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GALR1 Gene

protein-coding   GIFtS: 65
GCID: GC18P074962

Galanin Receptor 1


(Previous symbols: GALNR1, GALNR)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Galanin Receptor 11 2
GALNR1 2 3 5
GALNR11 2 3 5
GAL1-R2 3
GALR-12 3
Galanin Receptor Type 12

External Ids:    HGNC: 41321   Entrez Gene: 25872   Ensembl: ENSG000001665737   OMIM: 6003775   UniProtKB: P472113   

Export aliases for GALR1 gene to outside databases

Previous GC identifers: GC18M074531 GC18P075110 GC18P074724 GC18P073088 GC18P073090 GC18P071642


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GALR1 Gene:
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled
receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular
second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely
expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.
(provided by RefSeq, Jul 2008)

GeneCards Summary for GALR1 Gene:
GALR1 (galanin receptor 1) is a protein-coding gene. Diseases associated with GALR1 include mood disorder, and nicotine dependence. GO annotations related to this gene include galanin receptor activity and neuropeptide binding. An important paralog of this gene is SSTR3.

UniProtKB/Swiss-Prot: GALR1_HUMAN, P47211
Function: Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit
adenylate cyclase activity

summary for GALR1 Gene:
Galanin is widely distributed in the central and peripheral nervous systems and the endocrine system. Three
different galanin receptors (GAL1-3) have been identified which are Gi/o-protein-coupled. They are highly
expressed in hypothalamic nuclei and the brainstem. In addition, they are found in proliferating zones of
the fetal and adult brain and in peripheral tissues including the pancreas, heart, skin and gastrointestinal
tract. Galanin receptors mediate a variety of physiological functions including inhibition of
glucose-induced insulin secretion, stimulation of growth hormone release and modulation of gastrointestinal
motility. These receptors also modulate neuronal functions including memory, nociception, spinal reflexes
and feeding. Disruption of galanin expression or galanin receptor signaling is seen in many multifactoral
conditions, suggesting a role in the development and/or pathology of certain diseases. These include
Alzheimer's disease, epilepsy, diabetes, alcoholism, neuropathic pain and cancer.

Gene Wiki entry for GALR1 (Galanin receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the GALR1 gene promoter:
         Bach1   AhR   FOXD3   S8   PPAR-gamma1   POU2F1   POU2F1a   Msx-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGALR1 promoter sequence
   Search Chromatin IP Primers for GALR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GALR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q23   Ensembl cytogenetic band:  18q23   HGNC cytogenetic band: 18q23

GALR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GALR1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P074962:  view genomic region     (about GC identifiers)

Start:
74,962,008 bp from pter      End:
74,982,098 bp from pter
Size:
20,091 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GALR1_HUMAN, P47211 (See protein sequence)
Recommended Name: Galanin receptor type 1  
Size: 349 amino acids; 38953 Da
Secondary accessions: Q4VBL7

Explore the universe of human proteins at neXtProt for GALR1: NX_P47211

Explore proteomics data for GALR1 at MOPED

Post-translational modifications: 

  • Palmitoylated on at least one of the three cysteine residues present in the C-terminal part1
  • Glycosylation2 at Asn7, Asn12, Asn183
  • Modification sites at PhosphoSitePlus

  • See GALR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001471.2  
    ENSEMBL proteins: 
     ENSP00000299727  
    Reactome Protein details: P47211

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GALR: GPCR / Class A : Galanin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GAL1 receptor
    Galanin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003906 GAL1_rcpt
     IPR000405 Galanin_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P47211

    ProtoNet protein and cluster: P47211

    2 Blocks protein domains:
    IPB000405 Galanin receptor signature
    IPB003906 Galanin 1 receptor signature


    UniProtKB/Swiss-Prot: GALR1_HUMAN, P47211
    Similarity: Belongs to the G-protein coupled receptor 1 family


    GALR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GALR1_HUMAN, P47211
    Function: Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit
    adenylate cyclase activity

         Genatlas biochemistry entry for GALR1:
    galanin receptor 1,G protein coupled receptor superfamily,linked to voltage gated calcium channel,expressed in
    brain,also coexpressed with GALN in ciliary epithelium predominantly signaling through inhibition of adenylate
    cyclase

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004966galanin receptor activity IEA--
    GO:0005515protein binding IPI--
    GO:0042923neuropeptide binding IEA--
         
    GALR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GALR1:
     Increased HPV18 LCR reporter a 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Galr1):
     behavior/neurological  normal 

    GALR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Galr1tm1Tpi for GALR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GALR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GALR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GALR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GALR1

    miRNA
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    hsa-miR-30c hsa-miR-3163 hsa-miR-30a hsa-miR-30b hsa-miR-3143 hsa-miR-30d hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidGALR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GALR1

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GALR1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GALR1_HUMAN, P47211: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    GALR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GALR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for GALR1
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for GALR1 (see first 5)
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for GALR1):
        Neuroactive ligand-receptor interaction


    GALR1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GALR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GALR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GALR1 (P472111, 3 ENSP000002997274) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GALP224661, 3, ENSP000002656434EBI-6624741,EBI-6624800 I2D: score=1 STRING: ENSP00000265643
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY9ENSP000002940164STRING: ENSP00000294016
    ADORA1ENSP000003085494STRING: ENSP00000308549
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007194negative regulation of adenylate cyclase activity IEA--
    GO:0007204positive regulation of cytosolic calcium ion concentration IEA--
    GO:0007218neuropeptide signaling pathway TAS7524088

    GALR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GALR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    M617Selective GAL1 agonist[860790-38-1]
    Galanin (1-29) (rat, mouse) Non-selective galanin receptor agonist[114547-31-8]
    M40 Potent, non-selective galanin receptor antagonist [143896-17-7]
    M 1145Potent and selective GAL2 agonist[1172089-00-7]
    M871Selective GAL2 antagonist[908844-75-7]

    Selected IUPHAR Ligands for GALR1 (GAL1 receptor) (see all 52)    About this table
    LigandTypeActionAffinityPubmed IDs
    M35
    AntagonistAntagonist10.49168941
    galanin
    AgonistFull agonist9.57 - 9.8911481429 9685625 9168941
    galanin
    AgonistFull agonist9.899685625
    M32
    AntagonistAntagonist9.59 - 9.7411600206 9880084
    M617
    AgonistAgonist9.64--
    M242
    AgonistAgonist9.611600206
    galanin(1-19) (human)
    AgonistAgonist9.479168941
    Gal-(K)4
    AgonistAgonist9.419199479
    [Sar1, D-Ala12]galanin(1-16)
    AgonistAgonist9.411491429
    Gal-B2-MPEG4
    AgonistAgonist9.319199479

    3 Novoseek inferred chemical compound relationships for GALR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    galp 76.8 1 15944009 (1)
    adenylate 34.3 3 17982695 (2), 9832121 (1)
    calcium 0 2 9832121 (1), 11567049 (1)



    GALR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GALR1 gene: 
    NM_001480.3  

    Unigene Cluster for GALR1:

    Galanin receptor 1
    Hs.272191  [show with all ESTs]
    Unigene Representative Sequence: NM_001480
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299727(uc002lms.4) ENST00000582943
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidGALR1 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat GALR1

    Additional mRNA sequence: 

    AY541036.1 BC095530.1 L34339.1 U23854.1 U53511.1 

    1 DOTS entry:

    DT.75139260 

    10 AceView cDNA sequences:

    BF445747 U23854 BX282079 NM_001480 U53511 BV198993 CF147813 AA952998 
    AY541036 L34339 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GALR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATATTAA
    GALR1 Expression
    About this image


    GALR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             Olfactory Bulb   
    GALR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GALR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.272191
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GALR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GALR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GALR1
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    QuantiFast Probe-based Assays in human, mouse, rat GALR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GALR1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Galr11 , 5 galanin receptor 11, 5 87.64(n)1
    92.24(a)1
      18 (55.78 cM)5
    144271  NM_008082.21  NP_032108.11 
     823924965 
    chicken
    (Gallus gallus)
    Aves GALR11 galanin receptor 1 85.39(n)
    89.2(a)
      428512  NM_001128062.1  NP_001121534.1 
    lizard
    (Anolis carolinensis)
    Reptilia GALR16
    Uncharacterized protein
    78(a)
    1 ↔ 1
    4(51161839-51195455)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia galr11 galanin receptor 1 75.78(n)
    85.4(a)
      100135180  NM_001113883.1  NP_001107355.1 
    zebrafish
    (Danio rerio)
    Actinopterygii galr11 galanin receptor 1 70.28(n)
    74.61(a)
      567820  XM_691123.2  XP_696215.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AlstR3 G-protein coupled receptor protein
    signaling pathway more
    39(a)
    (best of 2)
      1 3E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea ZK455.33
    CELE_Y54E2A.11
    G-protein coupled receptor3
    CELE_Y54E2A.11
    30(a)3
    43.13(n)1
    34.77(a)1
      X(11363821-11367302)3
    1751311  NM_064656.51  NP_497057.21 


    ENSEMBL Gene Tree for GALR1 (if available)
    TreeFam Gene Tree for GALR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GALR1 gene
    SSTR32  OPRL12  OPRK12  NPBWR12  OPRD12  KISS1R2  SSTR42  GALR22  
    SSTR52  MCHR22  SSTR12  GALR32  SSTR22  MCHR12  OPRM12  NPBWR22  
    Selected SIMAP similar genes for GALR1 using alignment to 1 protein entry:     GALR1_HUMAN(see all similar genes):
    GALR2    CMKLR1    GPR18    GALR3    OPRD1    PRLHR
    SSTR2    SSTR3    BRS3    CHRM2    OPRK1    SSTR1
    OPRM1    QRFPR    CCR5    NPY2R    KISS1R    LTB4R

    GALR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GALR1 (see all 647)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1821296221,2
    --74812044(+) GTTAGC/TAATAA 1 -- us2k10--------
    rs1880591201,2
    C--74812175(+) AGGAAA/GGCTGT 1 -- us2k10--------
    rs782994441,2
    --74812273(+) CAAAAC/TATGTA 1 -- us2k10--------
    rs1415903051,2
    C--74812346(+) ATATA-/TTAT  
            
    TTAAG
    1 -- us2k10--------
    rs1910327001,2
    C--74812425(+) GAGATA/TGTGGG 1 -- us2k10--------
    rs1391513851,2
    C--74812429(+) TAGTG-/GGAGAGGT 1 -- us2k10--------
    rs1471538601,2
    C--74812740(+) AGGTCA/G/TGGGCA 1 -- us2k10--------
    rs1831411991,2
    --74812847(+) CCTTGC/TAAGGA 1 -- us2k10--------
    rs1883276101,2
    --74812873(+) ATGTAC/GATAAA 1 -- us2k10--------
    rs1403447251,2
    C--74813037(+) ACTGCA/GTCCGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GALR1 (74962008 - 74982098 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GALR1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717388CNV Deletion23290073
    esv2717438CNV Deletion23290073
    esv2717437CNV Deletion23290073
    esv2717436CNV Deletion23290073
    esv2169580CNV Deletion18987734
    esv2717439CNV Deletion23290073
    esv2717442CNV Deletion23290073
    esv2717435CNV Deletion23290073
    esv2717441CNV Deletion23290073
    nsv2364CNV Insertion18451855

    Human Gene Mutation Database (HGMD): GALR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GALR1
    DNA2.0 Custom Variant and Variant Library Synthesis for GALR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600377    OMIM disorders: --

    13 diseases for GALR1:    
    About MalaCards
    mood disorder    nicotine dependence    alzheimer's disease    anorexia nervosa
    oral squamous cell carcinoma    obesity    squamous cell carcinoma    esophagitis
    neuronitis    adenocarcinoma    melanoma    cerebritis
    colorectal cancer


    GALR1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for GALR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pathological processes 32 1 18500647 (1)
    mood disorders 24 1 18500647 (1)
    alzheimers disease 22 3 18500647 (1), 19159918 (1)
    obesity 0 4 15930442 (3)
    melanoma 0 1 15464198 (1)

    Genetic Association Database (GAD): GALR1
    Human Genome Epidemiology (HuGE) Navigator: GALR1 (9 documents)

    Export disorders for GALR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GALR1 gene, integrated from 10 sources (see all 82):
    (articles sorted by number of sources associating them with GALR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a functional human galanin receptor. (PubMed id 7524088)1, 2, 3 Habert-Ortoli E.... Mayaux J.-F. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity. (PubMed id 15930442)1, 4, 9 SchAouble N....Hinney A. (J. Nutr. 2005)
    3. Alcoholism is associated with GALR3 but not two other galanin receptor genes. (PubMed id 17083333)1, 4, 9 Belfer I....Enoch M.A. (Genes Brain Behav. 2007)
    4. Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene. (PubMed id 9367674)1, 2, 9 Jacoby A.S.... Iismaa T.P. (Genomics 1997)
    5. Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R). (PubMed id 9425310)1, 2, 9 Lorimer D.D.... Benya R.V. (Biochem. Biophys. Res. Commun. 1997)
    6. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    7. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    8. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2587 HGNC: 4132 AceView: GALR1 Ensembl:ENSG00000166573 euGenes: HUgn2587
    ECgene: GALR1 Kegg: 2587 H-InvDB: GALR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GALR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GALR1 gene:
    Search GeneIP for patents involving GALR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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