Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GALNT12 Gene

protein-coding   GIFtS: 62
GCID: GC09P101569

UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide
N-Acetylgalactosaminyltransferase 12 (GalNAc-T12)1 2
     UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 122 3
Polypeptide GalNAc Transferase 122 3     EC 2.4.1.413 8
Protein-UDP Acetylgalactosaminyltransferase 122 3     CRCS12 5
GalNAc-T122 3     Colorectal Cancer, Susceptibility To 12
Pp-GaNTase 122 3     Polypeptide N-Acetylgalactosaminyltransferase 122

External Ids:    HGNC: 198771   Entrez Gene: 796952   Ensembl: ENSG000001195147   OMIM: 6102905   UniProtKB: Q8IXK23   

Export aliases for GALNT12 gene to outside databases

Previous GC identifers: GC09P092385 GC09P093313 GC09P095027 GC09P096949 GC09P098649 GC09P100609 GC09P071168


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GALNT12 Gene:
This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which
catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a
polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated
with an increased susceptibility to colorectal cancer.(provided by RefSeq, Mar 2011)

GeneCards Summary for GALNT12 Gene: 
GALNT12 (UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)) is a protein-coding gene. Diseases associated with GALNT12 include colorectal cancer, and colon cancer, and among its related super-pathways are Mucin type O-Glycan biosynthesis and Post-translational protein modification. GO annotations related to this gene include polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT6.

UniProtKB/Swiss-Prot: GLT12_HUMAN, Q8IXK2
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an
N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward
non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays
enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated
Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide
biosynthesis in digestive organs




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GALNT12 gene promoter:
         ATF-2   MyoD   Lmo2   AP-2gamma   CRE-BP1   AP-2beta   ZIC2/Zic2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGALNT12 promoter sequence
   Search SABiosciences Chromatin IP Primers for GALNT12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GALNT12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.33   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q22.33

GALNT12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GALNT12 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P101569:  view genomic region     (about GC identifiers)

Start:
101,569,981 bp from pter      End:
101,612,363 bp from pter
Size:
42,383 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GLT12_HUMAN, Q8IXK2 (See protein sequence)
Recommended Name: Polypeptide N-acetylgalactosaminyltransferase 12  
Size: 581 amino acids; 66938 Da
Cofactor: Manganese (By similarity)
Cofactor: Calcium (By similarity)
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Sequence caution: Sequence=BAB15027.1; Type=Erroneous initiation;
Secondary accessions: Q5TCF7 Q8NG54 Q96CT9 Q9H771
Alternative splicing: 2 isoforms:  Q8IXK2-1   Q8IXK2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GALNT12: NX_Q8IXK2

Explore proteomics data for GALNT12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IXK2

  • 4/8 DME Specific Peptides for GALNT12 (Q8IXK2) (see all 8)
     VVCPVID  MAGGLFA  PTMAGGL  WGGENLE 

    GALNT12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GALNT12 Protein Expression
    REFSEQ proteins: NP_078918.3  
    ENSEMBL proteins: 
     ENSP00000364150  
    Reactome Protein details: Q8IXK2
    Human Recombinant Protein Products for GALNT12: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GALNT12
    GenScript Custom Purified and Recombinant Proteins Services for GALNT12
    Novus Biologicals GALNT12 Protein
    Novus Biologicals GALNT12 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GALNT12 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral to membrane IEA--

    GALNT12 for ontologies           About GeneDecksing



    GALNT12 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GALNT12
    GenScript Custom Superior Antibodies Services for GALNT12
    Novus Biologicals GALNT12 Antibodies
    Abcam antibodies for GALNT12
    Cloud-Clone Corp. Antibodies for GALNT12 
    ThermoFisher Antibodies for GALNT12
    Search LSBio for Antibodies for GALNT12 

    Assay Products for GALNT12: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GALNT12
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GALNT12
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GALNT12 
    Cloud-Clone Corp. CLIAs for GALNT12


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GLT2: Glycosyltransferase family 2 domain containing

    2 InterPro protein domains:
     IPR000772 Ricin_B_lectin
     IPR001173 Glyco_trans_2

    Graphical View of Domain Structure for InterPro Entry Q8IXK2

    ProtoNet protein and cluster: Q8IXK2

    2 Blocks protein domains:
    IPB000772 Ricin B lectin domain
    IPB001173 Glycosyl transferase


    UniProtKB/Swiss-Prot: GLT12_HUMAN, Q8IXK2
    Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also
    called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal
    domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal
    binding (By similarity)
    Domain: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By
    similarity)
    Similarity: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily
    Similarity: Contains 1 ricin B-type lectin domain


    GALNT12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLT12_HUMAN, Q8IXK2
    Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an
    N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward
    non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays
    enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated
    Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide
    biosynthesis in digestive organs
    Catalytic activity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP +
    N-acetyl-alpha-D-galactosaminyl-polypeptide

         Enzyme Number (IUBMB): EC 2.4.1.411 2

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004653polypeptide N-acetylgalactosaminyltransferase activity IEA--
         
    GALNT12 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GALNT12:
     Increased 8N DNA content 

         1 MGI phenotypic allele for Galnt12 (no phenotypes)

    GALNT12 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GALNT12 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GALNT12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GALNT12 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GALNT12 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GALNT12
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate GALNT12 (see all 9):
    hsa-miR-130a* hsa-miR-202 hsa-miR-23c hsa-miR-124 hsa-miR-629* hsa-miR-23b hsa-miR-129-5p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidGALNT12 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GALNT12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GALNT12

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GALNT12
    Sirion Biotech Customized adenovirus for overexpression of GALNT12

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GALNT12 (see all 8)
    OriGene ORF clones in mouse, rat for GALNT12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GALNT12 (NM_024642)
    Sino Biological Human cDNA Clone for GALNT12
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GALNT12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GALNT12
    Sirion Biotech Customized lentivirus for stable overexpression of GALNT12 
                         Customized lentivirus expression plasmids for stable overexpression of GALNT12 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GALNT12
    Search LifeMap BioReagents cell lines for GALNT12
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALNT12


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GALNT12 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.44
    Mucin type O-Glycan biosynthesis0.44
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35
    3Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3        Reactome Pathways for GALNT12
        O-linked glycosylation of mucins
    Metabolism of proteins
    Post-translational protein modification


    2         Kegg Pathways  (Kegg details for GALNT12):
        Mucin type O-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: GLT12_HUMAN, Q8IXK2
    Pathway: Protein modification; protein glycosylation


    GALNT12 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GALNT12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for GALNT12 (Q8IXK23 ENSP000003641504) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MUC7Q8TAX73, ENSP000003020214I2D: score=1 STRING: ENSP00000302021
    MUC1P159413, ENSP000003389834I2D: score=1 STRING: ENSP00000338983
    MUC2Q028173, ENSP000004151834I2D: score=1 STRING: ENSP00000415183
    C1GALT1C1ENSP000003043644STRING: ENSP00000304364
    GALNT1ENSP000002691954STRING: ENSP00000269195
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    GALNT12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GALNT12 (GLT12)

    5 HMDB Compounds for GALNT12    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Lactosaminebeta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose (see all 8)13000-25-4--
    Manganesemanganese 7439-96-5--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate-N-acetylgalactosamineUDP-N-acetyl-D-galactosamine (see all 17)7277-98-7--

    Search CenterWatch for drugs/clinical trials and news about GALNT12 / GLT12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GALNT12 gene: 
    NM_024642.4  

    Unigene Cluster for GALNT12:

    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)
    Hs.47099  [show with all ESTs]
    Unigene Representative Sequence: NM_024642
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375011(uc004ayz.3) ENST00000470473
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GALNT12
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate GALNT12 (see all 9):
    hsa-miR-130a* hsa-miR-202 hsa-miR-23c hsa-miR-124 hsa-miR-629* hsa-miR-23b hsa-miR-129-5p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidGALNT12 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GALNT12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GALNT12
    Clone
    Products:
         
    OriGene clones in human, mouse for GALNT12 (see all 8)
    OriGene ORF clones in mouse, rat for GALNT12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GALNT12 (NM_024642)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GALNT12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GALNT12
    Sirion Biotech Customized lentivirus for stable overexpression of GALNT12 
                         Customized lentivirus expression plasmids for stable overexpression of GALNT12 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GALNT12
    OriGene qSTAR qPCR primer pairs in human, mouse for GALNT12
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GALNT12
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GALNT12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GALNT12

    Additional mRNA sequence: 

    AB040673.1 AB078146.1 AJ132365.2 AJ505963.1 AK024865.1 BC013945.1 

    5 DOTS entries:

    DT.410726  DT.92017813  DT.121202140  DT.91683492  DT.95361670 

    24/90 AceView cDNA sequences (see all 90):

    AJ132365 CB242748 AI633475 AI636959 AA983811 BE218607 N50776 AA554045 
    AI357770 BU680603 NM_024642 AK024865 BP342287 AA830866 BM672583 BM978800 
    BF222363 BM970195 AI252790 AB078146 AI268570 AI222410 CB243715 AI690020 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GALNT12 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
    SP1:                    -                             -                                         -                     
    SP2:                                                                                            -                     
    SP3:                    -                       -     -                                                               
    SP4:                    -     -                       -                                                               
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for GALNT12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GALNT12 expression in normal human tissues (normalized intensities)      GALNT12 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATATCAT
    GALNT12 Expression
    About this image


    GALNT12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Diencephalic Roof Plate
     
     Brain (Nervous System)
             brain/midbrain   
     
     Colon (Gastrointestinal Tract)

     -- (Nervous System)
             mouse/organ system/nervous system/central nervous system   

    See GALNT12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GALNT12

    SOURCE GeneReport for Unigene cluster: Hs.47099

    UniProtKB/Swiss-Prot: GLT12_HUMAN, Q8IXK2
    Tissue specificity: Widely expressed at different levels of expression. Highly expressed in digestive organs such
    as small intestine, stomach, pancreas and colon. Expressed at intermediate level in testis, thyroid gland and
    spleen. Weakly expressed in whole brain, cerebral cortex, cerebellum, fetal brain, bone marrow, thymus,
    leukocytes, heart, skeletal muscle, liver, lung, esophagus, kidney, adrenal gland, mammary gland, uterus,
    placenta, ovary and prostate

        SABiosciences Expression via Pathway-Focused PCR Array including GALNT12: 
              Glycosylation in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GALNT12
    OriGene qSTAR qPCR primer pairs in human, mouse for GALNT12
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GALNT12
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GALNT12
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GALNT12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALNT12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GALNT12 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Galnt121 , 5 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more1, 5 83.88(n)1
    85.91(a)1
      4 (25.96 cM)5
    2301451  NM_172693.31  NP_766281.11 
     470919095 
    chicken
    (Gallus gallus)
    Aves GALNT121 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more 75.11(n)
    79.4(a)
      420978  XM_419065.3  XP_419065.3 
    lizard
    (Anolis carolinensis)
    Reptilia GALNT126
    Uncharacterized protein
    68(a)
    1 ↔ 1
    4(66887570-66934586)
    zebrafish
    (Danio rerio)
    Actinopterygii galnt121 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more 68.27(n)
    73.03(a)
      559736  XM_683102.1  XP_688194.1 


    ENSEMBL Gene Tree for GALNT12 (if available)
    TreeFam Gene Tree for GALNT12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GALNT12 gene
    GALNT62  POC1B-GALNT42  GALNT52  GALNT72  GALNT12  GALNTL62  GALNT142  GALNTL52  
    GALNT32  GALNT22  GALNT102  GALNT42  GALNT132  GALNT162  GALNT112  
    18/24 SIMAP similar genes for GALNT12 using alignment to 3 protein entries:     GLT12_HUMAN (see all proteins) (see all similar genes):
    GalNAc-T10    GALNT4    POC1B-GALNT4    GALNTL5    GALNT14    GALNT6
    GALNT10    GALNT3    GALNT15    GALNT1    GALNT16    GalNAc-T16
    GALNT13    GALNT19    GALNTL2    GALNTL6    WBSCR17    GALNT11

    GALNT12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/960 SNPs in GALNT12 are shown (see all 960)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0643574
    Colorectal cancer 1 (CRCS1)4--see VAR_0643572 R W mis40--------
    VAR_0643614
    Colorectal cancer 1 (CRCS1)4--see VAR_0643612 R H mis40--------
    VAR_0643624
    Colorectal cancer 1 (CRCS1)4--see VAR_0643622 C F mis40--------
    VAR_0643594
    Colorectal cancer 1 (CRCS1)4--see VAR_0643592 E D mis40--------
    VAR_0643634
    Colorectal cancer 1 (CRCS1)4--see VAR_0643632 T M mis40--------
    VAR_0643604
    Colorectal cancer 1 (CRCS1)4--see VAR_0643602 R H mis40--------
    VAR_0685094
    Colorectal cancer 1 (CRCS1)4--see VAR_0685092 Y C mis40--------
    rs1452369231,2,4
    C,FColorectal cancer 1 (CRCS1)4 --101608250(+) CCGTCG/AATGTC 2 /N /D mis12Minor allele frequency- A:0.00NA EU 5825
    VAR_0643524
    ----see VAR_0643522 G E mis40--------
    VAR_0643644
    ----see VAR_0643642 R K mis40--------

    HapMap Linkage Disequilibrium report for GALNT12 (101569981 - 101612363 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GALNT12:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv825009CNV Loss20364138
    nsv825010CNV Gain20364138
    dgv8264n71CNV Gain21882294
    nsv893617CNV Gain21882294


    Human Gene Mutation Database (HGMD): GALNT12

    Locus Specific Mutation Databases (LSDB): GALNT12
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GALNT12
    DNA2.0 Custom Variant and Variant Library Synthesis for GALNT12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610290   
    OMIM disorders: 608812  
    UniProtKB/Swiss-Prot: GLT12_HUMAN, Q8IXK2
  • Colorectal cancer 1 (CRCS1) [MIM:608812]: A complex disease characterized by malignant lesions arising
    from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated
    with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the
    colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry

  • 5 diseases for GALNT12:    About MalaCards
    colorectal cancer    colon cancer    cerebritis    thyroiditis
    prostatitis


    GALNT12 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GALNT12
    Human Genome Epidemiology (HuGE) Navigator: GALNT12 (2 documents)

    Export disorders for GALNT12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GALNT12 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with GALNT12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inactivating germ-line and somatic mutations in polyp eptide N-acetylgalactosaminyltransferase 12 in human colon cancers. (PubMed id 19617566)1, 2, 4, 9 Guda K....Markowitz S.D. (2009)
    2. Molecular cloning and characterization of a novel member of the UDP- GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp- GalNAc-T12(1). (PubMed id 12135769)1, 2, 3 Guo J.-M.... Narimatsu H. (2002)
    3. Inherited deleterious variants in GALNT12 are associated with CRC susceptibility. (PubMed id 22461326)1, 2 Clarke E.... Woods M.O. (2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    7. Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-12 in gastric and colonic cancer cell lines and in human colorectal cancer. (PubMed id 15557789)1, 9 Guo J.M....Narimatsu H. (2004)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79695 HGNC: 19877 AceView: GALNT12 Ensembl:ENSG00000119514 euGenes: HUgn79695
    ECgene: GALNT12 Kegg: 79695 H-InvDB: GALNT12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GALNT12 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_495

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GALNT12 gene:
    Search GeneIP for patents involving GALNT12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GALNT12  
     OriGene qPCR primer pairs and template standards for GALNT12   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GALNT12  
     OriGene qSTAR qPCR primer pairs in human, mouse for GALNT12   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GALNT12   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GALNT12   OriGene Custom Protein Services for GALNT12  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GALNT12
     QIAGEN SeqTarget long-range PCR primers for resequencing GALNT12
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GALNT12
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GALNT12
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GALNT12
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GALNT12
     GenScript Custom Purified and Recombinant Proteins Services for GALNT12 GenScript cDNA clones with any tag delivered in your preferred vector for GALNT12
     GenScript Custom Assay Services for GALNT12 GenScript Custom Superior Antibodies Services for GALNT12
     GenScript Custom overexpressing Cell Line Services for GALNT12 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GALNT12 promoter
     Search Chromatin IP Primers for GALNT12
     RT2 qPCR Primer Assay in human, mouse, rat GALNT12
     Search GNC Networks for GALNT12
     SABiosciences PCR Arrays including human, mouse, rat GALNT12
     Search Tocris compounds for GALNT12 (GLT12)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for GALNT12
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GALNT12 antibodies
     GALNT12 proteins
     GALNT12 lysates
     Antibodies for GALNT12
     See all of Abcam's Antibodies, Kits and Proteins for GALNT12
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for GALNT12
     Antibodies for GALNT12
     ELISAs for GALNT12
     CLIAs for GALNT12
     Search LifeMap BioReagents cell lines for GALNT12
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALNT12
     SwitchGear 3'UTR luciferase reporter plasmids for GALNT12
     SwitchGear Promoter luciferase reporter plasmids for GALNT12
     ThermoFisher Antibodies for GALNT12
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GALNT12
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GALNT12
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GALNT12
    Customized:
     lentivirus for stable overexpression of GALNT12
     lentivirus expression plasmids for stable overexpression of GALNT12
     adenovirus for overexpression of GALNT12
     Search LSBio for Antibodies for GALNT12
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GALNT12 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4