Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GALNT10 Gene

Aliases for GALNT10 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 10 2 3
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 10 (GalNAc-T10) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 10 3 4
  • Polypeptide GalNAc Transferase 10 2 4
  • EC 2.4.1.41 4 64
  • GALNACT10 3 6
  • Protein-UDP Acetylgalactosaminyltransferase 10 4
  • GalNAc Transferase 10 3
  • Pp-GaNTase 10 4
  • PPGALNACT10 3
  • PPGANTASE10 3
  • GalNAc-T10 4

External Ids for GALNT10 Gene

Summaries for GALNT10 Gene

Entrez Gene Summary for GALNT10 Gene

  • This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated peptides.[provided by RefSeq, Apr 2010]

GeneCards Summary for GALNT10 Gene

GALNT10 (Polypeptide N-Acetylgalactosaminyltransferase 10) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT4.

UniProtKB/Swiss-Prot for GALNT10 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT10 Gene

Genomics for GALNT10 Gene

Genomic Location for GALNT10 Gene

Start:
154,190,730 bp from pter
End:
154,420,984 bp from pter
Size:
230,255 bases
Orientation:
Plus strand

Genomic View for GALNT10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GALNT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT10 Gene

Regulatory Elements for GALNT10 Gene

Proteins for GALNT10 Gene

  • Protein details for GALNT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SR1-GLT10_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 10
    Protein Accession:
    Q86SR1
    Secondary Accessions:
    • B3KXC9
    • Q6IN56
    • Q86VP8
    • Q8IXJ2
    • Q8TEJ2
    • Q96IV2
    • Q9H8E1
    • Q9Y4M4

    Protein attributes for GALNT10 Gene

    Size:
    603 amino acids
    Molecular mass:
    68992 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14676.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GALNT10 Gene

    Alternative splice isoforms for GALNT10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALNT10 Gene

Proteomics data for GALNT10 Gene at MOPED

Post-translational modifications for GALNT10 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr39, Ser43, Thr62, Asn124, Asn146, and Asn593

Other Protein References for GALNT10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GALNT10 Gene

Gene Families for GALNT10 Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

UniProtKB/Swiss-Prot:

GLT10_HUMAN
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.:
    • Q86SR1
  • The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.:
    • Q86SR1
  • Contains 1 ricin B-type lectin domain.:
    • Q86SR1
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.:
    • Q86SR1
genes like me logo Genes that share domains with GALNT10: view

Function for GALNT10 Gene

Molecular function for GALNT10 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.
UniProtKB/Swiss-Prot Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates

Enzyme Numbers (IUBMB) for GALNT10 Gene

Gene Ontology (GO) - Molecular Function for GALNT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IDA 12417297
GO:0016757 transferase activity, transferring glycosyl groups --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GALNT10: view

Phenotypes for GALNT10 Gene

MGI mutant phenotypes for GALNT10:
inferred from 1 alleles
GenomeRNAi human phenotypes for GALNT10:
genes like me logo Genes that share phenotypes with GALNT10: view

miRNA for GALNT10 Gene

miRTarBase miRNAs that target GALNT10

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GALNT10 Gene

Localization for GALNT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT10 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GALNT10 Gene COMPARTMENTS Subcellular localization image for GALNT10 gene
Compartment Confidence
golgi apparatus 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GALNT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GALNT10: view

Pathways for GALNT10 Gene

genes like me logo Genes that share pathways with GALNT10: view

Pathways by source for GALNT10 Gene

UniProtKB/Swiss-Prot Q86SR1-GLT10_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for GALNT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0008152 metabolic process --
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with GALNT10: view

Compounds for GALNT10 Gene

(5) HMDB Compounds for GALNT10 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Lactosamine
  • beta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
13000-25-4
Manganese
  • manganese
7439-96-5
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with GALNT10: view

Transcripts for GALNT10 Gene

Unigene Clusters for GALNT10 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for GALNT10 Gene

GeneLoc Exon Structure for
GALNT10
ECgene alternative splicing isoforms for
GALNT10

Expression for GALNT10 Gene

mRNA expression in normal human tissues for GALNT10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GALNT10 Gene

SOURCE GeneReport for Unigene cluster for GALNT10 Gene Hs.631797

mRNA Expression by UniProt/SwissProt for GALNT10 Gene

Q86SR1-GLT10_HUMAN
Tissue specificity: Widely expressed. Expressed at high level in small intestine, and at intermediate levels in stomach, pancreas, ovary, thyroid gland and spleen. Weakly expressed in other tissues.
genes like me logo Genes that share expressions with GALNT10: view

Orthologs for GALNT10 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNT10 36
  • 99.52 (n)
  • 99.64 (a)
GALNT10 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GALNT10 36
  • 90.71 (n)
  • 95.24 (a)
GALNT10 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GALNT10 36
  • 91.87 (n)
  • 97.18 (a)
GALNT10 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Galnt10 36
  • 88.67 (n)
  • 95.36 (a)
Galnt10 16
Galnt10 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GALNT10 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GALNT10 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Galnt10 36
  • 88.5 (n)
  • 96.02 (a)
chicken
(Gallus gallus)
Aves GALNT10 36
  • 80.1 (n)
  • 89.22 (a)
GALNT10 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GALNT10 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt10 36
  • 70.56 (n)
  • 73.83 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12540 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010367 36
  • 52.04 (n)
  • 49.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31776 37
  • 33 (a)
ManyToMany
pgant4 37
  • 39 (a)
ManyToMany
pgant6 36
  • 56.59 (n)
  • 52.09 (a)
pgant6 37
  • 42 (a)
ManyToMany
pgant8 37
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea gly-10 36
  • 54.61 (n)
  • 51.33 (a)
gly-10 37
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 54 (a)
OneToMany
Species with no ortholog for GALNT10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNT10 Gene

ENSEMBL:
Gene Tree for GALNT10 (if available)
TreeFam:
Gene Tree for GALNT10 (if available)

Paralogs for GALNT10 Gene

Pseudogenes.org Pseudogenes for GALNT10 Gene

genes like me logo Genes that share paralogs with GALNT10: view

Variants for GALNT10 Gene

Sequence variations from dbSNP and Humsavar for GALNT10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs27150 -- 154,354,679(+) GGGTG(A/G)GGGGG intron-variant
rs27151 -- 154,354,718(+) ACATT(A/G)CAGAA intron-variant
rs27152 -- 154,355,022(+) TGCAT(C/T)GTACT intron-variant
rs27153 -- 154,359,025(-) TCAAC(A/T)CCGAA intron-variant
rs27154 -- 154,362,283(+) GGACC(A/G)AACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GALNT10 Gene

Variant ID Type Subtype PubMed ID
nsv883057 CNV Loss 21882294
esv23918 CNV Loss 19812545
esv2582402 CNV Insertion 19546169
esv2662546 CNV Deletion 23128226
nsv5079 CNV Insertion 18451855
nsv521696 CNV Loss 19592680
esv2730934 CNV Deletion 23290073
esv2730935 CNV Deletion 23290073
nsv830520 CNV Loss 17160897
nsv5080 CNV Insertion 18451855
nsv524343 CNV Loss 19592680

Relevant External Links for GALNT10 Gene

HapMap Linkage Disequilibrium report
GALNT10

Disorders for GALNT10 Gene

Relevant External Links for GALNT10

Genetic Association Database (GAD)
GALNT10
Human Genome Epidemiology (HuGE) Navigator
GALNT10
genes like me logo Genes that share disorders with GALNT10: view

No data available for UniProtKB/Swiss-Prot for GALNT10 Gene

Publications for GALNT10 Gene

  1. Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc- T10. (PMID: 12417297) Cheng L. … Narimatsu H. (FEBS Lett. 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3

Products for GALNT10 Gene

Sources for GALNT10 Gene

Back to Top

Content