Aliases for GALNT2 Gene
- Polypeptide N-Acetylgalactosaminyltransferase 2 2 3
- Polypeptide GalNAc Transferase 2 2 3 4
- UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-T2) 2 3
- UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 2 3 4
- Pp-GaNTase 2 3 4
- EC 188.8.131.52 4 64
- GalNAc-T2 3 4
- Protein-UDP Acetylgalactosaminyltransferase 2 4
External Ids for GALNT2 Gene
This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
GeneCards Summary for GALNT2 Gene
GALNT2 (Polypeptide N-Acetylgalactosaminyltransferase 2) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include manganese ion binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT4.
UniProtKB/Swiss-Prot for GALNT2 Gene
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.