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Aliases for GALNT16 Gene

Aliases for GALNT16 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 16 2 3 5
  • Polypeptide GalNAc Transferase 16 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase-Like 1 2 3
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 16 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 1 3 4
  • Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 1 3 4
  • Protein-UDP Acetylgalactosaminyltransferase-Like Protein 1 3 4
  • Polypeptide GalNAc Transferase-Like Protein 1 3 4
  • Pp-GaNTase-Like Protein 1 3 4
  • GalNAc-T-Like Protein 1 3 4
  • GalNAc-T16 3 4
  • GALNTL1 3 4
  • Putative Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 1 3
  • EC 2.4.1.41 4
  • GALNACT16 3
  • KIAA1130 4

External Ids for GALNT16 Gene

Previous HGNC Symbols for GALNT16 Gene

  • GALNTL1

Previous GeneCards Identifiers for GALNT16 Gene

  • GC14P069725

Summaries for GALNT16 Gene

GeneCards Summary for GALNT16 Gene

GALNT16 (Polypeptide N-Acetylgalactosaminyltransferase 16) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Mucin type O-glycan biosynthesis. GO annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT2.

UniProtKB/Swiss-Prot for GALNT16 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT16 Gene

Genomics for GALNT16 Gene

Regulatory Elements for GALNT16 Gene

Enhancers for GALNT16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F069464 0.8 Ensembl ENCODE 20.9 +205.7 205673 1.5 JUND JUN SIN3A FOS ZIC2 GALNT16 SLC39A9 ERH SRSF5 SMOC1 PLEKHD1
GH14F069353 1.4 FANTOM5 Ensembl ENCODE 11.1 +95.9 95916 2.4 HDGF MXI1 TBL1XR1 MAX BMI1 EBF1 ZIC2 RELA ZBTB48 EGR1 GALNT16 PLEKHD1 SRSF5 ENSG00000280073 LOC105370549
GH14F069423 0.7 ENCODE 20.4 +165.2 165244 1.2 SOX13 GATAD2A CTCF SAP130 TEAD1 FOXA3 HMG20A PPARG FOXA1 GATA3 GALNT16 ERH SLC39A9 PLEKHD1
GH14F069260 1.2 Ensembl ENCODE 9.3 +3.4 3436 3.7 KLF17 ZNF48 RAD21 YY1 GLIS2 EGR1 SCRT2 FOS EGR2 MIER2 GALNT16 SRSF5 ENSG00000258520 GC14M069298
GH14F069396 1.1 ENCODE 10.1 +139.1 139083 3.4 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 ZNF143 RPL7AP6 DDX18P1 SUSD6 ERH GALNT16 PLEKHD1 SLC39A9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GALNT16 on UCSC Golden Path with GeneCards custom track

Promoters for GALNT16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000420098 1423 2201 ARID4B ZNF48 GLIS2 ZNF143 ZNF207 KLF13 DEK MIER2 REST GLIS1

Genomic Location for GALNT16 Gene

Chromosome:
14
Start:
69,259,277 bp from pter
End:
69,379,904 bp from pter
Size:
120,628 bases
Orientation:
Plus strand

Genomic View for GALNT16 Gene

Genes around GALNT16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GALNT16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GALNT16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT16 Gene

Proteins for GALNT16 Gene

  • Protein details for GALNT16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N428-GLT16_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 16
    Protein Accession:
    Q8N428
    Secondary Accessions:
    • Q4KMG3
    • Q58A55
    • Q9ULT9

    Protein attributes for GALNT16 Gene

    Size:
    558 amino acids
    Molecular mass:
    63074 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86444.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for GALNT16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALNT16 Gene

Post-translational modifications for GALNT16 Gene

  • Glycosylation at Thr 55 and Thr 63
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GALNT16 Gene

Domains & Families for GALNT16 Gene

Gene Families for GALNT16 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N428

UniProtKB/Swiss-Prot:

GLT16_HUMAN :
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • Contains 1 ricin B-type lectin domain.
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNT16: view

Function for GALNT16 Gene

Molecular function for GALNT16 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=251 uM for Muc5AC {ECO:0000269 PubMed:22186971}; KM=310 uM for Muc5AC-3 {ECO:0000269 PubMed:22186971}; KM=390 uM for Muc5AC-13 {ECO:0000269 PubMed:22186971}; KM=332 uM for EA2 {ECO:0000269 PubMed:22186971};
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
UniProtKB/Swiss-Prot Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.

Enzyme Numbers (IUBMB) for GALNT16 Gene

Gene Ontology (GO) - Molecular Function for GALNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNT16: view
genes like me logo Genes that share phenotypes with GALNT16: view

Animal Model Products

miRNA for GALNT16 Gene

miRTarBase miRNAs that target GALNT16

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GALNT16 Gene

Localization for GALNT16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT16 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GALNT16 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
nucleus 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GALNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GALNT16: view

Pathways & Interactions for GALNT16 Gene

genes like me logo Genes that share pathways with GALNT16: view

Pathways by source for GALNT16 Gene

UniProtKB/Swiss-Prot Q8N428-GLT16_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for GALNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
genes like me logo Genes that share ontologies with GALNT16: view

No data available for SIGNOR curated interactions for GALNT16 Gene

Drugs & Compounds for GALNT16 Gene

(3) Drugs for GALNT16 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 34
Uridine-5'-Diphosphate Experimental Pharma 0
calcium Nutra 0

(3) Additional Compounds for GALNT16 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lactosamine
  • 2-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose
  • 2-Amino-2-deoxy-4-O-beta-delta-galactopyranosyl-delta-glucose
  • beta-D-Galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
  • beta-D-Galactopyranosyl-(1->4)-D-glucosamine
  • beta-delta-Galactopyranosyl-(1->4)-2-amino-2-deoxy-delta-glucose
13000-25-4
UDP-N-acetyl-alpha-D-galactosamine
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
  • Uridine 5'-diphospho-N-acetylgalactosamine
  • Uridine diphosphate-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT16: view

Transcripts for GALNT16 Gene

Unigene Clusters for GALNT16 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT16 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1: -
SP2:
SP3: - -
SP4:
SP5:
SP6: -

Relevant External Links for GALNT16 Gene

GeneLoc Exon Structure for
GALNT16
ECgene alternative splicing isoforms for
GALNT16

Expression for GALNT16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GALNT16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNT16 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.4).

Protein differential expression in normal tissues from HIPED for GALNT16 Gene

This gene is overexpressed in Spinal cord (33.8), Bone marrow mesenchymal stem cell (20.1), and Testis (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GALNT16 Gene



Protein tissue co-expression partners for GALNT16 Gene

NURSA nuclear receptor signaling pathways regulating expression of GALNT16 Gene:

GALNT16

SOURCE GeneReport for Unigene cluster for GALNT16 Gene:

Hs.21035
genes like me logo Genes that share expression patterns with GALNT16: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GALNT16 Gene

Orthologs for GALNT16 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNTL1 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia GALNT16 34 35
  • 92.04 (n)
cow
(Bos Taurus)
Mammalia GALNTL1 34 35
  • 91.32 (n)
mouse
(Mus musculus)
Mammalia Galnt16 34 16 35
  • 90.26 (n)
rat
(Rattus norvegicus)
Mammalia Galnt16 34
  • 89.73 (n)
oppossum
(Monodelphis domestica)
Mammalia GALNT16 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GALNT16 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves GALNT16 35
  • 77 (a)
OneToOne
GALNTL1 34
  • 75.68 (n)
lizard
(Anolis carolinensis)
Reptilia GALNT16 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt16 34
  • 70.93 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8926 34
zebrafish
(Danio rerio)
Actinopterygii galntl1 34
  • 69.71 (n)
galnt16 35
  • 66 (a)
OneToOne
Dr.22329 34
fruit fly
(Drosophila melanogaster)
Insecta pgant2 35
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gly-6 35
  • 32 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10774 35
  • 53 (a)
OneToMany
Species where no ortholog for GALNT16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNT16 Gene

ENSEMBL:
Gene Tree for GALNT16 (if available)
TreeFam:
Gene Tree for GALNT16 (if available)

Paralogs for GALNT16 Gene

Variants for GALNT16 Gene

Sequence variations from dbSNP and Humsavar for GALNT16 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10083335 -- 69,373,392(+) TTAAG(C/T)GATGT intron-variant
rs1010661 -- 69,350,995(+) CTTCT(C/G)CCCCT intron-variant
rs10130642 -- 69,368,020(+) agaaa(A/C)GAGAA intron-variant
rs10137211 -- 69,339,690(+) GAAGT(C/G)GTATG intron-variant
rs10137786 -- 69,299,738(+) TTCAT(A/G)AAGCC intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for GALNT16 Gene

Variant ID Type Subtype PubMed ID
nsv564966 CNV loss 21841781
nsv528359 CNV loss 19592680
nsv1333 CNV insertion 18451855
esv3634835 CNV loss 21293372
esv3634834 CNV loss 21293372
esv3551705 CNV deletion 23714750
esv3396168 CNV duplication 20981092
esv2671068 CNV deletion 23128226
dgv1289e59 CNV tandem duplication 20981092

Variation tolerance for GALNT16 Gene

Residual Variation Intolerance Score: 22.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.19; 84.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GALNT16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GALNT16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT16 Gene

Disorders for GALNT16 Gene

Relevant External Links for GALNT16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GALNT16

No disorders were found for GALNT16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GALNT16 Gene

Publications for GALNT16 Gene

  1. UDP-N-acetyl-I+-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree. (PMID: 22186971) Raman J. … Tabak L.A. (Glycobiology 2012) 2 3 4 64
  2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for GALNT16 Gene

Sources for GALNT16 Gene

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