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GALNT4 Gene

protein-coding   GIFtS: 51
GCID: GC12M089913

Polypeptide N-Acetylgalactosaminyltransferase 4

(Previous name: UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Polypeptide N-Acetylgalactosaminyltransferase 41 2     EC 2.4.1.413 8
Polypeptide GalNAc Transferase 41 2 3     GALNAC-T42
UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide
N-Acetylgalactosaminyltransferase 4 (GalNAc-T4)1 2
     GALNACT42
Protein-UDP Acetylgalactosaminyltransferase 42 3     GalNAc-T43
Pp-GaNTase 42 3     GalNAcT45
UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 42 3     

External Ids:    HGNC: 41261   Entrez Gene: 86932   Ensembl: ENSG000002575947   OMIM: 6035655   UniProtKB: Q8N4A03   

Export aliases for GALNT4 gene to outside databases

Previous GC identifers: GC12M089334 GC12M090360 GC12M089849 GC12M088419 GC12M088415


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GALNT4 Gene:
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase
(GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by
catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by
an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and
Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but
overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement
other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin
glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon. Fusion
transcripts, which combine part of this gene with the 5' exons of the neighboring POC1B (POC1 centriolar protein
homolog B) gene, also exist. (provided by RefSeq, Dec 2010)

GeneCards Summary for GALNT4 Gene:
GALNT4 (polypeptide N-acetylgalactosaminyltransferase 4) is a protein-coding gene. Diseases associated with GALNT4 include coronary artery disease, and breast cancer. GO annotations related to this gene include polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT12.

UniProtKB/Swiss-Prot: GALT4_HUMAN, Q8N4A0
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an
N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity
toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the GALNT4 gene promoter:
         Nkx3-1   Nkx3-1 v4   NRSF form 1   Nkx3-1 v1   CUTL1   NRSF form 2   Nkx3-1 v2   POU2F1   POU2F1a   Nkx3-1 v3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for GALNT4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GALNT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.33   Ensembl cytogenetic band:  12q21.33   HGNC cytogenetic band: 12q21.33

GALNT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GALNT4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M089913:  view genomic region     (about GC identifiers)

Start:
89,913,185 bp from pter      End:
89,920,039 bp from pter
Size:
6,855 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GALT4_HUMAN, Q8N4A0 (See protein sequence)
Recommended Name: Polypeptide N-acetylgalactosaminyltransferase 4  
Size: 578 amino acids; 66666 Da
Cofactor: Manganese (By similarity)
Secondary accessions: B2R775 B4DMX6 O00208
Alternative splicing: 2 isoforms:  Q8N4A0-1   Q8N4A0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GALNT4: NX_Q8N4A0

Explore proteomics data for GALNT4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn471
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GALNT4 (Q8N4A0) (see all 9)
     VVCPVID  MAGGLFA  PTMAGGL  WGGENLE 


    See GALNT4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003765.2  
    ENSEMBL proteins: 
     ENSP00000436604   ENSP00000389686  
    Reactome Protein details: Q8N4A0

    GALNT4 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for GALNT4
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    Novus Biologicals GALNT4 Protein
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    Cloud-Clone Corp. Proteins for GALNT4

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    ThermoFisher Antibodies for GALNT4
    LSBio Antibodies in human, mouse, rat for GALNT4

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    Cloud-Clone Corp. CLIAs for GALNT4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GLT2: Glycosyltransferase family 2 domain containing

    2 InterPro protein domains:
     IPR000772 Ricin_B_lectin
     IPR001173 Glyco_trans_2

    Graphical View of Domain Structure for InterPro Entry Q8N4A0

    ProtoNet protein and cluster: Q8N4A0

    2 Blocks protein domains:
    IPB000772 Ricin B lectin domain
    IPB001173 Glycosyl transferase


    UniProtKB/Swiss-Prot: GALT4_HUMAN, Q8N4A0
    Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also
    called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal
    domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal
    binding (By similarity)
    Domain: The ricin B-type lectin domain directs the glycopeptide specificity. It is required in the glycopeptide
    specificity of enzyme activity but not for activity with naked peptide substrates, suggesting that it triggers
    the catalytic domain to act on GalNAc-glycopeptide substrates
    Similarity: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily
    Similarity: Contains 1 ricin B-type lectin domain


    GALNT4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GALT4_HUMAN, Q8N4A0
    Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an
    N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity
    toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG
    Catalytic activity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP +
    N-acetyl-alpha-D-galactosaminyl-polypeptide

         Genatlas biochemistry entry for GALNT4:
    galactosamine

         Enzyme Number (IUBMB): EC 2.4.1.411 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004653polypeptide N-acetylgalactosaminyltransferase activity IEA--
    GO:0046872metal ion binding IEA--
         
    GALNT4 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Galnt4):
     normal 

    GALNT4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Galnt4tm1Tabk for GALNT4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GALNT4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GALNT4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GALNT4

    miRNA
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    Block miRNA regulation of human, mouse, rat GALNT4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GALNT4 (see all 51):
    hsa-miR-4328 hsa-let-7d hsa-miR-106a hsa-miR-218 hsa-miR-519a hsa-miR-877* hsa-let-7g hsa-miR-3142
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat GALNT4

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GALNT4

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALNT4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GALT4_HUMAN, Q8N4A0: Golgi apparatus membrane; Single-pass type II membrane protein (Probable)

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794colocalizes with Golgi apparatus IDA12506059
    GO:0016021integral component of membrane IEA--
    GO:0048471perinuclear region of cytoplasm IDA12506059
    GO:0070062extracellular vesicular exosome IDA19199708

    GALNT4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GALNT4 About    
    See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.47
    Mucin type O-Glycan biosynthesis0.47
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    3Metabolism
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for GALNT4
        O-linked glycosylation of mucins


    2 Kegg Pathways  (Kegg details for GALNT4):
        Mucin type O-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: GALT4_HUMAN, Q8N4A0
    Pathway: Protein modification; protein glycosylation


    GALNT4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GALNT4: 

              Glycosylation in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GALNT4

    1 Interacting protein for GALNT4 (Q8N4A03) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MUC1P159413I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process NAS9592121
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    GALNT4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GALNT4 (GALT4)

    5 HMDB Compounds for GALNT4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Lactosaminebeta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose (see all 8)13000-25-4--
    Manganesemanganese 7439-96-5--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate-N-acetylgalactosamineUDP-N-acetyl-D-galactosamine (see all 17)7277-98-7--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GALNT4 gene: 
    NM_003774.4  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529983(uc001tbd.3) ENST00000413530
    miRNA
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    Block miRNA regulation of human, mouse, rat GALNT4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GALNT4 (see all 51):
    hsa-miR-4328 hsa-let-7d hsa-miR-106a hsa-miR-218 hsa-miR-519a hsa-miR-877* hsa-let-7g hsa-miR-3142
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GALNT4
      QuantiTect SYBR Green Assays in human, mouse, rat GALNT4
      QuantiFast Probe-based Assays in human, mouse, rat GALNT4

    Selected AceView cDNA sequences (see all 161):

    AU279478 AI571939 AI745325 BM723514 CA441578 BC026080 AW131361 AK123625 
    AL832918 BX282160 BU521431 AI569994 BM982932 BM795268 CR594597 CA441661 
    NM_003774 AI444809 BM015484 BQ000466 CN484379 BX280973 BG182194 BX281240 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GALNT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GALNT4 Expression
    About this image


    GALNT4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Liver (Hepatobiliary System)
             Perivenous Hepatocytes Liver Lobule
     
     Intestine (Gastrointestinal Tract)
     
     Colon (Gastrointestinal Tract)
    GALNT4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GALNT4 Protein Expression

    UniProtKB/Swiss-Prot: GALT4_HUMAN, Q8N4A0
    Tissue specificity: Ubiquitous. Highly expressed in mucous cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GALNT4: 
              Glycosylation in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat GALNT4
    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GALNT4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Galnt41 , 5 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more1, 5 85.76(n)1
    91.35(a)1
      10 (51.06 cM)5
    144261  NM_015737.41  NP_056552.11 
     991081595 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    76(a)
    1 → many
    GL343332.1(1361662-1363413)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia galnt41 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more 71.6(n)
    77.82(a)
      780162  NM_001079237.2  NP_001072705.1 
    zebrafish
    (Danio rerio)
    Actinopterygii poc1bl1 POC1 centriolar protein homolog B (Chlamydomonas), more 67.65(n)
    72.13(a)
      503760  NM_001044778.2  NP_001038243.2 


    ENSEMBL Gene Tree for GALNT4 (if available)
    TreeFam Gene Tree for GALNT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GALNT4 gene
    GALNT122  GALNT12  GALNTL62  GALNT32  GALNT22  GALNT102  GALNT132  GALNT62  
    POC1B-GALNT42  GALNT152  GALNT72  GALNT52  GALNT142  GALNTL52  GALNT162  GALNT112  
    Selected SIMAP similar genes for GALNT4 using alignment to 2 protein entries:     GALT4_HUMAN (see all proteins) (see all similar genes):
    POC1B-GALNT4    GALNT12    GalNAc-T10    GALNT13    GALNT1    GALNT6
    GALNT3    GALNTL5    GALNTL6    GalNAc-T16    GALNT10    GALNT11
    GALNT14    GALNT5    GALNT15    GALNT2    GALNT16    GALNT18

    GALNT4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    3 SNPs for GALNT4    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22302831,2,4
    ----see VAR_0195772 mis40--------
    rs178536101,2,4
    ----see VAR_0652572 mis40--------
    rs22302811,2,4
    ----see VAR_0195762 mis40--------

    HapMap Linkage Disequilibrium report for GALNT4 (89913185 - 89920039 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GALNT4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832479CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing GALNT4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603565    OMIM disorders: --

    2 diseases for GALNT4:    
    About MalaCards
    coronary artery disease    breast cancer


    GALNT4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GALNT4
    Human Genome Epidemiology (HuGE) Navigator: GALNT4 (1 document)

    Export disorders for GALNT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GALNT4 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with GALNT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N- acetylgalactosaminyltransferase that complements other GalNAc- transferases in complete O-glycosylation of the MUC1 tandem repeat. (PubMed id 9804815)1, 2, 3 Bennett E.P.... Clausen H. (J. Biol. Chem. 1998)
    2. Genetic polymorphisms in platelet-related proteins and coronary artery disease: investigation of candidate genes, including N-acetylgalactosaminyltransferase 4 (GALNT4) and sulphotransferase 1A1/2 (SULT1A1/2). (PubMed id 18259693)1, 4, 9 O'Halloran A.M....Shields D.C. (J. Thromb. Thrombolysis 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The lectin domain of UDP-N-acetyl-D-galactosamine: polypeptide N- acetylgalactosaminyltransferase-T4 directs its glycopeptide specificities. (PubMed id 10984485)1, 2 Hassan H.... Clausen H. (J. Biol. Chem. 2000)
    5. The mucin-type glycosylating enzyme polypeptide N-acetylgalactosaminyltransferase 14 promotes the migration of ovarian cancer by modifying mucin 13. (PubMed id 23708057)1 Wang R....Yang Z. (Oncol. Rep. 2013)
    6. Estrogen regulates vesicle trafficking gene expression in EFF-3, EFM-19 and MCF-7 breast cancer cells. (PubMed id 19294005)1 Wright P.K....Westley B.R. (Int J Clin Exp Pathol 2009)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    8. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PubMed id 19199708)1 Gonzalez-Begne M....Yates J.R. (J. Proteome Res. 2009)
    9. Differential gene expression profiles of normal human parotid and submandibular glands. (PubMed id 18826381)1 Sun Q.F....Wang S. (Oral Dis 2008)
    10. The lectin domains of polypeptide GalNAc-transferases exhibit carbohydrate-binding specificity for GalNAc: lectin binding to GalNAc-glycopeptide substrates is required for high density GalNAc-O-glycosylation. (PubMed id 17215257)1 Wandall H.H....Clausen H. (Glycobiology 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8693 HGNC: 4126 AceView: GALNT4 Ensembl:ENSG00000257594 euGenes: HUgn8693
    ECgene: GALNT4 Kegg: 8693 H-InvDB: GALNT4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GALNT4 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=GALNT4
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_486

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GALNT4 gene:
    Search GeneIP for patents involving GALNT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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