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Aliases for GALNT7 Gene

Aliases for GALNT7 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 7 2 3
  • Polypeptide GalNAc Transferase 7 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 7 (GalNAc-T7) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 7 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 7 3 4
  • Pp-GaNTase 7 3 4
  • GALNAC-T7 3 4
  • N-Acetylgalactosaminyltransferase 7 3
  • EC 2.4.1.41 63
  • EC 2.4.1.37 63
  • EC 2.4.1.- 4
  • GalNAcT7 3
  • EC 2.4.1 63

External Ids for GALNT7 Gene

Summaries for GALNT7 Gene

Entrez Gene Summary for GALNT7 Gene

  • This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. This enzyme is a type II transmembrane protein and shares common sequence motifs with other family members. Unlike other family members, this enzyme shows exclusive specificity for partially GalNAc-glycosylated acceptor substrates and shows no activity with non-glycosylated peptides. This protein may function as a follow-up enzyme in the initiation step of O-glycosylation. [provided by RefSeq, Jul 2008]

GeneCards Summary for GALNT7 Gene

GALNT7 (Polypeptide N-Acetylgalactosaminyltransferase 7) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT4.

UniProtKB/Swiss-Prot for GALNT7 Gene

  • Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT7 Gene

Genomics for GALNT7 Gene

Genomic Location for GALNT7 Gene

Start:
173,168,753 bp from pter
End:
173,323,967 bp from pter
Size:
155,215 bases
Orientation:
Plus strand

Genomic View for GALNT7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GALNT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT7 Gene

Regulatory Elements for GALNT7 Gene

Proteins for GALNT7 Gene

  • Protein details for GALNT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SF2-GALT7_HUMAN
    Recommended name:
    N-acetylgalactosaminyltransferase 7
    Protein Accession:
    Q86SF2
    Secondary Accessions:
    • B3KQU3
    • Q7Z5W7
    • Q9UJ28

    Protein attributes for GALNT7 Gene

    Size:
    657 amino acids
    Molecular mass:
    75389 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for GALNT7 Gene

Proteomics data for GALNT7 Gene at MOPED

Post-translational modifications for GALNT7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GALNT7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GALNT7 Gene

Gene Families for GALNT7 Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

Graphical View of Domain Structure for InterPro Entry

Q86SF2

UniProtKB/Swiss-Prot:

GALT7_HUMAN
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.:
    • Q86SF2
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.:
    • Q86SF2
  • Contains 1 ricin B-type lectin domain.:
    • Q86SF2
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.:
    • Q86SF2
genes like me logo Genes that share domains with GALNT7: view

Function for GALNT7 Gene

Molecular function for GALNT7 Gene

UniProtKB/Swiss-Prot Function: Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified

Enzyme Numbers (IUBMB) for GALNT7 Gene

Gene Ontology (GO) - Molecular Function for GALNT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNT7: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GALNT7 Gene

Localization for GALNT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT7 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GALNT7 Gene COMPARTMENTS Subcellular localization image for GALNT7 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GALNT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with GALNT7: view

Pathways for GALNT7 Gene

genes like me logo Genes that share pathways with GALNT7: view

Pathways by source for GALNT7 Gene

UniProtKB/Swiss-Prot Q86SF2-GALT7_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for GALNT7 Gene

Gene Ontology (GO) - Biological Process for GALNT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 10544240
GO:0006493 protein O-linked glycosylation TAS --
GO:0008152 metabolic process --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with GALNT7: view

Compounds for GALNT7 Gene

(5) HMDB Compounds for GALNT7 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Lactosamine
  • beta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
13000-25-4
Manganese
  • manganese
7439-96-5
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT7: view

Transcripts for GALNT7 Gene

Unigene Clusters for GALNT7 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - -
SP2:
SP3:
SP4:
SP5:

Relevant External Links for GALNT7 Gene

GeneLoc Exon Structure for
GALNT7
ECgene alternative splicing isoforms for
GALNT7

Expression for GALNT7 Gene

mRNA expression in normal human tissues for GALNT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GALNT7 Gene

SOURCE GeneReport for Unigene cluster for GALNT7 Gene Hs.548088

mRNA Expression by UniProt/SwissProt for GALNT7 Gene

Q86SF2-GALT7_HUMAN
Tissue specificity: Widely expressed. Expressed in uterus, retina, kidney, small intestine, omentum, stomach and CNS.
genes like me logo Genes that share expressions with GALNT7: view

No data available for mRNA differential expression in normal tissues for GALNT7 Gene

Orthologs for GALNT7 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNT7 35
  • 99.44 (n)
  • 99.54 (a)
GALNT7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GALNT7 35
  • 88.76 (n)
  • 92.81 (a)
GALNT7 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GALNT7 36
  • 96 (a)
OneToOne
LOC102152620 35
  • 94.06 (n)
  • 95.74 (a)
mouse
(Mus musculus)
Mammalia Galnt7 35
  • 88.89 (n)
  • 93.3 (a)
Galnt7 16
Galnt7 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GALNT7 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GALNT7 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Galnt7 35
  • 90.26 (n)
  • 95.43 (a)
chicken
(Gallus gallus)
Aves GALNT7 35
  • 81.54 (n)
  • 88.11 (a)
GALNT7 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GALNT7 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt7 35
  • 73.31 (n)
  • 78.37 (a)
zebrafish
(Danio rerio)
Actinopterygii galnt7 35
  • 70.4 (n)
  • 79.75 (a)
galnt7 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000656 35
  • 49.57 (n)
  • 48.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta GalNAc-T2 35
  • 50.23 (n)
  • 49.12 (a)
GalNAc-T2 36
  • 44 (a)
OneToOne
CG7579 37
  • 31 (a)
CG7297 37
  • 34 (a)
CG6394 37
  • 36 (a)
CG7304 37
  • 28 (a)
CG2103 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea gly-7 35
  • 51.18 (n)
  • 48.04 (a)
gly-7 36
  • 42 (a)
OneToOne
Y45F10D.3 37
  • 40 (a)
gly-7 37
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToOne
Species with no ortholog for GALNT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNT7 Gene

ENSEMBL:
Gene Tree for GALNT7 (if available)
TreeFam:
Gene Tree for GALNT7 (if available)

Paralogs for GALNT7 Gene

genes like me logo Genes that share paralogs with GALNT7: view

Variants for GALNT7 Gene

Sequence variations from dbSNP and Humsavar for GALNT7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs722826 -- 173,176,909(-) CTCTC(C/T)TCACT intron-variant
rs722827 -- 173,176,866(-) CTTAT(A/G)GCCCA intron-variant
rs1006002 -- 173,171,437(+) GTTCT(G/T)CCTCT intron-variant
rs1006003 -- 173,171,640(+) TTCCC(A/G)TCTCT intron-variant
rs1008052 -- 173,173,380(-) CTAAA(A/G)CCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GALNT7 Gene

Variant ID Type Subtype PubMed ID
esv24067 CNV Loss 19812545
nsv518900 CNV Gain 19592680
nsv527434 CNV Gain 19592680
esv272207 CNV Insertion 20981092
esv267455 CNV Insertion 20981092
nsv4610 CNV Loss 18451855

Relevant External Links for GALNT7 Gene

HapMap Linkage Disequilibrium report
GALNT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT7 Gene

Disorders for GALNT7 Gene

No disorders were found for GALNT7 Gene.

No data available for UniProtKB/Swiss-Prot for GALNT7 Gene

Publications for GALNT7 Gene

  1. A novel human UDP-N-acetyl-D-galactosamine;polypeptide N- acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates. (PMID: 10544240) Bennett E.P. … Clausen H. (FEBS Lett. 1999) 2 3 4
  2. MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7. (PMID: 19844573) Kahai S. … Yang B.B. (PLoS ONE 2009) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for GALNT7 Gene

  • antibodies-online proteins for GALNT7
  • antibodies-online antibodies for GALNT7
  • antibodies-online kits for GALNT7

Sources for GALNT7 Gene

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