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Aliases for GALNTL6 Gene

Aliases for GALNTL6 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase-Like 6 2 3 5
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase-Like 6 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 17 3 4
  • Putative Polypeptide N-Acetylgalactosaminyltransferase 17 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 17 3 4
  • Polypeptide GalNAc Transferase-Like 6 2 3
  • Polypeptide GalNAc Transferase 17 3 4
  • Pp-GaNTase 17 3 4
  • EC 4 63
  • GalNAc-T17 3 4
  • GALNT17 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 20 3
  • GalNAc Transferase 17 3
  • GaNTase 17 3
  • GalNAc-T6L 3
  • GALNACT20 3

External Ids for GALNTL6 Gene

Previous GeneCards Identifiers for GALNTL6 Gene

  • GC04P172972
  • GC04P172735
  • GC04P168485

Summaries for GALNTL6 Gene

GeneCards Summary for GALNTL6 Gene

GALNTL6 (Polypeptide N-Acetylgalactosaminyltransferase-Like 6) is a Protein Coding gene. Among its related pathways are Metabolism and Mucin type O-Glycan biosynthesis. GO annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT4.

UniProtKB/Swiss-Prot for GALNTL6 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNTL6 Gene

Genomics for GALNTL6 Gene

Regulatory Elements for GALNTL6 Gene

Enhancers for GALNTL6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GALNTL6 on UCSC Golden Path with GeneCards custom track

Promoters for GALNTL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GALNTL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for GALNTL6 Gene

171,812,254 bp from pter
173,041,559 bp from pter
1,229,306 bases
Plus strand

Genomic View for GALNTL6 Gene

Genes around GALNTL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GALNTL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GALNTL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNTL6 Gene

Proteins for GALNTL6 Gene

  • Protein details for GALNTL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase-like 6
    Protein Accession:
    Secondary Accessions:
    • Q2L4S6

    Protein attributes for GALNTL6 Gene

    601 amino acids
    Molecular mass:
    69788 Da
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GALNTL6 Gene


neXtProt entry for GALNTL6 Gene

Proteomics data for GALNTL6 Gene at MOPED

Post-translational modifications for GALNTL6 Gene

  • Glycosylation at Asn 141 and Asn 588

Other Protein References for GALNTL6 Gene

Domains & Families for GALNTL6 Gene

Gene Families for GALNTL6 Gene

Suggested Antigen Peptide Sequences for GALNTL6 Gene

Graphical View of Domain Structure for InterPro Entry



  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • Contains 1 ricin B-type lectin domain.
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNTL6: view

Function for GALNTL6 Gene

Molecular function for GALNTL6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
UniProtKB/Swiss-Prot Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.

Enzyme Numbers (IUBMB) for GALNTL6 Gene

Gene Ontology (GO) - Molecular Function for GALNTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IEA --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with GALNTL6: view
genes like me logo Genes that share phenotypes with GALNTL6: view

Animal Model Products

miRNA for GALNTL6 Gene

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GALNTL6 Gene

Localization for GALNTL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNTL6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for GALNTL6 Gene COMPARTMENTS Subcellular localization image for GALNTL6 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for GALNTL6 Gene

Pathways & Interactions for GALNTL6 Gene

genes like me logo Genes that share pathways with GALNTL6: view

Pathways by source for GALNTL6 Gene

UniProtKB/Swiss-Prot Q49A17-GLTL6_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for GALNTL6 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000423313 for GALNTL6 Gene via STRING

Gene Ontology (GO) - Biological Process for GALNTL6 Gene


No data available for SIGNOR curated interactions for GALNTL6 Gene

Drugs & Compounds for GALNTL6 Gene

(3) Drugs for GALNTL6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine-5'-Diphosphate Experimental Pharma 0
Manganese Pharma 32
calcium Nutra 0

(3) Additional Compounds for GALNTL6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 2-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose
  • 2-Amino-2-deoxy-4-O-beta-delta-galactopyranosyl-delta-glucose
  • beta-D-Galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
  • beta-D-Galactopyranosyl-(1->4)-D-glucosamine
  • beta-delta-Galactopyranosyl-(1->4)-2-amino-2-deoxy-delta-glucose
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
  • Uridine 5'-diphospho-N-acetylgalactosamine
  • Uridine diphosphate-N-acetyl-D-galactosamine
genes like me logo Genes that share compounds with GALNTL6: view

Transcripts for GALNTL6 Gene

mRNA/cDNA for GALNTL6 Gene

(9) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GALNTL6 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GALNTL6 Gene

No ASD Table

Relevant External Links for GALNTL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GALNTL6 Gene

mRNA expression in normal human tissues for GALNTL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNTL6 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.6), Brain - Substantia nigra (x5.1), and Brain - Anterior cingulate cortex (BA24) (x4.7).

Protein differential expression in normal tissues from HIPED for GALNTL6 Gene

This gene is overexpressed in Heart (63.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GALNTL6 Gene

SOURCE GeneReport for Unigene cluster for GALNTL6 Gene Hs.386236

genes like me logo Genes that share expression patterns with GALNTL6: view

Protein tissue co-expression partners for GALNTL6 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GALNTL6 Gene

Orthologs for GALNTL6 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNTL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GALNTL6 35
  • 88.8 (n)
  • 96.51 (a)
  • 97 (a)
(Canis familiaris)
Mammalia GALNTL6 35
  • 94.18 (n)
  • 98 (a)
  • 99 (a)
(Mus musculus)
Mammalia Galntl6 35
  • 91.24 (n)
  • 96.17 (a)
Galntl6 16
Galntl6 36
  • 96 (a)
(Pan troglodytes)
Mammalia GALNTL6 35
  • 99.72 (n)
  • 99.83 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Galntl6 35
  • 90.68 (n)
  • 95.51 (a)
(Monodelphis domestica)
Mammalia GALNTL6 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia GALNTL6 36
  • 95 (a)
(Gallus gallus)
Aves GALNTL6 35
  • 84.08 (n)
  • 93.68 (a)
  • 94 (a)
(Anolis carolinensis)
Reptilia GALNTL6 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia galntl6 35
  • 79.53 (n)
  • 88.02 (a)
(Danio rerio)
Actinopterygii si:ch211-15e22.3 35
  • 74.44 (n)
  • 82 (a)
  • 82 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31776 36
  • 32 (a)
pgant4 36
  • 38 (a)
pgant6 36
  • 40 (a)
pgant8 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea gly-10 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for GALNTL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNTL6 Gene

Gene Tree for GALNTL6 (if available)
Gene Tree for GALNTL6 (if available)

Paralogs for GALNTL6 Gene

genes like me logo Genes that share paralogs with GALNTL6: view

Variants for GALNTL6 Gene

Sequence variations from dbSNP and Humsavar for GALNTL6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs230 -- 171,975,322(-) ATGAT(A/G)AGTAG intron-variant
rs802 -- 171,975,329(-) AACCA(A/G/T)TATGA intron-variant
rs3966 -- 172,204,699(+) TATGA(A/T)CCCTT intron-variant
rs4140 -- 172,280,144(-) ctcaa(A/G)agctt intron-variant
rs162814 -- 172,326,505(+) accta(C/T)taata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GALNTL6 Gene

Variant ID Type Subtype PubMed ID
nsv461838 CNV Gain 19166990
nsv881310 CNV Loss 21882294
esv2666802 CNV Deletion 23128226
nsv527739 CNV Loss 19592680
nsv881602 CNV Loss 21882294
esv2661674 CNV Deletion 23128226
nsv520744 CNV Gain 19592680
esv2667074 CNV Deletion 23128226
esv2661236 CNV Deletion 23128226
nsv519578 CNV Loss 19592680
nsv819975 CNV Loss 19587683
dgv992e199 CNV Deletion 23128226
nsv822836 CNV Loss 20364138
nsv830152 CNV Loss 17160897
nsv880759 CNV Loss 21882294
nsv525324 CNV Loss 19592680
nsv881219 CNV Loss 21882294
nsv4605 CNV Loss 18451855
nsv437950 CNV Loss 16468122
nsv508332 CNV Loss 20534489
nsv819440 CNV Loss 19587683
esv2607011 CNV Loss 19546169
esv2421911 CNV Deletion 20811451
nsv10611 CNV Loss 18304495
esv1011260 CNV Deletion 20482838
nsv436418 CNV Deletion 17901297
esv2565726 CNV Deletion 19546169
esv2033228 CNV Deletion 18987734
nsv513180 CNV Loss 21212237
esv8153 CNV Loss 19470904
esv2728753 CNV Deletion 23290073
esv2661339 CNV Deletion 23128226
nsv499494 CNV Loss 21111241
nsv289632 CNV Loss 16902084
esv27951 CNV Loss 19812545
nsv822837 CNV Loss 20364138
nsv514272 CNV Loss 21397061
nsv433470 CNV Loss 18776910
esv33022 CNV Gain 17666407
nsv830153 CNV Loss 17160897
esv2097954 CNV Deletion 18987734
esv2728754 CNV Deletion 23290073
nsv291048 CNV Loss 16902084
nsv880416 CNV Loss 21882294
nsv4606 CNV Insertion 18451855
nsv508333 CNV Loss 20534489
nsv4607 CNV Loss 18451855
nsv10612 CNV Loss 18304495
nsv263 CNV Loss 15895083
dgv98n16 CNV Deletion 17901297
esv2439458 CNV Loss 19546169
dgv46n50 CNV Loss 21212237
esv2546113 CNV Deletion 19546169
nsv10613 CNV Gain+Loss 18304495
esv2285591 CNV Deletion 18987734
esv2421402 CNV Deletion 20811451
nsv442931 CNV CNV 18776908
nsv820239 CNV Loss 19587683
esv4052 CNV Deletion 18987735
esv28615 CNV Gain+Loss 19812545
nsv821526 CNV Deletion 20802225
nsv822838 CNV Loss 20364138
esv2728755 CNV Deletion 23290073
esv8497 CNV Loss 19470904
nsv289548 CNV Loss 16902084
dgv910n67 CNV Loss 20364138
nsv514273 CNV Loss 21397061
esv33205 CNV Loss 17666407
esv2322806 CNV Deletion 18987734
nsv290804 CNV Insertion 16902084
esv1531442 CNV Insertion 17803354
esv269548 CNV Insertion 20981092
esv2728756 CNV Deletion 23290073
esv2728757 CNV Deletion 23290073
esv1008745 CNV Deletion 20482838
dgv181n6 CNV Loss 16902084
esv1235967 CNV Deletion 17803354
dgv5831n71 CNV Gain 21882294
esv2435425 CNV Deletion 19546169
esv274870 CNV Gain+Loss 21479260
nsv881394 CNV Loss 21882294
esv1004880 CNV Deletion 20482838
nsv289404 CNV Loss 16902084
nsv4608 CNV Loss 18451855
esv2728758 CNV Deletion 23290073

Variation tolerance for GALNTL6 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 26.99% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GALNTL6 Gene

Disorders for GALNTL6 Gene

Relevant External Links for GALNTL6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GALNTL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GALNTL6 Gene

Publications for GALNTL6 Gene

  1. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl G.R. … Lerman C. (Arch. Gen. Psychiatry 2008) 3 48 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Identification of a novel human UDP-GalNAc transferase with unique catalytic activity and expression profile. (PMID: 20977886) Peng C. … Zhang Y. (Biochem. Biophys. Res. Commun. 2010) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for GALNTL6 Gene

Sources for GALNTL6 Gene