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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GALNT10 Gene

protein-coding   GIFtS: 62
GCID: GC05P153550

UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase...

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide
N-Acetylgalactosaminyltransferase 10 (GalNAc-T10)1 2
     Polypeptide N-Acetylgalactosaminyltransferase 102
UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 102 3     GalNAc-T103
EC 2.4.1.413 8     Polypeptide GalNAc Transferase 103
GALNACT102     Pp-GaNTase 103
PPGALNACT102     Protein-UDP Acetylgalactosaminyltransferase 103
PPGANTASE102     GalNAcT105
GalNAc Transferase 102     

External Ids:    HGNC: 198731   Entrez Gene: 555682   Ensembl: ENSG000001645747   OMIM: 6080435   UniProtKB: Q86SR13   

Export aliases for GALNT10 gene to outside databases

Previous GC identifers: GC05P154165 GC05P153553 GC05P153598 GC05P148711


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GALNT10 Gene:
This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze
the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to
either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have
increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated
peptides.(provided by RefSeq, Apr 2010)

GeneCards Summary for GALNT10 Gene: 
GALNT10 (UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)) is a protein-coding gene. Diseases associated with GALNT10 include thyroiditis, and among its related super-pathways are Mucin type O-Glycan biosynthesis and Post-translational protein modification. GO annotations related to this gene include metal ion binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT6.

UniProtKB/Swiss-Prot: GLT10_HUMAN, Q86SR1
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an
N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward
Muc5Ac and EA2 peptide substrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_029289.11  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GALNT10 gene promoter:
         p53   HOXA3   Brachyury   GATA-1   c-Ets-1   AREB6   S8   GATA-6   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGALNT10 promoter sequence
   Search SABiosciences Chromatin IP Primers for GALNT10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GALNT10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.2   Ensembl cytogenetic band:  5q33.2   HGNC cytogenetic band: 5q34

GALNT10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GALNT10 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P153550:  view genomic region     (about GC identifiers)

Start:
153,570,290 bp from pter      End:
153,800,544 bp from pter
Size:
230,255 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GLT10_HUMAN, Q86SR1 (See protein sequence)
Recommended Name: Polypeptide N-acetylgalactosaminyltransferase 10  
Size: 603 amino acids; 68992 Da
Cofactor: Manganese (By similarity)
Cofactor: Calcium (By similarity)
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Caution: According to experiments made in rat, this enzyme is unable to transfer GalNAc onto serine or threonine
residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding
additional GalNAc moieties, thereby acting as a glycopeptide transferase
Sequence caution: Sequence=BAB14676.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for GALNT10:
2D7I (3D)        2D7R (3D)    
Secondary accessions: B3KXC9 Q6IN56 Q86VP8 Q8IXJ2 Q8TEJ2 Q96IV2 Q9H8E1 Q9Y4M4
Alternative splicing: 4 isoforms:  Q86SR1-1   Q86SR1-2   Q86SR1-3   Q86SR1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GALNT10: NX_Q86SR1

Explore proteomics data for GALNT10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86SR1

  • 4/22 DME Specific Peptides for GALNT10 (Q86SR1) (see all 22)
     LNRSLPD  LLRTVHS  MAGGLFA  FLDSHCE 

    GALNT10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GALNT10 Protein Expression
    REFSEQ proteins: NP_938080.1  
    ENSEMBL proteins: 
     ENSP00000415210   ENSP00000297107   ENSP00000428573   ENSP00000366889   ENSP00000366885  
    Reactome Protein details: Q86SR1
    Human Recombinant Protein Products for GALNT10: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral to membrane IEA--

    GALNT10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GLT2: Glycosyltransferase family 2 domain containing

    2 InterPro protein domains:
     IPR000772 Ricin_B_lectin
     IPR001173 Glyco_trans_2

    Graphical View of Domain Structure for InterPro Entry Q86SR1

    ProtoNet protein and cluster: Q86SR1

    2 Blocks protein domains:
    IPB000772 Ricin B lectin domain
    IPB001173 Glycosyl transferase


    UniProtKB/Swiss-Prot: GLT10_HUMAN, Q86SR1
    Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also
    called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal
    domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal
    binding (By similarity)
    Domain: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By
    similarity)
    Similarity: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily
    Similarity: Contains 1 ricin B-type lectin domain


    GALNT10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLT10_HUMAN, Q86SR1
    Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an
    N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward
    Muc5Ac and EA2 peptide substrates
    Catalytic activity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP +
    N-acetyl-alpha-D-galactosaminyl-polypeptide

         Enzyme Number (IUBMB): EC 2.4.1.411 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004653polypeptide N-acetylgalactosaminyltransferase activity IEA--
    GO:0016757transferase activity, transferring glycosyl groups ----
    GO:0046872metal ion binding IEA--
         
    GALNT10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GALNT10:
     Decreased cilium length after  

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Galnt10):
     normal 

    GALNT10 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GALNT10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.44
    Mucin type O-Glycan biosynthesis0.44
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35
    3Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for GALNT10
        O-linked glycosylation of mucins
    Metabolism of proteins
    Post-translational protein modification


    2         Kegg Pathways  (Kegg details for GALNT10):
        Mucin type O-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: GLT10_HUMAN, Q86SR1
    Pathway: Protein modification; protein glycosylation


    GALNT10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GALNT10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for GALNT10 (Q86SR12, 3 ENSP000002971074) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MUC7Q8TAX73, ENSP000003020214I2D: score=1 STRING: ENSP00000302021
    MUC1P159413, ENSP000003389834I2D: score=1 STRING: ENSP00000338983
    PTCH1Q136353I2D: score=3 
    GALNT1ENSP000002691954STRING: ENSP00000269195
    GALNT12ENSP000003641504STRING: ENSP00000364150
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006493protein O-linked glycosylation ----
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    GALNT10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for GALNT10 (GLT10)

    5 HMDB Compounds for GALNT10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Lactosaminebeta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose (see all 8)13000-25-4--
    Manganesemanganese 7439-96-5--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate-N-acetylgalactosamineUDP-N-acetyl-D-galactosamine (see all 17)7277-98-7--

    Search CenterWatch for drugs/clinical trials and news about GALNT10 / GLT10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GALNT10 gene (3 alternative transcripts): 
    NM_198321.3  NM_017540.3  NM_024564.1  

    Unigene Cluster for GALNT10:

    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
    Hs.631797  [show with all ESTs]
    Unigene Representative Sequence: NM_198321
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425427(uc003lvg.1) ENST00000297107(uc003lvh.3 uc010jic.3 uc010jid.3)
    ENST00000520647 ENST00000521786 ENST00000377661 ENST00000521781 ENST00000519571
    ENST00000519544 ENST00000519235 ENST00000517958 ENST00000377657
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    Additional mRNA sequence: 

    AB078145.1 AF086521.1 AJ505950.1 AK023782.1 AK023815.1 AK074132.1 AK127135.1 AL096739.1 
    BC007224.1 BC050333.1 BC072450.1 BC098444.1 

    10 DOTS entries:

    DT.91756427  DT.100815179  DT.455010  DT.207887  DT.207888  DT.429265  DT.99950840  DT.120855848 
    DT.95326329  DT.100815178 

    24/292 AceView cDNA sequences (see all 292):

    BF195398 BX092243 BQ227630 AI620102 BQ581613 NM_017540 BE550908 AL713447 
    AI467894 AI393316 BU737617 BE045356 BM127601 BM822193 BX092156 AI923899 
    AI910809 D45606 AI056422 AI754901 CN480265 BQ549377 BQ430127 BF115390 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GALNT10    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                        -     -                                       
    SP2:                                      -                 -     -                                       
    SP3:                                                                                                      
    SP4:                                                                                                      


    ECgene alternative splicing isoforms for GALNT10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GALNT10 expression in normal human tissues (normalized intensities)      GALNT10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGACTCCT
    GALNT10 Expression
    About this image


    GALNT10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
             optic nerve head astrocytes   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Chorion (Extraembryonic Tissues)
             chorion villus cells   
     
     Eye (Sensory Organs)
             optic nerve head astrocytes   

    See GALNT10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GALNT10

    SOURCE GeneReport for Unigene cluster: Hs.631797

    UniProtKB/Swiss-Prot: GLT10_HUMAN, Q86SR1
    Tissue specificity: Widely expressed. Expressed at high level in small intestine, and at intermediate levels in
    stomach, pancreas, ovary, thyroid gland and spleen. Weakly expressed in other tissues

        SABiosciences Expression via Pathway-Focused PCR Array including GALNT10: 
              Glycosylation in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GALNT10 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Galnt101 , 5 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more1, 5 88.67(n)1
    95.36(a)1
      11 (35.27 cM)5
    1712121  NM_134189.21  NP_598950.21 
     576454425 
    chicken
    (Gallus gallus)
    Aves GALNT101 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more 80.04(n)
    89.22(a)
      416260  XM_414578.2  XP_414578.2 
    lizard
    (Anolis carolinensis)
    Reptilia GALNT106
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-a...
    84(a)
    1 ↔ 1
    GL343205.1(275420-354425)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL878409.22   -- 76.69(n)    AL878409.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.125402 Transcribed sequence with weak similarity to protein more 74.66(n)    BI472749.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pgant61 polypeptide GalNAc transferase 6 56.62(n)
    52.29(a)
      38346  NM_139492.2  NP_647749.2 
    worm
    (Caenorhabditis elegans)
    Secernentea gly-101 Protein GLY-10 55.04(n)
    52.68(a)
      178343  NM_001047571.1  NP_001041036.1 


    ENSEMBL Gene Tree for GALNT10 (if available)
    TreeFam Gene Tree for GALNT10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GALNT10 gene
    GALNT62  POC1B-GALNT42  GALNT122  GALNT52  GALNT72  GALNT12  GALNTL62  GALNT142  
    GALNTL52  GALNT32  GALNT22  GALNT42  GALNT132  GALNT162  GALNT112  
    18/24 SIMAP similar genes for GALNT10 using alignment to 5 protein entries:     GLT10_HUMAN (see all proteins) (see all similar genes):
    GALNTL6    GALNTL5    GALNT6    GALNT1    GALNT12    GALNT4
    GalNAc-T10    GALNT15    GALNT16    GALNT5    GALNT13    GalNAc-T16
    GALNT3    GALNT14    GALNT2    WBSCR17    POC1B-GALNT4    GALNT7

    GALNT10 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GALNT10
    PGOHUM00000262872


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3892 SNPs in GALNT10 are shown (see all 3892)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1380070011,2
    Cuntested1153709279(+) CTGGTC/TGACGA 2 V syn11Minor allele frequency- T:0.00NA 4552
    rs1136276681,2
    C--148711814(+) TCCCACCCCC/
            
    CCCCC
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs613901211,2
    C--148838843(+) ATATA-/TAAAAGA 1 -- int11Minor allele frequency- TA:0.00NA 2
    rs1850885751,2
    --153568338(+) CGCCAC/TCACGC 1 -- us2k10--------
    rs1899461061,2
    --153568381(+) GGTTTC/TGCCAT 1 -- us2k10--------
    rs1825770341,2
    --153568485(+) TCATTC/TGCCAA 1 -- us2k10--------
    rs1872726431,2
    --153568640(+) CCTGAC/GGAGGA 1 -- us2k10--------
    rs1919824561,2
    C--153568652(+) TTTTAA/GAAGGC 1 -- us2k10--------
    rs1171821941,2
    F--153568905(+) GGTGAT/CGGAAG 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1838009281,2
    --153568998(+) AGAACC/TTGGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GALNT10 (153570290 - 153800544 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for GALNT10 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2730935CNV Deletion23290073
    esv2662546CNV Deletion23128226
    esv2730934CNV Deletion23290073
    nsv5080CNV Insertion18451855
    nsv5079CNV Insertion18451855
    esv2582402CNV Insertion19546169
    esv23918CNV Loss19812545
    nsv524343CNV Loss19592680
    nsv883057CNV Loss21882294
    nsv521696CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608043    OMIM disorders: --

    2 diseases for GALNT10:    About MalaCards
    thyroiditis    


    GALNT10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GALNT10
    Human Genome Epidemiology (HuGE) Navigator: GALNT10 (1 document)

    Export disorders for GALNT10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GALNT10 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with GALNT10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc- T10. (PubMed id 12417297)1, 2, 3 Cheng L....Narimatsu H. (2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A meta-analysis identifies new loci associated with bo dy mass index in individuals of African ancestry. (PubMed id 23583978)1 Monda K.L....Haiman C.A. (2013)
    6. Genome-Wide Association of BMI in African Americans. (PubMed id 21701570)1 Ng M.C....Bowden D.W. (2011)
    7. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
    8. Glycopeptide-preferring polypeptide GalNAc transferas e 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNA c-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2 . (PubMed id 19460755)1 Perrine C.L....Gerken T.A. (2009)
    9. The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection. (PubMed id 18562306)1 Raman J....Tabak L.A. (2008)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55568 HGNC: 19873 AceView: GALNT10 Ensembl:ENSG00000164574 euGenes: HUgn55568
    ECgene: GALNT10 Kegg: 55568 H-InvDB: GALNT10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GALNT10 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_492
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_493

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GALNT10 gene:
    Search GeneIP for patents involving GALNT10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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