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Aliases for GALNT16 Gene

Aliases for GALNT16 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 16 2 3
  • Polypeptide GalNAc Transferase 16 2 3 4
  • GALNTL1 3 4 6
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase-Like 1 2 3
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 16 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 1 3 4
  • Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 1 3 4
  • Protein-UDP Acetylgalactosaminyltransferase-Like Protein 1 3 4
  • Polypeptide GalNAc Transferase-Like Protein 1 3 4
  • Pp-GaNTase-Like Protein 1 3 4
  • GalNAc-T-Like Protein 1 3 4
  • GalNAc-T16 3 4
  • GALNACT16 3 6
  • KIAA1130 4 6
  • Putative Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 1 3
  • EC 2.4.1.41 4

External Ids for GALNT16 Gene

Previous Symbols for GALNT16 Gene

  • GALNTL1

Summaries for GALNT16 Gene

GeneCards Summary for GALNT16 Gene

GALNT16 (Polypeptide N-Acetylgalactosaminyltransferase 16) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT4.

UniProtKB/Swiss-Prot for GALNT16 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT16 Gene

Genomics for GALNT16 Gene

Genomic Location for GALNT16 Gene

Start:
69,259,277 bp from pter
End:
69,357,033 bp from pter
Size:
97,757 bases
Orientation:
Plus strand

Genomic View for GALNT16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GALNT16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT16 Gene

No data available for Regulatory Elements for GALNT16 Gene

Proteins for GALNT16 Gene

  • Protein details for GALNT16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N428-GLT16_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 16
    Protein Accession:
    Q8N428
    Secondary Accessions:
    • Q4KMG3
    • Q58A55
    • Q9ULT9

    Protein attributes for GALNT16 Gene

    Size:
    558 amino acids
    Molecular mass:
    63074 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86444.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for GALNT16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALNT16 Gene

Proteomics data for GALNT16 Gene at MOPED

Post-translational modifications for GALNT16 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr55, Thr61, and Thr63

Other Protein References for GALNT16 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GALNT16 Gene

Domains for GALNT16 Gene

Gene Families for GALNT16 Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

UniProtKB/Swiss-Prot:

GLT16_HUMAN
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.:
    • Q8N428
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.:
    • Q8N428
  • Contains 1 ricin B-type lectin domain.:
    • Q8N428
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.:
    • Q8N428
genes like me logo Genes that share domains with GALNT16: view

Function for GALNT16 Gene

Molecular function for GALNT16 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=251 uM for Muc5AC {ECO:0000269 PubMed:22186971}; KM=310 uM for Muc5AC-3 {ECO:0000269 PubMed:22186971}; KM=390 uM for Muc5AC-13 {ECO:0000269 PubMed:22186971}; KM=332 uM for EA2 {ECO:0000269 PubMed:22186971};
UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
UniProtKB/Swiss-Prot Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.

Enzyme Numbers (IUBMB) for GALNT16 Gene

Gene Ontology (GO) - Molecular Function for GALNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IEA --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNT16: view

miRNA for GALNT16 Gene

miRTarBase miRNAs that target GALNT16

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GALNT16 Gene

Localization for GALNT16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT16 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for GALNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GALNT16: view

Pathways for GALNT16 Gene

genes like me logo Genes that share pathways with GALNT16: view

Pathways by source for GALNT16 Gene

UniProtKB/Swiss-Prot Q8N428-GLT16_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for GALNT16 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000336729%0d%0a9606.ENSP00000365920%0d%0a9606.ENSP00000304364%0d%0a9606.ENSP00000156626%0d%0a9606.ENSP00000223122%0d%0a
Selected Interacting proteins: ENSP00000336729 for GALNT16 Gene via STRING

Gene Ontology (GO) - Biological Process for GALNT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
genes like me logo Genes that share ontologies with GALNT16: view

Transcripts for GALNT16 Gene

Unigene Clusters for GALNT16 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT16 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1: -
SP2:
SP3: - -
SP4:
SP5:
SP6: -

Relevant External Links for GALNT16 Gene

GeneLoc Exon Structure for
GALNT16
ECgene alternative splicing isoforms for
GALNT16

Expression for GALNT16 Gene

mRNA expression in normal human tissues for GALNT16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNT16 Gene

This gene is overexpressed in Heart - Left Ventricle (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GALNT16 Gene

SOURCE GeneReport for Unigene cluster for GALNT16 Gene Hs.21035

genes like me logo Genes that share expressions with GALNT16: view

Orthologs for GALNT16 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNTL1 36
  • 99.52 (n)
  • 100 (a)
GALNTL1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GALNTL1 36
  • 91.32 (n)
  • 93.9 (a)
GALNTL1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GALNT16 36
  • 92.04 (n)
  • 93.9 (a)
GALNT16 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Galnt16 36
  • 90.26 (n)
  • 96.06 (a)
Galnt16 16
Galnt16 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GALNT16 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GALNT16 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Galnt16 36
  • 89.73 (n)
  • 96.06 (a)
chicken
(Gallus gallus)
Aves GALNT16 37
  • 77 (a)
OneToOne
GALNTL1 36
  • 75.68 (n)
  • 78.7 (a)
lizard
(Anolis carolinensis)
Reptilia GALNT16 37
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8926 36
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt16 36
  • 70.93 (n)
  • 74.44 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.22329 36
galnt16 37
  • 66 (a)
OneToOne
galntl1 36
  • 69.71 (n)
  • 71.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta pgant2 37
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gly-6 37
  • 32 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10774 37
  • 53 (a)
OneToMany
Species with no ortholog for GALNT16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNT16 Gene

ENSEMBL:
Gene Tree for GALNT16 (if available)
TreeFam:
Gene Tree for GALNT16 (if available)

Paralogs for GALNT16 Gene

genes like me logo Genes that share paralogs with GALNT16: view

Variants for GALNT16 Gene

Sequence variations from dbSNP and Humsavar for GALNT16 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs745781 -- 69,312,014(+) CCTAG(C/G)GTAAC intron-variant
rs749726 -- 69,338,346(+) ATGCC(A/G)CTGTT intron-variant
rs753218 -- 69,339,079(-) CCATG(A/C)CCAGC intron-variant
rs867402 -- 69,291,545(+) CTTCT(A/T)CCACA intron-variant
rs877266 -- 69,312,744(-) TCAGA(C/T)AGGGA intron-variant

Relevant External Links for GALNT16 Gene

HapMap Linkage Disequilibrium report
GALNT16

No data available for Structural Variations from Database of Genomic Variants (DGV) for GALNT16 Gene

Disorders for GALNT16 Gene

No disorders were found for GALNT16 Gene.

No data available for UniProtKB/Swiss-Prot for GALNT16 Gene

Publications for GALNT16 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4
  2. UDP-N-acetyl-I+-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree. (PMID: 22186971) Raman J. … Tabak L.A. (Glycobiology 2012) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for GALNT16 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GALNT16
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GALNT16
    • Block miRNA regulation of GALNT16 using miScript Target Protectors

    Sources for GALNT16 Gene

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