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Aliases for GALP Gene

Aliases for GALP Gene

  • Galanin Like Peptide 2 3 5
  • Gal-Like Peptide 3
  • Alarin 3

External Ids for GALP Gene

Previous GeneCards Identifiers for GALP Gene

  • GC19P057141
  • GC19P061363
  • GC19P061379
  • GC19P056688
  • GC19P052997

Summaries for GALP Gene

Entrez Gene Summary for GALP Gene

  • This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.[provided by RefSeq, Nov 2014]

GeneCards Summary for GALP Gene

GALP (Galanin Like Peptide) is a Protein Coding gene. Diseases associated with GALP include Ganglioneuroblastoma and Ganglioneuroma. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for GALP Gene

  • Isoform 1: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.

  • Isoform 2: Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Exhibits antimicrobial activity against Gram-negative bacterias, inducing bacterial membrane blebbing (PubMed:23537644).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALP Gene

Genomics for GALP Gene

Regulatory Elements for GALP Gene

Enhancers for GALP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GALP on UCSC Golden Path with GeneCards custom track

Genomic Location for GALP Gene

Chromosome:
19
Start:
56,176,020 bp from pter
End:
56,185,775 bp from pter
Size:
9,756 bases
Orientation:
Plus strand

Genomic View for GALP Gene

Genes around GALP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GALP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GALP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALP Gene

Proteins for GALP Gene

  • Protein details for GALP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBC7-GALP_HUMAN
    Recommended name:
    Galanin-like peptide
    Protein Accession:
    Q9UBC7
    Secondary Accessions:
    • A1KXL3

    Protein attributes for GALP Gene

    Size:
    116 amino acids
    Molecular mass:
    12545 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GALP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALP Gene

Proteomics data for GALP Gene at MOPED

Post-translational modifications for GALP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GALP Gene

No data available for DME Specific Peptides for GALP Gene

Domains & Families for GALP Gene

Gene Families for GALP Gene

Protein Domains for GALP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GALP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBC7

UniProtKB/Swiss-Prot:

GALP_HUMAN :
  • Belongs to the galanin family.
Family:
  • Belongs to the galanin family.
genes like me logo Genes that share domains with GALP: view

Function for GALP Gene

Molecular function for GALP Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.
UniProtKB/Swiss-Prot Function:
Isoform 2: Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Exhibits antimicrobial activity against Gram-negative bacterias, inducing bacterial membrane blebbing (PubMed:23537644).
genes like me logo Genes that share phenotypes with GALP: view

Animal Models for GALP Gene

MGI Knock Outs for GALP:

Animal Model Products

  • Taconic Biosciences Mouse Models for GALP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GALP Gene

Localization for GALP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GALP Gene COMPARTMENTS Subcellular localization image for GALP gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for GALP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with GALP: view

Pathways & Interactions for GALP Gene

SuperPathways for GALP Gene

No Data Available

Interacting Proteins for GALP Gene

SIGNOR curated interactions for GALP Gene

Activates:

Gene Ontology (GO) - Biological Process for GALP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway IEA --
GO:0008150 biological_process ND --
GO:0032098 regulation of appetite IEA --
GO:0032868 response to insulin IEA --
GO:0042742 defense response to bacterium IEA --
genes like me logo Genes that share ontologies with GALP: view

No data available for Pathways by source for GALP Gene

Drugs & Compounds for GALP Gene

(4) Drugs for GALP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for GALP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GALP: view

Transcripts for GALP Gene

mRNA/cDNA for GALP Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GALP Gene

Galanin-like peptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GALP Gene

No ASD Table

Relevant External Links for GALP Gene

GeneLoc Exon Structure for
GALP
ECgene alternative splicing isoforms for
GALP

Expression for GALP Gene

mRNA expression in normal human tissues for GALP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALP Gene

This gene is overexpressed in Liver (x15.1), Brain - Amygdala (x7.7), Brain - Hypothalamus (x4.4), and Brain - Nucleus accumbens (basal ganglia) (x4.2).

SOURCE GeneReport for Unigene cluster for GALP Gene Hs.283915

mRNA Expression by UniProt/SwissProt for GALP Gene

Q9UBC7-GALP_HUMAN
Tissue specificity: Isoform 2 is found in ganglia of ganglioneuroma and ganglioneuroblastoma, as well as in differentiated tumor cells of neuroblastoma tissues. Not found in undifferentiated neuroblasts. Isoform 2 is found in the skin, in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels, isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is not detected in endothelial cells.
genes like me logo Genes that share expression patterns with GALP: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GALP Gene

Orthologs for GALP Gene

This gene was present in the common ancestor of mammals.

Orthologs for GALP Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia GALP 35
  • 77.43 (n)
  • 64.58 (a)
GALP 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Galp 35
  • 75.17 (n)
  • 66.33 (a)
Galp 16
Galp 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GALP 35
  • 98.56 (n)
  • 98.28 (a)
GALP 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Galp 35
  • 75.6 (n)
  • 65.98 (a)
Species with no ortholog for GALP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GALP Gene

ENSEMBL:
Gene Tree for GALP (if available)
TreeFam:
Gene Tree for GALP (if available)

Paralogs for GALP Gene

No data available for Paralogs for GALP Gene

Variants for GALP Gene

Sequence variations from dbSNP and Humsavar for GALP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3745833 - 56,182,251(-) TCACC(A/C/G/T)ATGGC reference, missense, utr-variant-3-prime
rs7258532 -- 56,185,370(+) GAAGT(G/T)AAATA utr-variant-3-prime
rs7258661 -- 56,180,232(+) gtgtg(A/C)aacac intron-variant
rs7258706 -- 56,180,042(+) AAAGT(A/G)CTGAG intron-variant
rs12978815 -- 56,176,396(+) GGCGG(A/C)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GALP Gene

Variant ID Type Subtype PubMed ID
dgv206n21 CNV Loss 19592680
nsv912516 CNV Gain 21882294
nsv528361 CNV Loss 19592680
esv27902 CNV Loss 19812545
esv2719025 CNV Deletion 23290073
esv2719026 CNV Deletion 23290073
esv2663363 CNV Deletion 23128226

Variation tolerance for GALP Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.82; 83.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GALP Gene

Human Gene Mutation Database (HGMD)
GALP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALP Gene

Disorders for GALP Gene

MalaCards: The human disease database

(2) MalaCards diseases for GALP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ganglioneuroblastoma
ganglioneuroma
- elite association - COSMIC cancer census association via MalaCards
Search GALP in MalaCards View complete list of genes associated with diseases

Relevant External Links for GALP

Genetic Association Database (GAD)
GALP
Human Genome Epidemiology (HuGE) Navigator
GALP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GALP
genes like me logo Genes that share disorders with GALP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GALP Gene

Publications for GALP Gene

  1. Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus. (PMID: 10601261) Ohtaki T. … Fujino M. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Assessment of Alzheimer's disease case-control associations using family-based methods. (PMID: 18830724) Schjeide B.M. … Bertram L. (Neurogenetics 2009) 3 23
  3. The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease. (PMID: 17604107) Lang R. … Kofler B. (Pharmacol. Ther. 2007) 3 23
  4. Galanin/GALP receptors and CNS homeostatic processes. (PMID: 16787232) Robinson J.K. … Langel U. (CNS Neurol Disord Drug Targets 2006) 3 23
  5. Gangliocytes in neuroblastic tumors express alarin, a novel peptide derived by differential splicing of the galanin-like peptide gene. (PMID: 16954604) Santic R. … Kofler B. (J. Mol. Neurosci. 2006) 3 23

Products for GALP Gene

Sources for GALP Gene

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