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Aliases for GALNT4 Gene

Aliases for GALNT4 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 4 2 3
  • Polypeptide GalNAc Transferase 4 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 4 (GalNAc-T4) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 4 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 4 3 4
  • Pp-GaNTase 4 3 4
  • EC 2.4.1.41 4 63
  • GALNAC-T4 3 4
  • GALNACT4 3 6

External Ids for GALNT4 Gene

Summaries for GALNT4 Gene

Entrez Gene Summary for GALNT4 Gene

  • This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon. Fusion transcripts, which combine part of this gene with the 5' exons of the neighboring POC1B (POC1 centriolar protein homolog B) gene, also exist. [provided by RefSeq, Dec 2010]

GeneCards Summary for GALNT4 Gene

GALNT4 (Polypeptide N-Acetylgalactosaminyltransferase 4) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT13.

UniProtKB/Swiss-Prot for GALNT4 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates Thr-57 of SELPLG

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT4 Gene

Genomics for GALNT4 Gene

Genomic Location for GALNT4 Gene

Start:
89,519,408 bp from pter
End:
89,524,806 bp from pter
Size:
5,399 bases
Orientation:
Minus strand

Genomic View for GALNT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GALNT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT4 Gene

Regulatory Elements for GALNT4 Gene

Proteins for GALNT4 Gene

  • Protein details for GALNT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4A0-GALT4_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 4
    Protein Accession:
    Q8N4A0
    Secondary Accessions:
    • B2R775
    • B4DMX6
    • O00208

    Protein attributes for GALNT4 Gene

    Size:
    578 amino acids
    Molecular mass:
    66666 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GALNT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALNT4 Gene

Proteomics data for GALNT4 Gene at MOPED

Selected DME Specific Peptides for GALNT4 Gene

Post-translational modifications for GALNT4 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn471

Other Protein References for GALNT4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GALNT4 Gene

Gene Families for GALNT4 Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

Suggested Antigen Peptide Sequences for GALNT4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N4A0

UniProtKB/Swiss-Prot:

GALT4_HUMAN
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.:
    • Q8N4A0
  • The ricin B-type lectin domain directs the glycopeptide specificity. It is required in the glycopeptide specificity of enzyme activity but not for activity with naked peptide substrates, suggesting that it triggers the catalytic domain to act on GalNAc-glycopeptide substrates.:
    • Q8N4A0
  • Contains 1 ricin B-type lectin domain.:
    • Q8N4A0
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.:
    • Q8N4A0
genes like me logo Genes that share domains with GALNT4: view

Function for GALNT4 Gene

Molecular function for GALNT4 Gene

GENATLAS Biochemistry: galactosamine
UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
UniProtKB/Swiss-Prot Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates Thr-57 of SELPLG

Enzyme Numbers (IUBMB) for GALNT4 Gene

Gene Ontology (GO) - Molecular Function for GALNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IEA --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNT4: view

Phenotypes for GALNT4 Gene

MGI mutant phenotypes for GALNT4:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with GALNT4: view

Animal Models for GALNT4 Gene

MGI Knock Outs for GALNT4:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for GALNT4 Gene

Localization for GALNT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT4 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for GALNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 colocalizes_with Golgi apparatus IDA 12506059
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 12506059
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with GALNT4: view

No data available for Subcellular locations from COMPARTMENTS for GALNT4 Gene

Pathways for GALNT4 Gene

genes like me logo Genes that share pathways with GALNT4: view

Pathways by source for GALNT4 Gene

UniProtKB/Swiss-Prot Q8N4A0-GALT4_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for GALNT4 Gene

Gene Ontology (GO) - Biological Process for GALNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process NAS 9592121
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with GALNT4: view

Compounds for GALNT4 Gene

(5) HMDB Compounds for GALNT4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Lactosamine
  • beta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
13000-25-4
Manganese
  • manganese
7439-96-5
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT4: view

Transcripts for GALNT4 Gene

mRNA/cDNA for GALNT4 Gene

(1) REFSEQ mRNAs :
(161) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT4 Gene

No ASD Table

Relevant External Links for GALNT4 Gene

GeneLoc Exon Structure for
GALNT4
ECgene alternative splicing isoforms for
GALNT4

Expression for GALNT4 Gene

mRNA expression in normal human tissues for GALNT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GALNT4 Gene

mRNA Expression by UniProt/SwissProt for GALNT4 Gene

Q8N4A0-GALT4_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in mucous cells.
genes like me logo Genes that share expressions with GALNT4: view

No data available for mRNA differential expression in normal tissues for GALNT4 Gene

Orthologs for GALNT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNT4 35
  • 99.6 (n)
  • 99.48 (a)
cow
(Bos Taurus)
Mammalia GALNT4 35
  • 88.68 (n)
  • 91.33 (a)
mouse
(Mus musculus)
Mammalia Galnt4 35
  • 85.76 (n)
  • 91.35 (a)
Galnt4 16
Galnt4 36
  • 91 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Galnt4 35
  • 86.33 (n)
  • 91.18 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 76 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt4 35
  • 71.6 (n)
  • 77.82 (a)
zebrafish
(Danio rerio)
Actinopterygii poc1bl 35
  • 67.65 (n)
  • 72.13 (a)
poc1bl 36
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7579 37
  • 31 (a)
CG7297 37
  • 31 (a)
CG7304 37
  • 30 (a)
CG2103 37
  • 37 (a)
GalNAc-T1 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea Y45F10D.3 37
  • 36 (a)
Y39E4B.12a 37
  • 47 (a)
Y47D3A.23 37
  • 37 (a)
Y39E4B.12b 37
  • 46 (a)
Y39E4B.12c 37
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4670 36
  • 61 (a)
OneToMany
Species with no ortholog for GALNT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNT4 Gene

ENSEMBL:
Gene Tree for GALNT4 (if available)
TreeFam:
Gene Tree for GALNT4 (if available)

Paralogs for GALNT4 Gene

genes like me logo Genes that share paralogs with GALNT4: view

Variants for GALNT4 Gene

Sequence variations from dbSNP and Humsavar for GALNT4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
VAR_019576 -
VAR_019577 -
VAR_065257 -

Structural Variations from Database of Genomic Variants (DGV) for GALNT4 Gene

Variant ID Type Subtype PubMed ID
nsv832479 CNV Gain 17160897

Relevant External Links for GALNT4 Gene

HapMap Linkage Disequilibrium report
GALNT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT4 Gene

Disorders for GALNT4 Gene

Relevant External Links for GALNT4

Genetic Association Database (GAD)
GALNT4
Human Genome Epidemiology (HuGE) Navigator
GALNT4
genes like me logo Genes that share disorders with GALNT4: view

No data available for UniProtKB/Swiss-Prot for GALNT4 Gene

Publications for GALNT4 Gene

  1. Genetic polymorphisms in platelet-related proteins and coronary artery disease: investigation of candidate genes, including N-acetylgalactosaminyltransferase 4 (GALNT4) and sulphotransferase 1A1/2 (SULT1A1/2). (PMID: 18259693) O'Halloran A.M. … Shields D.C. (J. Thromb. Thrombolysis 2009) 3 23 48
  2. Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N- acetylgalactosaminyltransferase that complements other GalNAc- transferases in complete O-glycosylation of the MUC1 tandem repeat. (PMID: 9804815) Bennett E.P. … Clausen H. (J. Biol. Chem. 1998) 2 3 4
  3. The lectin domain of UDP-N-acetyl-D-galactosamine: polypeptide N- acetylgalactosaminyltransferase-T4 directs its glycopeptide specificities. (PMID: 10984485) Hassan H. … Clausen H. (J. Biol. Chem. 2000) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for GALNT4 Gene

Sources for GALNT4 Gene

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