Aliases for GALNT3 Gene
- Polypeptide N-Acetylgalactosaminyltransferase 3 2 3
- Polypeptide GalNAc Transferase 3 2 3 4
- UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 3 (GalNAc-T3) 2 3
- UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 3 3 4
- Protein-UDP Acetylgalactosaminyltransferase 3 3 4
- Pp-GaNTase 3 3 4
- EC 188.8.131.52 4 64
External Ids for GALNT3 Gene
This gene encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members, however the enzymes have different substrate specificities. [provided by RefSeq, Jul 2008]
GeneCards Summary for GALNT3 Gene
GALNT3 (Polypeptide N-Acetylgalactosaminyltransferase 3) is a Protein Coding gene. Diseases associated with GALNT3 include hyperphosphatemic familial tumoral calcinosis, galnt3-related and hyperphosphatemia. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include calcium ion binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT4.
UniProtKB/Swiss-Prot for GALNT3 Gene
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis.