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Aliases for GALNT7 Gene

Aliases for GALNT7 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 7 2 3 5
  • Polypeptide GalNAc Transferase 7 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 7 (GalNAc-T7) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 7 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 7 3 4
  • Pp-GaNTase 7 3 4
  • GALNAC-T7 3 4
  • N-Acetylgalactosaminyltransferase 7 3
  • EC 2.4.1.41 61
  • EC 2.4.1.37 61
  • EC 2.4.1.- 4
  • GalNAcT7 3
  • EC 2.4.1 61

External Ids for GALNT7 Gene

Previous GeneCards Identifiers for GALNT7 Gene

  • GC04P175010
  • GC04P174627
  • GC04P174785
  • GC04P174464
  • GC04P174326
  • GC04P174089
  • GC04P169916

Summaries for GALNT7 Gene

Entrez Gene Summary for GALNT7 Gene

  • This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. This enzyme is a type II transmembrane protein and shares common sequence motifs with other family members. Unlike other family members, this enzyme shows exclusive specificity for partially GalNAc-glycosylated acceptor substrates and shows no activity with non-glycosylated peptides. This protein may function as a follow-up enzyme in the initiation step of O-glycosylation. [provided by RefSeq, Jul 2008]

GeneCards Summary for GALNT7 Gene

GALNT7 (Polypeptide N-Acetylgalactosaminyltransferase 7) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Mucin type O-glycan biosynthesis. GO annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT10.

UniProtKB/Swiss-Prot for GALNT7 Gene

  • Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT7 Gene

Genomics for GALNT7 Gene

Regulatory Elements for GALNT7 Gene

Enhancers for GALNT7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F173241 0.6 Ensembl ENCODE 6.9 +74.6 74553 2.6 INSM2 EBF1 NR2F2 OSR2 JUND FOS ZBTB33 WT1 SP7 MIR548T LOC101930370 GALNT7
GH04F173236 0.5 Ensembl ENCODE 6.5 +68.6 68628 2.4 HDAC1 PKNOX1 TBL1XR1 ARNT SIN3A FEZF1 RAD21 CHAMP1 ZNF335 GATA2 LOC101930370 GALNT7 MIR548T
GH04F173208 1.3 Ensembl ENCODE 6.4 +41.6 41564 4.6 CBX3 PKNOX1 SIN3A FEZF1 RAD21 ZNF366 RCOR1 FOS JUNB ZHX2 LOC101930370 GALNT7 MIR548T
GH04F173229 0.5 Ensembl ENCODE 6.4 +62.2 62157 2.8 BCOR CTCF PKNOX1 ZMYM3 REST RAD21 ZNF335 JUND ZNF24 FOXP2 LOC101930370 GALNT7 MIR548T
GH04F173179 1.1 Ensembl ENCODE 6.1 +12.6 12574 4.3 PKNOX1 JUN GLI4 ZIC2 HIC1 ZNF316 GATA3 CTBP1 ZNF157 FOS LOC101930370 GALNT7 MIR548T
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GALNT7 on UCSC Golden Path with GeneCards custom track

Promoters for GALNT7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001437537 547 3401 HDGF PKNOX1 CREB3L1 ZFP64 SIN3A FEZF1 GLI4 ZNF2 GLIS2 ZNF263

Genomic Location for GALNT7 Gene

Chromosome:
4
Start:
173,168,753 bp from pter
End:
173,323,967 bp from pter
Size:
155,215 bases
Orientation:
Plus strand

Genomic View for GALNT7 Gene

Genes around GALNT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GALNT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GALNT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT7 Gene

Proteins for GALNT7 Gene

  • Protein details for GALNT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SF2-GALT7_HUMAN
    Recommended name:
    N-acetylgalactosaminyltransferase 7
    Protein Accession:
    Q86SF2
    Secondary Accessions:
    • B3KQU3
    • Q7Z5W7
    • Q9UJ28

    Protein attributes for GALNT7 Gene

    Size:
    657 amino acids
    Molecular mass:
    75389 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for GALNT7 Gene

Post-translational modifications for GALNT7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GALNT7 Gene

Domains & Families for GALNT7 Gene

Gene Families for GALNT7 Gene

Graphical View of Domain Structure for InterPro Entry

Q86SF2

UniProtKB/Swiss-Prot:

GALT7_HUMAN :
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • Contains 1 ricin B-type lectin domain.
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNT7: view

Function for GALNT7 Gene

Molecular function for GALNT7 Gene

UniProtKB/Swiss-Prot Function:
Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.

Enzyme Numbers (IUBMB) for GALNT7 Gene

Gene Ontology (GO) - Molecular Function for GALNT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNT7: view
genes like me logo Genes that share phenotypes with GALNT7: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GALNT7 Gene

Localization for GALNT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT7 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GALNT7 Gene COMPARTMENTS Subcellular localization image for GALNT7 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GALNT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with GALNT7: view

Pathways & Interactions for GALNT7 Gene

genes like me logo Genes that share pathways with GALNT7: view

Pathways by source for GALNT7 Gene

UniProtKB/Swiss-Prot Q86SF2-GALT7_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for GALNT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 10544240
GO:0006486 protein glycosylation IEA --
GO:0006493 protein O-linked glycosylation TAS 10544240
GO:0016266 O-glycan processing TAS --
genes like me logo Genes that share ontologies with GALNT7: view

No data available for SIGNOR curated interactions for GALNT7 Gene

Drugs & Compounds for GALNT7 Gene

(3) Drugs for GALNT7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 34
Uridine-5'-Diphosphate Experimental Pharma 0
calcium Nutra 0

(2) Additional Compounds for GALNT7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lactosamine
  • 2-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose
  • 2-Amino-2-deoxy-4-O-beta-delta-galactopyranosyl-delta-glucose
  • beta-D-Galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
  • beta-D-Galactopyranosyl-(1->4)-D-glucosamine
  • beta-delta-Galactopyranosyl-(1->4)-2-amino-2-deoxy-delta-glucose
13000-25-4
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
  • Uridine 5'-diphospho-N-acetylgalactosamine
  • Uridine diphosphate-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT7: view

Transcripts for GALNT7 Gene

Unigene Clusters for GALNT7 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - -
SP2:
SP3:
SP4:
SP5:

Relevant External Links for GALNT7 Gene

GeneLoc Exon Structure for
GALNT7
ECgene alternative splicing isoforms for
GALNT7

Expression for GALNT7 Gene

mRNA expression in normal human tissues for GALNT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GALNT7 Gene

This gene is overexpressed in Oral epithelium (20.6) and Breast (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GALNT7 Gene



NURSA nuclear receptor signaling pathways regulating expression of GALNT7 Gene:

GALNT7

SOURCE GeneReport for Unigene cluster for GALNT7 Gene:

Hs.548088

mRNA Expression by UniProt/SwissProt for GALNT7 Gene:

Q86SF2-GALT7_HUMAN
Tissue specificity: Widely expressed. Expressed in uterus, retina, kidney, small intestine, omentum, stomach and CNS.
genes like me logo Genes that share expression patterns with GALNT7: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for GALNT7 Gene

Orthologs for GALNT7 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNT7 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia GALNT7 35
  • 96 (a)
OneToOne
LOC102152620 34
  • 94.06 (n)
rat
(Rattus norvegicus)
Mammalia Galnt7 34
  • 90.26 (n)
mouse
(Mus musculus)
Mammalia Galnt7 34 16 35
  • 88.89 (n)
cow
(Bos Taurus)
Mammalia GALNT7 34 35
  • 88.76 (n)
oppossum
(Monodelphis domestica)
Mammalia GALNT7 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GALNT7 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves GALNT7 34 35
  • 81.54 (n)
lizard
(Anolis carolinensis)
Reptilia GALNT7 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt7 34
  • 73.31 (n)
zebrafish
(Danio rerio)
Actinopterygii galnt7 34 35
  • 70.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta GalNAc-T2 34 35
  • 50.23 (n)
CG2103 36
  • 37 (a)
CG6394 36
  • 36 (a)
CG7297 36
  • 34 (a)
CG7579 36
  • 31 (a)
CG7304 36
  • 28 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000656 34
  • 49.57 (n)
worm
(Caenorhabditis elegans)
Secernentea gly-7 36 34 35
  • 51.18 (n)
Y45F10D.3 36
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 56 (a)
OneToOne
Species where no ortholog for GALNT7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNT7 Gene

ENSEMBL:
Gene Tree for GALNT7 (if available)
TreeFam:
Gene Tree for GALNT7 (if available)

Paralogs for GALNT7 Gene

Variants for GALNT7 Gene

Sequence variations from dbSNP and Humsavar for GALNT7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10001613 -- 173,210,995(+) tcagc(A/G)tgtaa intron-variant
rs10005325 -- 173,219,701(+) taagg(C/T)ggtat intron-variant, upstream-variant-2KB
rs10007072 -- 173,313,086(+) TTAAA(A/G)AAAGG intron-variant
rs10007279 -- 173,224,753(+) cacgc(C/T)tgtaa intron-variant
rs10009352 -- 173,319,057(+) CAGTG(A/G)GATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GALNT7 Gene

Variant ID Type Subtype PubMed ID
dgv9397n54 CNV gain 21841781
esv24067 CNV loss 19812545
esv3303175 CNV mobile element insertion 20981092
esv3307933 CNV mobile element insertion 20981092
esv3340436 CNV insertion 20981092
esv3351993 CNV insertion 20981092
esv3397362 CNV insertion 20981092
esv3603210 CNV loss 21293372
nsv1074239 CNV deletion 25765185
nsv1120145 OTHER inversion 24896259
nsv4610 CNV deletion 18451855
nsv518900 CNV gain 19592680
nsv527434 CNV gain 19592680
nsv596224 CNV loss 21841781
nsv596232 CNV gain 21841781

Variation tolerance for GALNT7 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GALNT7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GALNT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT7 Gene

Disorders for GALNT7 Gene

Relevant External Links for GALNT7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GALNT7

No disorders were found for GALNT7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GALNT7 Gene

Publications for GALNT7 Gene

  1. A novel human UDP-N-acetyl-D-galactosamine;polypeptide N- acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates. (PMID: 10544240) Bennett E.P. … Clausen H. (FEBS Lett. 1999) 2 3 4 64
  2. MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7. (PMID: 19844573) Kahai S. … Yang B.B. (PLoS ONE 2009) 3 22 64
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for GALNT7 Gene

Sources for GALNT7 Gene

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