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Aliases for GALNT13 Gene

Aliases for GALNT13 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 13 2 3
  • Polypeptide GalNAc Transferase 13 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 13 (GalNAc-T13) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 13 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 13 3 4
  • Pp-GaNTase 13 3 4
  • EC 2.4.1.41 4 64
  • GalNAc-T13 3 4
  • KIAA1918 4 6
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 13 2
  • GalNAc Transferase 13 3

External Ids for GALNT13 Gene

Summaries for GALNT13 Gene

Entrez Gene Summary for GALNT13 Gene

  • The GALNT13 protein is a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAcT; EC 2.4.1.41) family, which initiate O-linked glycosylation of mucins (see MUC3A, MIM 158371) by the initial transfer of N-acetylgalactosamine (GalNAc) with an alpha-linkage to a serine or threonine residue.[supplied by OMIM, Apr 2004]

GeneCards Summary for GALNT13 Gene

GALNT13 (Polypeptide N-Acetylgalactosaminyltransferase 13) is a Protein Coding gene. Diseases associated with GALNT13 include tricuspid valve insufficiency and osteochondrosis. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT4.

UniProtKB/Swiss-Prot for GALNT13 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a much stronger activity than GALNT1 to transfer GalNAc to mucin peptides, such as Muc5Ac and Muc7. Able to glycosylate SDC3. May be responsible for the synthesis of Tn antigen in neuronal cells

Gene Wiki entry for GALNT13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT13 Gene

Genomics for GALNT13 Gene

Genomic Location for GALNT13 Gene

Start:
153,732,809 bp from pter
End:
154,453,977 bp from pter
Size:
721,169 bases
Orientation:
Plus strand

Genomic View for GALNT13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GALNT13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT13 Gene

Regulatory Elements for GALNT13 Gene

Proteins for GALNT13 Gene

  • Protein details for GALNT13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUC8-GLT13_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 13
    Protein Accession:
    Q8IUC8
    Secondary Accessions:
    • Q08ER7
    • Q68VI8
    • Q6ZWG1
    • Q96PX0
    • Q9UIE5

    Protein attributes for GALNT13 Gene

    Size:
    556 amino acids
    Molecular mass:
    64051 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF19246.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC85542.1; Type=Miscellaneous discrepancy; Note=Chimera. Chimeric at the N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for GALNT13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALNT13 Gene

Proteomics data for GALNT13 Gene at MOPED

Post-translational modifications for GALNT13 Gene

  • Glycosylation at Asn94, Asn116, and Asn551

Other Protein References for GALNT13 Gene

Domains for GALNT13 Gene

Gene Families for GALNT13 Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

UniProtKB/Swiss-Prot:

GLT13_HUMAN
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.:
    • Q8IUC8
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.:
    • Q8IUC8
  • Contains 1 ricin B-type lectin domain.:
    • Q8IUC8
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.:
    • Q8IUC8
genes like me logo Genes that share domains with GALNT13: view

Function for GALNT13 Gene

Molecular function for GALNT13 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
UniProtKB/Swiss-Prot Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a much stronger activity than GALNT1 to transfer GalNAc to mucin peptides, such as Muc5Ac and Muc7. Able to glycosylate SDC3. May be responsible for the synthesis of Tn antigen in neuronal cells

Enzyme Numbers (IUBMB) for GALNT13 Gene

Gene Ontology (GO) - Molecular Function for GALNT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IEA --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNT13: view

Phenotypes for GALNT13 Gene

MGI mutant phenotypes for GALNT13:
inferred from 1 alleles
GenomeRNAi human phenotypes for GALNT13:
genes like me logo Genes that share phenotypes with GALNT13: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GALNT13 Gene

Localization for GALNT13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT13 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GALNT13 Gene COMPARTMENTS Subcellular localization image for GALNT13 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 1
extracellular 1
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GALNT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GALNT13: view

Pathways for GALNT13 Gene

genes like me logo Genes that share pathways with GALNT13: view

Pathways by source for GALNT13 Gene

UniProtKB/Swiss-Prot Q8IUC8-GLT13_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for GALNT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with GALNT13: view

Compounds for GALNT13 Gene

(5) HMDB Compounds for GALNT13 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Lactosamine
  • beta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
13000-25-4
Manganese
  • manganese
7439-96-5
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT13: view

Transcripts for GALNT13 Gene

Unigene Clusters for GALNT13 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT13 Gene

No ASD Table

Relevant External Links for GALNT13 Gene

GeneLoc Exon Structure for
GALNT13
ECgene alternative splicing isoforms for
GALNT13

Expression for GALNT13 Gene

mRNA expression in normal human tissues for GALNT13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GALNT13 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (7.7), Brain - Cerebellum (6.4), and Brain - Spinal cord (cervical c-1) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GALNT13 Gene

SOURCE GeneReport for Unigene cluster for GALNT13 Gene Hs.470277

mRNA Expression by UniProt/SwissProt for GALNT13 Gene

Q8IUC8-GLT13_HUMAN
Tissue specificity: Specifically expressed in neuronal cells. Expressed in fetal brain, whole adult brain, cerebral cortex and cerebellum. Not expressed in other tissues tested.
genes like me logo Genes that share expressions with GALNT13: view

Orthologs for GALNT13 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNT13 36
  • 99.88 (n)
  • 100 (a)
GALNT13 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GALNT13 36
  • 94.96 (n)
  • 99.46 (a)
GALNT13 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GALNT13 36
  • 95.2 (n)
  • 99.28 (a)
GALNT13 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Galnt13 36
  • 92.57 (n)
  • 99.46 (a)
Galnt13 16
Galnt13 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GALNT13 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GALNT13 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Galnt13 36
  • 92.15 (n)
  • 99.28 (a)
chicken
(Gallus gallus)
Aves GALNT13 36
  • 78.78 (n)
  • 90.6 (a)
GALNT13 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GALNT13 37
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt13 36
  • 76.11 (n)
  • 88.75 (a)
zebrafish
(Danio rerio)
Actinopterygii galnt13 36
  • 74.62 (n)
  • 84.63 (a)
galnt13 37
  • 88 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pgant5 37
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gly-3 37
  • 46 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3944 36
Species with no ortholog for GALNT13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNT13 Gene

ENSEMBL:
Gene Tree for GALNT13 (if available)
TreeFam:
Gene Tree for GALNT13 (if available)

Paralogs for GALNT13 Gene

genes like me logo Genes that share paralogs with GALNT13: view

Variants for GALNT13 Gene

Sequence variations from dbSNP and Humsavar for GALNT13 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1674 -- 154,259,226(-) CAAAA(A/G)TGATT intron-variant
rs697644 -- 154,423,680(+) AATTG(A/T)TCTCT intron-variant
rs697645 -- 154,423,942(+) ctttg(A/T)ggtct intron-variant
rs697646 -- 154,428,167(+) GTCCA(A/C)AATGA intron-variant
rs707022 -- 154,330,411(+) GAAAC(A/G)AATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GALNT13 Gene

Variant ID Type Subtype PubMed ID
nsv7331 OTHER Inversion 18451855
nsv875303 CNV Loss 21882294
esv2720978 CNV Deletion 23290073
esv2448327 CNV Insertion 19546169
esv269021 CNV Insertion 20981092
esv272792 CNV Insertion 20981092
esv1089043 CNV Insertion 17803354
esv275575 CNV Loss 21479260
esv2678681 CNV Deletion 23128226
esv2660348 CNV Deletion 23128226
nsv511169 CNV Loss 21212237
nsv820193 CNV Gain 19587683
esv1008587 CNV Deletion 20482838
nsv821760 CNV Loss 20364138
nsv820980 CNV Deletion 20802225
esv28933 CNV Gain+Loss 19812545
nsv511818 CNV Loss 21212237
esv2674091 CNV Deletion 23128226
esv2720979 CNV Deletion 23290073
dgv741e199 CNV Deletion 23128226
dgv670n67 CNV Loss 20364138
nsv821762 CNV Gain 20364138
nsv508115 CNV Loss 20534489
esv33780 CNV Loss 17666407
nsv433208 CNV Loss 18776910
nsv2983 CNV Insertion 18451855
esv2350918 CNV Deletion 18987734
nsv834427 CNV Loss 17160897
nsv834428 CNV Gain+Loss 17160897
nsv518339 CNV Loss 19592680
esv1519312 CNV Deletion 17803354
nsv875304 CNV Loss 21882294
nsv459829 CNV Loss 19166990
nsv459851 CNV Loss 19166990
esv269323 CNV Insertion 20981092
esv2658246 CNV Deletion 23128226
esv2720980 CNV Deletion 23290073

Relevant External Links for GALNT13 Gene

HapMap Linkage Disequilibrium report
GALNT13

Disorders for GALNT13 Gene

(2) University of Copenhagen DISEASES for GALNT13 Gene

Relevant External Links for GALNT13

Genetic Association Database (GAD)
GALNT13
Human Genome Epidemiology (HuGE) Navigator
GALNT13
genes like me logo Genes that share disorders with GALNT13: view

No data available for UniProtKB/Swiss-Prot for GALNT13 Gene

Publications for GALNT13 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Cloning and characterization of a new human UDP-N-acetyl-alpha-D- galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen. (PMID: 12407114) Zhang Y. … Narimatsu H. (J. Biol. Chem. 2003) 2 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta K.L. … Murabito J.M. (BMC Med. Genet. 2007) 3 49
  5. Replication of a genome-wide case-control study of esophageal squamous cell carcinoma. (PMID: 18649358) Ng D. … Taylor P.R. (Int. J. Cancer 2008) 3 49

Products for GALNT13 Gene

Sources for GALNT13 Gene

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