Aliases for GALNT8 Gene
External Ids for GALNT8 Gene
Previous GeneCards Identifiers for GALNT8 Gene
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. [provided by RefSeq, Jul 2008]
GeneCards Summary for GALNT8 Gene
GALNT8 (Polypeptide N-Acetylgalactosaminyltransferase 8) is a Protein Coding gene. Among its related pathways are Mucin type O-glycan biosynthesis and O-linked glycosylation. GO annotations related to this gene include carbohydrate binding and voltage-gated potassium channel activity. An important paralog of this gene is GALNT18.
UniProtKB/Swiss-Prot for GALNT8 Gene
Probably catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.