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Aliases for GALNT15 Gene

Aliases for GALNT15 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 15 2 3 5
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase-Like 2 2 3
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 15 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 2 3 4
  • Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 2 3 4
  • Protein-UDP Acetylgalactosaminyltransferase-Like Protein 2 3 4
  • Polypeptide GalNAc Transferase-Like Protein 2 3 4
  • Polypeptide GalNAc Transferase 15 2 3
  • Pp-GaNTase-Like Protein 2 3 4
  • GalNAc-T-Like Protein 2 3 4
  • GALNTL2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 7 3
  • Pregnancy-Induced Hypertension Syndrome-Related Protein 5 3
  • Polypeptide N-Acetylgalactosaminyltransferase 13 3
  • UDP-GalNAc Transferase T15 3
  • Pp-GalNAc-T15 3
  • EC 2.4.1.41 4
  • GALNACT15 3
  • GALNT13 3
  • GALNT7 3
  • PIH5 3

External Ids for GALNT15 Gene

Previous HGNC Symbols for GALNT15 Gene

  • GALNTL2

Previous GeneCards Identifiers for GALNT15 Gene

  • GC07P150968
  • GC07P151045
  • GC03P016216

Summaries for GALNT15 Gene

GeneCards Summary for GALNT15 Gene

GALNT15 (Polypeptide N-Acetylgalactosaminyltransferase 15) is a Protein Coding gene. Among its related pathways are Metabolism and Mucin type O-Glycan biosynthesis. GO annotations related to this gene include carbohydrate binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT4.

UniProtKB/Swiss-Prot for GALNT15 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate.

Gene Wiki entry for GALNT15 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT15 Gene

Genomics for GALNT15 Gene

Regulatory Elements for GALNT15 Gene

Enhancers for GALNT15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GALNT15 on UCSC Golden Path with GeneCards custom track

Promoters for GALNT15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GALNT15 on UCSC Golden Path with GeneCards custom track

Genomic Location for GALNT15 Gene

Chromosome:
3
Start:
16,174,579 bp from pter
End:
16,246,333 bp from pter
Size:
71,755 bases
Orientation:
Plus strand

Genomic View for GALNT15 Gene

Genes around GALNT15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GALNT15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GALNT15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT15 Gene

Proteins for GALNT15 Gene

  • Protein details for GALNT15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3T1-GLT15_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 15
    Protein Accession:
    Q8N3T1
    Secondary Accessions:
    • A6NMN1
    • B2R638
    • F1LIP6
    • Q86T60
    • Q96C46
    • Q96DJ5

    Protein attributes for GALNT15 Gene

    Size:
    639 amino acids
    Molecular mass:
    73063 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD89983.1; Type=Frameshift; Positions=169, 192, 206, 222, 270; Evidence={ECO:0000305};

neXtProt entry for GALNT15 Gene

Proteomics data for GALNT15 Gene at MOPED

Post-translational modifications for GALNT15 Gene

  • Glycosylation at Asn 107 and Asn 574
  • Modification sites at PhosphoSitePlus

Other Protein References for GALNT15 Gene

No data available for DME Specific Peptides for GALNT15 Gene

Domains & Families for GALNT15 Gene

Gene Families for GALNT15 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N3T1

UniProtKB/Swiss-Prot:

GLT15_HUMAN :
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • Contains 1 ricin B-type lectin domain.
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNT15: view

Function for GALNT15 Gene

Molecular function for GALNT15 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
UniProtKB/Swiss-Prot Function:
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate.

Enzyme Numbers (IUBMB) for GALNT15 Gene

Gene Ontology (GO) - Molecular Function for GALNT15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IEA,TAS --
genes like me logo Genes that share ontologies with GALNT15: view
genes like me logo Genes that share phenotypes with GALNT15: view

Animal Model Products

miRNA for GALNT15 Gene

miRTarBase miRNAs that target GALNT15

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GALNT15 Gene

Localization for GALNT15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT15 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GALNT15 Gene

Pathways & Interactions for GALNT15 Gene

genes like me logo Genes that share pathways with GALNT15: view

Pathways by source for GALNT15 Gene

UniProtKB/Swiss-Prot Q8N3T1-GLT15_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for GALNT15 Gene

Gene Ontology (GO) - Biological Process for GALNT15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with GALNT15: view

No data available for SIGNOR curated interactions for GALNT15 Gene

Drugs & Compounds for GALNT15 Gene

(3) Drugs for GALNT15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine-5'-Diphosphate Experimental Pharma 0
Manganese Pharma 32
calcium Nutra 0

(3) Additional Compounds for GALNT15 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lactosamine
  • 2-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose
  • 2-Amino-2-deoxy-4-O-beta-delta-galactopyranosyl-delta-glucose
  • beta-D-Galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
  • beta-D-Galactopyranosyl-(1->4)-D-glucosamine
  • beta-delta-Galactopyranosyl-(1->4)-2-amino-2-deoxy-delta-glucose
13000-25-4
UDP-N-acetyl-alpha-D-galactosamine
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
  • Uridine 5'-diphospho-N-acetylgalactosamine
  • Uridine diphosphate-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT15: view

Transcripts for GALNT15 Gene

Unigene Clusters for GALNT15 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14
SP1: - - -
SP2: - - - - -
SP3:
SP4:
SP5: - - - - - - - - - - - - -
SP6:

Relevant External Links for GALNT15 Gene

GeneLoc Exon Structure for
GALNT15
ECgene alternative splicing isoforms for
GALNT15

Expression for GALNT15 Gene

mRNA expression in normal human tissues for GALNT15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNT15 Gene

This gene is overexpressed in Adipose - Subcutaneous (x6.4).

Protein differential expression in normal tissues from HIPED for GALNT15 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GALNT15 Gene



SOURCE GeneReport for Unigene cluster for GALNT15 Gene Hs.411308

mRNA Expression by UniProt/SwissProt for GALNT15 Gene

Q8N3T1-GLT15_HUMAN
Tissue specificity: Widely expressed. Highly expressed in small intestine, placenta, spleen, cerebral cortex and ovary. Expressed at intermediate level in uterus, mammary gland, stomach, cerebellum and whole brain. Weakly expressed in fetal brain, bone marrow, thyroid gland, thymus, heart, skeletal muscle, lung, liver, colon, pancreas, kidney and testis. Not expressed in leukocyte. Expressed in both normal and osteoarthritic cartilage. Expressed at low level in chondrocytes in all zones of both normal and osteoarthritic cartilage.
genes like me logo Genes that share expression patterns with GALNT15: view

Protein tissue co-expression partners for GALNT15 Gene

Primer Products

Orthologs for GALNT15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GALNT15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GALNTL2 35
  • 79.04 (n)
  • 74.09 (a)
GALNT15 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GALNT15 35
  • 87.75 (n)
  • 86.59 (a)
GALNT15 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Galnt15 35
  • 82.42 (n)
  • 78.02 (a)
Galnt15 16
Galnt15 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GALNTL2 35
  • 99.17 (n)
  • 99.06 (a)
GALNTL2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Galnt15 35
  • 79.02 (n)
  • 75.39 (a)
oppossum
(Monodelphis domestica)
Mammalia GALNT15 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GALNT15 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves GALNTL2 35
  • 66.82 (n)
  • 59.15 (a)
GALNT15 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GALNT15 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt15 35
  • 57 (n)
  • 51.33 (a)
Species with no ortholog for GALNT15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GALNT15 Gene

ENSEMBL:
Gene Tree for GALNT15 (if available)
TreeFam:
Gene Tree for GALNT15 (if available)

Paralogs for GALNT15 Gene

genes like me logo Genes that share paralogs with GALNT15: view

Variants for GALNT15 Gene

Sequence variations from dbSNP and Humsavar for GALNT15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2271077 - 16,219,913(+) AGCTC(C/T)ACAAC reference, missense
rs36026882 - 16,175,354(+) TTGGG(G/T)ACTGG reference, missense
rs11715981 - 16,175,603(+) GACCC(C/T)GTTCA reference, missense
rs12634179 - 16,208,561(+) ATTAC(C/G)CCTCA reference, missense
rs17851238 - 16,212,665(+) AGGAG(A/G)CCACC reference, missense

Variation tolerance for GALNT15 Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.21; 90.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for GALNT15 Gene

Disorders for GALNT15 Gene

Relevant External Links for GALNT15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GALNT15

No disorders were found for GALNT15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GALNT15 Gene

Publications for GALNT15 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc- T15. (PMID: 15147861) Cheng L. … Narimatsu H. (FEBS Lett. 2004) 2 3
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3

Products for GALNT15 Gene

Sources for GALNT15 Gene

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