Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GALNT6 Gene

Aliases for GALNT6 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 6 2 3
  • Polypeptide GalNAc Transferase 6 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 6 (GalNAc-T6) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 6 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 6 3 4
  • Pp-GaNTase 6 3 4
  • EC 2.4.1.41 4 63
  • GALNAC-T6 3 4
  • GalNAcT6 3 6
  • UDP-N-Acetyl-Alpha-D-Galactosamine: Polypeptide N-Acetylgalactosaminyltransferase 6 3
  • GalNAc Transferase 6 3

External Ids for GALNT6 Gene

Summaries for GALNT6 Gene

Entrez Gene Summary for GALNT6 Gene

  • This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008]

GeneCards Summary for GALNT6 Gene

GALNT6 (Polypeptide N-Acetylgalactosaminyltransferase 6) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT4.

UniProtKB/Swiss-Prot for GALNT6 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides

Gene Wiki entry for GALNT6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT6 Gene

Genomics for GALNT6 Gene

Genomic Location for GALNT6 Gene

Start:
51,351,247 bp from pter
End:
51,392,867 bp from pter
Size:
41,621 bases
Orientation:
Minus strand

Genomic View for GALNT6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GALNT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT6 Gene

Regulatory Elements for GALNT6 Gene

Proteins for GALNT6 Gene

  • Protein details for GALNT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCL4-GALT6_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 6
    Protein Accession:
    Q8NCL4
    Secondary Accessions:
    • Q8IYH4
    • Q9H6G2
    • Q9UIV5

    Protein attributes for GALNT6 Gene

    Size:
    622 amino acids
    Molecular mass:
    71159 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15297.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GALNT6 Gene

Proteomics data for GALNT6 Gene at MOPED

Post-translational modifications for GALNT6 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr38, Asn86, and Asn476

Domains for GALNT6 Gene

Gene Families for GALNT6 Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

Graphical View of Domain Structure for InterPro Entry

Q8NCL4

UniProtKB/Swiss-Prot:

GALT6_HUMAN
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.:
    • Q8NCL4
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.:
    • Q8NCL4
  • Contains 1 ricin B-type lectin domain.:
    • Q8NCL4
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.:
    • Q8NCL4
genes like me logo Genes that share domains with GALNT6: view

Function for GALNT6 Gene

Molecular function for GALNT6 Gene

GENATLAS Biochemistry: galactosamine
UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
UniProtKB/Swiss-Prot Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides

Enzyme Numbers (IUBMB) for GALNT6 Gene

Gene Ontology (GO) - Molecular Function for GALNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNT6: view

Phenotypes for GALNT6 Gene

GenomeRNAi human phenotypes for GALNT6:
genes like me logo Genes that share phenotypes with GALNT6: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GALNT6 Gene

Localization for GALNT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GALNT6 Gene COMPARTMENTS Subcellular localization image for GALNT6 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GALNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IDA 12506059
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 12506059
genes like me logo Genes that share ontologies with GALNT6: view

Pathways for GALNT6 Gene

genes like me logo Genes that share pathways with GALNT6: view

Pathways by source for GALNT6 Gene

UniProtKB/Swiss-Prot Q8NCL4-GALT6_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for GALNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0008152 metabolic process --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with GALNT6: view

Compounds for GALNT6 Gene

(5) HMDB Compounds for GALNT6 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Lactosamine
  • beta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
13000-25-4
Manganese
  • manganese
7439-96-5
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT6: view

Transcripts for GALNT6 Gene

Unigene Clusters for GALNT6 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h ^ 8 ^ 9 ^ 10 ^
SP1: - - - - - -
SP2: - - -
SP3: - - - - - -
SP4: -
SP5:
SP6: - - - - - - - - -
SP7: - - - - -
SP8: -
SP9: - -
SP10: - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - -
SP13:

ExUns: 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for GALNT6 Gene

GeneLoc Exon Structure for
GALNT6
ECgene alternative splicing isoforms for
GALNT6

Expression for GALNT6 Gene

mRNA expression in normal human tissues for GALNT6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNT6 Gene

This gene is overexpressed in Stomach (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GALNT6 Gene

SOURCE GeneReport for Unigene cluster for GALNT6 Gene Hs.505575

mRNA Expression by UniProt/SwissProt for GALNT6 Gene

Q8NCL4-GALT6_HUMAN
Tissue specificity: Expressed in placenta and trachea. Weakly expressed in brain and pancreas. Expressed in fibroblast. Weakly or not expressed in lung, liver, muscle, kidney, spleen, thymus, prostate, testis, ovary, intestine, colon, leukocyte, stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland and bone marrow.
genes like me logo Genes that share expressions with GALNT6: view

Orthologs for GALNT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNT6 35
  • 96.57 (n)
  • 95.98 (a)
GALNT6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GALNT6 35
  • 89.17 (n)
  • 89.23 (a)
GALNT6 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GALNT6 35
  • 90.12 (n)
  • 90.66 (a)
GALNT6 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Galnt6 35
  • 86.87 (n)
  • 88.59 (a)
Galnt6 16
Galnt6 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Galnt6 35
  • 86.98 (n)
  • 87.94 (a)
chicken
(Gallus gallus)
Aves GALNT6 35
  • 74.83 (n)
  • 76.33 (a)
GALNT6 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GALNT6 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt6 35
  • 68.77 (n)
  • 73.51 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11246 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
galnt6 35
  • 66.5 (n)
  • 68.75 (a)
galnt6 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7579 37
  • 30 (a)
CG7297 37
  • 33 (a)
CG7304 37
  • 32 (a)
GalNAc-T1 37
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea Y39E4B.12a 37
  • 44 (a)
Y47D3A.23 37
  • 37 (a)
Y39E4B.12b 37
  • 45 (a)
Y39E4B.12c 37
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
Species with no ortholog for GALNT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNT6 Gene

ENSEMBL:
Gene Tree for GALNT6 (if available)
TreeFam:
Gene Tree for GALNT6 (if available)

Paralogs for GALNT6 Gene

genes like me logo Genes that share paralogs with GALNT6: view

Variants for GALNT6 Gene

Sequence variations from dbSNP and Humsavar for GALNT6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2519 -- 51,351,906(-) GTCTC(A/G)GTGGA downstream-variant-500B, utr-variant-3-prime
rs10516 -- 51,352,050(-) CCTGC(A/G)GGAGG utr-variant-3-prime
rs11341 -- 51,352,038(-) CGCCT(A/G)CATCC downstream-variant-500B, utr-variant-3-prime
rs747300 - 51,359,233(-) CTAGT(A/G)TCATT missense, reference
rs747301 -- 51,358,836(-) ATGGC(C/T)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GALNT6 Gene

Variant ID Type Subtype PubMed ID
nsv832408 CNV Gain 17160897
esv2745883 CNV Deletion 23290073

Relevant External Links for GALNT6 Gene

HapMap Linkage Disequilibrium report
GALNT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT6 Gene

Disorders for GALNT6 Gene

Relevant External Links for GALNT6

Genetic Association Database (GAD)
GALNT6
Human Genome Epidemiology (HuGE) Navigator
GALNT6
genes like me logo Genes that share disorders with GALNT6: view

No data available for UniProtKB/Swiss-Prot for GALNT6 Gene

Publications for GALNT6 Gene

  1. Cloning and characterization of a close homologue of human UDP-N- acetyl--D-galactosamine:polypeptide N-acetylgalactosaminyltransferase- T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy. (PMID: 10464263) Bennett E.P. … Clausen H. (J. Biol. Chem. 1999) 2 3 4
  2. Expression of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma. (PMID: 18854599) Gomes J. … Reis C.A. (J. Histochem. Cytochem. 2009) 3 23
  3. Prognostic utility of glycosyltransferase expression in breast cancer. (PMID: 19287074) Patani N. … Mokbel K. (Cancer Genomics Proteomics 2008) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for GALNT6 Gene

Sources for GALNT6 Gene

Back to Top

Content