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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GALNT10 Gene

protein-coding   GIFtS: 61
GCID: GC05P153550

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase...
 Explore 1 disease affiliated with
GALNT10 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GALNT10    

Aliases
for GALNT10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide
N-Acetylgalactosaminyltransferase 10 (GalNAc-T10)1 2
     GalNAc Transferase 102
UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 102 3     Polypeptide N-Acetylgalactosaminyltransferase 102
EC 2.4.1.413 8     GalNAc-T103
DKFZp586H06231     Polypeptide GalNAc Transferase 103
GALNACT102     Pp-GaNTase 103
PPGALNACT102     Protein-UDP Acetylgalactosaminyltransferase 103
PPGANTASE102     GalNAcT105

External Ids:    HGNC: 198731   Entrez Gene: 555682   Ensembl: ENSG000001645747   OMIM: 6080435   UniProtKB: Q86SR13   

Export aliases for GALNT10 gene to outside databases

Previous GC identifers: GC05P154165 GC05P153553 GC05P153598 GC05P148711


Summaries
for GALNT10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GALNT10:
This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the
first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either
serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic
activity toward glycosylated peptides compared to activity toward non-glycosylated peptides.(provided by RefSeq, Apr
2010)

UniProtKB/Swiss-Prot: GLT10_HUMAN, Q86SR1
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an
N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac
and EA2 peptide substrates




Genomic Views
for GALNT10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GALNT10 gene promoter:
         p53   HOXA3   Brachyury   GATA-1   c-Ets-1   AREB6   S8   GATA-6   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GALNT10 promoter sequence
   Search SABiosciences Chromatin IP Primers for GALNT10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GALNT10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.2   Ensembl cytogenetic band:  5q33.2   HGNC cytogenetic band: 5q34

GALNT10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GALNT10 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P153550:  view genomic region     (about GC identifiers)

Start:
 153,570,290 bp from pter      End:
 153,800,544 bp from pter
Size:
 230,255 bases      Orientation:
 plus strand

Proteins
for GALNT10 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GLT10_HUMAN, Q86SR1 (See protein sequence)
Recommended Name: Polypeptide N-acetylgalactosaminyltransferase 10  
Size: 603 amino acids; 68992 Da
Cofactor: Manganese (By similarity)
Cofactor: Calcium (By similarity)
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Caution: According to experiments made in rat, this enzyme is unable to transfer GalNAc onto serine or threonine
residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding
additional GalNAc moieties, thereby acting as a glycopeptide transferase
Sequence caution: Sequence=BAB14676.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for GALNT10:
2D7I (3D)        2D7R (3D)    
Secondary accessions: B3KXC9 Q6IN56 Q86VP8 Q8IXJ2 Q8TEJ2 Q96IV2 Q9H8E1 Q9Y4M4
Alternative splicing: 4 isoforms:  Q86SR1-1   Q86SR1-2   Q86SR1-3   Q86SR1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GALNT10: NX_Q86SR1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86SR1

    • 4/22 DME Specific Peptides for GALNT10 (Q86SR1) (see all 22)
     LNRSLPD  LLRTVHS  MAGGLFA  FLDSHCE 

    GALNT10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_938080.1  
    ENSEMBL proteins: 
     ENSP00000415210   ENSP00000297107   ENSP00000428573   ENSP00000366889   ENSP00000366885  
    Reactome Protein details: Q86SR1
    Human Recombinant Protein Products: 
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    Uscn Proteins for GALNT10

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral to membrane IEA--


    GALNT10 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for GALNT10 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GALNT10 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000772 Ricin_B_lectin
     IPR001173 Glyco_trans_2

    Graphical View of Domain Structure for InterPro Entry Q86SR1

    ProtoNet protein and cluster: Q86SR1

    2 Blocks protein families:
    IPB000772 Ricin B lectin domain
    IPB001173 Glycosyl transferase


    UniProtKB/Swiss-Prot: GLT10_HUMAN, Q86SR1
    Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called
    GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain
    (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By
    similarity)
    Domain: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)
    Similarity: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily
    Similarity: Contains 1 ricin B-type lectin domain


    Function
    for GALNT10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GLT10_HUMAN, Q86SR1
    Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an
    N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac
    and EA2 peptide substrates
    Catalytic activity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP +
    N-acetyl-alpha-D-galactosaminyl-polypeptide

    Enzyme Number (IUBMB): EC 2.4.1.411 2

    miRNA
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    hsa-miR-194* hsa-miR-3938 hsa-miR-520e hsa-miR-302d hsa-miR-4328 hsa-miR-106a hsa-miR-146a hsa-miR-650
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004653polypeptide N-acetylgalactosaminyltransferase activity IEA--
    GO:0016740transferase activity ----
    GO:0016757transferase activity, transferring glycosyl groups ----
    GO:0030246carbohydrate binding ----
    GO:0046872metal ion binding IEA--


    GALNT10 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for GALNT10:
     Decreased cilium length after  

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Galnt10):
     normal 

    GALNT10 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GALNT10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
    		O-linked glycosylation of mucins0.28
    		Mucin type O-Glycan biosynthesis0.00
    2Asparagine N-linked glycosylation
    		Post-translational protein modification0.44
    		Metabolism of proteins0.15
    3Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for GALNT10
        O-linked glycosylation of mucins
    Metabolism of proteins
    Post-translational protein modification


    2         Kegg Pathways  (Kegg details for GALNT10):
        Mucin type O-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: GLT10_HUMAN, Q86SR1
    Pathway: Protein modification; protein glycosylation


    GALNT10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GALNT10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for GALNT10 (Q86SR12, 3 ENSP000002971074) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MUC7Q8TAX73, ENSP000003020214I2D: score=1 STRING: ENSP00000302021
    MUC1P159413, ENSP000003389834I2D: score=1 STRING: ENSP00000338983
    PTCH1Q136353I2D: score=3 
    GALNT1ENSP000002691954STRING: ENSP00000269195
    GALNT12ENSP000003641504STRING: ENSP00000364150
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006493protein O-linked glycosylation ----
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--


    GALNT10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GALNT10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for GALNT10

    5 HMDB Compounds for GALNT10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Lactosaminebeta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose (see all 8)13000-25-4--
    Manganesemanganese 7439-96-5--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate-N-acetylgalactosamineUDP-N-acetyl-D-galactosamine (see all 17)7277-98-7--
    Search CenterWatch for drugs/clinical trials and news about GALNT10 / GLT10 

    Transcripts
    for GALNT10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GALNT10 gene (3 alternative transcripts): 
    NM_198321.3  NM_017540.3  NM_024564.1  

    Unigene Cluster for GALNT10:

    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
    Hs.631797  [show with all ESTs]
    Unigene Representative Sequence: NM_198321
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425427(uc003lvg.1) ENST00000297107(uc003lvh.3 uc010jic.3 uc010jid.3)
    ENST00000520647 ENST00000521786 ENST00000377661 ENST00000521781 ENST00000519571
    ENST00000519544 ENST00000519235 ENST00000517958 ENST00000377657

    miRNA
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    hsa-miR-194* hsa-miR-3938 hsa-miR-520e hsa-miR-302d hsa-miR-4328 hsa-miR-106a hsa-miR-146a hsa-miR-650
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB078145.1 AF086521.1 AJ505950.1 AK023782.1 AK023815.1 AK074132.1 AK127135.1 AL096739.1 
    BC007224.1 BC050333.1 BC072450.1 BC098444.1 

    10 DOTS entries:

    DT.91756427  DT.100815179  DT.455010  DT.207887  DT.207888  DT.429265  DT.99950840  DT.120855848 
    DT.95326329  DT.100815178 

    24/292 AceView cDNA sequences (see all 292):

    BC072450 NM_198321 AI393316 BQ581613 BQ430127 BU737617 AI923899 BF195398 
    BE906572 BQ009557 AI817880 BM127601 CN480265 BF115390 AI146361 AI810607 
    AI701438 AW304717 BE670947 D45606 AL713447 BF058164 AI765120 BU193910 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GALNT10    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                        -     -                                       
    SP2:                                      -                 -     -                                       
    SP3:                                                                                                      
    SP4:                                                                                                      


    ECgene alternative splicing isoforms for GALNT10

    Expression
    for GALNT10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GALNT10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAGACTCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GALNT10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See GALNT10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GALNT10

    SOURCE GeneReport for Unigene cluster: Hs.631797

    UniProtKB/Swiss-Prot: GLT10_HUMAN, Q86SR1
    Tissue specificity: Widely expressed. Expressed at high level in small intestine, and at intermediate levels in
    stomach, pancreas, ovary, thyroid gland and spleen. Weakly expressed in other tissues

        SABiosciences Expression via Pathway-Focused PCR Array including GALNT10: 
              Glycosylation in human mouse rat

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    In Situ
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    Orthologs
    for GALNT10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for GALNT10 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Galnt101 , 5 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more1, 5 88.67(n)1
    95.36(a)1    		   11 (35.27 cM)5
    1712121  NM_134189.21  NP_598950.21 
     576454425 
    chicken
    (Gallus gallus)    		 Aves GALNT101 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more 80.04(n)
    89.22(a)    		   416260  XM_414578.2  XP_414578.2 
    lizard
    (Anolis carolinensis)    		 Reptilia GALNT106
    		 --
    		 88(a)
    		 1 ↔ 1
    		 GL343205.1(311514-354392)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia AL878409.22   -- 76.69(n)    AL878409.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.125402 Transcribed sequence with weak similarity to protein more 74.66(n)    BI472749.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta pgant61 polypeptide GalNAc transferase 6 56.62(n)
    52.29(a)    		   38346  NM_139492.2  NP_647749.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea gly-101 Protein GLY-10 55.04(n)
    52.68(a)    		   178343  NM_001047571.1  NP_001041036.1 


    ENSEMBL Gene Tree for GALNT10 (if available)
    TreeFam Gene Tree for GALNT10 (if available) 

    Paralogs
    for GALNT10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GALNT10 gene
    GALNT62  POC1B-GALNT42  GALNT122  GALNT52  GALNT72  GALNT12  GALNTL62  GALNT142  
    GALNTL52  GALNT32  GALNT22  GALNT42  GALNT132  GALNT162  GALNT112  
    18/25 SIMAP similar genes for GALNT10 using alignment to 5 protein entries:     GLT10_HUMAN (see all proteins) (see all similar genes):
    GALNTL6    GALNTL5    GALNTL2    GALNT6    GALNT1    GALNT12
    GALNT4    GalNAc-T10    GALNT15    GALNT16    GALNT5    GALNTL1
    GALNT13    GalNAc-T16    GALNT3    GALNT14    GALNT2    WBSCR17

    GALNT10 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GALNT10
    PGOHUM00000262872


    Genomic Variants
    for GALNT10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4064 NCBI SNPs in GALNT10 are shown (see all 4064)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1380070011,2
    		Cother153709279(+) CTGGTC/TGACGA 2 V syn11Minor allele frequency- T:0.00NA 4552
    rs1850885751,2
    		--153568338(+) CGCCAC/TCACGC 1 -- us2k10--------
    rs1899461061,2
    		--153568381(+) GGTTTC/TGCCAT 1 -- us2k10--------
    rs1825770341,2
    		--153568485(+) TCATTC/TGCCAA 1 -- us2k10--------
    rs1872726431,2
    		--153568640(+) CCTGAC/GGAGGA 1 -- us2k10--------
    rs1919824561,2
    		C,--153568652(+) TTTTAA/GAAGGC 1 -- us2k10--------
    rs1171821941,2
    		--153568905(+) GGTGAT/CGGAAG 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1838009281,2
    		--153568998(+) AGAACC/TTGGAG 1 -- us2k10--------
    rs1485986521,2
    		--153569040(+) AGTGGC/TAGCTA 1 -- us2k10--------
    rs68804621,2
    		C,F,H,--153569041(+) GTGGCG/AGCTAG 1 -- us2k122Minor allele frequency- A:0.04NS EA NA WA CSA 2124

    HapMap Linkage Disequilibrium report for GALNT10 (153570290 - 153800544 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for GALNT10
         1 CNV: 64341
         1 Indel: 99328

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    Disorders / Diseases
    for GALNT10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GALNT10 for disorders           About GeneDecksing

    OMIM gene information: 608043    OMIM disorders: --

    1 disease for GALNT10:    About MalaCards
    thyroiditis

    Human Genome Epidemiology (HuGE) Navigator: GALNT10 (1 document)

    Export disorders for GALNT10 gene to outside databases

    Publications
    for GALNT10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GALNT10 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with GALNT10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc- T10. (PubMed id 12417297)1, 2, 3 Cheng L....Narimatsu H. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Genome-Wide Association of BMI in African Americans. (PubMed id 21701570)1 Ng M.C....Bowden D.W. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. Glycopeptide-preferring polypeptide GalNAc transferas e 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNA c-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2 . (PubMed id 19460755)1 Perrine C.L....Gerken T.A. (2009)
    7. The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection. (PubMed id 18562306)1 Raman J....Tabak L.A. (2008)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. Structural basis of carbohydrate transfer activity by human UDP- GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferase (pp- GalNAc-T10). (PubMed id 16650853)2 Kubota T.... Narimatsu H. (2006)
    10. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)2 Jikuya H....Ohara O. (2003)

    External Searches for GALNT10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GALNT10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55568 HGNC: 19873 AceView: GALNT10 Ensembl:ENSG00000164574 euGenes: HUgn55568
    ECgene: GALNT10 Kegg: 55568 H-InvDB: GALNT10

    Other Databases showing GALNT10 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GALNT10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GALNT10 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_492
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_493

    Intellectual Property
    for GALNT10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GALNT10 gene:
    Search GeneIP for patents involving GALNT10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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