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Aliases for GALNT5 Gene

Aliases for GALNT5 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 5 2 3
  • Polypeptide GalNAc Transferase 5 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 5 (GalNAc-T5) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 5 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 5 3 4
  • Pp-GaNTase 5 3 4
  • EC 2.4.1.41 4 63
  • GALNAC-T5 3 4
  • GALNACT5 3 6

External Ids for GALNT5 Gene

Previous GeneCards Identifiers for GALNT5 Gene

  • GC02P156046
  • GC02P156644
  • GC02P158079
  • GC02P158316
  • GC02P157939
  • GC02P157822
  • GC02P149999

Summaries for GALNT5 Gene

GeneCards Summary for GALNT5 Gene

GALNT5 (Polypeptide N-Acetylgalactosaminyltransferase 5) is a Protein Coding gene. Diseases associated with GALNT5 include hereditary multiple exostoses and exostosis. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT4.

UniProtKB/Swiss-Prot for GALNT5 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2 or Muc1b substrates (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT5 Gene

Genomics for GALNT5 Gene

Regulatory Elements for GALNT5 Gene

Genomic Location for GALNT5 Gene

Start:
157,257,598 bp from pter
End:
157,314,211 bp from pter
Size:
56,614 bases
Orientation:
Plus strand

Genomic View for GALNT5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GALNT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT5 Gene

Proteins for GALNT5 Gene

  • Protein details for GALNT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7M9-GALT5_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 5
    Protein Accession:
    Q7Z7M9
    Secondary Accessions:
    • A5PKZ1
    • Q9UGK7
    • Q9UHL6

    Protein attributes for GALNT5 Gene

    Size:
    940 amino acids
    Molecular mass:
    106266 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with EXT2. Does not interact with EXT1, EXTL1 or EXTL3.

neXtProt entry for GALNT5 Gene

Proteomics data for GALNT5 Gene at MOPED

Selected DME Specific Peptides for GALNT5 Gene

Post-translational modifications for GALNT5 Gene

  • Glycosylation at Ser69, Ser70, Thr94, Thr108, Thr134, Thr138, Thr149, Ser154, Ser155, Thr159, Thr163, Thr164, Ser192, Ser200, Ser202, Ser204, Ser205, Thr207, Ser208, Asn217, Asn256, Asn273, Thr274, Ser275, Ser292, Thr296, Ser300, Ser302, Asn316, Asn362, Ser379, Thr381, Thr386, Asn395, Asn406, Thr420, Thr429, Asn578, Asn776, Asn827, Asn845, and Asn912
  • Modification sites at PhosphoSitePlus

Other Protein References for GALNT5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GALNT5 Gene

Gene Families for GALNT5 Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

Graphical View of Domain Structure for InterPro Entry

Q7Z7M9

UniProtKB/Swiss-Prot:

GALT5_HUMAN :
  • Q7Z7M9
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • Contains 1 ricin B-type lectin domain.
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNT5: view

Function for GALNT5 Gene

Molecular function for GALNT5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide
UniProtKB/Swiss-Prot Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2 or Muc1b substrates (By similarity).

Enzyme Numbers (IUBMB) for GALNT5 Gene

Gene Ontology (GO) - Molecular Function for GALNT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IDA 10545594
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNT5: view

Phenotypes for GALNT5 Gene

MGI mutant phenotypes for GALNT5:
inferred from 1 alleles
GenomeRNAi human phenotypes for GALNT5:
genes like me logo Genes that share phenotypes with GALNT5: view

Animal Models for GALNT5 Gene

MGI Knock Outs for GALNT5:

miRNA for GALNT5 Gene

miRTarBase miRNAs that target GALNT5

No data available for Transcription Factor Targeting and HOMER Transcription for GALNT5 Gene

Localization for GALNT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT5 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GALNT5 Gene COMPARTMENTS Subcellular localization image for GALNT5 gene
Compartment Confidence
golgi apparatus 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GALNT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GALNT5: view

Pathways for GALNT5 Gene

genes like me logo Genes that share pathways with GALNT5: view

Pathways by source for GALNT5 Gene

UniProtKB/Swiss-Prot Q7Z7M9-GALT5_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for GALNT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006024 glycosaminoglycan biosynthetic process TAS 10545594
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with GALNT5: view

Compounds for GALNT5 Gene

(5) HMDB Compounds for GALNT5 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Lactosamine
  • beta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
13000-25-4
Manganese
  • manganese
7439-96-5
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT5: view

Transcripts for GALNT5 Gene

mRNA/cDNA for GALNT5 Gene

Unigene Clusters for GALNT5 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT5 Gene

No ASD Table

Relevant External Links for GALNT5 Gene

GeneLoc Exon Structure for
GALNT5
ECgene alternative splicing isoforms for
GALNT5

Expression for GALNT5 Gene

mRNA expression in normal human tissues for GALNT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNT5 Gene

This gene is overexpressed in Minor Salivary Gland (7.5), Colon - Transverse (5.3), Vagina (4.9), and Esophagus - Mucosa (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GALNT5 Gene

SOURCE GeneReport for Unigene cluster for GALNT5 Gene Hs.269027

genes like me logo Genes that share expressions with GALNT5: view

No data available for mRNA Expression by UniProt/SwissProt for GALNT5 Gene

Orthologs for GALNT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNT5 35
  • 99.26 (n)
  • 98.62 (a)
GALNT5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GALNT5 35
  • 85.13 (n)
  • 80.62 (a)
GALNT5 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GALNT5 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Galnt5 35
  • 81.29 (n)
  • 75.16 (a)
Galnt5 16
Galnt5 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GALNT5 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GALNT5 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Galnt5 35
  • 80.79 (n)
  • 75.05 (a)
chicken
(Gallus gallus)
Aves GALNT5 35
  • 58.83 (n)
  • 56.62 (a)
GALNT5 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GALNT5 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta GalNAc-T1 36
  • 34 (a)
OneToOne
CG7579 37
  • 31 (a)
CG7297 37
  • 32 (a)
CG7304 37
  • 31 (a)
CG2103 37
  • 38 (a)
GalNAc-T1 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea gly-9 36
  • 36 (a)
OneToOne
Y47D3A.23 37
  • 47 (a)
H38K22.5c 37
  • 45 (a)
Y39E4B.12b 37
  • 42 (a)
Y39E4B.12c 37
  • 42 (a)
Species with no ortholog for GALNT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for GALNT5 Gene

ENSEMBL:
Gene Tree for GALNT5 (if available)
TreeFam:
Gene Tree for GALNT5 (if available)

Paralogs for GALNT5 Gene

Selected SIMAP similar genes for GALNT5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GALNT5: view

Variants for GALNT5 Gene

Sequence variations from dbSNP and Humsavar for GALNT5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs714648 -- 157,284,559(-) TGTAC(A/G)ATGTT intron-variant
rs714649 -- 157,284,580(-) CTCCA(A/C/T)GTAAA intron-variant
rs895498 -- 157,304,983(-) CTATA(G/T)GACAT intron-variant
rs895499 -- 157,304,519(-) GGATT(A/C/G)TCCCT intron-variant
rs895500 -- 157,304,511(-) CCTGA(G/T)AATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GALNT5 Gene

Variant ID Type Subtype PubMed ID
nsv875328 CNV Loss 21882294
esv2661479 CNV Deletion 23128226
nsv834432 CNV Gain 17160897

Relevant External Links for GALNT5 Gene

HapMap Linkage Disequilibrium report
GALNT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT5 Gene

Disorders for GALNT5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for GALNT5 Gene including...

Search for GALNT5 Gene in MalaCards »

(1) University of Copenhagen DISEASES for GALNT5 Gene

genes like me logo Genes that share disorders with GALNT5: view

No data available for UniProtKB/Swiss-Prot for GALNT5 Gene

Publications for GALNT5 Gene

  1. A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses. (PMID: 10545594) Simmons A.D. … Lovett M. (Hum. Mol. Genet. 1999) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PMID: 17203973) Vasilescu J. … Figeys D. (J. Proteome Res. 2007) 3
  4. Clinical significance of polypeptide N-acetylgalactosaminyl transferase-5 (GalNAc-T5) expression in patients with gastric cancer. (PMID: 24619076) He H. … Sun Y. (Br. J. Cancer 2014) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for GALNT5 Gene

  • antibodies-online peptides for GALNT5
  • antibodies-online antibodies for GALNT5
  • antibodies-online kits for GALNT5

Sources for GALNT5 Gene

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