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Aliases for GALNT2 Gene

Aliases for GALNT2 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 2 2 3
  • Polypeptide GalNAc Transferase 2 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-T2) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 2 3 4
  • Pp-GaNTase 2 3 4
  • EC 2.4.1.41 4 63
  • GalNAc-T2 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 2 4

External Ids for GALNT2 Gene

Previous GeneCards Identifiers for GALNT2 Gene

  • GC01P228683
  • GC01P225931
  • GC01P226676
  • GC01P227237
  • GC01P227238
  • GC01P226509
  • GC01P228269
  • GC01P230193
  • GC01P200802

Summaries for GALNT2 Gene

Entrez Gene Summary for GALNT2 Gene

  • This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for GALNT2 Gene

GALNT2 (Polypeptide N-Acetylgalactosaminyltransferase 2) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include manganese ion binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT4.

UniProtKB/Swiss-Prot for GALNT2 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.

Gene Wiki entry for GALNT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT2 Gene

Genomics for GALNT2 Gene

Regulatory Elements for GALNT2 Gene

Genomic Location for GALNT2 Gene

Start:
230,057,990 bp from pter
End:
230,282,129 bp from pter
Size:
224,140 bases
Orientation:
Plus strand

Genomic View for GALNT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GALNT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT2 Gene

Proteins for GALNT2 Gene

  • Protein details for GALNT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10471-GALT2_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 2
    Protein Accession:
    Q10471
    Secondary Accessions:
    • A8K1Y3
    • B7Z8V8
    • C5HU00
    • Q9NPY4

    Protein attributes for GALNT2 Gene

    Size:
    571 amino acids
    Molecular mass:
    64733 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GALNT2 Gene

    Alternative splice isoforms for GALNT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALNT2 Gene

Proteomics data for GALNT2 Gene at MOPED

Selected DME Specific Peptides for GALNT2 Gene

Post-translational modifications for GALNT2 Gene

  • Ubiquitination at Lys103
  • Glycosylation at Ser67, Thr70, and Thr368
  • Modification sites at PhosphoSitePlus

Other Protein References for GALNT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GALNT2 Gene

Gene Families for GALNT2 Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

Graphical View of Domain Structure for InterPro Entry

Q10471

UniProtKB/Swiss-Prot:

GALT2_HUMAN :
  • Q10471
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • Contains 1 ricin B-type lectin domain.
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNT2: view

Function for GALNT2 Gene

Molecular function for GALNT2 Gene

GENATLAS Biochemistry: galactosamine
UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
UniProtKB/Swiss-Prot Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.

Enzyme Numbers (IUBMB) for GALNT2 Gene

Gene Ontology (GO) - Molecular Function for GALNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IDA 12438318
GO:0005515 protein binding IPI 25416956
GO:0030145 manganese ion binding IDA 16434399
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with GALNT2: view

miRNA for GALNT2 Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GALNT2 Gene

Localization for GALNT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GALNT2 Gene COMPARTMENTS Subcellular localization image for GALNT2 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GALNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 colocalizes_with Golgi apparatus IDA 12506059
GO:0005795 Golgi stack IDA 9852147
GO:0016020 membrane IDA 19946888
GO:0030173 integral component of Golgi membrane NAS 9852147
genes like me logo Genes that share ontologies with GALNT2: view

Pathways for GALNT2 Gene

genes like me logo Genes that share pathways with GALNT2: view

Pathways by source for GALNT2 Gene

UniProtKB/Swiss-Prot Q10471-GALT2_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for GALNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002378 immunoglobulin biosynthetic process IDA 12438318
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0018242 protein O-linked glycosylation via serine IDA 12438318
GO:0018243 protein O-linked glycosylation via threonine IDA 12438318
genes like me logo Genes that share ontologies with GALNT2: view

Compounds for GALNT2 Gene

(5) HMDB Compounds for GALNT2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Lactosamine
  • beta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
13000-25-4
Manganese
  • manganese
7439-96-5
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT2: view

Transcripts for GALNT2 Gene

Unigene Clusters for GALNT2 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: -
SP5:
SP6: - -
SP7: -
SP8:
SP9:

ExUns: 18b · 18c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for GALNT2 Gene

GeneLoc Exon Structure for
GALNT2
ECgene alternative splicing isoforms for
GALNT2

Expression for GALNT2 Gene

mRNA expression in normal human tissues for GALNT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNT2 Gene

This gene is overexpressed in Liver (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GALNT2 Gene

SOURCE GeneReport for Unigene cluster for GALNT2 Gene Hs.743964

mRNA Expression by UniProt/SwissProt for GALNT2 Gene

Q10471-GALT2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with GALNT2: view

Orthologs for GALNT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNT2 35
  • 99.82 (n)
  • 100 (a)
GALNT2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GALNT2 35
  • 89.94 (n)
  • 98.07 (a)
GALNT2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GALNT2 35
  • 91.26 (n)
  • 98.3 (a)
GALNT2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Galnt2 35
  • 87.37 (n)
  • 95.79 (a)
Galnt2 16
Galnt2 36
  • 96 (a)
OneToMany
Gm20388 36
  • 95 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia GALNT2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GALNT2 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Galnt2 35
  • 87.6 (n)
  • 97.89 (a)
chicken
(Gallus gallus)
Aves GALNT2 35
  • 80.88 (n)
  • 94.77 (a)
GALNT2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GALNT2 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21180 35
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt2 35
  • 75.85 (n)
  • 89.09 (a)
zebrafish
(Danio rerio)
Actinopterygii galnt2 35
  • 77.06 (n)
  • 87.1 (a)
galnt2 36
  • 86 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010078 35
  • 60.92 (n)
  • 63.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta pgant2 35
  • 63.9 (n)
  • 66.6 (a)
pgant2 36
  • 54 (a)
OneToMany
CG10000 37
  • 35 (a)
CG7579 37
  • 29 (a)
CG7297 37
  • 34 (a)
CG3254 37
  • 66 (a)
CG7304 37
  • 28 (a)
CG2103 37
  • 37 (a)
GalNAc-T1 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea gly-4 35
  • 52.38 (n)
  • 54.16 (a)
gly-5 36
  • 35 (a)
ManyToMany
Y39E4B.12a 37
  • 44 (a)
Y47D3A.23 37
  • 38 (a)
H38K22.5c 37
  • 47 (a)
Y39E4B.12b 37
  • 44 (a)
Y39E4B.12c 37
  • 44 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2977 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10774 36
  • 67 (a)
OneToMany
Species with no ortholog for GALNT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNT2 Gene

ENSEMBL:
Gene Tree for GALNT2 (if available)
TreeFam:
Gene Tree for GALNT2 (if available)

Paralogs for GALNT2 Gene

genes like me logo Genes that share paralogs with GALNT2: view

Variants for GALNT2 Gene

Sequence variations from dbSNP and Humsavar for GALNT2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7022 -- 230,281,918(-) GACCA(C/G)CACAG utr-variant-3-prime
rs10005 -- 230,281,207(-) ACACA(C/T)GTGGG utr-variant-3-prime
rs11620 -- 230,281,662(-) CCCCC(A/G)GGGCA utr-variant-3-prime
rs13490 -- 230,281,014(-) GAGAC(C/T)GAGCA utr-variant-3-prime
rs13728 -- 230,280,472(-) CTCAC(A/G)CAGAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GALNT2 Gene

Variant ID Type Subtype PubMed ID
nsv832814 CNV Gain 17160897
esv275327 CNV Gain+Loss 21479260
nsv873286 CNV Gain 21882294
nsv873287 CNV Loss 21882294
esv2668920 CNV Deletion 23128226
nsv528956 CNV Loss 19592680
nsv832825 CNV Loss 17160897
nsv873288 CNV Loss 21882294
esv2724572 CNV Deletion 23290073
esv2724584 CNV Deletion 23290073
esv2724595 CNV Deletion 23290073
nsv827186 CNV Loss 20364138
nsv518223 CNV Loss 19592680
nsv873289 CNV Loss 21882294
esv2724606 CNV Deletion 23290073
esv2724617 CNV Deletion 23290073
esv2724628 CNV Deletion 23290073
nsv520656 CNV Loss 19592680
nsv516432 CNV Loss 19592680

Relevant External Links for GALNT2 Gene

HapMap Linkage Disequilibrium report
GALNT2
Human Gene Mutation Database (HGMD)
GALNT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT2 Gene

Disorders for GALNT2 Gene

Relevant External Links for GALNT2

Genetic Association Database (GAD)
GALNT2
Human Genome Epidemiology (HuGE) Navigator
GALNT2
genes like me logo Genes that share disorders with GALNT2: view

No data available for UniProtKB/Swiss-Prot for GALNT2 Gene

Publications for GALNT2 Gene

  1. Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- acetylgalactosaminyltransferase 2. (PMID: 12438318) Iwasaki H. … Narimatsu H. (J. Biol. Chem. 2003) 3 4 23
  2. Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D- galactosamine:polypeptide N-acetylgalactosaminyltransferase. (PMID: 7592619) White T. … Clausen H. (J. Biol. Chem. 1995) 2 3 4
  3. Substrate specificities of three members of the human UDP-N-acetyl- alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3. (PMID: 9295285) Wandall H.H. … Clausen H. (J. Biol. Chem. 1997) 3 4
  4. Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus. (PMID: 9394011) Roettger S. … Nilsson T. (J. Cell Sci. 1998) 3 4
  5. Genomic organization and chromosomal localization of three members of the UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase family. (PMID: 9592121) Bennett E.P. … Clausen H. (Glycobiology 1998) 2 3

Products for GALNT2 Gene

Sources for GALNT2 Gene

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