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GALR1 Gene

protein-coding   GIFtS: 65
GCID: GC18P074962

Galanin Receptor 1


(Previous symbols: GALNR1, GALNR)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Galanin Receptor 11 2
GALNR1 2 3 5
GALNR11 2 3 5
GAL1-R2 3
GALR-12 3
Galanin Receptor Type 12

External Ids:    HGNC: 41321   Entrez Gene: 25872   Ensembl: ENSG000001665737   OMIM: 6003775   UniProtKB: P472113   

Export aliases for GALR1 gene to outside databases

Previous GC identifers: GC18M074531 GC18P075110 GC18P074724 GC18P073088 GC18P073090 GC18P071642


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GALR1 Gene:
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled
receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular
second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely
expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.
(provided by RefSeq, Jul 2008)

GeneCards Summary for GALR1 Gene:
GALR1 (galanin receptor 1) is a protein-coding gene. GO annotations related to this gene include galanin receptor activity and neuropeptide binding. An important paralog of this gene is SSTR3.

UniProtKB/Swiss-Prot: GALR1_HUMAN, P47211
Function: Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit
adenylate cyclase activity

summary for GALR1 Gene:
Galanin is widely distributed in the central and peripheral nervous systems and the endocrine system. Three
different galanin receptors (GAL1-3) have been identified which are Gi/o-protein-coupled. They are highly
expressed in hypothalamic nuclei and the brainstem. In addition, they are found in proliferating zones of
the fetal and adult brain and in peripheral tissues including the pancreas, heart, skin and gastrointestinal
tract. Galanin receptors mediate a variety of physiological functions including inhibition of
glucose-induced insulin secretion, stimulation of growth hormone release and modulation of gastrointestinal
motility. These receptors also modulate neuronal functions including memory, nociception, spinal reflexes
and feeding. Disruption of galanin expression or galanin receptor signaling is seen in many multifactoral
conditions, suggesting a role in the development and/or pathology of certain diseases. These include
Alzheimer's disease, epilepsy, diabetes, alcoholism, neuropathic pain and cancer.

Gene Wiki entry for GALR1 (Galanin receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the GALR1 gene promoter:
         Bach1   AhR   FOXD3   S8   PPAR-gamma1   POU2F1   POU2F1a   Msx-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGALR1 promoter sequence
   Search Chromatin IP Primers for GALR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GALR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q23   Ensembl cytogenetic band:  18q23   HGNC cytogenetic band: 18q23

GALR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GALR1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P074962:  view genomic region     (about GC identifiers)

Start:
74,962,008 bp from pter      End:
74,982,098 bp from pter
Size:
20,091 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GALR1_HUMAN, P47211 (See protein sequence)
Recommended Name: Galanin receptor type 1  
Size: 349 amino acids; 38953 Da
Secondary accessions: Q4VBL7

Explore the universe of human proteins at neXtProt for GALR1: NX_P47211

Explore proteomics data for GALR1 at MOPED

Post-translational modifications: 

  • Palmitoylated on at least one of the three cysteine residues present in the C-terminal part1
  • Glycosylation2 at Asn7, Asn12, Asn183
  • Modification sites at PhosphoSitePlus

  • See GALR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001471.2  
    ENSEMBL proteins: 
     ENSP00000299727  
    Reactome Protein details: P47211

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GALR: GPCR / Class A : Galanin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GAL1 receptor
    Galanin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003906 GAL1_rcpt
     IPR000405 Galanin_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P47211

    ProtoNet protein and cluster: P47211

    2 Blocks protein domains:
    IPB000405 Galanin receptor signature
    IPB003906 Galanin 1 receptor signature


    UniProtKB/Swiss-Prot: GALR1_HUMAN, P47211
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with GALR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GALR1_HUMAN, P47211
    Function: Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit
    adenylate cyclase activity

         Genatlas biochemistry entry for GALR1:
    galanin receptor 1,G protein coupled receptor superfamily,linked to voltage gated calcium channel,expressed in
    brain,also coexpressed with GALN in ciliary epithelium predominantly signaling through inhibition of adenylate
    cyclase

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004966galanin receptor activity IEA--
    GO:0005515protein binding IPI--
    GO:0042923neuropeptide binding IEA--
         
    Find genes that share ontologies with GALR1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GALR1:
     Increased HPV18 LCR reporter a 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Galr1):
     behavior/neurological  normal 

    Find genes that share phenotypes with GALR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Galr1tm1Tpi for GALR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GALR1
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    SwitchGear 3'UTR luciferase reporter plasmidGALR1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GALR1_HUMAN, P47211: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with GALR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GALR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with GALR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for GALR1
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for GALR1
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for GALR1):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GALR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GALR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    143 Interacting proteins for GALR1 (P472111, 3 ENSP000002997274) via UniProtKB, MINT, STRING, and/or I2D (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GALP224661, 3, ENSP000002656434EBI-6624741,EBI-6624800 I2D: score=1 STRING: ENSP00000265643
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY9ENSP000002940164STRING: ENSP00000294016
    ADORA1ENSP000003085494STRING: ENSP00000308549
    CCR1ENSP000002961404STRING: ENSP00000296140
    CHRM2ENSP000003199844STRING: ENSP00000319984
    CHRM4ENSP000004093784STRING: ENSP00000409378
    DRD3ENSP000003731694STRING: ENSP00000373169
    GALR2ENSP000003296844STRING: ENSP00000329684
    GALR3ENSP000002490414STRING: ENSP00000249041
    GNAI2ENSP000003129994STRING: ENSP00000312999
    GPR17ENSP000002726444STRING: ENSP00000272644
    HCAR2ENSP000003750664STRING: ENSP00000375066
    HRH3ENSP000003425604STRING: ENSP00000342560
    HRH4ENSP000002569064STRING: ENSP00000256906
    HTR1AENSP000003162444STRING: ENSP00000316244
    HTR1EENSP000003077664STRING: ENSP00000307766
    HTR1FENSP000003229244STRING: ENSP00000322924
    KNG1ENSP000002650234STRING: ENSP00000265023
    MCHR1ENSP000002490164STRING: ENSP00000249016
    MTNR1AENSP000003028114STRING: ENSP00000302811
    NMSENSP000003660614STRING: ENSP00000366061
    NMUENSP000002642184STRING: ENSP00000264218
    NMUR1ENSP000003058774STRING: ENSP00000305877
    NMUR2ENSP000002552624STRING: ENSP00000255262
    NPYENSP000002421524STRING: ENSP00000242152
    NPY1RENSP000003546524STRING: ENSP00000354652
    NPY2RENSP000003325914STRING: ENSP00000332591
    NPY4RENSP000003634314STRING: ENSP00000363431
    OPRK1ENSP000002655724STRING: ENSP00000265572
    OPRL1ENSP000003367644STRING: ENSP00000336764
    OPRM1ENSP000003946244STRING: ENSP00000394624
    P2RY14ENSP000003083614STRING: ENSP00000308361
    PDYNENSP000002173054STRING: ENSP00000217305
    PENKENSP000003242484STRING: ENSP00000324248
    PNOCENSP000003019084STRING: ENSP00000301908
    POMCENSP000002647084STRING: ENSP00000264708
    PPYENSP000002259924STRING: ENSP00000225992
    PYYENSP000003531984STRING: ENSP00000353198
    RXFP4ENSP000003573014STRING: ENSP00000357301
    SSTENSP000002876414STRING: ENSP00000287641
    SSTR1ENSP000002673774STRING: ENSP00000267377
    SSTR2ENSP000003501984STRING: ENSP00000350198
    SSTR3ENSP000003301384STRING: ENSP00000330138
    SSTR4ENSP000002550084STRING: ENSP00000255008
    SSTR5ENSP000002938974STRING: ENSP00000293897
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY6ENSP000003114054STRING: ENSP00000311405
    ADCY7ENSP000002542354STRING: ENSP00000254235
    ADCY8ENSP000002863554STRING: ENSP00000286355
    ADORA3ENSP000003587304STRING: ENSP00000358730
    ADRA2AENSP000002801554STRING: ENSP00000280155
    ADRA2BENSP000003872814STRING: ENSP00000387281
    ADRA2CENSP000003860694STRING: ENSP00000386069
    AGTR2ENSP000003609734STRING: ENSP00000360973
    ANXA1ENSP000002574974STRING: ENSP00000257497
    APLNENSP000003054644STRING: ENSP00000305464
    APLNRENSP000002572544STRING: ENSP00000257254
    APPENSP000002849814STRING: ENSP00000284981
    BDKRB1ENSP000002166294STRING: ENSP00000216629
    BDKRB2ENSP000003077134STRING: ENSP00000307713
    C3ENSP000002459074STRING: ENSP00000245907
    C3AR1ENSP000003020794STRING: ENSP00000302079
    C5ENSP000002236424STRING: ENSP00000223642
    C5AR1ENSP000003471974STRING: ENSP00000347197
    CASRENSP000002961544STRING: ENSP00000296154
    CCL16ENSP000002932754STRING: ENSP00000293275
    CCL19ENSP000003088154STRING: ENSP00000308815
    CCL20ENSP000003516714STRING: ENSP00000351671
    CCL21ENSP000002596074STRING: ENSP00000259607
    CCL25ENSP000003750864STRING: ENSP00000375086
    CCL27ENSP000002596314STRING: ENSP00000259631
    CCL28ENSP000003544164STRING: ENSP00000354416
    CCL5ENSP000002932724STRING: ENSP00000293272
    CCR3ENSP000003500034STRING: ENSP00000350003
    CCR5ENSP000002923034STRING: ENSP00000292303
    CCR6ENSP000003393934STRING: ENSP00000339393
    CCR7ENSP000002466574STRING: ENSP00000246657
    CCR8ENSP000003264324STRING: ENSP00000326432
    CXCL1ENSP000003791104STRING: ENSP00000379110
    CXCL10ENSP000003056514STRING: ENSP00000305651
    CXCL11ENSP000003068844STRING: ENSP00000306884
    CXCL13ENSP000002867584STRING: ENSP00000286758
    CXCL16ENSP000002937784STRING: ENSP00000293778
    CXCL3ENSP000002960264STRING: ENSP00000296026
    CXCL5ENSP000002960274STRING: ENSP00000296027
    CXCL6ENSP000002263174STRING: ENSP00000226317
    CXCL9ENSP000003549014STRING: ENSP00000354901
    CXCR1ENSP000002956834STRING: ENSP00000295683
    CXCR2ENSP000003196354STRING: ENSP00000319635
    CXCR5ENSP000002921744STRING: ENSP00000292174
    CXCR6ENSP000003044144STRING: ENSP00000304414
    DRD2ENSP000003548594STRING: ENSP00000354859
    DRD4ENSP000001761834STRING: ENSP00000176183
    FPR1ENSP000003027074STRING: ENSP00000302707
    FPR2ENSP000003401914STRING: ENSP00000340191
    FPR3ENSP000003418214STRING: ENSP00000341821
    GNG2ENSP000003344484STRING: ENSP00000334448
    GPER1ENSP000002974694STRING: ENSP00000297469
    GPR18ENSP000003434284STRING: ENSP00000343428
    GPR55ENSP000003758934STRING: ENSP00000375893
    HEBP1ENSP000000149304STRING: ENSP00000014930
    HTR1BENSP000003589634STRING: ENSP00000358963
    HTR1DENSP000003136614STRING: ENSP00000313661
    HTR5AENSP000002879074STRING: ENSP00000287907
    LPAR1ENSP000003517554STRING: ENSP00000351755
    LPAR2ENSP000003846654STRING: ENSP00000384665
    LPAR3ENSP000003596434STRING: ENSP00000359643
    MCHR2ENSP000002818064STRING: ENSP00000281806
    MTNR1BENSP000002570684STRING: ENSP00000257068
    NPBENSP000003327664STRING: ENSP00000332766
    NPBWR1ENSP000003302844STRING: ENSP00000330284
    NPBWR2ENSP000003587834STRING: ENSP00000358783
    NPWENSP000003300704STRING: ENSP00000330070
    NPY5RENSP000003393774STRING: ENSP00000339377
    OPRD1ENSP000002349614STRING: ENSP00000234961
    OXER1ENSP000003679304STRING: ENSP00000367930
    P2RY12ENSP000003072594STRING: ENSP00000307259
    P2RY13ENSP000003203764STRING: ENSP00000320376
    P2RY4ENSP000003636434STRING: ENSP00000363643
    PMCHENSP000003322254STRING: ENSP00000332225
    PPBPENSP000002960284STRING: ENSP00000296028
    PTGDR2ENSP000003328124STRING: ENSP00000332812
    PTGER3ENSP000003490034STRING: ENSP00000349003
    RGS1ENSP000003564294STRING: ENSP00000356429
    RGS10ENSP000003580994STRING: ENSP00000358099
    RGS14ENSP000003862294STRING: ENSP00000386229
    RGS18ENSP000003564304STRING: ENSP00000356430
    RGS19ENSP000003331944STRING: ENSP00000333194
    RGS20ENSP000002973134STRING: ENSP00000297313
    RGS4ENSP000003971814STRING: ENSP00000397181
    RGS6ENSP000003839534STRING: ENSP00000383953
    RGS7ENSP000003555204STRING: ENSP00000355520
    RXFP3ENSP000003287084STRING: ENSP00000328708
    S1PR1ENSP000003054164STRING: ENSP00000305416
    S1PR3ENSP000003508784STRING: ENSP00000350878
    S1PR4ENSP000002461154STRING: ENSP00000246115
    S1PR5ENSP000003284724STRING: ENSP00000328472
    --ENSP000003220494STRING: ENSP00000322049
    --ENSP000002644924STRING: ENSP00000264492
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007194negative regulation of adenylate cyclase activity IEA--
    GO:0007204positive regulation of cytosolic calcium ion concentration IEA--
    GO:0007218neuropeptide signaling pathway TAS7524088

    Find genes that share ontologies with GALR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Compounds for GALR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    M617Selective GAL1 agonist[860790-38-1]
    Galanin (1-29) (rat, mouse) Non-selective galanin receptor agonist[114547-31-8]
    M40 Potent, non-selective galanin receptor antagonist [143896-17-7]
    M 1145Potent and selective GAL2 agonist[1172089-00-7]
    M871Selective GAL2 antagonist[908844-75-7]

    Selected IUPHAR Ligands for GALR1 (GAL1 receptor) (see all 52)    About this table
    LigandTypeActionAffinityPubmed IDs
    M35
    AntagonistAntagonist10.49168941
    galanin
    AgonistFull agonist9.57 - 9.8911481429 9685625 9168941
    galanin
    AgonistFull agonist9.899685625
    M32
    AntagonistAntagonist9.59 - 9.7411600206 9880084
    M617
    AgonistAgonist9.64--
    M242
    AgonistAgonist9.611600206
    galanin(1-19) (human)
    AgonistAgonist9.479168941
    Gal-(K)4
    AgonistAgonist9.419199479
    [Sar1, D-Ala12]galanin(1-16)
    AgonistAgonist9.411491429
    Gal-B2-MPEG4
    AgonistAgonist9.319199479

    3 Novoseek inferred chemical compound relationships for GALR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    galp 76.8 1 15944009 (1)
    adenylate 34.3 3 17982695 (2), 9832121 (1)
    calcium 0 2 9832121 (1), 11567049 (1)



    Find genes that share compounds with GALR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for GALR1 gene: 
    NM_001480.3  

    Unigene Cluster for GALR1:

    Galanin receptor 1
    Hs.272191  [show with all ESTs]
    Unigene Representative Sequence: NM_001480
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299727(uc002lms.4) ENST00000582943
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidGALR1 3' UTR sequence
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    Additional mRNA sequence: 

    AY541036.1 BC095530.1 L34339.1 U23854.1 U53511.1 

    1 DOTS entry:

    DT.75139260 

    10 AceView cDNA sequences:

    BF445747 U23854 BX282079 NM_001480 U53511 BV198993 CF147813 AA952998 
    AY541036 L34339 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GALR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATATTAA
    GALR1 Expression
    About this image


    GALR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             Olfactory Bulb   
    GALR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GALR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.272191
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GALR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GALR1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Galr11 , 5 galanin receptor 11, 5 87.64(n)1
    92.24(a)1
      18 (55.78 cM)5
    144271  NM_008082.21  NP_032108.11 
     823924965 
    chicken
    (Gallus gallus)
    Aves GALR11 galanin receptor 1 85.39(n)
    89.2(a)
      428512  NM_001128062.1  NP_001121534.1 
    lizard
    (Anolis carolinensis)
    Reptilia GALR16
    Uncharacterized protein
    78(a)
    1 ↔ 1
    4(51161839-51195455)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia galr11 galanin receptor 1 75.78(n)
    85.4(a)
      100135180  NM_001113883.1  NP_001107355.1 
    zebrafish
    (Danio rerio)
    Actinopterygii galr11 galanin receptor 1 70.28(n)
    74.61(a)
      567820  XM_691123.2  XP_696215.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AlstR3 G-protein coupled receptor protein
    signaling pathway more
    39(a)
    (best of 2)
      1 3E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea ZK455.33
    CELE_Y54E2A.11
    G-protein coupled receptor3
    CELE_Y54E2A.11
    30(a)3
    43.13(n)1
    34.77(a)1
      X(11363821-11367302)3
    1751311  NM_064656.51  NP_497057.21 


    ENSEMBL Gene Tree for GALR1 (if available)
    TreeFam Gene Tree for GALR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GALR1 gene
    SSTR32  OPRL12  OPRK12  NPBWR12  OPRD12  KISS1R2  SSTR42  GALR22  
    SSTR52  MCHR22  SSTR12  GALR32  SSTR22  MCHR12  OPRM12  NPBWR22  
    Selected SIMAP similar genes for GALR1 using alignment to 1 protein entry:     GALR1_HUMAN(see all similar genes):
    GALR2    CMKLR1    GPR18    GALR3    OPRD1    PRLHR
    SSTR2    SSTR3    BRS3    CHRM2    OPRK1    SSTR1
    OPRM1    QRFPR    CCR5    NPY2R    KISS1R    LTB4R

    Find genes that share paralogs with GALR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GALR1 (see all 647)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1821296221,2
    --74812044(+) GTTAGC/TAATAA 1 -- us2k10--------
    rs1880591201,2
    C--74812175(+) AGGAAA/GGCTGT 1 -- us2k10--------
    rs782994441,2
    --74812273(+) CAAAAC/TATGTA 1 -- us2k10--------
    rs1415903051,2
    C--74812346(+) ATATA-/TTAT  
            
    TTAAG
    1 -- us2k10--------
    rs1910327001,2
    C--74812425(+) GAGATA/TGTGGG 1 -- us2k10--------
    rs1391513851,2
    C--74812429(+) TAGTG-/GGAGAGGT 1 -- us2k10--------
    rs1471538601,2
    C--74812740(+) AGGTCA/G/TGGGCA 1 -- us2k10--------
    rs1831411991,2
    --74812847(+) CCTTGC/TAAGGA 1 -- us2k10--------
    rs1883276101,2
    --74812873(+) ATGTAC/GATAAA 1 -- us2k10--------
    rs1403447251,2
    C--74813037(+) ACTGCA/GTCCGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GALR1 (74962008 - 74982098 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GALR1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717388CNV Deletion23290073
    esv2717438CNV Deletion23290073
    esv2717437CNV Deletion23290073
    esv2717436CNV Deletion23290073
    esv2169580CNV Deletion18987734
    esv2717439CNV Deletion23290073
    esv2717442CNV Deletion23290073
    esv2717435CNV Deletion23290073
    esv2717441CNV Deletion23290073
    nsv2364CNV Insertion18451855

    Human Gene Mutation Database (HGMD): GALR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GALR1
    DNA2.0 Custom Variant and Variant Library Synthesis for GALR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600377    OMIM disorders: --


    Find genes that share disorders with GALR1           About GenesLikeMe

    5 Novoseek inferred disease relationships for GALR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pathological processes 32 1 18500647 (1)
    mood disorders 24 1 18500647 (1)
    alzheimers disease 22 3 18500647 (1), 19159918 (1)
    obesity 0 4 15930442 (3)
    melanoma 0 1 15464198 (1)

    Genetic Association Database (GAD): GALR1
    Human Genome Epidemiology (HuGE) Navigator: GALR1 (9 documents)

    Export disorders for GALR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GALR1 gene, integrated from 10 sources (see all 82):
    (articles sorted by number of sources associating them with GALR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a functional human galanin receptor. (PubMed id 7524088)1, 2, 3 Habert-Ortoli E.... Mayaux J.-F. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity. (PubMed id 15930442)1, 4, 9 SchAouble N....Hinney A. (J. Nutr. 2005)
    3. Alcoholism is associated with GALR3 but not two other galanin receptor genes. (PubMed id 17083333)1, 4, 9 Belfer I....Enoch M.A. (Genes Brain Behav. 2007)
    4. Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene. (PubMed id 9367674)1, 2, 9 Jacoby A.S.... Iismaa T.P. (Genomics 1997)
    5. Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R). (PubMed id 9425310)1, 2, 9 Lorimer D.D.... Benya R.V. (Biochem. Biophys. Res. Commun. 1997)
    6. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    7. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    8. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2587 HGNC: 4132 AceView: GALR1 Ensembl:ENSG00000166573 euGenes: HUgn2587
    ECgene: GALR1 Kegg: 2587 H-InvDB: GALR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GALR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GALR1 gene:
    Search GeneIP for patents involving GALR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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