --74818224(+) CTTCAA/GTGGGG 1 -- int10--------
    rs27171571,2
    C,F,A--74818271(+) GCTATT/CGAAGA 1 -- int18Minor allele frequency- C:0.16NA WA CSA EA 368
    rs1165004601,2
    C,F--74818280(+) GAGAAG/ACAGAG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1125254691,2
    F--74818326(+) CCATTC/TAACAG 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs621052091,2
    C,F--74818337(+) CATTCA/CACATT 1 -- int15Minor allele frequency- C:0.18NA CSA WA EA 362
    rs751378801,2
    C,F--74818492(+) GCCTCT/GCCTGT 1 -- int11Minor allele frequency- G:0.09WA 118
    rs1916632251,2
    --74818592(+) TTGGGC/TAGGGT 1 -- int10--------
    rs28508821,2
    C,F,A--74818658(-) CAGGGG/ATTTCC 1 -- int110Minor allele frequency- A:0.47NA WA CSA EA 371
    rs1427125301,2
    --74818709(+) TCGGCA/TGGTAG 1 -- int10--------
    rs800512071,2
    C,F--74818725(+) TAAACT/GAACAC 1 -- int11Minor allele frequency- G:0.07NA 120
    rs1822890681,2
    --74818796(+) TGCAGA/TTGTTG 1 -- int10--------
    rs1159606841,2
    C,F--74818819(+) AGGAAG/ATGGGA 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1866055591,2
    --74818866(+) TTCACA/GTCCCT 1 -- int10--------
    rs99654321,2
    C,F--74818870(+) CGTCCC/GTGGGG 1 -- int15Minor allele frequency- G:0.27WA CSA EA 244
    rs72274591,2
    C,F,A,H--74818880(+) GTGGCA/TGCTTG 1 -- int111Minor allele frequency- T:0.47NA WA CSA EA 373
    rs1911449501,2
    --74818898(+) GCATAC/GGGCCT 1 -- int10--------
    rs1855683311,2
    --74818940(+) AAGTAA/GGGTGT 1 -- int10--------
    rs1173260111,2
    F--74819010(+) CAATTC/TGATTA 1 -- int11Minor allele frequency- T:0.01EA 120
    rs1507240731,2
    --74819066(+) CTTCCA/GGTTCC 1 -- int10--------
    rs99656521,2
    C,F,A--74819101(+) AGATGC/ATCTAA 1 -- int15Minor allele frequency- A:0.27WA CSA EA 244
    rs1904765311,2
    --74819118(+) TAGTCA/GCCCTG 1 -- int10--------
    rs729786951,2
    C--74819190(+) TTCTGC/GAGGCT 1 -- int10--------
    rs99651421,2
    C,F,A--74819311(+) TTTCTG/TTAATT 1 -- int110Minor allele frequency- T:0.19NA WA CSA EA 372
    rs124589851,2
    C,F,H--74819401(+) TCAGTG/AACGCT 1 -- int12Minor allele frequency- A:0.08NA EA 124
    rs762550491,2
    C,F--74819403(+) AGTGAC/TGCTGA 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1120262921,2
    C,F--74819404(+) GTGACG/ACTGAA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs19445451,2
    C,F,O,A,H--74819413(-) TATTGA/GGGATT 1 -- int126Minor allele frequency- G:0.19MN NS EA NA WA CSA 2539
    rs28508811,2
    C,H--74819495(-) CCGTAC/TGGCAA 1 -- int112Minor allele frequency- T:0.08NA WA CSA EA 375
    rs27171591,2
    C,H--74819498(+) CCATAA/CGGAGA 1 -- int111Minor allele frequency- C:0.08WA NA CSA EA 373
    rs1177366881,2
    F--74819509(+) ATTGCA/GGTGGA 1 -- int11Minor allele frequency- G:0.02EA 120
    rs1152561001,2
    C,F--74819544(+) AGAATA/GTTTTG 1 -- int11Minor allele frequency- G:0.02WA 118
    rs27171601,2
    C,F,A,H--74819557(+) ACAAAT/CGCTGG 1 -- int111Minor allele frequency- C:0.44NA WA CSA EA 376
    rs621052101,2
    C,F--74819634(+) CTTTCC/TGCATC 1 -- int15Minor allele frequency- T:0.19CSA WA NA EA 362
    rs124572811,2
    C,A,H--74819653(+) AATTTC/TGGAAG 1 -- int18Minor allele frequency- T:0.17WA NA CSA EA 367
    rs124540151,2
    C,A,H--74819654(+) ATTTTA/GGAAGG 1 -- int17Minor allele frequency- G:0.42WA NA EA 366
    rs27171611,2
    C,F,A,H--74819680(+) TTCGAC/TGCATC 1 -- int111Minor allele frequency- T:0.48NA WA CSA EA 376
    rs127170411,2
    C,F--74819716(+) GTAGCA/GGGGAC 1 -- int17Minor allele frequency- G:0.09NA CSA WA EA 366
    rs1133004911,2
    C,F--74819746(+) GGGGTC/ACTGGA 1 -- int12Minor allele frequency- A:0.04CSA WA 120
    rs3745275211,2
    C--74819809(+) GGCTG-/GTTTTCT 1 -- int10--------
    rs99599241,2
    C,F,A,H--74819883(+) TTGTCT/CGGCTG 1 -- int122Minor allele frequency- C:0.25NS EA NA WA CSA 2347
    rs1125589811,2
    C,F--74819935(+) TGTATT/CTGGCA 1 -- int12Minor allele frequency- C:0.04CSA WA 122
    rs1929860331,2
    C--74820072(+) TGAGGC/TGAACT 1 -- int10--------
    rs1440973141,2
    C--74820073(+) GAGGCA/GAACTG 1 -- int10--------
    rs1489350121,2
    C--74820083(+) GATTTC/TAATAG 1 -- int11Minor allele frequency- T:0.00EU 1323
    rs1887938781,2
    C--74820088(+) CAATAA/GTCTGT 1 -- int10--------
    rs1483180411,2
    F--74820103(+) TTCAGG/TTCCTT 2 V F mis11Minor allele frequency- T:0.00NA 4528
    rs1486774241,2
    C--74820137(+) GAACAG/TGTCAA 2 R M mis10--------
    rs2001111211,2
    C--74820161(+) ATCCAA/GGAAAA 2 K R mis10--------
    rs1501408711,2
    C--74820182(+) CACAA-/ATATATA 1 -- int10--------
    rs1433693011,2
    C--74820209(+) TCAGAA/GCTTAG 1 -- int10--------
    rs1148291541,2
    C,F--74820244(+) CCTCAC/TGTCCA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs72277221,2
    C,F,H--74820284(+) GTGTGG/ACTAAG 1 -- int18Minor allele frequency- A:0.14NS EA WA CSA 652
    rs27171621,2
    C,F,A,H--74820316(+) ACCGTT/CAGGAT 1 -- int121Minor allele frequency- C:0.40NS EA NA WA CSA 2344
    rs1139351761,2
    C,F--74820338(+) GTCGGC/TCTTGG 1 -- int12Minor allele frequency- T:0.05CSA WA 122
    rs27171631,2
    C,F,A--74820353(+) GGCACC/TGTGGG 1 -- int15Minor allele frequency- T:0.26WA CSA EA 243
    rs1139984331,2
    C,F--74820359(+) GTGGGT/CCACTC 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1144401401,2
    C,F--74820365(+) CACTCC/TGTGCT 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1465878091,2
    --74820418(+) GGATTA/CTGCTG 1 -- int10--------
    rs1151924371,2
    C,F--74820431(+) TGTGCG/CCCTCA 1 -- int11Minor allele frequency- C:0.03WA 118
    rs570179141,2
    C--74820446(+) GAGGT-/GA/   
       TGCTT
    GTGCA
    1 -- int10--------
    rs799323111,2
    C--74820447(+) AGGTGA/TGTGCA 1 -- int10--------
    rs2011336931,2
    C--74820449(+) GTGAG-/TGCA  
            
    CTTAG
    1 -- int10--------
    rs718289591,2
    C--74820451(+) GAGTG-/CACTTAG 1 -- int10--------
    rs3712477621,2
    C--74820471(+) GACAG-/GAGAGTGC 1 -- cds10--------
    rs1812114731,2
    --74820517(+) AAAGTA/GTAGTC 1 -- int10--------
    rs27171641,2
    C,F,A,H--74820545(+) CAATCT/GCTGAT 1 -- int122Minor allele frequency- G:0.21NS EA NA WA CSA 2482
    rs1855803981,2
    --74820559(+) ATTCCA/GAAAAG 1 -- int10--------
    rs1412871151,2
    C--74820578(+) TGGTTC/TTTGTT 1 -- int10--------
    rs1166714121,2
    F--74820590(+) AAGACA/GACATT 1 -- int11Minor allele frequency- G:0.03WA 118
    rs28508801,2
    C,F--74820593(-) AACAAT/CGTTGT 1 -- int110Minor allele frequency- C:0.43NA WA CSA EA 372
    rs781497411,2
    C,F--74820632(+) CTGGGC/GCATTC 1 -- int13Minor allele frequency- G:0.05WA NA EA 358
    rs784372221,2
    F--74820721(+) CTCCCG/ATTGCT 1 -- int11Minor allele frequency- A:0.01WA 118
    rs764405111,2
    C,F--74820759(+) ATTTAA/GACAAG 1 -- int12Minor allele frequency- G:0.07NA EA 240
    rs1883593961,2
    C--74820808(+) GGTCAC/TGATAT 1 -- int10--------
    rs1436673231,2
    C--74821052(+) ATTATA/GGTTTA 1 -- int10--------
    rs1512526261,2
    --74821061(+) TAGATC/TATGTT 1 -- int10--------
    rs1806725741,2
    --74821228(+) TTTTTC/TCCCTG 1 -- int10--------
    rs1404207951,2
    --74821259(+) GTTAGA/CAATGC 1 -- int10--------
    rs343015661,2
    C,F--74821266(+) ATGCAA/GTCATA 1 -- int15Minor allele frequency- G:0.05NA EA 246
    rs621052111,2
    C,F--74821273(+) CATACA/GGTGTT 1 -- int12Minor allele frequency- G:0.05NA 122
    rs1504952861,2
    C--74821303(+) TACAAA/GGTGCA 1 -- int10--------
    rs28508791,2
    C,F,H--74821311(-) ATTTAT/CACTGC 1 -- int16Minor allele frequency- C:0.01NS EA NA WA 406
    rs1162742451,2
    C,F--74821327(+) GACCAT/CGCTAT 1 -- int11Minor allele frequency- C:0.07WA 118
    rs739719251,2
    C,F--74821345(+) TTCCAC/TTGATC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs751769711,2
    C,F--74821438(+) GTTATA/GTGAAT 1 -- int11Minor allele frequency- G:0.09WA 118
    rs354163671,2
    C,F--74821504(+) ATGGTA/GGAGAT 1 -- int14Minor allele frequency- G:0.08NA EA 244
    rs1383225931,2
    C--74821584(+) CTTTAA/GAGACA 1 -- int10--------
    rs1167556391,2
    C,F--74821645(+) GCTCTG/ATGTAG 1 -- int11Minor allele frequency- A:0.05WA 118
    rs28508781,2
    C,F,A,H--74821651(-) TTGGTC/TCTACA 1 -- int130Minor allele frequency- N:0.00EA NA NS WA CSA 2568
    rs27171661,2
    C,F,A,H--74821662(+) GCCGAC/TCCAGG 1 -- int110Minor allele frequency- T:0.32WA NA CSA EA 371
    rs348766981,2
    C,F--74821690(+) GGCTCC/TGCATG 1 -- int18Minor allele frequency- T:0.10NA WA EA 546
    rs99663131,2
    C,F,A,H--74821706(+) CAACAC/TTGTAA 1 -- int111Minor allele frequency- T:0.32NA WA CSA EA 374
    rs28508771,2
    C,F,A,H--74821722(-) ACATTG/TATCTC 1 -- int17Minor allele frequency- T:0.01NS EA NA 562
    rs1467137511,2
    C--74821727(+) CAATGC/TGTGAG 1 -- int10--------
    rs28508761,2
    C,F,A--74821738(-) GGCCTC/TTGGGA 1 -- int14Minor allele frequency- T:0.03NA WA 260
    rs1392138651,2
    --74821751(+) TTCAAC/GGGGGC 1 -- int10--------
    rs1922444181,2
    --74821752(+) TCAAGC/GGGGCA 1 -- int10--------
    rs1836237471,2
    --74821814(+) GGCTCA/GTCAAA 1 -- int10--------
    rs1857780861,2
    --74821831(+) CTGAGA/GAGACA 1 -- int10--------
    rs1902379811,2
    --74821837(+) AGACAC/TCATTG 1 -- int10--------
    rs1427591901,2
    C--74821849(+) TCTGTC/GATAAA 1 -- int10--------
    rs1825832641,2
    --74821899(+) GAAATA/GAAACC 1 -- int10--------
    rs1868373911,2
    --74821942(+) TGTGTC/TGATGG 1 -- int10--------
    rs801199291,2
    F--74821977(+) AAGTAT/CTGGAG 1 -- int11Minor allele frequency- C:0.01EA 120
    rs99516961,2
    C,F,H--74822090(+) GATCAG/ATGATT 1 -- int14Minor allele frequency- A:0.01NS EA 420
    rs1479827421,2
    C--74822199(+) CATATA/GCTAAA 1 -- int10--------
    rs1143161401,2
    F--74822248(+) TGAGGA/GTCTAG 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1997552651,2
    --74822357(+) TGCCT-/CCTTGT 1 -- int10--------
    rs1429802231,2
    --74822837(+) GTGGT-/GGGTGG 1 -- int10--------
    rs3712030711,2
    C--74822850(+) ATGTGA/GTGGTG 1 -- int10--------
    rs1144707731,2
    C--74822904(+) TGATGA/GCAATT 1 -- int10--------
    rs1457930081,2
    C--74822976(+) TGGTGA/GTGGTG 1 -- int10--------
    rs1469988541,2
    C--74822994(+) TGGTGA/GTGATG 1 -- int10--------
    rs1417733421,2
    C--74823110(+) GGTGA-/TGGTGGTG 1 -- int10--------
    rs1505009361,2
    C--74823245(+) GTGGA-/TGGATGGT 1 -- cds10--------
    rs1897104451,2
    C--74823400(+) TGGTGA/GTGTTG 1 -- int10--------
    rs2004099971,2
    C--74823424(+) TCATGA/GTGGTC 1 -- int10--------
    rs1806901041,2
    C--74823443(+) GATGAC/TGGTGG 1 -- int10--------
    rs1861289331,2
    C--74823448(+) TGGTGA/GTGATG 1 -- int10--------
    rs1918382181,2
    C--74823518(+) TGGTGA/GTGTTG 1 -- int10--------
    rs2013204091,2
    C--74823547(+) GTGGTC/TATGGT 1 -- int10--------
    rs1996585541,2
    C--74823579(+) GATGAC/TGGTGA 1 -- int10--------
    rs1133016011,2
    C--74823840(+) TGGTGG/ATGGTG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1913146161,2
    --74823873(+) TATGTA/GTGTGT 1 -- int10--------
    rs1479563601,2
    C--74823877(+) TGTGTA/GTCTAA 1 -- int10--------
    rs1417950231,2
    --74823985(+) CAGGAC/GAGGTG 1 -- int10--------
    rs1437556441,2
    --74824058(+) GGGTTG/TGTCCA 1 -- int10--------
    rs1827955671,2
    --74824159(+) ATTTGC/GCTACT 1 -- int10--------
    rs1509658631,2
    --74824193(+) GTATAA/CGTAAA 1 -- int10--------
    rs745402851,2
    C,F--74824211(+) TTCTCA/TGCTCT 1 -- int13Minor allele frequency- T:0.03WA NA EA 358
    rs1162145401,2
    --74824236(+) TAGTAC/TGTTCA 1 -- int10--------
    rs1407899851,2
    --74824256(+) AAGAAA/GATACC 1 -- int10--------
    rs1889570211,2
    --74824297(+) TTTATA/TTCTTG 1 -- int10--------
    rs744944151,2
    C,F--74824322(+) GGAAGC/TCTGAA 1 -- int13Minor allele frequency- T:0.03WA NA EA 358
    rs778837221,2
    C--74824492(+) GGCAGC/GTCTCT 1 -- int13Minor allele frequency- G:0.05CSA WA NA 240
    rs1501059251,2
    --74824536(+) CCTCAC/TAGGGT 1 -- int10--------
    rs1177086531,2
    C,F--74824580(+) CATAAG/AGGCAC 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1932301481,2
    --74824585(+) GGGCAC/TGGATC 1 -- int10--------
    rs798636691,2
    C,F--74824586(+) GGCACG/AGATCC 1 -- int11Minor allele frequency- A:0.05WA 118
    rs795789301,2
    C--74824592(+) GATCCC/GATTAT 1 -- int14Minor allele frequency- G:0.04CSA WA NA EA 360
    rs794192311,2
    F--74824610(+) CCCCCC/TACCTC 1 -- int11Minor allele frequency- T:0.02WA 118
    rs28508861,2
    C,F,H--74824656(+) ataccA/Gtcacc 1 -- int14Minor allele frequency- G:0.01NS EA 404
    rs1128319631,2
    C,F--74824689(+) TGAATT/ATTTTG 1 -- int12Minor allele frequency- A:0.06CSA WA 120
    rs1116879771,2
    C,F--74824732(+) CCGCCG/ATCCAT 1 -- int12Minor allele frequency- A:0.07CSA WA 120
    rs1130921301,2
    C--74824740(+) CATACG/AGGGCT 1 -- int14Minor allele frequency- A:0.05CSA WA NA EA 360
    rs1402322361,2
    --74824890(+) ATCACA/GTGCTT 1 -- int10--------
    rs795850831,2
    C,F--74824900(+) TTTCTT/CAAACT 1 -- int11Minor allele frequency- C:0.05NA 120
    rs1170234661,2
    F--74824961(+) TGGAAG/AACCTC 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1385633491,2
    C--74825005(+) TTCCT-/GGAGAA 1 -- int10--------
    rs351560151,2
    C--74825152(+) TTTTT-/A/T/TT
            
    ATCAT
    1 -- int11NA 2
    rs1143121501,2
    F--74825386(+) ATTTAG/ACACAT 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1852978291,2
    --74825401(+) TTAAAC/TAATAA 1 -- int10--------
    rs1173269061,2
    C,F--74825438(+) GAGATT/CCTATA 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1891242511,2
    --74825445(+) TATACG/TCTAAA 1 -- int10--------
    rs1920322311,2
    --74825475(+) GTGCAC/GACACA 1 -- int10--------
    rs1381113301,2
    --74825499(+) TCTGAC/TGGAGA 1 -- int10--------
    rs99616221,2
    C,F,A,H--74825522(+) TAAGAG/CAGTAG 1 -- int111Minor allele frequency- C:0.12NS EA NA WA 784
    rs734862241,2
    C,F--74825591(+) TCTCTA/GTGTTA 1 -- int12Minor allele frequency- G:0.10WA 120
    rs1841982291,2
    --74825681(+) CAACGA/GAAATG 1 -- int10--------
    rs1495168261,2
    --74825727(+) TCACGC/TTCCTG 1 -- int10--------
    rs741826951,2
    C--74825747(+) TGTTTTGTTACT 
    TTCTGA
    /-
    TGTTA
    1 -- int11Minor allele frequency- -:0.50NA 2
    rs1885273921,2
    --74826085(+) GCCTCC/TTGCAT 1 -- int10--------
    rs760293131,2
    C,F--74826107(+) CACGTG/ACACAC 1 -- int11Minor allele frequency- A:0.06NA 120
    rs1810426301,2
    --74826148(+) TTTTTG/TAAAGG 1 -- int10--------
    rs1440608101,2
    C--74826160(+) GGGGAC/TTCAGG 1 -- int10--------
    rs1482373311,2
    --74826203(+) TCAAGC/TGATCC 1 -- int10--------
    rs791829761,2
    C,F--74826262(+) TTATCT/GGGCTG 1 -- int12Minor allele frequency- G:0.04WA NA 238
    rs1418962891,2
    --74826351(+) CTATCC/TGAATT 1 -- int10--------
    rs773965111,2
    F--74826413(+) CTTAAA/GTCCCA 1 -- int11Minor allele frequency- G:0.01WA 118
    rs98072081,2
    C,F,H--74826437(+) TACACG/ATGCAT 1 -- int126Minor allele frequency- A:0.43NS EA NA WA CSA 2764
    rs1844697561,2
    --74826636(+) TTTCAA/GCCATG 1 -- int10--------
    rs1176010551,2
    C,F--74826639(+) CAACCA/GTGCAC 1 -- int11Minor allele frequency- G:0.03NA 120
    rs1147266621,2
    F--74826736(+) CATGGA/GGTTGG 1 -- int11Minor allele frequency- G:0.01WA 118
    rs558155151,2
    C,F--74826918(+) ATTAAG/TCCTTC 1 -- int16Minor allele frequency- T:0.19NA CSA WA EA 363
    rs1905026141,2
    --74826978(+) GCTGGC/TAAACC 1 -- int10--------
    rs1823256131,2
    --74827100(+) GAGAAA/TACACT 1 -- int10--------
    rs558301181,2
    C,F--74827116(+) CTCAGG/AGCACA 1 -- int15Minor allele frequency- A:0.18NA CSA WA EA 362
    rs1407626641,2
    --74827135(+) TGCCCG/TGTGGA 1 -- int10--------
    rs1446097861,2
    --74827166(+) TATCAA/GTAAGC 1 -- int10--------
    rs1470048141,2
    C--74827225(+) ACAAT-/GAAATG 1 -- int10--------
    rs1861255291,2
    --74827405(+) GAAGGA/CACTCC 1 -- int10--------
    rs1475453001,2
    C--74827417(+) TTAATA/GTATGT 1 -- int10--------
    rs1393989981,2
    C--74827497(+) AAACCC/GGTACT 1 -- int10--------
    rs1905866881,2
    --74827530(+) TTGTCA/GTGTTT 1 -- int10--------
    rs1500551461,2
    C--74827632(+) CAAAGC/GTCATA 1 -- int10--------
    rs1813957851,2
    --74827641(+) TACAAC/TCAGCT 1 -- int10--------
    rs10103931,2
    C,F,A,H--74827718(-) CCTATC/TGAGAG 1 -- int14Minor allele frequency- T:0.00NS EA 416
    rs1491812641,2
    --74827721(+) TCGATA/GGGGAG 1 -- int10--------
    rs729806201,2
    C,F--74827722(+) CGATAG/AGGAGC 1 -- int15Minor allele frequency- A:0.18NA CSA WA EA 362
    rs1178949771,2
    F--74827727(+) GGGAGC/ATTAAC 1 -- int11Minor allele frequency- A:0.01EA 120
    rs1856294741,2
    --74827793(+) TAGCCC/TTCCCT 1 -- int10--------
    rs75067641,2
    H--74827860(+) GATAAA/CCATCA 1 -- int14Minor allele frequency- C:0.00NS EA 394
    rs1914048201,2
    --74827926(+) CGTTAC/TAGTCT 1 -- int10--------
    rs1432747281,2
    --74827965(+) CAGTTC/TATGGG 1 -- int10--------
    rs1826745491,2
    --74827997(+) TGGCCA/GGGCAC 1 -- int10--------
    rs599510001,2
    C--74828010(+) TGGCTC/TATGCC 1 -- int10--------
    rs129693481,2
    C,F,A--74828106(+) CGTCTA/CTACTA 1 -- int15Minor allele frequency- C:0.40NA CSA 10
    rs129694821,2
    C,F,A--74828141(+) GTGGCA/GCACAC 1 -- int14Minor allele frequency- G:0.38NA CSA 8
    rs1877959301,2
    --74828194(+) TTGAAC/TGTGGG 1 -- int10--------
    rs112982351,2
    C,F--74828282(+) AAAAA-/A/AAAA
            
    AAAAA
    1 -- int1 trp32NA 4
    rs129555331,2
    C,F,H--74828342(+) CAGTGT/CGGAGC 1 -- int19Minor allele frequency- C:0.04NS EA NA 642
    rs1906373701,2
    --74828363(+) ACTGCC/TCTGTG 1 -- int10--------
    rs72432041,2
    C,F,H--74828364(+) CTGCCC/GTGTGA 1 -- int113Minor allele frequency- G:0.41NS EA NA WA CSA 730
    rs1841215801,2
    --74828416(+) AAGTCC/GTATGT 1 -- int10--------
    rs1877132781,2
    --74828443(+) TGGTGA/GGACAG 1 -- int10--------
    rs27171731,2
    C,F,H--74828537(-) AAAGAA/CTGAAA 1 -- int1 trp35Minor allele frequency- C:0.01NS EA WA 536
    rs341357171,2
    C,F--74828698(+) CTGCTC/TCATGA 1 -- int17Minor allele frequency- T:0.13NA WA EA 366
    rs1922048951,2
    --74828706(+) TGAAAC/GCCAGT 1 -- int10--------
    rs28508531,2
    C,F--74828753(-) tagcaG/Ctgcaa 1 -- int11Minor allele frequency- C:0.03WA 118
    rs344953211,2
    C,F--74828768(+) AGACAT/CACCCA 1 -- int14Minor allele frequency- C:0.14NA WA EA 244
    rs1845060661,2
    --74828926(+) GGTGGA/GAAAAG 1 -- int10--------
    rs1378665391,2
    --74828953(+) AGATCC/TCATGA 1 -- int10--------
    rs1873434901,2
    --74828968(+) TCATTC/TGCTAT 1 -- int10--------
    rs593600131,2
    C,F--74829017(+) GTTACC/TTCCTT 1 -- int12Minor allele frequency- T:0.05NA EA 240
    rs344285921,2
    C,F--74829034(+) TCCTGC/ACACCA 1 -- int13Minor allele frequency- A:0.08NA 124
    rs1501561441,2
    --74829206(+) AGCATC/TAACTC 1 -- int10--------
    rs1385889291,2
    --74829287(+) AGCACA/GTACCT 1 -- int10--------
    rs1492964781,2
    --74829377(+) AAGAGG/TCTACA 1 -- int10--------
    rs1472836411,2
    C--74829695(+) TCTGTA/GTGGGA 1 -- int10--------
    rs1928730521,