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Aliases for GALNTL5 Gene

Aliases for GALNTL5 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase-Like 5 2 3
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase-Like 5 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 15 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 15 3 4
  • Polypeptide GalNAc Transferase-Like 5 2 3
  • Polypeptide GalNAc Transferase 15 3 4
  • Pp-GaNTase 15 3 4
  • GalNAc-T15 3 4
  • GALNACT19 3 6
  • GALNT15 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 15 2
  • Inactive Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 5 3
  • Putative Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 5 3
  • EC 2.4.1.41 63
  • GalNAc-T5L 3

External Ids for GALNTL5 Gene

Previous HGNC Symbols for GALNTL5 Gene

  • GALNT15

Previous GeneCards Identifiers for GALNTL5 Gene

  • GC07P151091
  • GC07P151284
  • GC07P151653
  • GC07P145465

Summaries for GALNTL5 Gene

GeneCards Summary for GALNTL5 Gene

GALNTL5 (Polypeptide N-Acetylgalactosaminyltransferase-Like 5) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include transferase activity, transferring glycosyl groups. An important paralog of this gene is GALNT4.

UniProtKB/Swiss-Prot for GALNTL5 Gene

  • Probable inactive glycosyltransferase required during spermatid development. May participate to protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNTL5 Gene

Genomics for GALNTL5 Gene

Regulatory Elements for GALNTL5 Gene

Genomic Location for GALNTL5 Gene

Start:
151,956,379 bp from pter
End:
152,019,934 bp from pter
Size:
63,556 bases
Orientation:
Plus strand

Genomic View for GALNTL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GALNTL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNTL5 Gene

Proteins for GALNTL5 Gene

  • Protein details for GALNTL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4T8-GLTL5_HUMAN
    Recommended name:
    Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5
    Protein Accession:
    Q7Z4T8
    Secondary Accessions:
    • Q75KN2
    • Q75MD3
    • Q8NCV4
    • Q8WW05
    • Q9UDR9

    Protein attributes for GALNTL5 Gene

    Size:
    443 amino acids
    Molecular mass:
    51427 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM20912.1; Type=Frameshift; Positions=114, 122; Evidence={ECO:0000305}; Sequence=AAP97318.1; Type=Frameshift; Positions=114, 122; Evidence={ECO:0000305};

    Alternative splice isoforms for GALNTL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALNTL5 Gene

Proteomics data for GALNTL5 Gene at MOPED

Selected DME Specific Peptides for GALNTL5 Gene

Post-translational modifications for GALNTL5 Gene

  • Glycosylation at Asn87
  • Modification sites at PhosphoSitePlus

Other Protein References for GALNTL5 Gene

Domains for GALNTL5 Gene

Gene Families for GALNTL5 Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

Protein Domains for GALNTL5 Gene

Suggested Antigen Peptide Sequences for GALNTL5 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z4T8

UniProtKB/Swiss-Prot:

GLTL5_HUMAN :
  • Q7Z4T8
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNTL5: view

Function for GALNTL5 Gene

Molecular function for GALNTL5 Gene

UniProtKB/Swiss-Prot Function: Probable inactive glycosyltransferase required during spermatid development. May participate to protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region

Enzyme Numbers (IUBMB) for GALNTL5 Gene

Gene Ontology (GO) - Molecular Function for GALNTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity --
GO:0016757 NOT transferase activity, transferring glycosyl groups IDA 24398516
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNTL5: view

Animal Model Products

CRISPR Products

miRNA for GALNTL5 Gene

miRTarBase miRNAs that target GALNTL5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GALNTL5

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GALNTL5 Gene

Localization for GALNTL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNTL5 Gene

Late endosome membrane; Single-pass type II membrane protein. Note=Localizes to the juxtanuclear region, possibly the late endosome. Not localized in the Golgi apparatus in round spermatids (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GALNTL5 Gene COMPARTMENTS Subcellular localization image for GALNTL5 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for GALNTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0016021 integral component of membrane IEA --
GO:0031902 late endosome membrane IEA --
genes like me logo Genes that share ontologies with GALNTL5: view

Pathways for GALNTL5 Gene

genes like me logo Genes that share pathways with GALNTL5: view

Pathways by source for GALNTL5 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GALNTL5 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000376548%0d%0a9606.ENSP00000365920%0d%0a9606.ENSP00000304364%0d%0a9606.ENSP00000156626%0d%0a9606.ENSP00000223122%0d%0a
Selected Interacting proteins: ENSP00000376548 for GALNTL5 Gene via STRING

Gene Ontology (GO) - Biological Process for GALNTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 NOT protein glycosylation IDA 24398516
GO:0007286 spermatid development IMP 24398516
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with GALNTL5: view

Compounds for GALNTL5 Gene

(5) HMDB Compounds for GALNTL5 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Lactosamine
  • beta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
13000-25-4
Manganese
  • manganese
7439-96-5
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNTL5: view

Transcripts for GALNTL5 Gene

Unigene Clusters for GALNTL5 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GALNTL5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GALNTL5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: - -

Relevant External Links for GALNTL5 Gene

GeneLoc Exon Structure for
GALNTL5
ECgene alternative splicing isoforms for
GALNTL5

Expression for GALNTL5 Gene

mRNA expression in normal human tissues for GALNTL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNTL5 Gene

This gene is overexpressed in Testis (31.8), Brain - Cortex (4.7), and Brain - Frontal Cortex (BA9) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GALNTL5 Gene

SOURCE GeneReport for Unigene cluster for GALNTL5 Gene Hs.647077

mRNA Expression by UniProt/SwissProt for GALNTL5 Gene

Q7Z4T8-GLTL5_HUMAN
Tissue specificity: Mainly expressed in testis. Weakly or not expressed in other tissues.
genes like me logo Genes that share expressions with GALNTL5: view

In Situ Assay Products

Orthologs for GALNTL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNTL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNTL5 35
  • 98.49 (n)
  • 96.6 (a)
GALNTL5 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GALNTL5 35
  • 80.15 (n)
  • 70.11 (a)
GALNTL5 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GALNTL5 35
  • 82.46 (n)
  • 73.58 (a)
GALNTL5 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Galntl5 35
  • 75.04 (n)
  • 66.75 (a)
Galntl5 16
Galntl5 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Galntl5 35
  • 75.1 (n)
  • 67.61 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01069344.1 36
  • 19 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Pgant35A 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gly-11 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5330 36
  • 26 (a)
ManyToMany
Species with no ortholog for GALNTL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GALNTL5 Gene

ENSEMBL:
Gene Tree for GALNTL5 (if available)
TreeFam:
Gene Tree for GALNTL5 (if available)

Paralogs for GALNTL5 Gene

genes like me logo Genes that share paralogs with GALNTL5: view

Variants for GALNTL5 Gene

Sequence variations from dbSNP and Humsavar for GALNTL5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1019173 -- 152,013,462(+) CAACA(A/G)GCAAT intron-variant
rs1105320 -- 151,967,141(-) CTTGG(C/T)TTAAA intron-variant
rs1112401 -- 151,971,237(+) TTCTA(C/G/T)TTCAA intron-variant
rs1406522 -- 151,984,737(+) TTGGT(A/G)ACTTG intron-variant
rs1406523 -- 151,985,326(+) GTGTG(C/T)TTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GALNTL5 Gene

Variant ID Type Subtype PubMed ID
nsv889494 CNV Gain 21882294
esv2174500 CNV Deletion 18987734
esv2735440 CNV Deletion 23290073
esv2735441 CNV Deletion 23290073
esv3445 CNV Deletion 18987735
esv2660963 CNV Deletion 23128226
esv2735442 CNV Deletion 23290073
nsv523467 CNV Loss 19592680

Relevant External Links for GALNTL5 Gene

HapMap Linkage Disequilibrium report
GALNTL5
Human Gene Mutation Database (HGMD)
GALNTL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNTL5 Gene

Disorders for GALNTL5 Gene

UniProtKB/Swiss-Prot

GLTL5_HUMAN
  • Note=Defects in GALNTL5 have been found in a patient with primary infertility due to asthenozoospermia. {ECO:0000269 PubMed:24398516}.

No disorders were found for GALNTL5 Gene.

Publications for GALNTL5 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A heterozygous mutation of GALNTL5 affects male infertility with impairment of sperm motility. (PMID: 24398516) Takasaki N. … Narimatsu H. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for GALNTL5 Gene

Sources for GALNTL5 Gene

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