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Aliases for GALNT11 Gene

Aliases for GALNT11 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 11 2 3
  • Polypeptide GalNAc Transferase 11 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 11 (GalNAc-T11) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 11 3 4
  • Protein-UDP Acetylgalactosaminyltransferase 11 3 4
  • Pp-GaNTase 11 3 4
  • EC 2.4.1.41 4 64
  • GALNAC-T11 3 4
  • GALNACT11 3 6

External Ids for GALNT11 Gene

Summaries for GALNT11 Gene

GeneCards Summary for GALNT11 Gene

GALNT11 (Polypeptide N-Acetylgalactosaminyltransferase 11) is a Protein Coding gene. Diseases associated with GALNT11 include heterotaxy. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT4.

UniProtKB/Swiss-Prot for GALNT11 Gene

  • Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO).

Gene Wiki entry for GALNT11 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT11 Gene

Genomics for GALNT11 Gene

Genomic Location for GALNT11 Gene

Start:
152,025,674 bp from pter
End:
152,122,347 bp from pter
Size:
96,674 bases
Orientation:
Plus strand

Genomic View for GALNT11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GALNT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT11 Gene

Regulatory Elements for GALNT11 Gene

Proteins for GALNT11 Gene

  • Protein details for GALNT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCW6-GLT11_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 11
    Protein Accession:
    Q8NCW6
    Secondary Accessions:
    • B3KWF4
    • Q6PCD1
    • Q9H6C2
    • Q9H6Z5
    • Q9UDR8

    Protein attributes for GALNT11 Gene

    Size:
    608 amino acids
    Molecular mass:
    68919 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with NOTCH1.
    SequenceCaution:
    • Sequence=BAB15338.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for GALNT11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALNT11 Gene

Proteomics data for GALNT11 Gene at MOPED

Post-translational modifications for GALNT11 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn428

Domains for GALNT11 Gene

Gene Families for GALNT11 Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

UniProtKB/Swiss-Prot:

GLT11_HUMAN
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.:
    • Q8NCW6
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.:
    • Q8NCW6
  • Contains 1 ricin B-type lectin domain.:
    • Q8NCW6
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.:
    • Q8NCW6
genes like me logo Genes that share domains with GALNT11: view

Function for GALNT11 Gene

Molecular function for GALNT11 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
UniProtKB/Swiss-Prot Function: Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO).

Enzyme Numbers (IUBMB) for GALNT11 Gene

Gene Ontology (GO) - Molecular Function for GALNT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IDA 24226769
GO:0005112 Notch binding IDA 24226769
GO:0016740 transferase activity --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNT11: view

miRNA for GALNT11 Gene

miRTarBase miRNAs that target GALNT11

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GALNT11 Gene

Localization for GALNT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT11 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GALNT11 Gene COMPARTMENTS Subcellular localization image for GALNT11 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GALNT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GALNT11: view

Pathways for GALNT11 Gene

genes like me logo Genes that share pathways with GALNT11: view

Pathways by source for GALNT11 Gene

UniProtKB/Swiss-Prot Q8NCW6-GLT11_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for GALNT11 Gene

Selected Interacting proteins: Q8NCW6-GLT11_HUMAN for GALNT11 Gene via I2D

Symbol External ID(s) Details
MUC4

Gene Ontology (GO) - Biological Process for GALNT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0007220 Notch receptor processing ISS --
GO:0007368 determination of left/right symmetry ISS --
GO:0008152 metabolic process --
GO:0008593 regulation of Notch signaling pathway ISS --
genes like me logo Genes that share ontologies with GALNT11: view

Compounds for GALNT11 Gene

(3) HMDB Compounds for GALNT11 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Manganese
  • manganese
7439-96-5
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT11: view

Transcripts for GALNT11 Gene

Unigene Clusters for GALNT11 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - - - - -
SP2: -
SP3:
SP4: - - - - -
SP5: - - -
SP6: - - -
SP7:

Relevant External Links for GALNT11 Gene

GeneLoc Exon Structure for
GALNT11
ECgene alternative splicing isoforms for
GALNT11

Expression for GALNT11 Gene

mRNA expression in normal human tissues for GALNT11 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for GALNT11 Gene

SOURCE GeneReport for Unigene cluster for GALNT11 Gene Hs.647109

mRNA Expression by UniProt/SwissProt for GALNT11 Gene

Q8NCW6-GLT11_HUMAN
Tissue specificity: Highly expressed in kidney. Expressed at intermediate level in brain, heart and skeletal muscle. Weakly expressed other tissues. In kidney, it is strongly expressed in tubules but not expressed in glomeruli.
genes like me logo Genes that share expressions with GALNT11: view

Orthologs for GALNT11 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNT11 36
  • 99.45 (n)
  • 99.34 (a)
GALNT11 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GALNT11 36
  • 88.93 (n)
  • 92.56 (a)
GALNT11 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GALNT11 36
  • 90.17 (n)
  • 92.75 (a)
GALNT11 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Galnt11 36
  • 85.31 (n)
  • 87.83 (a)
Galnt11 16
Galnt11 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GALNT11 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GALNT11 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Galnt11 36
  • 84.54 (n)
  • 88.65 (a)
chicken
(Gallus gallus)
Aves GALNT11 36
  • 77.1 (n)
  • 79.41 (a)
GALNT11 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GALNT11 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4426 36
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt11 36
  • 70.26 (n)
  • 74.51 (a)
zebrafish
(Danio rerio)
Actinopterygii galnt11 36
  • 69.1 (n)
  • 73.51 (a)
galnt11 37
  • 73 (a)
OneToOne
sbcb921 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004429 36
  • 51.52 (n)
  • 46.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pgant35A 36
  • 52.28 (n)
  • 48.91 (a)
Pgant35A 37
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gly-11 36
  • 51.4 (n)
  • 48.17 (a)
gly-11 37
  • 38 (a)
OneToMany
Species with no ortholog for GALNT11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNT11 Gene

ENSEMBL:
Gene Tree for GALNT11 (if available)
TreeFam:
Gene Tree for GALNT11 (if available)

Paralogs for GALNT11 Gene

Pseudogenes.org Pseudogenes for GALNT11 Gene

genes like me logo Genes that share paralogs with GALNT11: view

Variants for GALNT11 Gene

Sequence variations from dbSNP and Humsavar for GALNT11 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs967093 -- 152,121,692(+) TGTGG(C/T)GGGAA utr-variant-3-prime
rs2079843 -- 152,037,808(+) ttgtc(A/G)cccag intron-variant
rs2079844 -- 152,037,967(+) gtctc(A/G/T)ccatg intron-variant
rs2361218 -- 152,034,020(-) ctggg(G/T)aagtt intron-variant
rs2361219 -- 152,032,943(-) TCCGA(A/G)GAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GALNT11 Gene

Variant ID Type Subtype PubMed ID
nsv889494 CNV Gain 21882294
esv2671400 CNV Deletion 23128226
esv2735443 CNV Deletion 23290073
nsv889495 CNV Gain 21882294
nsv831191 CNV Gain 17160897
esv1004658 CNV Deletion 20482838
dgv7549n71 CNV Gain 21882294

Relevant External Links for GALNT11 Gene

HapMap Linkage Disequilibrium report
GALNT11

Disorders for GALNT11 Gene

UniProtKB/Swiss-Prot

GLT11_HUMAN
  • Note=Defects in GALNT11 may be a cause of heterotaxy, a congenital heart disease resulting from abnormalities in left-right (LR) body patterning. {ECO:0000269 PubMed:21282601}.

(1) MalaCards Diseases for GALNT11 Gene

Search for GALNT11 Gene in MalaCards »

Relevant External Links for GALNT11

Human Genome Epidemiology (HuGE) Navigator
GALNT11
genes like me logo Genes that share disorders with GALNT11: view

Publications for GALNT11 Gene

  1. Functional conservation of subfamilies of putative UDP-N- acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila. (PMID: 11925450) Schwientek T. … Clausen H. (J. Biol. Chem. 2002) 2 3 4
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A Japanese-specific allele in the GALNT11 gene. (PMID: 20547088) Yuasa I. … Henke J. (Leg Med (Tokyo) 2010) 3 4

Products for GALNT11 Gene

Sources for GALNT11 Gene

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