Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GALNT9 Gene

protein-coding   GIFtS: 58
GCID: GC12M132680

UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide
N-Acetylgalactosaminyltransferase 9 (GalNAc-T9)1 2
     GALNAC-T92
Polypeptide GalNAc Transferase 92 3     GALNACT92
Protein-UDP Acetylgalactosaminyltransferase 92 3     GalNAc Transferase 92
Pp-GaNTase 92 3     Polypeptide N-Acetylgalactosaminyltransferase 92
UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 92 3     UDP-GalNAc: Polypeptide N-Acetylgalactosaminyltransferase 92
EC 2.4.1.413 8     GalNAc-T93

External Ids:    HGNC: 41311   Entrez Gene: 506142   Ensembl: ENSG000001828707   OMIM: 6062515   UniProtKB: Q9HCQ53   

Export aliases for GALNT9 gene to outside databases

Previous GC identifers: GC00U990692 GC12U900004 GC12M132561 GC12M131176 GC12M131177 GC12M131347 GC12M129565


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GALNT9 Gene:
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase
(GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by
catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by
an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and
Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but
overlapping, substrate specificities and patterns of expression. This gene is expressed specifically in the
brain, with highest expression in the cerebellum. Multiple transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for GALNT9 Gene: 
GALNT9 (UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)) is a protein-coding gene. Diseases associated with GALNT9 include sideroblastic anemia, and williams-beuren syndrome, and among its related super-pathways are Mucin type O-Glycan biosynthesis and Post-translational protein modification. GO annotations related to this gene include polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT8.

UniProtKB/Swiss-Prot: GALT9_HUMAN, Q9HCQ5
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an
N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate
apomucin or SDC3




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009755.19  NT_024477.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GALNT9 gene promoter:
         Nkx3-1   AREB6   p53   Pbx1a   Nkx3-1 v1   Cdc5   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGALNT9 promoter sequence
   Search SABiosciences Chromatin IP Primers for GALNT9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GALNT9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

GALNT9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GALNT9 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M132680:  view genomic region     (about GC identifiers)

Start:
132,680,917 bp from pter      End:
132,905,935 bp from pter
Size:
225,019 bases      Orientation:
minus strand

1 alternative location:
Chr12-,NW_003315937 12,716-103,358     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GALT9_HUMAN, Q9HCQ5 (See protein sequence)
Recommended Name: Polypeptide N-acetylgalactosaminyltransferase 9  
Size: 603 amino acids; 68359 Da
Cofactor: Manganese (By similarity)
Cofactor: Calcium (By similarity)
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Secondary accessions: Q52LR8 Q6NT54 Q8NFR1
Alternative splicing: 2 isoforms:  Q9HCQ5-1   Q9HCQ5-2   

Explore the universe of human proteins at neXtProt for GALNT9: NX_Q9HCQ5

Explore proteomics data for GALNT9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HCQ5

  • 3 DME Specific Peptides for GALNT9 (Q9HCQ5)
     GLIRARL  IFVNEALS  RAAEVWMD 

    GALNT9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GALNT9 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001116108.1  NP_068580.2  

    ENSEMBL proteins: 
     ENSP00000380488   ENSP00000394446   ENSP00000329846   ENSP00000440544   ENSP00000444709  
     ENSP00000438221   ENSP00000439745  
    Reactome Protein details: Q9HCQ5
    Human Recombinant Protein Products for GALNT9: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GALNT9
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GALNT9
    GenScript Custom Purified and Recombinant Proteins Services for GALNT9
    Novus Biologicals GALNT9 Proteins
    Novus Biologicals GALNT9 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GALNT9 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus ----
    GO:0016020membrane NAS--
    GO:0016021integral to membrane IEA--

    GALNT9 for ontologies           About GeneDecksing



    GALNT9 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GALNT9
    GenScript Custom Superior Antibodies Services for GALNT9
    Novus Biologicals GALNT9 Antibodies
    Abcam antibodies for GALNT9
    Cloud-Clone Corp. Antibodies for GALNT9 
    ThermoFisher Antibodies for GALNT9
    LSBio Antibodies in human, mouse, rat for GALNT9 

    Assay Products for GALNT9: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GALNT9
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GALNT9
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GALNT9 
    Cloud-Clone Corp. CLIAs for GALNT9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GLT2: Glycosyltransferase family 2 domain containing

    3 InterPro protein domains:
     IPR000772 Ricin_B_lectin
     IPR001173 Glyco_trans_2
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry Q9HCQ5

    ProtoNet protein and cluster: Q9HCQ5

    2 Blocks protein domains:
    IPB000772 Ricin B lectin domain
    IPB001173 Glycosyl transferase


    UniProtKB/Swiss-Prot: GALT9_HUMAN, Q9HCQ5
    Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also
    called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal
    domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal
    binding (By similarity)
    Domain: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By
    similarity)
    Similarity: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily
    Similarity: Contains 1 ricin B-type lectin domain


    GALNT9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GALT9_HUMAN, Q9HCQ5
    Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an
    N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate
    apomucin or SDC3
    Catalytic activity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP +
    N-acetyl-alpha-D-galactosaminyl-polypeptide

         Enzyme Number (IUBMB): EC 2.4.1.411 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004653polypeptide N-acetylgalactosaminyltransferase activity NAS10978536
    GO:0016740transferase activity ----
    GO:0016757transferase activity, transferring glycosyl groups ----
         
    GALNT9 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GALNT9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GALNT9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GALNT9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GALNT9 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GALNT9
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate GALNT9:
    hsa-miR-124 hsa-miR-506 hsa-miR-3622a-5p
    SwitchGear 3'UTR luciferase reporter plasmidGALNT9 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GALNT9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GALNT9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GALNT9
    Sirion Biotech Customized adenovirus for overexpression of GALNT9

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GALNT9 (see all 11)
    OriGene ORF clones in mouse, rat for GALNT9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GALNT9 (NM_001122636)
    Sino Biological Human cDNA Clone for GALNT9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GALNT9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GALNT9
    Sirion Biotech Customized lentivirus for stable overexpression of GALNT9 
                         Customized lentivirus expression plasmids for stable overexpression of GALNT9 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GALNT9
    Search LifeMap BioReagents cell lines for GALNT9
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALNT9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GALNT9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.44
    Mucin type O-Glycan biosynthesis0.44
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35
    3Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3        Reactome Pathways for GALNT9
        O-linked glycosylation of mucins
    Metabolism of proteins
    Post-translational protein modification


    2         Kegg Pathways  (Kegg details for GALNT9):
        Mucin type O-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: GALT9_HUMAN, Q9HCQ5
    Pathway: Protein modification; protein glycosylation


    GALNT9 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GALNT9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for GALNT9 (ENSP000003804884) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    GALNT1ENSP000002691954STRING: ENSP00000269195
    GALNT10ENSP000002971074STRING: ENSP00000297107
    GALNT11ENSP000003158354STRING: ENSP00000315835
    GALNT12ENSP000003641504STRING: ENSP00000364150
    GALNT14ENSP000002889884STRING: ENSP00000288988
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation ----
    GO:0006493protein O-linked glycosylation NAS10978536
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    GALNT9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GALNT9 (GALT9)

    5 HMDB Compounds for GALNT9    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Lactosaminebeta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose (see all 8)13000-25-4--
    Manganesemanganese 7439-96-5--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate-N-acetylgalactosamineUDP-N-acetyl-D-galactosamine (see all 17)7277-98-7--

    Search CenterWatch for drugs/clinical trials and news about GALNT9 / GALT9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GALNT9 gene (2 alternative transcripts): 
    NM_001122636.1  NM_021808.3  

    Unigene Clusters for GALNT9:

    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
    Hs.301062  [show with all ESTs], Hs.658249  [show with all ESTs]
    Unigene Representative Sequences: NM_001122636, AK092825
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397325(uc001uka.3) ENST00000411988 ENST00000328957(uc001ukb.3 uc001ukc.4)
    ENST00000541995 ENST00000538356 ENST00000542942 ENST00000424720(uc009zys.3)
    ENST00000535208 ENST00000540493 ENST00000535228(uc009zyr.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GALNT9
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate GALNT9:
    hsa-miR-124 hsa-miR-506 hsa-miR-3622a-5p
    SwitchGear 3'UTR luciferase reporter plasmidGALNT9 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GALNT9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GALNT9
    Clone
    Products:
         
    OriGene clones in human, mouse for GALNT9 (see all 11)
    OriGene ORF clones in mouse, rat for GALNT9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GALNT9 (NM_001122636)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GALNT9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GALNT9
    Sirion Biotech Customized lentivirus for stable overexpression of GALNT9 
                         Customized lentivirus expression plasmids for stable overexpression of GALNT9 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GALNT9
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GALNT9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GALNT9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GALNT9

    Additional mRNA sequence: 

    AK092825.1 BC157845.1 BC171844.1 

    10 DOTS entries:

    DT.95366782  DT.91748318  DT.95365156  DT.95365157  DT.99936579  DT.121179916  DT.100751930  DT.100751931 
    DT.97768808  DT.99935521 

    24/31 AceView cDNA sequences (see all 31):

    BM672467 BF940925 BE048657 AW294162 BX099049 BI760629 BF437227 AI202851 
    BM715840 AF458594 BU622800 CB154648 BG715648 BI760734 BM687318 AI695868 
    AI870792 NM_021808 AJ505960 BF511723 AA974365 BI822362 AI434403 BI756878 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GALNT9 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b · 18c
    SP1:        -           -     -     -                                   -     -     -     -     -     -                                                   
    SP2:                                                                          -     -     -     -     -                                                   
    SP3:                                                                                            -     -                                                   
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for GALNT9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GALNT9 expression in normal human tissues (normalized intensities)      GALNT9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAGCGACA
    GALNT9 Expression
    About this image


    GALNT9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Septum   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Fibroblast
             Human Ovarian Fibroblasts (HOF)   
     
     Eye (Sensory Organs)
             Retina

    See GALNT9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GALNT9

    SOURCE GeneReport for Unigene clusters: Hs.301062 Hs.658249

    UniProtKB/Swiss-Prot: GALT9_HUMAN, Q9HCQ5
    Tissue specificity: Specifically expressed in brain. Not expressed in heart, placenta, lung, liver, skeletal
    muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte. In
    brain, it is expressed in cerebellum, frontal lobe, temporal lobe, putamen and spinal cord, weakly expressed in
    cerebral cortex. Not expressed in medulla and occipital pole

        SABiosciences Expression via Pathway-Focused PCR Array including GALNT9: 
              Glycosylation in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GALNT9
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GALNT9
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GALNT9
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GALNT9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALNT9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GALNT9 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Galnt91 , 5 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more1, 5 86.01(n)1
    91.54(a)1
      5 (53.66 cM)5
    2316051  NM_198306.21  NP_938048.21 
     1105443455 
    chicken
    (Gallus gallus)
    Aves GALNT91 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more 79.38(n)
    90.22(a)
      416796  XM_415088.2  XP_415088.2 
    lizard
    (Anolis carolinensis)
    Reptilia GALNT96
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-a...
    31(a)
    1 ↔ 1
    GL343364.1(231255-301632)
    zebrafish
    (Danio rerio)
    Actinopterygii galnt91 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more 75.23(n)
    83.58(a)
      797549  XM_001337982.4  XP_001338018.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73043 polypeptide
    N-acetylgalactosaminyltransferase
    32(a)   71F1   --
    worm
    (Caenorhabditis elegans)
    Secernentea gly-86
    Probable N-acetylgalactosaminyltransferase 8
    8(a)
    1 → many
    III(11624991-11628238)


    ENSEMBL Gene Tree for GALNT9 (if available)
    TreeFam Gene Tree for GALNT9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GALNT9 gene
    GALNT82  GALNT182  WBSCR172  GALNT152  
    18/24 SIMAP similar genes for GALNT9 using alignment to 8 protein entries:     GALT9_HUMAN (see all proteins) (see all similar genes):
    WBSCR17    GALNT19    DKFZp434I2216    GALNTL6    GALNT18    GALNTL4
    GALNT11    GALNT8    GALNT3    GALNT14    GALNT1    GALNT16
    GalNAc-T16    GALNT6    GALNT13    GalNAc-T10    GALNTL5    GALNT2

    GALNT9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/575 SNPs in GALNT9 are shown (see all 575)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423003301,2
    C--132680527(+) CCTCGA/TCCTCC 1 -- ds50010--------
    rs1457199591,2
    C--132680558(+) CTGGA-/GTCCCT 1 -- ds50010--------
    rs1832096811,2
    --132680567(+) CTGGCA/GTCTGC 1 -- ds50010--------
    rs1887549081,2
    --132680583(+) CCTCTC/GTGCGT 1 -- ds50010--------
    rs1932906051,2
    --132680587(+) TCTGCA/GTCATG 1 -- ds50010--------
    rs766070641,2
    C,F--132680596(+) TGTGCA/GTGCAG 1 -- ds50012Minor allele frequency- G:0.12CSA WA 120
    rs1163359981,2
    --132680712(+) GCTCTC/TCTCCA 1 -- ds50010--------
    rs802282741,2
    C,F--132680724(+) TTTCCC/TGGCTG 1 -- ds50012Minor allele frequency- T:0.07CSA WA 119
    rs1175753741,2
    C,F--132680734(+) GCATCG/AAGTTC 1 -- ds50011Minor allele frequency- A:0.02NA 120
    rs756595111,2
    C,F--132680756(+) GCACAC/TGTGAG 1 -- ds50011Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for GALNT9 (132680917 - 132905935 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/86 variations for GALNT9 (see all 86):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2746925CNV Deletion23290073
    esv1357697CNV Deletion17803354
    esv2665547CNV Deletion23128226
    esv1005562CNV Deletion20482838
    esv2746946CNV Deletion23290073
    esv2746953CNV Deletion23290073
    esv2746929CNV Deletion23290073
    esv1095643CNV Deletion17803354
    esv2746935CNV Deletion23290073
    esv2746951CNV Deletion23290073


    Human Gene Mutation Database (HGMD): GALNT9
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing GALNT9
    DNA2.0 Custom Variant and Variant Library Synthesis for GALNT9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606251    OMIM disorders: --

    8 diseases for GALNT9:    About MalaCards
    sideroblastic anemia    williams-beuren syndrome    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    anemia    cerebritis    neuronitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for GALNT9:
    Williams-Beuren syndrome

    GALNT9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GALNT9

    Export disorders for GALNT9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GALNT9 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with GALNT9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a new human UDP-N-acetyl-alpha-D- galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen. (PubMed id 12407114)1, 2, 3 Zhang Y....Narimatsu H. (2003)
    2. Brain-specific expression of a novel human UDP-GalNAc:polypeptide N- acetylgalactosaminyltransferase (GalNAc-T9). (PubMed id 10978536)1, 2, 3 Toba S.... Kurosaka A. (2000)
    3. GALNT9 gene expression is a prognostic marker in neuro blastoma patients. (PubMed id 23136245)1 Berois N....Osinaga E. (2013)
    4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
    10. Cloning and expression of a brain-specific putative U DP-GalNAc: polypeptide N-acetylgalactosaminyltransferase gene. (PubMed id 15744064)9 Nakamura N....Kurosaka A. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50614 HGNC: 4131 AceView: GALNT9 Ensembl:ENSG00000182870 euGenes: HUgn50614
    ECgene: GALNT9 Kegg: 50614 H-InvDB: GALNT9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GALNT9 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_491

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GALNT9 gene:
    Search GeneIP for patents involving GALNT9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GALNT9  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for GALNT9  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GALNT9  
     OriGene qSTAR qPCR primer pairs in human, mouse for GALNT9   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GALNT9   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GALNT9   OriGene Custom Protein Services for GALNT9  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GALNT9
     QIAGEN SeqTarget long-range PCR primers for resequencing GALNT9
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GALNT9
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GALNT9
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GALNT9
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GALNT9
     GenScript Custom Purified and Recombinant Proteins Services for GALNT9 GenScript cDNA clones with any tag delivered in your preferred vector for GALNT9
     GenScript Custom Assay Services for GALNT9 GenScript Custom Superior Antibodies Services for GALNT9
     GenScript Custom overexpressing Cell Line Services for GALNT9 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GALNT9 promoter
     Search Chromatin IP Primers for GALNT9
     RT2 qPCR Primer Assay in human, mouse / rat GALNT9
     Search GNC Networks for GALNT9
     SABiosciences PCR Arrays including human, mouse, rat GALNT9
     Search Tocris compounds for GALNT9 (GALT9)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for GALNT9
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GALNT9 antibodies
     GALNT9 proteins
     GALNT9 lysates
     Antibodies for GALNT9
     See all of Abcam's Antibodies, Kits and Proteins for GALNT9
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for GALNT9
     Antibodies for GALNT9
     ELISAs for GALNT9
     CLIAs for GALNT9
     Search LifeMap BioReagents cell lines for GALNT9
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALNT9
     SwitchGear 3'UTR luciferase reporter plasmids for GALNT9
     SwitchGear Promoter luciferase reporter plasmids for GALNT9
     ThermoFisher Antibodies for GALNT9
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GALNT9
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GALNT9
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GALNT9
    Customized:
     lentivirus for stable overexpression of GALNT9
     lentivirus expression plasmids for stable overexpression of GALNT9
     adenovirus for overexpression of GALNT9
     LSBio Antibodies in human, mouse, rat for GALNT9
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GALNT9 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4