Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GALNT14 Gene

protein-coding   GIFtS: 63
GCID: GC02M031044

UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase...

Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide
N-Acetylgalactosaminyltransferase 14 (GalNAc-T14)1 2
     GalNac-T102
Polypeptide GalNAc Transferase 142 3     GalNac-T142
Protein-UDP Acetylgalactosaminyltransferase 142 3     Polypeptide N-Acetylgalactosaminyltransferase 142
Pp-GaNTase 142 3     Polypeptide N-Acetylgalactosaminyltransferase 152
UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 142 3     UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase T102
EC 2.4.1.413 8     UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase T142
GALNT152     GalNAc-T143

External Ids:    HGNC: 229461   Entrez Gene: 796232   Ensembl: ENSG000001580897   OMIM: 6082255   UniProtKB: Q96FL93   

Export aliases for GALNT14 gene to outside databases

Previous GC identifers: GC02M031107 GC02M030871


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GALNT14 Gene:
This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase
(ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the
hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer
GalNAc to large proteins like mucins. Multiple transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for GALNT14 Gene: 
GALNT14 (UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)) is a protein-coding gene. Diseases associated with GALNT14 include breast cancer, and among its related super-pathways are Mucin type O-Glycan biosynthesis and Post-translational protein modification. GO annotations related to this gene include polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT6.

UniProtKB/Swiss-Prot: GLT14_HUMAN, Q96FL9
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an
N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity
toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in
O-glycosylation in kidney

Gene Wiki entry for GALNT14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GALNT14 gene promoter:
         NRSF form 1   CUTL1   Nkx2-5   NRSF form 2   GATA-1   AREB6   Chx10   FOXO1a   ZID   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGALNT14 promoter sequence
   Search SABiosciences Chromatin IP Primers for GALNT14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GALNT14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.1   Ensembl cytogenetic band:  2p23.1   HGNC cytogenetic band: 2p23.2

GALNT14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GALNT14 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M031044:  view genomic region     (about GC identifiers)

Start:
31,133,333 bp from pter      End:
31,378,068 bp from pter
Size:
244,736 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GLT14_HUMAN, Q96FL9 (See protein sequence)
Recommended Name: Polypeptide N-acetylgalactosaminyltransferase 14  
Size: 552 amino acids; 64321 Da
Cofactor: Manganese (By similarity)
Cofactor: Calcium (By similarity)
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Sequence caution: Sequence=BAB14795.1; Type=Miscellaneous discrepancy; Note=Chimeric at the C-terminus;
Secondary accessions: B3KV89 Q4ZG75 Q53SU1 Q53TJ0 Q8IVI4 Q9BRH1 Q9H827 Q9H9J8
Alternative splicing: 4 isoforms:  Q96FL9-1   Q96FL9-2   Q96FL9-3   Q96FL9-4   (Minor isoform)

Explore the universe of human proteins at neXtProt for GALNT14: NX_Q96FL9

Explore proteomics data for GALNT14 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96FL9

  • 4/9 DME Specific Peptides for GALNT14 (Q96FL9) (see all 9)
     VVCPVID  FLDSHCE  PCSRVGH  VGHVFRK 

    GALNT14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GALNT14 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001240755.1  NP_001240756.1  NP_078848.2  

    ENSEMBL proteins: 
     ENSP00000314500   ENSP00000288988   ENSP00000385435   ENSP00000406399   ENSP00000399886  
     ENSP00000398723   ENSP00000348497   ENSP00000415514  
    Reactome Protein details: Q96FL9
    Human Recombinant Protein Products for GALNT14: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GALNT14
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GALNT14
    GenScript Custom Purified and Recombinant Proteins Services for GALNT14
    Novus Biologicals GALNT14 Proteins
    Novus Biologicals GALNT14 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GALNT14 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus ----
    GO:0016021integral to membrane IEA--

    GALNT14 for ontologies           About GeneDecksing



    GALNT14 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GALNT14
    GenScript Custom Superior Antibodies Services for GALNT14
    Novus Biologicals GALNT14 Antibodies
    Abcam antibodies for GALNT14
    Cloud-Clone Corp. Antibodies for GALNT14 
    ThermoFisher Antibodies for GALNT14
    LSBio Antibodies in human, mouse, rat for GALNT14 

    Assay Products for GALNT14: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GALNT14
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GALNT14
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GALNT14 
    Cloud-Clone Corp. CLIAs for GALNT14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GLT2: Glycosyltransferase family 2 domain containing

    3 InterPro protein domains:
     IPR000772 Ricin_B_lectin
     IPR001173 Glyco_trans_2
     IPR003859 Galactosyl_T_2_met

    Graphical View of Domain Structure for InterPro Entry Q96FL9

    ProtoNet protein and cluster: Q96FL9

    2 Blocks protein domains:
    IPB000772 Ricin B lectin domain
    IPB001173 Glycosyl transferase


    UniProtKB/Swiss-Prot: GLT14_HUMAN, Q96FL9
    Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also
    called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal
    domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal
    binding (By similarity)
    Domain: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By
    similarity)
    Similarity: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily
    Similarity: Contains 1 ricin B-type lectin domain


    GALNT14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLT14_HUMAN, Q96FL9
    Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an
    N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity
    toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in
    O-glycosylation in kidney
    Catalytic activity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP +
    N-acetyl-alpha-D-galactosaminyl-polypeptide

         Enzyme Number (IUBMB): EC 2.4.1.411 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004653polypeptide N-acetylgalactosaminyltransferase activity IEA--
    GO:0016757transferase activity, transferring glycosyl groups ----
         
    GALNT14 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for GALNT14:
     Decreased nuclei size in G2M  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Galnt14 (no phenotypes)

    GALNT14 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Galnt14tm1Lex for GALNT14

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GALNT14 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GALNT14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GALNT14 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GALNT14 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GALNT14
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate GALNT14:
    hsa-miR-4324 hsa-miR-125a-5p hsa-miR-670 hsa-miR-125b hsa-miR-3176 hsa-miR-3922-3p hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidGALNT14 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GALNT14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GALNT14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GALNT14
    Sirion Biotech Customized adenovirus for overexpression of GALNT14

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GALNT14 (see all 8)
    OriGene ORF clones in mouse, rat for GALNT14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GALNT14 (NM_024572)
    Sino Biological Human cDNA Clone for GALNT14
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GALNT14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GALNT14
    Sirion Biotech Customized lentivirus for stable overexpression of GALNT14 
                         Customized lentivirus expression plasmids for stable overexpression of GALNT14 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GALNT14
    LifeMap BioReagents: cell line associated with GALNT14: PureStem ES-209, Meso-prx/latp Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALNT14


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GALNT14 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.44
    Mucin type O-Glycan biosynthesis0.44
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35
    3Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3        Reactome Pathways for GALNT14
        O-linked glycosylation of mucins
    Metabolism of proteins
    Post-translational protein modification


    2         Kegg Pathways  (Kegg details for GALNT14):
        Mucin type O-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: GLT14_HUMAN, Q96FL9
    Pathway: Protein modification; protein glycosylation


    GALNT14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GALNT14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for GALNT14 (Q96FL93 ENSP000002889884) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MUC7Q8TAX73, ENSP000003020214I2D: score=2 STRING: ENSP00000302021
    MUC13Q9H3R23, ENSP000003122354I2D: score=1 STRING: ENSP00000312235
    MUC2Q028173, ENSP000004151834I2D: score=2 STRING: ENSP00000415183
    GALNT1ENSP000002691954STRING: ENSP00000269195
    GALNT10ENSP000002971074STRING: ENSP00000297107
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006486protein glycosylation ----
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    GALNT14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GALNT14 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GALNT14 (GLT14)

    5 HMDB Compounds for GALNT14    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Lactosaminebeta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose (see all 8)13000-25-4--
    Manganesemanganese 7439-96-5--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate-N-acetylgalactosamineUDP-N-acetyl-D-galactosamine (see all 17)7277-98-7--

    3 PharmGKB related drug/compound annotations for GALNT14 gene    About this table
    Drug/compound PharmGKB Annotation
    cisplatinCA  
    fluorouracilCA  
    mitoxantroneCA  

    Search CenterWatch for drugs/clinical trials and news about GALNT14 / GLT14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GALNT14 gene (3 alternative transcripts): 
    NM_001253826.1  NM_001253827.1  NM_024572.3  

    Unigene Cluster for GALNT14:

    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
    Hs.468058  [show with all ESTs]
    Unigene Representative Sequence: NR_045602
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324589 ENST00000349752(uc002rns.3 uc010ymr.2 uc002rnr.3 uc010ezo.2)
    ENST00000406653(uc002rnq.3) ENST00000475320 ENST00000486564 ENST00000430167
    ENST00000455477 ENST00000464038(uc010ezp.1) ENST00000481023 ENST00000424136
    ENST00000496397 ENST00000461193 ENST00000490212 ENST00000498206 ENST00000485468
    ENST00000356174 ENST00000420311
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GALNT14
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate GALNT14:
    hsa-miR-4324 hsa-miR-125a-5p hsa-miR-670 hsa-miR-125b hsa-miR-3176 hsa-miR-3922-3p hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidGALNT14 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GALNT14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GALNT14
    Clone
    Products:
         
    OriGene clones in human, mouse for GALNT14 (see all 8)
    OriGene ORF clones in mouse, rat for GALNT14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GALNT14 (NM_024572)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GALNT14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GALNT14
    Sirion Biotech Customized lentivirus for stable overexpression of GALNT14 
                         Customized lentivirus expression plasmids for stable overexpression of GALNT14 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GALNT14
    OriGene qSTAR qPCR primer pairs in human, mouse for GALNT14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GALNT14
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GALNT14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GALNT14

    Additional mRNA sequence: 

    AB078144.1 AJ505966.1 AK022753.1 AK074394.1 AK091313.1 AK122747.1 AK225808.1 AK298735.1 
    AK309417.1 AY358758.1 BC006269.2 BC010659.1 NR_045602.1 Y09324.4 

    10 DOTS entries:

    DT.451780  DT.100817457  DT.100817449  DT.120936518  DT.95161152  DT.100817448  DT.413822  DT.100817456 
    DT.91754029  DT.120936547 

    24/124 AceView cDNA sequences (see all 124):

    AW072938 BI061029 AK122747 BU179584 AU149561 BC006269 AA805374 AK022753 
    BG164940 AB078144 NM_024572 BU164615 BQ433154 AA358668 CA414661 BC010659 
    BF195889 AA358669 AY358758 AW662278 BF434511 AJ505966 BF434569 CK300628 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for GALNT14 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a ·
    SP1:                                            -     -                                                                                   -                     
    SP2:              -     -     -                 -     -     -                                                                             -                     
    SP3:              -     -     -     -     -     -     -                                                                                   -                     
    SP4:                                                                                                                                                            
    SP5:                                -     -     -     -                                                                                                         

    ExUns: 21b · 21c
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for GALNT14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GALNT14 expression in normal human tissues (normalized intensities)      GALNT14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTCAAGGC
    GALNT14 Expression
    About this image


    GALNT14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             brain/midbrain   
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose/nasal cavity   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Human Renal Epithelial Cells (HREpiC)   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             Human Renal Epithelial Cells (HREpiC)   

    See GALNT14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GALNT14

    SOURCE GeneReport for Unigene cluster: Hs.468058

    UniProtKB/Swiss-Prot: GLT14_HUMAN, Q96FL9
    Tissue specificity: Highly expressed in fetal and adult kidney. Widely expressed at low level. Weakly expressed in
    whole brain, cerebellum, thymus, lung, mammary gland, liver, stomach, small intestine, colon, pancreas, spleen,
    bladder, uterus, placenta, testis, ovary, skeletal muscle, leukocyte, B-cell, bone marrow, fetal brain, fetal
    thymus, fetal lung, fetal liver, fetal small intestine, fetal spleen, fetal skeletal and fetus

        SABiosciences Expression via Pathway-Focused PCR Array including GALNT14: 
              Glycosylation in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GALNT14
    OriGene qSTAR qPCR primer pairs in human, mouse for GALNT14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GALNT14
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GALNT14
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GALNT14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALNT14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GALNT14 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Galnt141 , 5 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more1, 5 86.85(n)1
    91.82(a)1
      17 (44.88 cM)5
    716851  NM_027864.21  NP_082140.21 
     734932285 
    chicken
    (Gallus gallus)
    Aves GALNT141 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more 72.89(n)
    72.46(a)
      421305  XM_419370.3  XP_419370.3 
    lizard
    (Anolis carolinensis)
    Reptilia GALNT146
    Uncharacterized protein
    61(a)
    1 ↔ 1
    1(250181031-250468520)
    zebrafish
    (Danio rerio)
    Actinopterygii galnt141 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more 63.75(n)
    62.84(a)
      562739  NM_001044995.2  NP_001038460.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pgant26
    polypeptide GalNAc transferase 2
    39(a)
    1 → many
    2L(3404460-3426642)
    worm
    (Caenorhabditis elegans)
    Secernentea gly-46
    Polypeptide N-acetylgalactosaminyltransferase 4
    36(a)
    1 → many
    V(19881372-19895350)


    ENSEMBL Gene Tree for GALNT14 (if available)
    TreeFam Gene Tree for GALNT14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GALNT14 gene
    GALNT62  POC1B-GALNT42  GALNT122  GALNT52  GALNT72  GALNT12  GALNTL62  GALNTL52  
    GALNT32  GALNT22  GALNT102  GALNT42  GALNT132  GALNT162  GALNT112  
    18/23 SIMAP similar genes for GALNT14 using alignment to 5 protein entries:     GLT14_HUMAN (see all proteins) (see all similar genes):
    GalNAc-T16    GALNT16    GALNT15    GALNT2    GALNT1    GALNT13
    GALNTL5    GALNT11    GALNTL6    GALNT12    GalNAc-T10    GALNT3
    GALNT4    POC1B-GALNT4    GALNT7    GALNT9    GALNT6    WBSCR17

    GALNT14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5274 SNPs in GALNT14 are shown (see all 5274)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs32230431,2
    C--30960926(-) acaca-/CA/   
      CACACA
    gttgg
    7 -- int1 cds10--------
    rs3775889201,2
    C--31091316(+) cgcgc-/ACctgtg 4 -- int1 us2k11Minor allele frequency- AC:0.00NA 2
    rs65436061,2
    C,F,A,H--31092165(+) CACTTC/TAGAAA 1 -- us2k122Minor allele frequency- T:0.44NS EA WA NA CSA 2341
    rs1895213561,2
    --31133011(+) GCATGG/TCACAT 4 -- ds50010--------
    rs134057111,2
    C,F--31133024(+) ATACAT/CATGTA 4 -- ds50015Minor allele frequency- C:0.44NA WA CSA 9
    rs1437993521,2
    --31133060(+) ACCCTA/GAAACT 4 -- ds50010--------
    rs2018120271,2
    C--31133078(+) TAATA-/TAAAAA 4 -- ds50010--------
    rs1828320631,2
    --31133337(+) GTCCAA/GAGACA 4 -- nc-transcript-variantut310--------
    rs1164783571,2
    C,F--31133392(+) TTCATC/TTCTCA 4 -- nc-transcript-variantut311Minor allele frequency- T:0.02NA 120
    rs1468773891,2
    --31133398(+) TCTCAA/GTGTAG 4 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for GALNT14 (31133333 - 31378068 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for GALNT14:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2719870CNV Deletion23290073
    esv2719869CNV Deletion23290073
    esv2674441CNV Deletion23128226
    esv2719868CNV Deletion23290073
    dgv690e199CNV Deletion23128226
    esv1683223CNV Deletion17803354
    esv2719871CNV Deletion23290073
    esv3567CNV Deletion18987735
    esv22531CNV Loss19812545
    nsv833659CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GALNT14
    DNA2.0 Custom Variant and Variant Library Synthesis for GALNT14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608225    OMIM disorders: --

    2 diseases for GALNT14:    About MalaCards
    breast cancer    


    GALNT14 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GALNT14
    Human Genome Epidemiology (HuGE) Navigator: GALNT14 (2 documents)

    Export disorders for GALNT14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GALNT14 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with GALNT14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel UDP-GalNAc:polypeptide N- acetylgalactosaminyltransferase, pp-GalNAc-T14. (PubMed id 12507512)1, 2, 3 Wang H.... Narimatsu H. (2003)
    2. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)1, 4 Lingappa J.R....Goldstein D. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. N-Acetylgalactosaminyltransferase 14, a novel insulin-like growth factor binding protein-3 binding partner. (PubMed id 17434446)1, 9 Wu C....Xu D. (2007)
    9. N-Acetylgalactosaminyltransferase-14 as a potential b iomarker for breast cancer by immunohistochemistry. (PubMed id 20356418)1, 9 Wu C....Zhu M. (2010)
    10. GalNAc-T14 may be involved in regulating the apoptoti c action of IGFBP-3. (PubMed id 19805900)1, 9 Wu C....Xu D. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79623 HGNC: 22946 AceView: GALNT14 Ensembl:ENSG00000158089 euGenes: HUgn79623
    ECgene: GALNT14 Kegg: 79623 H-InvDB: GALNT14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GALNT14 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_497

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GALNT14 gene:
    Search GeneIP for patents involving GALNT14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GALNT14  
     OriGene qPCR primer pairs and template standards for GALNT14   OriGene Protein Over-expression Lysate for GALNT14  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GALNT14  
     OriGene qSTAR qPCR primer pairs in human, mouse for GALNT14   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GALNT14   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GALNT14   OriGene Custom Protein Services for GALNT14  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GALNT14
     QIAGEN SeqTarget long-range PCR primers for resequencing GALNT14
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GALNT14
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GALNT14
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GALNT14
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GALNT14
     GenScript Custom Purified and Recombinant Proteins Services for GALNT14 GenScript cDNA clones with any tag delivered in your preferred vector for GALNT14
     GenScript Custom Assay Services for GALNT14 GenScript Custom Superior Antibodies Services for GALNT14
     GenScript Custom overexpressing Cell Line Services for GALNT14 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GALNT14 promoter
     Search Chromatin IP Primers for GALNT14
     RT2 qPCR Primer Assay in human, mouse, rat GALNT14
     GNC Network for GALNT14
     SABiosciences PCR Arrays including human, mouse, rat GALNT14
     Search Tocris compounds for GALNT14 (GLT14)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for GALNT14
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GALNT14 antibodies
     GALNT14 proteins
     GALNT14 lysates
     Antibodies for GALNT14
     See all of Abcam's Antibodies, Kits and Proteins for GALNT14
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for GALNT14
     Antibodies for GALNT14
     ELISAs for GALNT14
     CLIAs for GALNT14
     Cell Line associated with GALNT14: PureStem ES-209, Meso-prx/latp Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALNT14
     SwitchGear 3'UTR luciferase reporter plasmids for GALNT14
     SwitchGear Promoter luciferase reporter plasmids for GALNT14
     ThermoFisher Antibodies for GALNT14
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GALNT14
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GALNT14
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GALNT14
    Customized:
     lentivirus for stable overexpression of GALNT14
     lentivirus expression plasmids for stable overexpression of GALNT14
     adenovirus for overexpression of GALNT14
     LSBio Antibodies in human, mouse, rat for GALNT14
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GALNT14 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4