Aliases for GALR1 Gene
External Ids for GALR1 Gene
Previous HGNC Symbols for GALR1 Gene
Previous GeneCards Identifiers for GALR1 Gene
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]
GeneCards Summary for GALR1 Gene
GALR1 (Galanin Receptor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include neuropeptide binding and galanin receptor activity. An important paralog of this gene is GALR2.
UniProtKB/Swiss-Prot for GALR1 Gene
Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity
Galanin is widely distributed in the central and peripheral nervous systems and the endocrine system. Three different galanin receptors (GAL1-3) have been identified which are Gi/o-protein-coupled. They are highly expressed in hypothalamic nuclei and the brainstem. In addition, they are found in proliferating zones of the fetal and adult brain and in peripheral tissues including the pancreas, heart, skin and gastrointestinal tract. Galanin receptors mediate a variety of physiological functions including inhibition of glucose-induced insulin secretion, stimulation of growth hormone release and modulation of gastrointestinal motility. These receptors also modulate neuronal functions including memory, nociception, spinal reflexes and feeding. Disruption of galanin expression or galanin receptor signaling is seen in many multifactoral conditions, suggesting a role in the development and/or pathology of certain diseases. These include Alzheimer's disease, epilepsy, diabetes, alcoholism, neuropathic pain and cancer.