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Aliases for GALNT16 Gene

Aliases for GALNT16 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 16 2 3 5
  • Polypeptide GalNAc Transferase 16 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase-Like 1 2 3
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 16 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 1 3 4
  • Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 1 3 4
  • Protein-UDP Acetylgalactosaminyltransferase-Like Protein 1 3 4
  • Polypeptide GalNAc Transferase-Like Protein 1 3 4
  • Pp-GaNTase-Like Protein 1 3 4
  • GalNAc-T-Like Protein 1 3 4
  • GalNAc-T16 3 4
  • GALNTL1 3 4
  • Putative Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 1 3
  • EC 2.4.1.41 4
  • GALNACT16 3
  • KIAA1130 4

External Ids for GALNT16 Gene

Previous HGNC Symbols for GALNT16 Gene

  • GALNTL1

Previous GeneCards Identifiers for GALNT16 Gene

  • GC14P069725

Summaries for GALNT16 Gene

GeneCards Summary for GALNT16 Gene

GALNT16 (Polypeptide N-Acetylgalactosaminyltransferase 16) is a Protein Coding gene. Among its related pathways are Mucin type O-glycan biosynthesis and O-linked glycosylation. GO annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT2.

UniProtKB/Swiss-Prot for GALNT16 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.

Additional gene information for GALNT16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT16 Gene

Genomics for GALNT16 Gene

Regulatory Elements for GALNT16 Gene

Enhancers for GALNT16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H069353 1.4 FANTOM5 Ensembl ENCODE 11.1 +95.9 95887 2 HDGF TBL1XR1 BMI1 BATF SCRT2 ZNF207 ATF7 ETV6 RUNX3 CREM GALNT16 PLEKHD1 SRSF5 ENSG00000280073 LOC105370549
GH14H069423 0.7 ENCODE 20.4 +165.2 165244 1 SOX13 GATAD2A FOXA2 SAP130 TEAD1 FOXA3 CEBPG HMG20A PPARG FOXA1 GALNT16 SLC39A9 ERH PLEKHD1
GH14H069396 1.1 ENCODE 10.1 +139.1 139083 3 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF207 SRSF5 DDX18P1 DCAF5 RPL7AP6 SUSD6 GALNT16 PLEKHD1 SLC39A9 ERH
GH14H069464 0.5 ENCODE 20.9 +205.7 205673 1 JUND POLR2A JUN FOS GALNT16 ERH SLC39A9 SRSF5 SMOC1 PLEKHD1
GH14H069260 1.1 Ensembl ENCODE 9.3 +3.4 3436 3 KLF17 RAD21 GLIS2 SCRT2 ZNF143 FOS EGR2 ZEB2 REST MIER2 GALNT16 SRSF5 ENSG00000258520 GC14M069298
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GALNT16 on UCSC Golden Path with GeneCards custom track

Promoters for GALNT16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000275081 923 1201 CTCF MXI1 KLF1 NFIB SIN3A BMI1 E2F1 ZFHX2 PRDM10 ZBTB20

Genomic Location for GALNT16 Gene

Chromosome:
14
Start:
69,259,277 bp from pter
End:
69,379,904 bp from pter
Size:
120,628 bases
Orientation:
Plus strand

Genomic View for GALNT16 Gene

Genes around GALNT16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GALNT16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GALNT16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT16 Gene

Proteins for GALNT16 Gene

  • Protein details for GALNT16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N428-GLT16_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 16
    Protein Accession:
    Q8N428
    Secondary Accessions:
    • Q4KMG3
    • Q58A55
    • Q9ULT9

    Protein attributes for GALNT16 Gene

    Size:
    558 amino acids
    Molecular mass:
    63074 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86444.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for GALNT16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALNT16 Gene

Post-translational modifications for GALNT16 Gene

  • Glycosylation at posLast=5555 and isoforms=263
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GALNT16 Gene

Domains & Families for GALNT16 Gene

Gene Families for GALNT16 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N428

UniProtKB/Swiss-Prot:

GLT16_HUMAN :
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNT16: view

Function for GALNT16 Gene

Molecular function for GALNT16 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=251 uM for Muc5AC {ECO:0000269 PubMed:22186971}; KM=310 uM for Muc5AC-3 {ECO:0000269 PubMed:22186971}; KM=390 uM for Muc5AC-13 {ECO:0000269 PubMed:22186971}; KM=332 uM for EA2 {ECO:0000269 PubMed:22186971};
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
UniProtKB/Swiss-Prot Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.

Enzyme Numbers (IUBMB) for GALNT16 Gene

Phenotypes From GWAS Catalog for GALNT16 Gene

Gene Ontology (GO) - Molecular Function for GALNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IDA,IEA 22186971
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNT16: view
genes like me logo Genes that share phenotypes with GALNT16: view

Animal Model Products

CRISPR Products

miRNA for GALNT16 Gene

miRTarBase miRNAs that target GALNT16

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GALNT16
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GALNT16 Gene

Localization for GALNT16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT16 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GALNT16 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
nucleus 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GALNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GALNT16: view

Pathways & Interactions for GALNT16 Gene

genes like me logo Genes that share pathways with GALNT16: view

Pathways by source for GALNT16 Gene

UniProtKB/Swiss-Prot Q8N428-GLT16_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for GALNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0018242 protein O-linked glycosylation via serine IDA 22186971
GO:0018243 protein O-linked glycosylation via threonine IDA 22186971
genes like me logo Genes that share ontologies with GALNT16: view

No data available for SIGNOR curated interactions for GALNT16 Gene

Drugs & Compounds for GALNT16 Gene

(3) Drugs for GALNT16 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 35
Uridine-5'-Diphosphate Experimental Pharma 0
calcium Nutra 0

(3) Additional Compounds for GALNT16 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lactosamine
  • 2-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose
  • 2-Amino-2-deoxy-4-O-beta-delta-galactopyranosyl-delta-glucose
  • beta-D-Galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
  • beta-D-Galactopyranosyl-(1->4)-D-glucosamine
  • beta-delta-Galactopyranosyl-(1->4)-2-amino-2-deoxy-delta-glucose
13000-25-4
UDP-N-acetyl-alpha-D-galactosamine
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
  • Uridine 5'-diphospho-N-acetylgalactosamine
  • Uridine diphosphate-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT16: view

Transcripts for GALNT16 Gene

Unigene Clusters for GALNT16 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GALNT16
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT16 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1: -
SP2:
SP3: - -
SP4:
SP5:
SP6: -

Relevant External Links for GALNT16 Gene

GeneLoc Exon Structure for
GALNT16
ECgene alternative splicing isoforms for
GALNT16

Expression for GALNT16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GALNT16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNT16 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.4).

Protein differential expression in normal tissues from HIPED for GALNT16 Gene

This gene is overexpressed in Spinal cord (33.8), Bone marrow mesenchymal stem cell (20.1), and Testis (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GALNT16 Gene



Protein tissue co-expression partners for GALNT16 Gene

NURSA nuclear receptor signaling pathways regulating expression of GALNT16 Gene:

GALNT16

SOURCE GeneReport for Unigene cluster for GALNT16 Gene:

Hs.21035

Evidence on tissue expression from TISSUES for GALNT16 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with GALNT16: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GALNT16 Gene

Orthologs for GALNT16 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNTL1 33 34
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia GALNT16 33 34
  • 92.04 (n)
cow
(Bos Taurus)
Mammalia GALNTL1 33 34
  • 91.32 (n)
mouse
(Mus musculus)
Mammalia Galnt16 33 16 34
  • 90.26 (n)
rat
(Rattus norvegicus)
Mammalia Galnt16 33
  • 89.73 (n)
oppossum
(Monodelphis domestica)
Mammalia GALNT16 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GALNT16 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves GALNT16 34
  • 77 (a)
OneToOne
GALNTL1 33
  • 75.68 (n)
lizard
(Anolis carolinensis)
Reptilia GALNT16 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt16 33
  • 70.93 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8926 33
zebrafish
(Danio rerio)
Actinopterygii galntl1 33
  • 69.71 (n)
galnt16 34
  • 66 (a)
OneToOne
Dr.22329 33
fruit fly
(Drosophila melanogaster)
Insecta pgant2 34
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gly-6 34
  • 32 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10774 34
  • 53 (a)
OneToMany
Species where no ortholog for GALNT16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNT16 Gene

ENSEMBL:
Gene Tree for GALNT16 (if available)
TreeFam:
Gene Tree for GALNT16 (if available)

Paralogs for GALNT16 Gene

Variants for GALNT16 Gene

Sequence variations from dbSNP and Humsavar for GALNT16 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000060803 -- 69,318,260(+) TCCCA(A/G)TAGCA intron-variant
rs1000078546 -- 69,311,777(+) TTCTA(A/G)TGTGT intron-variant
rs1000087175 -- 69,352,596(+) GGAAA(C/T)TGGGC intron-variant, utr-variant-3-prime
rs1000091696 -- 69,270,153(+) CAGAC(C/G)CCCTG intron-variant
rs1000113725 -- 69,375,379(+) TTAGA(A/C)CATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GALNT16 Gene

Variant ID Type Subtype PubMed ID
dgv1289e59 CNV tandem duplication 20981092
esv2671068 CNV deletion 23128226
esv3396168 CNV duplication 20981092
esv3551705 CNV deletion 23714750
esv3634834 CNV loss 21293372
esv3634835 CNV loss 21293372
nsv1333 CNV insertion 18451855
nsv528359 CNV loss 19592680
nsv564966 CNV loss 21841781

Variation tolerance for GALNT16 Gene

Residual Variation Intolerance Score: 22.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.19; 84.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GALNT16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GALNT16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT16 Gene

Disorders for GALNT16 Gene

Relevant External Links for GALNT16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GALNT16

No disorders were found for GALNT16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GALNT16 Gene

Publications for GALNT16 Gene

  1. UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree. (PMID: 22186971) Raman J … Tabak LA (Glycobiology 2012) 2 3 4 60
  2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for GALNT16 Gene

Sources for GALNT16 Gene

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