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GALNT14 Gene

protein-coding   GIFtS: 61
GCID: GC02M031044

Polypeptide N-Acetylgalactosaminyltransferase 14

(Previous name: UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Polypeptide N-Acetylgalactosaminyltransferase 141 2     GALNT152
Polypeptide GalNAc Transferase 141 2 3     GalNac-T102
UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide
N-Acetylgalactosaminyltransferase 14 (GalNAc-T14)1 2
     GalNac-T142
Protein-UDP Acetylgalactosaminyltransferase 142 3     Polypeptide N-Acetylgalactosaminyltransferase 152
Pp-GaNTase 142 3     UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase T102
UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 142 3     UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase T142
EC 2.4.1.413 8     GalNAc-T143

External Ids:    HGNC: 229461   Entrez Gene: 796232   Ensembl: ENSG000001580897   OMIM: 6082255   UniProtKB: Q96FL93   

Export aliases for GALNT14 gene to outside databases

Previous GC identifers: GC02M031107 GC02M030871


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GALNT14 Gene:
This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase
(ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the
hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer
GalNAc to large proteins like mucins. Multiple transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for GALNT14 Gene:
GALNT14 (polypeptide N-acetylgalactosaminyltransferase 14) is a protein-coding gene. GO annotations related to this gene include polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT12.

UniProtKB/Swiss-Prot: GLT14_HUMAN, Q96FL9
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an
N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity
toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in
O-glycosylation in kidney

Gene Wiki entry for GALNT14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GALNT14 gene promoter:
         NRSF form 1   CUTL1   Nkx2-5   NRSF form 2   GATA-1   AREB6   Chx10   FOXO1a   ZID   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGALNT14 promoter sequence
   Search Chromatin IP Primers for GALNT14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GALNT14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.1   Ensembl cytogenetic band:  2p23.1   HGNC cytogenetic band: 2p23.2

GALNT14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GALNT14 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M031044:  view genomic region     (about GC identifiers)

Start:
31,133,333 bp from pter      End:
31,378,068 bp from pter
Size:
244,736 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GLT14_HUMAN, Q96FL9 (See protein sequence)
Recommended Name: Polypeptide N-acetylgalactosaminyltransferase 14  
Size: 552 amino acids; 64321 Da
Cofactor: Manganese (By similarity)
Sequence caution: Sequence=BAB14795.1; Type=Miscellaneous discrepancy; Note=Chimeric at the C-terminus;
Secondary accessions: B3KV89 Q4ZG75 Q53SU1 Q53TJ0 Q8IVI4 Q9BRH1 Q9H827 Q9H9J8
Alternative splicing: 4 isoforms:  Q96FL9-1   Q96FL9-2   Q96FL9-3   Q96FL9-4   (Minor isoform)

Explore the universe of human proteins at neXtProt for GALNT14: NX_Q96FL9

Explore proteomics data for GALNT14 at MOPED

Selected DME Specific Peptides for GALNT14 (Q96FL9) (see all 9)
 VVCPVID  FLDSHCE  PCSRVGH  VGHVFRK 


See GALNT14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001240755.1  NP_001240756.1  NP_078848.2  

ENSEMBL proteins: 
 ENSP00000314500   ENSP00000288988   ENSP00000385435   ENSP00000406399   ENSP00000399886  
 ENSP00000398723   ENSP00000348497   ENSP00000415514  
Reactome Protein details: Q96FL9

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
GLT2: Glycosyltransferase family 2 domain containing

3 InterPro protein domains:
 IPR000772 Ricin_B_lectin
 IPR001173 Glyco_trans_2
 IPR027791 Galactosyl_T_C

Graphical View of Domain Structure for InterPro Entry Q96FL9

ProtoNet protein and cluster: Q96FL9

2 Blocks protein domains:
IPB000772 Ricin B lectin domain
IPB001173 Glycosyl transferase


UniProtKB/Swiss-Prot: GLT14_HUMAN, Q96FL9
Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also
called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal
domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal
binding (By similarity)
Domain: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By
similarity)
Similarity: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily
Similarity: Contains 1 ricin B-type lectin domain


Find genes that share domains with GALNT14           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: GLT14_HUMAN, Q96FL9
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an
N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity
toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in
O-glycosylation in kidney
Catalytic activity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP +
N-acetyl-alpha-D-galactosaminyl-polypeptide

     Enzyme Number (IUBMB): EC 2.4.1.411 2

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004653polypeptide N-acetylgalactosaminyltransferase activity IEA--
GO:0016757transferase activity, transferring glycosyl groups ----
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with GALNT14           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for GALNT14:
 Decreased nuclei size in G2M  Synthetic lethal with Ras 

     1 MGI phenotypic allele for Galnt14 (no phenotypes)

Find genes that share phenotypes with GALNT14           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Galnt14tm1Lex for GALNT14

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SwitchGear 3'UTR luciferase reporter plasmidGALNT14 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
GLT14_HUMAN, Q96FL9: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
golgi apparatus5
plasma membrane3
endoplasmic reticulum1
extracellular1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000139Golgi membrane TAS--
GO:0005794Golgi apparatus ----
GO:0016021integral component of membrane IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for GALNT14 About    
See pathways by source

SuperPathContained pathways About
1O-linked glycosylation of mucins
O-linked glycosylation of mucins0.47
Mucin type O-Glycan biosynthesis0.47
2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Post-translational protein modification0.43
Metabolism of proteins0.30
3Metabolism
Metabolic pathways0.38


Find genes that share SuperPaths with GALNT14           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Reactome Pathway for GALNT14
    O-linked glycosylation of mucins


2 Kegg Pathways  (Kegg details for GALNT14):
    Mucin type O-Glycan biosynthesis
Metabolic pathways

UniProtKB/Swiss-Prot: GLT14_HUMAN, Q96FL9
Pathway: Protein modification; protein glycosylation

    Pathway & Disease-focused RT2 Profiler PCR Array including GALNT14: 

          Glycosylation in human mouse rat

Interactions:

    GeneGlobe Interaction Network for GALNT14

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for GALNT14 (Q96FL93 ENSP000002889884) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
InteractantInteraction Details
GeneCardExternal ID(s)
MUC7Q8TAX73, ENSP000003020214I2D: score=2 STRING: ENSP00000302021
MUC13Q9H3R23, ENSP000003122354I2D: score=1 STRING: ENSP00000312235
MUC2Q028173, ENSP000004151834I2D: score=2 STRING: ENSP00000415183
GALNT1ENSP000002691954STRING: ENSP00000269195
GALNT10ENSP000002971074STRING: ENSP00000297107
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006486protein glycosylation ----
GO:0016266O-glycan processing TAS--
GO:0043687post-translational protein modification TAS--
GO:0044267cellular protein metabolic process TAS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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  Browse compounds at ApexBio 

Browse Tocris compounds for GALNT14 (GLT14)

5 HMDB Compounds for GALNT14    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--
Lactosaminebeta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose (see all 8)13000-25-4--
Manganesemanganese 7439-96-5--
Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
Uridine diphosphate-N-acetylgalactosamineUDP-N-acetyl-D-galactosamine (see all 17)7277-98-7--

3 PharmGKB related drug/compound annotations for GALNT14 gene    About this table
Drug/compound PharmGKB Annotation
cisplatinCA  
fluorouracilCA  
mitoxantroneCA  



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for GALNT14 gene (3 alternative transcripts): 
NM_001253826.1  NM_001253827.1  NM_024572.3  

Unigene Cluster for GALNT14:

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
Hs.468058  [show with all ESTs]
Unigene Representative Sequence: NR_045602
17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000324589 ENST00000349752(uc002rns.3 uc010ymr.2 uc002rnr.3 uc010ezo.2)
ENST00000406653(uc002rnq.3) ENST00000475320 ENST00000486564 ENST00000430167
ENST00000455477 ENST00000464038(uc010ezp.1) ENST00000481023 ENST00000424136
ENST00000496397 ENST00000461193 ENST00000490212 ENST00000498206 ENST00000485468
ENST00000356174 ENST00000420311
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SwitchGear 3'UTR luciferase reporter plasmidGALNT14 3' UTR sequence
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GenScript: all cDNA clones in your preferred vector: GALNT14 (NM_024572)
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  QuantiFast Probe-based Assays in human, mouse, rat GALNT14

Additional mRNA sequence: 

AB078144.1 AJ505966.1 AK022753.1 AK074394.1 AK091313.1 AK122747.1 AK225808.1 AK298735.1 
AK309417.1 AY358758.1 BC006269.2 BC010659.1 NR_045602.1 Y09324.4 

10 DOTS entries:

DT.451780  DT.100817457  DT.100817449  DT.120936518  DT.95161152  DT.100817448  DT.413822  DT.100817456 
DT.91754029  DT.120936547 

Selected AceView cDNA sequences (see all 124):

NM_024572 BU164615 BQ433154 AA358668 CA414661 BC010659 BF195889 AA358669 
AY358758 AW662278 AW072938 BI061029 AK122747 BU179584 AU149561 BC006269 
AA805374 AK022753 BG164940 AB078144 BQ720143 BG519546 BG699028 W56733 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for GALNT14 (see all 8)    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a ·
SP1:                                            -     -                                                                                   -                     
SP2:              -     -     -                 -     -     -                                                                             -                     
SP3:              -     -     -     -     -     -     -                                                                                   -                     
SP4:                                                                                                                                                            
SP5:                                -     -     -     -                                                                                                         

ExUns: 21b · 21c
SP1:            
SP2:            
SP3:            
SP4:            
SP5:            


ECgene alternative splicing isoforms for GALNT14

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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GALNT14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTCTCAAGGC
GALNT14 Expression
About this image


GALNT14 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
         Human embryonic stem cells (family)
 
 Neural Tube (Nervous System)    fully expand to see all 2 entries
         Telencephalon
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Cerebral Cortex
 
 Kidney (Urinary System)
 
 Spinal Cord (Nervous System)
GALNT14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

GALNT14 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.468058

UniProtKB/Swiss-Prot: GLT14_HUMAN, Q96FL9
Tissue specificity: Detected in renal tubules (at protein level). Highly expressed in fetal and adult kidney.
Widely expressed at low level. Weakly expressed in whole brain, cerebellum, thymus, lung, mammary gland, liver,
stomach, small intestine, colon, pancreas, spleen, bladder, uterus, placenta, testis, ovary, skeletal muscle,
leukocyte, B-cell, bone marrow, fetal brain, fetal thymus, fetal lung, fetal liver, fetal small intestine, fetal
spleen, fetal skeletal and fetus. Detected in renal tubules (at protein level)

    Pathway & Disease-focused RT2 Profiler PCR Array including GALNT14: 
          Glycosylation in human mouse rat

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for GALNT14 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Galnt141 , 5 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more1, 5 86.85(n)1
91.82(a)1
  17 (44.88 cM)5
716851  NM_027864.21  NP_082140.21 
 734932285 
chicken
(Gallus gallus)
Aves GALNT141 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more 72.89(n)
72.46(a)
  421305  XM_419370.4  XP_419370.3 
lizard
(Anolis carolinensis)
Reptilia GALNT146
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-a...
61(a)
1 ↔ 1
1(250181031-250468520)
tropical clawed frog
(Xenopus tropicalis)
Amphibia galnt141 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more 69.59(n)
70.8(a)
  779822  NM_001078901.1  NP_001072369.1 
zebrafish
(Danio rerio)
Actinopterygii galnt141 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more 63.75(n)
62.84(a)
  562739  NM_001044995.2  NP_001038460.1 
fruit fly
(Drosophila melanogaster)
Insecta pgant26
polypeptide GalNAc transferase 2
40(a)
1 → many
2L(3404460-3426642)
worm
(Caenorhabditis elegans)
Secernentea gly-46
Protein GLY-4, isoform c (gly-4) mRNA, complete cd...
38(a)
many ↔ many
V(19881372-19895350) WBGene00001629


ENSEMBL Gene Tree for GALNT14 (if available)
TreeFam Gene Tree for GALNT14 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for GALNT14 gene
GALNT122  GALNT12  GALNTL62  GALNT32  GALNT102  GALNT22  GALNT132  GALNT62  
POC1B-GALNT42  GALNT152  GALNT72  GALNT52  GALNTL52  GALNT42  GALNT162  GALNT112  
Selected SIMAP similar genes for GALNT14 using alignment to 5 protein entries:     GLT14_HUMAN (see all proteins) (see all similar genes):
GalNAc-T16    GALNT16    GALNT15    GALNT2    GALNT1    GALNT13
GALNTL5    GALNT11    GALNTL6    GALNT12    GalNAc-T10    GALNT3
GALNT4    POC1B-GALNT4    GALNT7    GALNT9    GALNT6    WBSCR17

Find genes that share paralogs with GALNT14           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for GALNT14 (see all 5274)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs32230431,2
C--30960926(-) acaca-/CA/   
  CACACA
gttgg
7 -- int1 cds10--------
rs3775889201,2
C--31091316(+) cgcgc-/ACctgtg 4 -- int1 us2k11Minor allele frequency- AC:0.00NA 2
rs65436061,2
C,F,A,H--31092165(+) CACTTC/TAGAAA 1 -- us2k122Minor allele frequency- T:0.44NS EA WA NA CSA 2341
rs1895213561,2
--31133011(+) GCATGG/TCACAT 4 -- ds50010--------
rs134057111,2
C,F--31133024(+) ATACAT/CATGTA 4 -- ds50015Minor allele frequency- C:0.44NA WA CSA 9
rs1437993521,2
--31133060(+) ACCCTA/GAAACT 4 -- ds50010--------
rs2018120271,2
C--31133078(+) TAATA-/TAAAAA 4 -- ds50010--------
rs1828320631,2
--31133337(+) GTCCAA/GAGACA 4 -- nc-transcript-variantut310--------
rs1164783571,2
C,F--31133392(+) TTCATC/TTCTCA 4 -- nc-transcript-variantut311Minor allele frequency- T:0.02NA 120
rs1468773891,2
--31133398(+) TCTCAA/GTGTAG 4 -- nc-transcript-variantut310--------

HapMap Linkage Disequilibrium report for GALNT14 (31133333 - 31378068 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for GALNT14:    About this table    
Variant IDTypeSubtypePubMed ID
esv2719870CNV Deletion23290073
esv2719869CNV Deletion23290073
esv2674441CNV Deletion23128226
esv2719868CNV Deletion23290073
dgv690e199CNV Deletion23128226
esv1683223CNV Deletion17803354
esv2719871CNV Deletion23290073
esv3567CNV Deletion18987735
esv22531CNV Loss19812545
nsv833659CNV Gain17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608225    OMIM disorders: --


Find genes that share disorders with GALNT14           About GenesLikeMe

Genetic Association Database (GAD): GALNT14
Human Genome Epidemiology (HuGE) Navigator: GALNT14 (2 documents)

Export disorders for GALNT14 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for GALNT14 gene, integrated from 10 sources (see all 19):
(articles sorted by number of sources associating them with GALNT14)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and characterization of a novel UDP-GalNAc:polypeptide N- acetylgalactosaminyltransferase, pp-GalNAc-T14. (PubMed id 12507512)1, 2, 3 Wang H.... Narimatsu H. (Biochem. Biophys. Res. Commun. 2003)
  2. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)1, 4 Lingappa J.R....Goldstein D. (PLoS ONE 2011)
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  4. Development of immunohistochemistry assays to assess GALNT14 and FUT3/6 in clinical trials of dulanermin and drozitumab. (PubMed id 20179215)1, 2 Stern H.M....Ashkenazi A. (Clin. Cancer Res. 2010)
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  9. N-Acetylgalactosaminyltransferase 14, a novel insulin-like growth factor binding protein-3 binding partner. (PubMed id 17434446)1, 9 Wu C....Xu D. (Biochem. Biophys. Res. Commun. 2007)
  10. N-Acetylgalactosaminyltransferase-14 as a potential biomarker for breast cancer by immunohistochemistry. (PubMed id 20356418)1, 9 Wu C....Zhu M. (BMC Cancer 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79623 HGNC: 22946 AceView: GALNT14 Ensembl:ENSG00000158089 euGenes: HUgn79623
ECgene: GALNT14 Kegg: 79623 H-InvDB: GALNT14

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for GALNT14 Pharmacogenomics, SNPs, Pathways
GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=GALNT14
Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_497

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for GALNT14 gene:
Search GeneIP for patents involving GALNT14

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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