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Aliases for GALNT9 Gene

Aliases for GALNT9 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 9 2 3
  • Polypeptide GalNAc Transferase 9 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 9 (GalNAc-T9) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 9 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 9 3 4
  • Pp-GaNTase 9 3 4
  • EC 4 63
  • GALNAC-T9 3 4
  • GALNACT9 3 6
  • UDP-GalNAc: Polypeptide N-Acetylgalactosaminyltransferase 9 3
  • GalNAc Transferase 9 3

External Ids for GALNT9 Gene

Previous GeneCards Identifiers for GALNT9 Gene

  • GC00U990692
  • GC12U900004
  • GC12M132561
  • GC12M131176
  • GC12M131177
  • GC12M131347
  • GC12M132680
  • GC12M129565

Summaries for GALNT9 Gene

Entrez Gene Summary for GALNT9 Gene

  • This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. This gene is expressed specifically in the brain, with highest expression in the cerebellum. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GALNT9 Gene

GALNT9 (Polypeptide N-Acetylgalactosaminyltransferase 9) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is WBSCR17.

UniProtKB/Swiss-Prot for GALNT9 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate apomucin or SDC3

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT9 Gene

Genomics for GALNT9 Gene

Regulatory Elements for GALNT9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GALNT9 Gene

132,196,372 bp from pter
132,329,349 bp from pter
132,978 bases
Minus strand

Genomic View for GALNT9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GALNT9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT9 Gene

Proteins for GALNT9 Gene

  • Protein details for GALNT9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 9
    Protein Accession:
    Secondary Accessions:
    • Q52LR8
    • Q6NT54
    • Q8NFR1

    Protein attributes for GALNT9 Gene

    603 amino acids
    Molecular mass:
    68359 Da
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GALNT9 Gene


neXtProt entry for GALNT9 Gene

Proteomics data for GALNT9 Gene at MOPED

Selected DME Specific Peptides for GALNT9 Gene

Post-translational modifications for GALNT9 Gene

  • Glycosylation at Asn460
  • Modification sites at PhosphoSitePlus

Other Protein References for GALNT9 Gene

Antibody Products

Domains for GALNT9 Gene

Gene Families for GALNT9 Gene

  • GLT2 :Glycosyltransferase family 2 domain containing

Graphical View of Domain Structure for InterPro Entry



  • Q9HCQ5
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • Contains 1 ricin B-type lectin domain.
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNT9: view

Function for GALNT9 Gene

Molecular function for GALNT9 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
UniProtKB/Swiss-Prot Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate apomucin or SDC3

Enzyme Numbers (IUBMB) for GALNT9 Gene

Gene Ontology (GO) - Molecular Function for GALNT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity NAS 10978536
GO:0016757 transferase activity, transferring glycosyl groups --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNT9: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GALNT9

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GALNT9 Gene

Localization for GALNT9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT9 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for GALNT9 Gene COMPARTMENTS Subcellular localization image for GALNT9 gene
Compartment Confidence
golgi apparatus 5
extracellular 3
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GALNT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GALNT9: view

Pathways for GALNT9 Gene

genes like me logo Genes that share pathways with GALNT9: view

Pathways by source for GALNT9 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9HCQ5-GALT9_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for GALNT9 Gene

Gene Ontology (GO) - Biological Process for GALNT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation --
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with GALNT9: view

Compounds for GALNT9 Gene

(5) HMDB Compounds for GALNT9 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • beta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
  • manganese
Uridine 5'-diphosphate
  • 5'-UDP
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-acetyl-D-galactosamine
genes like me logo Genes that share compounds with GALNT9: view

Transcripts for GALNT9 Gene

Unigene Clusters for GALNT9 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GALNT9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT9 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: - - - - - - - - - -
SP2: - - - - -
SP3: - -

Relevant External Links for GALNT9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GALNT9 Gene

mRNA expression in normal human tissues for GALNT9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNT9 Gene

This gene is overexpressed in Brain - Cerebellum (10.9), Brain - Cerebellar Hemisphere (10.2), Brain - Cortex (6.8), Brain - Frontal Cortex (BA9) (5.1), and Brain - Anterior cingulate cortex (BA24) (4.5).

Protein differential expression in normal tissues for GALNT9 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GALNT9 Gene

SOURCE GeneReport for Unigene cluster for GALNT9 Gene Hs.301062

mRNA Expression by UniProt/SwissProt for GALNT9 Gene

Tissue specificity: Specifically expressed in brain. Not expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte. In brain, it is expressed in cerebellum, frontal lobe, temporal lobe, putamen and spinal cord, weakly expressed in cerebral cortex. Not expressed in medulla and occipital pole.
genes like me logo Genes that share expressions with GALNT9: view

Expression partners for GALNT9 Gene

In Situ Assay Products

Orthologs for GALNT9 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT9 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia GALNT9 35
  • 85.68 (n)
  • 86.9 (a)
  • 36 (a)
(Mus musculus)
Mammalia Galnt9 35
  • 86.01 (n)
  • 91.54 (a)
Galnt9 16
Galnt9 36
  • 38 (a)
(Rattus norvegicus)
Mammalia Galnt9 35
  • 85.71 (n)
  • 91.53 (a)
(Bos Taurus)
Mammalia WBSCR17 36
  • 36 (a)
(Monodelphis domestica)
Mammalia GALNT9 36
  • 41 (a)
(Ornithorhynchus anatinus)
Mammalia GALNT9 36
  • 77 (a)
(Pan troglodytes)
Mammalia GALNT9 36
  • 98 (a)
(Gallus gallus)
Aves GALNT9 35
  • 79.38 (n)
  • 90.22 (a)
  • 36 (a)
(Anolis carolinensis)
Reptilia GALNT9 36
  • 31 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt9 35
  • 74.07 (n)
  • 87.73 (a)
(Danio rerio)
Actinopterygii galnt9 35
  • 75.23 (n)
  • 83.58 (a)
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7304 37
  • 32 (a)
CG7579 36
  • 11 (a)
(Caenorhabditis elegans)
Secernentea gly-8 36
  • 8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
Species with no ortholog for GALNT9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNT9 Gene

Gene Tree for GALNT9 (if available)
Gene Tree for GALNT9 (if available)

Paralogs for GALNT9 Gene

Paralogs for GALNT9 Gene

genes like me logo Genes that share paralogs with GALNT9: view

Variants for GALNT9 Gene

Sequence variations from dbSNP and Humsavar for GALNT9 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3935241 -- 132,204,900(-) GGCCT(A/G)GCACA intron-variant
rs3935242 -- 132,204,802(-) GTCAG(C/G)CGTGG intron-variant
rs3935243 -- 132,204,666(-) GTGGG(C/T)TTAGC intron-variant
rs3935476 -- 132,204,297(+) TCCTA(C/T)ACGTG intron-variant
rs3935477 -- 132,204,440(+) GAGCC(A/G)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GALNT9 Gene

Variant ID Type Subtype PubMed ID
nsv899699 CNV Gain 21882294
dgv1519n71 CNV Loss 21882294
dgv1520n71 CNV Loss 21882294
nsv428285 CNV Gain 18775914
dgv1522n71 CNV Loss 21882294
dgv1524n71 CNV Loss 21882294
nsv470333 CNV Loss 18288195
dgv103n21 CNV Loss 19592680
nsv826563 CNV Gain 20364138
dgv1525n71 CNV Loss 21882294
nsv899743 CNV Loss 21882294
nsv899748 CNV Gain 21882294
dgv1526n71 CNV Loss 21882294
nsv528119 CNV Loss 19592680
nsv899752 CNV Loss 21882294
nsv899753 CNV Loss 21882294
dgv1528n71 CNV Loss 21882294
nsv520897 CNV Loss 19592680
dgv1529n71 CNV Gain 21882294
dgv1530n71 CNV Loss 21882294
nsv512300 CNV Loss 21212237
esv27874 CNV Loss 19812545
esv2746924 CNV Deletion 23290073
esv1766304 CNV Deletion 17803354
esv2746925 CNV Deletion 23290073
esv2746926 CNV Deletion 23290073
esv1994448 CNV Deletion 18987734
esv2746927 CNV Deletion 23290073
esv2746928 CNV Deletion 23290073
esv23126 CNV Gain+Loss 19812545
esv2746929 CNV Deletion 23290073
esv996047 CNV Deletion 20482838
esv996584 CNV Deletion 20482838
esv1566393 CNV Deletion 17803354
esv2663155 CNV Deletion 23128226
esv1661581 CNV Deletion 17803354
esv2668049 CNV Deletion 23128226
esv1746298 CNV Deletion 17803354
esv1133096 CNV Deletion 17803354
esv1095643 CNV Deletion 17803354
esv1357697 CNV Deletion 17803354
esv1462855 CNV Deletion 17803354
nsv53189 CNV Insertion 16902084
esv2746931 CNV Deletion 23290073
esv2746932 CNV Deletion 23290073
nsv52579 CNV Loss 16902084
esv2746933 CNV Deletion 23290073
esv2746934 CNV Deletion 23290073
esv2670347 CNV Deletion 23128226
esv2746935 CNV Deletion 23290073
esv1156001 CNV Deletion 17803354
esv1005562 CNV Deletion 20482838
esv2673626 CNV Deletion 23128226
esv2746936 CNV Deletion 23290073
esv26563 CNV Gain 19812545
esv2746937 CNV Deletion 23290073
esv2473849 CNV Deletion 19546169
nsv512301 CNV Loss 21212237
esv2746938 CNV Deletion 23290073
esv1257970 CNV Deletion 17803354
esv1160630 CNV Deletion 17803354
esv2746939 CNV Deletion 23290073
esv2746940 CNV Deletion 23290073
nsv52990 CNV Insertion 16902084
esv2746942 CNV Deletion 23290073
esv2746943 CNV Deletion 23290073
esv2746944 CNV Deletion 23290073
nsv826565 CNV Gain+Loss 20364138
esv998915 CNV Loss 20482838
nsv826566 CNV Gain 20364138
esv29785 CNV Gain 19812545
esv2658877 CNV Deletion 23128226
esv2746945 CNV Deletion 23290073
esv2665547 CNV Deletion 23128226
esv2746946 CNV Deletion 23290073
dgv234e201 CNV Deletion 23290073
esv25270 CNV Loss 19812545
esv2746948 CNV Deletion 23290073
dgv235e201 CNV Deletion 23290073
dgv236e201 CNV Deletion 23290073
esv2746950 CNV Deletion 23290073
esv2746951 CNV Deletion 23290073
esv2746953 CNV Deletion 23290073
esv991305 CNV Insertion 20482838
esv1002994 CNV Insertion 20482838
nsv899765 CNV Loss 21882294

Relevant External Links for GALNT9 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT9 Gene

Disorders for GALNT9 Gene

(1) University of Copenhagen DISEASES for GALNT9 Gene

Relevant External Links for GALNT9

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with GALNT9: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for GALNT9 Gene

Publications for GALNT9 Gene

  1. Brain-specific expression of a novel human UDP-GalNAc:polypeptide N- acetylgalactosaminyltransferase (GalNAc-T9). (PMID: 10978536) Toba S. … Kurosaka A. (Biochim. Biophys. Acta 2000) 2 3 4
  2. Cloning and characterization of a new human UDP-N-acetyl-alpha-D- galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen. (PMID: 12407114) Zhang Y. … Narimatsu H. (J. Biol. Chem. 2003) 2 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for GALNT9 Gene

Sources for GALNT9 Gene

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