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Aliases for GALNTL5 Gene

Aliases for GALNTL5 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase-Like 5 2 3 5
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase-Like 5 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 15 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 15 3 4
  • Polypeptide GalNAc Transferase-Like 5 2 3
  • Polypeptide GalNAc Transferase 15 3 4
  • Pp-GaNTase 15 3 4
  • GalNAc-T15 3 4
  • GALNT15 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 15 2
  • Putative Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 5 3
  • Testis Tissue Sperm-Binding Protein Li 61n 3
  • EC 2.4.1.41 63
  • GalNAc-T5L 3
  • GALNACT19 3

External Ids for GALNTL5 Gene

Previous HGNC Symbols for GALNTL5 Gene

  • GALNT15

Previous GeneCards Identifiers for GALNTL5 Gene

  • GC07P151091
  • GC07P151284
  • GC07P151653
  • GC07P145465

Summaries for GALNTL5 Gene

GeneCards Summary for GALNTL5 Gene

GALNTL5 (Polypeptide N-Acetylgalactosaminyltransferase-Like 5) is a Protein Coding gene. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include transferase activity, transferring glycosyl groups and transferase activity. An important paralog of this gene is GALNT4.

UniProtKB/Swiss-Prot for GALNTL5 Gene

  • Probable inactive glycosyltransferase required during spermatid development. May participate to protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNTL5 Gene

Genomics for GALNTL5 Gene

Regulatory Elements for GALNTL5 Gene

Enhancers for GALNTL5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GALNTL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for GALNTL5 Gene

Chromosome:
7
Start:
151,956,379 bp from pter
End:
152,019,934 bp from pter
Size:
63,556 bases
Orientation:
Plus strand

Genomic View for GALNTL5 Gene

Genes around GALNTL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GALNTL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GALNTL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNTL5 Gene

Proteins for GALNTL5 Gene

  • Protein details for GALNTL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4T8-GLTL5_HUMAN
    Recommended name:
    Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5
    Protein Accession:
    Q7Z4T8
    Secondary Accessions:
    • Q75KN2
    • Q75MD3
    • Q8NCV4
    • Q8WW05
    • Q9UDR9

    Protein attributes for GALNTL5 Gene

    Size:
    443 amino acids
    Molecular mass:
    51427 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM20912.1; Type=Frameshift; Positions=114, 122; Evidence={ECO:0000305}; Sequence=AAP97318.1; Type=Frameshift; Positions=114, 122; Evidence={ECO:0000305};

    Alternative splice isoforms for GALNTL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALNTL5 Gene

Proteomics data for GALNTL5 Gene at MOPED

Selected DME Specific Peptides for GALNTL5 Gene

Post-translational modifications for GALNTL5 Gene

  • Glycosylation at Asn 87
  • Modification sites at PhosphoSitePlus

Domains & Families for GALNTL5 Gene

Gene Families for GALNTL5 Gene

Protein Domains for GALNTL5 Gene

Suggested Antigen Peptide Sequences for GALNTL5 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z4T8

UniProtKB/Swiss-Prot:

GLTL5_HUMAN :
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNTL5: view

Function for GALNTL5 Gene

Molecular function for GALNTL5 Gene

UniProtKB/Swiss-Prot Function:
Probable inactive glycosyltransferase required during spermatid development. May participate to protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region.

Enzyme Numbers (IUBMB) for GALNTL5 Gene

Gene Ontology (GO) - Molecular Function for GALNTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016757 NOT transferase activity, transferring glycosyl groups IDA 24398516
genes like me logo Genes that share ontologies with GALNTL5: view
genes like me logo Genes that share phenotypes with GALNTL5: view

Human Phenotype Ontology for GALNTL5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GALNTL5 Gene

MGI Knock Outs for GALNTL5:

Animal Model Products

miRNA for GALNTL5 Gene

miRTarBase miRNAs that target GALNTL5

No data available for Transcription Factor Targets and HOMER Transcription for GALNTL5 Gene

Localization for GALNTL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNTL5 Gene

Late endosome membrane; Single-pass type II membrane protein. Note=Localizes to the juxtanuclear region, possibly the late endosome. Not localized in the Golgi apparatus in round spermatids (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GALNTL5 Gene COMPARTMENTS Subcellular localization image for GALNTL5 gene
Compartment Confidence
endosome 3
golgi apparatus 3
mitochondrion 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for GALNTL5 Gene

Pathways & Interactions for GALNTL5 Gene

genes like me logo Genes that share pathways with GALNTL5: view

Pathways by source for GALNTL5 Gene

Interacting Proteins for GALNTL5 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000376548%0d%0a9606.ENSP00000365920%0d%0a9606.ENSP00000304364%0d%0a9606.ENSP00000156626%0d%0a9606.ENSP00000223122%0d%0a
Selected Interacting proteins: ENSP00000376548 for GALNTL5 Gene via STRING

Gene Ontology (GO) - Biological Process for GALNTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development IMP 24398516
genes like me logo Genes that share ontologies with GALNTL5: view

No data available for SIGNOR curated interactions for GALNTL5 Gene

Drugs & Compounds for GALNTL5 Gene

(3) Drugs for GALNTL5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine-5'-Diphosphate Experimental Pharma 0
Manganese Pharma 32
calcium Nutra 0

(2) Additional Compounds for GALNTL5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lactosamine
  • 2-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose
  • 2-Amino-2-deoxy-4-O-beta-delta-galactopyranosyl-delta-glucose
  • beta-D-Galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
  • beta-D-Galactopyranosyl-(1->4)-D-glucosamine
  • beta-delta-Galactopyranosyl-(1->4)-2-amino-2-deoxy-delta-glucose
13000-25-4
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
  • Uridine 5'-diphospho-N-acetylgalactosamine
  • Uridine diphosphate-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNTL5: view

Transcripts for GALNTL5 Gene

Unigene Clusters for GALNTL5 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GALNTL5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: - -

Relevant External Links for GALNTL5 Gene

GeneLoc Exon Structure for
GALNTL5
ECgene alternative splicing isoforms for
GALNTL5

Expression for GALNTL5 Gene

mRNA expression in normal human tissues for GALNTL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNTL5 Gene

This gene is overexpressed in Testis (x31.8), Brain - Cortex (x4.7), and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for GALNTL5 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GALNTL5 Gene



SOURCE GeneReport for Unigene cluster for GALNTL5 Gene Hs.647077

mRNA Expression by UniProt/SwissProt for GALNTL5 Gene

Q7Z4T8-GLTL5_HUMAN
Tissue specificity: Mainly expressed in testis. Weakly or not expressed in other tissues.
genes like me logo Genes that share expression patterns with GALNTL5: view

Protein tissue co-expression partners for GALNTL5 Gene

- Elite partner

Primer Products

Orthologs for GALNTL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNTL5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GALNTL5 35
  • 80.15 (n)
  • 70.11 (a)
GALNTL5 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GALNTL5 35
  • 82.46 (n)
  • 73.58 (a)
GALNTL5 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Galntl5 35
  • 75.04 (n)
  • 66.75 (a)
Galntl5 16
Galntl5 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GALNTL5 35
  • 98.49 (n)
  • 96.6 (a)
GALNTL5 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Galntl5 35
  • 75.1 (n)
  • 67.61 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01069344.1 36
  • 19 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Pgant35A 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gly-11 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5330 36
  • 26 (a)
ManyToMany
Species with no ortholog for GALNTL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GALNTL5 Gene

ENSEMBL:
Gene Tree for GALNTL5 (if available)
TreeFam:
Gene Tree for GALNTL5 (if available)

Paralogs for GALNTL5 Gene

genes like me logo Genes that share paralogs with GALNTL5: view

Variants for GALNTL5 Gene

Sequence variations from dbSNP and Humsavar for GALNTL5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6960270 - 151,982,987(+) GCAGG(C/T)GTCTT nc-transcript-variant, reference, missense
rs6947736 -- 152,017,303(+) cacaa(C/T)ggtaa intron-variant
rs1019173 -- 152,013,462(+) CAACA(A/G)GCAAT intron-variant
rs6948317 -- 151,996,784(+) AACAT(A/G)ACGTG intron-variant
rs6948441 -- 151,960,008(+) AACCT(G/T)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GALNTL5 Gene

Variant ID Type Subtype PubMed ID
nsv889494 CNV Gain 21882294
esv2174500 CNV Deletion 18987734
esv2735440 CNV Deletion 23290073
esv2735441 CNV Deletion 23290073
esv3445 CNV Deletion 18987735
esv2660963 CNV Deletion 23128226
esv2735442 CNV Deletion 23290073
nsv523467 CNV Loss 19592680

Variation tolerance for GALNTL5 Gene

Residual Variation Intolerance Score: 92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.36; 88.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GALNTL5 Gene

Human Gene Mutation Database (HGMD)
GALNTL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNTL5 Gene

Disorders for GALNTL5 Gene

UniProtKB/Swiss-Prot

GLTL5_HUMAN
  • Note=Defects in GALNTL5 have been found in a patient with primary infertility due to asthenozoospermia. {ECO:0000269 PubMed:24398516}.

Relevant External Links for GALNTL5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GALNTL5

No disorders were found for GALNTL5 Gene.

No data available for MalaCards and Genatlas for GALNTL5 Gene

Publications for GALNTL5 Gene

  1. A heterozygous mutation of GALNTL5 affects male infertility with impairment of sperm motility. (PMID: 24398516) Takasaki N. … Narimatsu H. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 4 67
  2. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for GALNTL5 Gene

Sources for GALNTL5 Gene

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