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Aliases for GALNT14 Gene

Aliases for GALNT14 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 14 2 3
  • Polypeptide GalNAc Transferase 14 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 14 (GalNAc-T14) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 14 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 14 3 4
  • Pp-GaNTase 14 3 4
  • EC 2.4.1.41 4 63
  • GalNac-T14 3 4
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase T10 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase T14 3
  • Polypeptide N-Acetylgalactosaminyltransferase 15 3
  • GalNAc-T10 3
  • GALNT15 3

External Ids for GALNT14 Gene

Previous GeneCards Identifiers for GALNT14 Gene

  • GC02M031107
  • GC02M031044

Summaries for GALNT14 Gene

Entrez Gene Summary for GALNT14 Gene

  • This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for GALNT14 Gene

GALNT14 (Polypeptide N-Acetylgalactosaminyltransferase 14) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT4.

UniProtKB/Swiss-Prot for GALNT14 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney

Gene Wiki entry for GALNT14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT14 Gene

Genomics for GALNT14 Gene

Regulatory Elements for GALNT14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GALNT14 Gene

Start:
30,910,465 bp from pter
End:
31,155,202 bp from pter
Size:
244,738 bases
Orientation:
Minus strand

Genomic View for GALNT14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GALNT14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT14 Gene

Proteins for GALNT14 Gene

  • Protein details for GALNT14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FL9-GLT14_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 14
    Protein Accession:
    Q96FL9
    Secondary Accessions:
    • B3KV89
    • Q4ZG75
    • Q53SU1
    • Q53TJ0
    • Q8IVI4
    • Q9BRH1
    • Q9H827
    • Q9H9J8

    Protein attributes for GALNT14 Gene

    Size:
    552 amino acids
    Molecular mass:
    64321 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14795.1; Type=Miscellaneous discrepancy; Note=Chimeric at the C-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for GALNT14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALNT14 Gene

Proteomics data for GALNT14 Gene at MOPED

Selected DME Specific Peptides for GALNT14 Gene

Post-translational modifications for GALNT14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GALNT14 Gene

Antibody Products

Domains for GALNT14 Gene

Gene Families for GALNT14 Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

Graphical View of Domain Structure for InterPro Entry

Q96FL9

UniProtKB/Swiss-Prot:

GLT14_HUMAN :
  • Q96FL9
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
  • Contains 1 ricin B-type lectin domain.
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
genes like me logo Genes that share domains with GALNT14: view

Function for GALNT14 Gene

Molecular function for GALNT14 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
UniProtKB/Swiss-Prot Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney

Enzyme Numbers (IUBMB) for GALNT14 Gene

Gene Ontology (GO) - Molecular Function for GALNT14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNT14: view

Phenotypes for GALNT14 Gene

GenomeRNAi human phenotypes for GALNT14:
genes like me logo Genes that share phenotypes with GALNT14: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GALNT14

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GALNT14 Gene

Localization for GALNT14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT14 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GALNT14 Gene COMPARTMENTS Subcellular localization image for GALNT14 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for GALNT14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GALNT14: view

Pathways for GALNT14 Gene

genes like me logo Genes that share pathways with GALNT14: view

Pathways by source for GALNT14 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q96FL9-GLT14_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for GALNT14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0008152 metabolic process --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with GALNT14: view

Compounds for GALNT14 Gene

(5) HMDB Compounds for GALNT14 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Lactosamine
  • beta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
13000-25-4
Manganese
  • manganese
7439-96-5
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-acetyl-D-galactosamine
7277-98-7

(3) PharmGKB related drug/compound annotations for GALNT14 Gene

Drug/compound Annotation
cisplatin CA
fluorouracil CA
mitoxantrone CA
genes like me logo Genes that share compounds with GALNT14: view

Transcripts for GALNT14 Gene

Unigene Clusters for GALNT14 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GALNT14

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT14 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a ·
SP1: - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4:
SP5: - - - -
SP6: -
SP7: - - - - - - - -
SP8:

ExUns: 21b · 21c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for GALNT14 Gene

GeneLoc Exon Structure for
GALNT14
ECgene alternative splicing isoforms for
GALNT14

Expression for GALNT14 Gene

mRNA expression in normal human tissues for GALNT14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNT14 Gene

This gene is overexpressed in Whole Blood (10.2), Kidney - Cortex (9.6), and Esophagus - Mucosa (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GALNT14 Gene

SOURCE GeneReport for Unigene cluster for GALNT14 Gene Hs.468058

mRNA Expression by UniProt/SwissProt for GALNT14 Gene

Q96FL9-GLT14_HUMAN
Tissue specificity: Detected in renal tubules (at protein level). Highly expressed in fetal and adult kidney. Widely expressed at low level. Weakly expressed in whole brain, cerebellum, thymus, lung, mammary gland, liver, stomach, small intestine, colon, pancreas, spleen, bladder, uterus, placenta, testis, ovary, skeletal muscle, leukocyte, B-cell, bone marrow, fetal brain, fetal thymus, fetal lung, fetal liver, fetal small intestine, fetal spleen, fetal skeletal and fetus. Detected in renal tubules (at protein level).
genes like me logo Genes that share expressions with GALNT14: view

In Situ Assay Products

Orthologs for GALNT14 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNT14 35
  • 99.19 (n)
  • 99.39 (a)
cow
(Bos Taurus)
Mammalia GALNT14 35
  • 89.01 (n)
  • 90.22 (a)
GALNT14 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GALNT14 35
  • 89.73 (n)
  • 90.04 (a)
GALNT14 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Galnt14 35
  • 86.85 (n)
  • 91.82 (a)
Galnt14 16
Galnt14 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GALNT14 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GALNT14 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Galnt14 35
  • 87.86 (n)
  • 92.21 (a)
chicken
(Gallus gallus)
Aves GALNT14 35
  • 72.89 (n)
  • 72.46 (a)
GALNT14 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GALNT14 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt14 35
  • 69.59 (n)
  • 70.8 (a)
zebrafish
(Danio rerio)
Actinopterygii galnt14 35
  • 63.75 (n)
  • 62.84 (a)
galnt14 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pgant2 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gly-4 36
  • 38 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10774 36
  • 45 (a)
OneToMany
Species with no ortholog for GALNT14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNT14 Gene

ENSEMBL:
Gene Tree for GALNT14 (if available)
TreeFam:
Gene Tree for GALNT14 (if available)

Paralogs for GALNT14 Gene

genes like me logo Genes that share paralogs with GALNT14: view

Variants for GALNT14 Gene

Sequence variations from dbSNP and Humsavar for GALNT14 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs719979 -- 30,994,727(+) CCATA(A/G)AACTG intron-variant
rs731325 -- 30,925,159(+) CGCTG(C/G)GGCTC intron-variant
rs744638 -- 31,013,541(+) tccaa(A/G)tgtga intron-variant
rs749708 -- 31,084,474(-) CACAT(C/T)AACTG intron-variant
rs749709 -- 31,084,356(-) CAGTA(C/T)CTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GALNT14 Gene

Variant ID Type Subtype PubMed ID
nsv833659 CNV Gain 17160897
esv2719868 CNV Deletion 23290073
esv2674441 CNV Deletion 23128226
esv22531 CNV Loss 19812545
esv2719869 CNV Deletion 23290073
esv2719870 CNV Deletion 23290073
esv3567 CNV Deletion 18987735
dgv690e199 CNV Deletion 23128226
esv2719871 CNV Deletion 23290073
esv1683223 CNV Deletion 17803354

Relevant External Links for GALNT14 Gene

HapMap Linkage Disequilibrium report
GALNT14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALNT14 Gene

Disorders for GALNT14 Gene

Relevant External Links for GALNT14

Genetic Association Database (GAD)
GALNT14
Human Genome Epidemiology (HuGE) Navigator
GALNT14
genes like me logo Genes that share disorders with GALNT14: view

No data available for UniProtKB/Swiss-Prot for GALNT14 Gene

Publications for GALNT14 Gene

  1. Cloning and characterization of a novel UDP-GalNAc:polypeptide N- acetylgalactosaminyltransferase, pp-GalNAc-T14. (PMID: 12507512) Wang H. … Narimatsu H. (Biochem. Biophys. Res. Commun. 2003) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. GalNAc-T14 may be involved in regulating the apoptotic action of IGFBP-3. (PMID: 19805900) Wu C. … Xu D. (J. Biosci. 2009) 3 23

Products for GALNT14 Gene

Sources for GALNT14 Gene

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