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Aliases for GALR1 Gene

Aliases for GALR1 Gene

  • Galanin Receptor 1 2 3 5
  • GALNR1 3 4
  • GAL1-R 3 4
  • GALR-1 3 4
  • GALNR 3 4
  • Galanin Receptor Type 1 3

External Ids for GALR1 Gene

Previous HGNC Symbols for GALR1 Gene

  • GALNR1
  • GALNR

Previous GeneCards Identifiers for GALR1 Gene

  • GC18M074531
  • GC18P075110
  • GC18P074724
  • GC18P073088
  • GC18P073090
  • GC18P074962
  • GC18P071642

Summaries for GALR1 Gene

Entrez Gene Summary for GALR1 Gene

  • The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]

GeneCards Summary for GALR1 Gene

GALR1 (Galanin Receptor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide binding. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for GALR1 Gene

  • Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

Tocris Summary for GALR1 Gene

  • Galanin is widely distributed in the central and peripheral nervous systems and the endocrine system. Three different galanin receptors (GAL1-3) have been identified. Disruption of galanin expression or galanin receptor signaling is seen in many multifactoral conditions.

Gene Wiki entry for GALR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALR1 Gene

Genomics for GALR1 Gene

Regulatory Elements for GALR1 Gene

Enhancers for GALR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F077249 0.6 Ensembl 11.4 -0.8 -752 0.2 KLF1 ZBTB8A ZBTB26 ZNF18 EZH2 GALR1 GC18M077130
GH18F077251 0.7 FANTOM5 7.8 +1.7 1731 0.3 CTCF ZNF654 RNF2 NR2F1 FEZF1 REST RAD21 RAD51 KDM6A EZH2 GALR1 ENSG00000264015
GH18F077223 0.6 Ensembl 4.8 -26.5 -26451 0.8 JUND MAFF JUN CEBPB FOS EP300 GALR1 GC18M077130
GH18F077254 0.4 ENCODE 0.8 +4.8 4775 0.5 NFE2 MAFK GALR1 ENSG00000264015
GH18F077321 0.9 ENCODE 0.2 +71.9 71928 0.1 HDAC1 ARNT MLX YY1 GATA2 CREM NCOA1 ZEB2 NR2F2 RAD51 GALR1 ENSG00000264015
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GALR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GALR1 Gene

Chromosome:
18
Start:
77,250,052 bp from pter
End:
77,277,896 bp from pter
Size:
27,845 bases
Orientation:
Plus strand

Genomic View for GALR1 Gene

Genes around GALR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GALR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GALR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALR1 Gene

Proteins for GALR1 Gene

  • Protein details for GALR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47211-GALR1_HUMAN
    Recommended name:
    Galanin receptor type 1
    Protein Accession:
    P47211
    Secondary Accessions:
    • Q4VBL7

    Protein attributes for GALR1 Gene

    Size:
    349 amino acids
    Molecular mass:
    38953 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GALR1 Gene

Post-translational modifications for GALR1 Gene

  • Palmitoylated on at least one of the three cysteine residues present in the C-terminal part.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GALR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GALR1 Gene

Domains & Families for GALR1 Gene

Gene Families for GALR1 Gene

Suggested Antigen Peptide Sequences for GALR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47211

UniProtKB/Swiss-Prot:

GALR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GALR1: view

Function for GALR1 Gene

Molecular function for GALR1 Gene

GENATLAS Biochemistry:
galanin receptor 1,G protein coupled receptor superfamily,linked to voltage gated calcium channel,expressed in brain,also coexpressed with GALN in ciliary epithelium predominantly signaling through inhibition of adenylate cyclase
UniProtKB/Swiss-Prot Function:
Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

Gene Ontology (GO) - Molecular Function for GALR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004966 galanin receptor activity IDA,TAS 24517231
GO:0005515 protein binding IPI 23597562
GO:0017046 peptide hormone binding IDA 24517231
GO:0042923 neuropeptide binding IEA --
genes like me logo Genes that share ontologies with GALR1: view
genes like me logo Genes that share phenotypes with GALR1: view

Animal Models for GALR1 Gene

MGI Knock Outs for GALR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for GALR1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GALR1 Gene

Localization for GALR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GALR1 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for GALR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS 7524088
genes like me logo Genes that share ontologies with GALR1: view

Pathways & Interactions for GALR1 Gene

genes like me logo Genes that share pathways with GALR1: view

Gene Ontology (GO) - Biological Process for GALR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA --
GO:0007194 negative regulation of adenylate cyclase activity IEA,TAS --
genes like me logo Genes that share ontologies with GALR1: view

No data available for SIGNOR curated interactions for GALR1 Gene

Drugs & Compounds for GALR1 Gene

(59) Drugs for GALR1 Gene - From: PharmGKB, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bupropion Approved Pharma 319
Nicotine Approved Pharma Antagonist 1050
M617 Pharma Agonist Selective GAL1 agonist 0
M871 Pharma Antagonist Selective GAL2 antagonist 0
galnon Pharma Agonist 0

(3) Additional Compounds for GALR1 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
galanin(2?ao29) (rat/mouse)
Full agonist, Agonist

(5) Tocris Compounds for GALR1 Gene

Compound Action Cas Number
Galanin (1-29) (rat, mouse) Non-selective galanin receptor agonist 114547-31-8
Galanin (1-30) (human) Endogenous galanin receptor agonist 119418-04-1
M 1145 Potent and selective GAL2 agonist 1172089-00-7
M617 Selective GAL1 agonist 860790-38-1
M871 Selective GAL2 antagonist 908844-75-7

(10) ApexBio Compounds for GALR1 Gene

Compound Action Cas Number
Galanin (1-15) (porcine, rat) 112747-70-3
Galanin (1-29) (rat, mouse) 114547-31-8
Galanin (1-30) (human) 119418-04-1
Galanin (2-29) (rat) 141696-11-9
Galanin (porcine) 88813-36-9
Galnon 475115-35-6
M 1145 1172089-00-7
M40 143896-17-7
M617 860790-38-1
M871 908844-75-7
genes like me logo Genes that share compounds with GALR1: view

Transcripts for GALR1 Gene

mRNA/cDNA for GALR1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GALR1 Gene

Galanin receptor 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GALR1 Gene

No ASD Table

Relevant External Links for GALR1 Gene

GeneLoc Exon Structure for
GALR1
ECgene alternative splicing isoforms for
GALR1

Expression for GALR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GALR1 Gene

mRNA differential expression in normal tissues according to GTEx for GALR1 Gene

This gene is overexpressed in Pituitary (x11.1).

NURSA nuclear receptor signaling pathways regulating expression of GALR1 Gene:

GALR1

SOURCE GeneReport for Unigene cluster for GALR1 Gene:

Hs.272191
genes like me logo Genes that share expression patterns with GALR1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GALR1 Gene

Orthologs for GALR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALR1 34 35
  • 99.24 (n)
cow
(Bos Taurus)
Mammalia GALR1 34 35
  • 91.79 (n)
dog
(Canis familiaris)
Mammalia GALR1 34 35
  • 89.78 (n)
mouse
(Mus musculus)
Mammalia Galr1 34 16 35
  • 87.64 (n)
rat
(Rattus norvegicus)
Mammalia Galr1 34
  • 86.51 (n)
oppossum
(Monodelphis domestica)
Mammalia GALR1 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GALR1 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves GALR1 34
  • 85.39 (n)
GALR 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GALR1 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia galr1 34
  • 75.78 (n)
zebrafish
(Danio rerio)
Actinopterygii galr1 34 35
  • 70.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta AlstR 36 35
  • 39 (a)
AR-2 36 35
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y54E2A.1 34
  • 43.13 (n)
ZK455.3 36
  • 30 (a)
npr-9 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for GALR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALR1 Gene

ENSEMBL:
Gene Tree for GALR1 (if available)
TreeFam:
Gene Tree for GALR1 (if available)

Paralogs for GALR1 Gene

Paralogs for GALR1 Gene

genes like me logo Genes that share paralogs with GALR1: view

Variants for GALR1 Gene

Sequence variations from dbSNP and Humsavar for GALR1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1010393 -- 77,263,580(-) CCTAT(C/T)GAGAG intron-variant
rs111164272 -- 77,259,263(+) TGGTG(A/G)TGTTG intron-variant
rs111164274 -- 77,259,410(+) GTGGT(C/T)ATGGT intron-variant
rs111171259 -- 77,259,058(+) GATGA(C/T)GGTGG intron-variant
rs111211719 -- 77,258,738(+) GGTGA(C/T)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GALR1 Gene

Variant ID Type Subtype PubMed ID
dgv1005e212 CNV loss 25503493
dgv1006e212 CNV loss 25503493
dgv196n21 CNV gain 19592680
dgv3407n100 CNV gain 25217958
esv2169580 CNV deletion 18987734
esv2717388 CNV deletion 23290073
esv2717435 CNV deletion 23290073
esv2717436 CNV deletion 23290073
esv2717437 CNV deletion 23290073
esv2717438 CNV deletion 23290073
esv2717439 CNV deletion 23290073
esv2717441 CNV deletion 23290073
esv2717442 CNV deletion 23290073
esv2751779 CNV gain 17911159
esv2758740 CNV loss 17122850
nsv2364 CNV insertion 18451855
nsv130653 CNV deletion 16902084
nsv1121539 CNV deletion 24896259
nsv1071868 CNV deletion 25765185
esv7653 CNV loss 19470904
esv3643201 CNV loss 21293372
esv3583165 CNV loss 25503493
esv3397365 CNV duplication 20981092

Variation tolerance for GALR1 Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.28; 62.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GALR1 Gene

Human Gene Mutation Database (HGMD)
GALR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GALR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALR1 Gene

Disorders for GALR1 Gene

Relevant External Links for GALR1

Genetic Association Database (GAD)
GALR1
Human Genome Epidemiology (HuGE) Navigator
GALR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GALR1

No disorders were found for GALR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GALR1 Gene

Publications for GALR1 Gene

  1. Alcoholism is associated with GALR3 but not two other galanin receptor genes. (PMID: 17083333) Belfer I. … Enoch M.A. (Genes Brain Behav. 2007) 3 22 46 64
  2. Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity. (PMID: 15930442) SchAouble N. … Hinney A. (J. Nutr. 2005) 3 22 46 64
  3. Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene. (PMID: 9367674) Jacoby A.S. … Iismaa T.P. (Genomics 1997) 3 4 22 64
  4. Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R). (PMID: 9425310) Lorimer D.D. … Benya R.V. (Biochem. Biophys. Res. Commun. 1997) 3 4 22 64
  5. Molecular cloning of a functional human galanin receptor. (PMID: 7524088) Habert-Ortoli E. … Mayaux J.-F. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 64

Products for GALR1 Gene

Sources for GALR1 Gene

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