Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GALNT10 Gene

protein-coding   GIFtS: 62
GCID: GC05P153550

Polypeptide N-Acetylgalactosaminyltransferase 10

(Previous name: UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase...)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Polypeptide N-Acetylgalactosaminyltransferase 101 2     PPGANTASE102
UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide
N-Acetylgalactosaminyltransferase 10 (GalNAc-T10)1 2
     GalNAc Transferase 102
Polypeptide GalNAc Transferase 101 3     GalNAc-T103
UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 102 3     Pp-GaNTase 103
EC 2.4.1.413 8     Protein-UDP Acetylgalactosaminyltransferase 103
GALNACT102     GalNAcT105
PPGALNACT102     

External Ids:    HGNC: 198731   Entrez Gene: 555682   Ensembl: ENSG000001645747   OMIM: 6080435   UniProtKB: Q86SR13   

Export aliases for GALNT10 gene to outside databases

Previous GC identifers: GC05P154165 GC05P153553 GC05P153598 GC05P148711


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GALNT10 Gene:
This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze
the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to
either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have
increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated
peptides.(provided by RefSeq, Apr 2010)

GeneCards Summary for GALNT10 Gene:
GALNT10 (polypeptide N-acetylgalactosaminyltransferase 10) is a protein-coding gene. GO annotations related to this gene include polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT12.

UniProtKB/Swiss-Prot: GLT10_HUMAN, Q86SR1
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an
N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward
Muc5Ac and EA2 peptide substrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the GALNT10 gene promoter:
         p53   HOXA3   Brachyury   GATA-1   c-Ets-1   AREB6   S8   GATA-6   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGALNT10 promoter sequence
   Search Chromatin IP Primers for GALNT10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GALNT10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.2   Ensembl cytogenetic band:  5q33.2   HGNC cytogenetic band: 5q34

GALNT10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GALNT10 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P153550:  view genomic region     (about GC identifiers)

Start:
153,570,290 bp from pter      End:
153,800,544 bp from pter
Size:
230,255 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GLT10_HUMAN, Q86SR1 (See protein sequence)
Recommended Name: Polypeptide N-acetylgalactosaminyltransferase 10  
Size: 603 amino acids; 68992 Da
Cofactor: Manganese (By similarity)
Caution: According to experiments made in rat, this enzyme is unable to transfer GalNAc onto serine or threonine
residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding
additional GalNAc moieties, thereby acting as a glycopeptide transferase
Sequence caution: Sequence=BAB14676.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for GALNT10:
2D7I (3D)        2D7R (3D)    
Secondary accessions: B3KXC9 Q6IN56 Q86VP8 Q8IXJ2 Q8TEJ2 Q96IV2 Q9H8E1 Q9Y4M4
Alternative splicing: 4 isoforms:  Q86SR1-1   Q86SR1-2   Q86SR1-3   Q86SR1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GALNT10: NX_Q86SR1

Explore proteomics data for GALNT10 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr39, Ser43, Thr62, Asn124, Asn146, Asn593
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GALNT10 (Q86SR1) (see all 22)
     LNRSLPD  LLRTVHS  MAGGLFA  FLDSHCE 


    See GALNT10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_938080.1  
    ENSEMBL proteins: 
     ENSP00000415210   ENSP00000297107   ENSP00000428573   ENSP00000366889   ENSP00000366885  
    Reactome Protein details: Q86SR1

    GALNT10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for GALNT10 (Polypeptide GalNac Transferase 10/GALNT10)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GALNT10
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GALNT10
    GenScript Custom Purified and Recombinant Proteins Services for GALNT10
    Novus Biologicals GALNT10 Proteins
    Novus Biologicals GALNT10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GALNT10

     
    Search eBioscience for Proteins for GALNT10 

    GALNT10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for GALNT10 (Polypeptide GalNac Transferase 10/GALNT10)
    OriGene Antibodies for GALNT10
    OriGene Custom Antibody Services for GALNT10
    Novus Biologicals GALNT10 Antibodies
    Abcam antibodies for GALNT10
    Cloud-Clone Corp. Antibodies for GALNT10
    ThermoFisher Antibodies for GALNT10
    LSBio Antibodies in human, mouse, rat for GALNT10

    GALNT10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GALNT10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GALNT10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GALNT10
    Cloud-Clone Corp. CLIAs for GALNT10
    Search eBioscience for ELISAs for GALNT10 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GLT2: Glycosyltransferase family 2 domain containing

    2 InterPro protein domains:
     IPR000772 Ricin_B_lectin
     IPR001173 Glyco_trans_2

    Graphical View of Domain Structure for InterPro Entry Q86SR1

    ProtoNet protein and cluster: Q86SR1

    2 Blocks protein domains:
    IPB000772 Ricin B lectin domain
    IPB001173 Glycosyl transferase


    UniProtKB/Swiss-Prot: GLT10_HUMAN, Q86SR1
    Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also
    called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal
    domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal
    binding (By similarity)
    Domain: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By
    similarity)
    Similarity: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily
    Similarity: Contains 1 ricin B-type lectin domain


    Find genes that share domains with GALNT10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLT10_HUMAN, Q86SR1
    Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an
    N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward
    Muc5Ac and EA2 peptide substrates
    Catalytic activity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP +
    N-acetyl-alpha-D-galactosaminyl-polypeptide

         Enzyme Number (IUBMB): EC 2.4.1.411 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004653polypeptide N-acetylgalactosaminyltransferase activity IEA--
    GO:0016757transferase activity, transferring glycosyl groups ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with GALNT10           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GALNT10:
     Decreased cilium length after  

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Galnt10):
     normal 

    Find genes that share phenotypes with GALNT10           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GALNT10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GALNT10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GALNT10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GALNT10

    miRNA
    Products:
        
    miRTarBase miRNAs that target GALNT10:
    hsa-mir-122-5p (MIRT003102)

    Block miRNA regulation of human, mouse, rat GALNT10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GALNT10 (see all 61):
    hsa-miR-194* hsa-miR-3938 hsa-miR-520e hsa-miR-302d hsa-miR-4328 hsa-miR-106a hsa-miR-146a hsa-miR-650
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GALNT10
    Predesigned siRNA for gene silencing in human, mouse, rat GALNT10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GALNT10

    Clone
    Products:
         
    OriGene clones in human, mouse for GALNT10 (see all 10)
    OriGene ORF clones in mouse, rat for GALNT10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GALNT10 (NM_198321)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GALNT10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GALNT10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GALNT10
    Browse ESI BIO Cell Lines and PureStem Progenitors for GALNT10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALNT10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GLT10_HUMAN, Q86SR1: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol1
    endoplasmic reticulum1
    extracellular1
    lysosome1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with GALNT10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GALNT10 About    
    See pathways by source

    SuperPathContained pathways About
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.47
    Mucin type O-Glycan biosynthesis0.47
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    3Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with GALNT10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for GALNT10
        O-linked glycosylation of mucins


    2 Kegg Pathways  (Kegg details for GALNT10):
        Mucin type O-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: GLT10_HUMAN, Q86SR1
    Pathway: Protein modification; protein glycosylation

        Pathway & Disease-focused RT2 Profiler PCR Array including GALNT10: 

              Glycosylation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GALNT10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GALNT10 (Q86SR12, 3 ENSP000002971074) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MUC7Q8TAX73, ENSP000003020214I2D: score=1 STRING: ENSP00000302021
    MUC1P159413, ENSP000003389834I2D: score=1 STRING: ENSP00000338983
    PTCH1Q136353I2D: score=3 
    C1GALT1ENSP000002231224STRING: ENSP00000223122
    GALNT1ENSP000002691954STRING: ENSP00000269195
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006493protein O-linked glycosylation ----
    GO:0016266O-glycan processing TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with GALNT10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GALNT10 (GLT10)

    5 HMDB Compounds for GALNT10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Lactosaminebeta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose (see all 8)13000-25-4--
    Manganesemanganese 7439-96-5--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate-N-acetylgalactosamineUDP-N-acetyl-D-galactosamine (see all 17)7277-98-7--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GALNT10 gene (3 alternative transcripts): 
    NM_198321.3  NM_017540.3  NM_024564.1  

    Unigene Cluster for GALNT10:

    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
    Hs.631797  [show with all ESTs]
    Unigene Representative Sequence: NM_198321
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425427(uc003lvg.1) ENST00000297107(uc003lvh.3 uc010jic.3 uc010jid.3)
    ENST00000520647 ENST00000521786 ENST00000377661 ENST00000521781 ENST00000519571
    ENST00000519544 ENST00000519235 ENST00000517958 ENST00000377657
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GALNT10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GALNT10 (see all 61):
    hsa-miR-194* hsa-miR-3938 hsa-miR-520e hsa-miR-302d hsa-miR-4328 hsa-miR-106a hsa-miR-146a hsa-miR-650
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GALNT10
    Predesigned siRNA for gene silencing in human, mouse, rat GALNT10
    Clone
    Products:
         
    OriGene clones in human, mouse for GALNT10 (see all 10)
    OriGene ORF clones in mouse, rat for GALNT10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GALNT10 (NM_198321)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GALNT10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GALNT10
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GALNT10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GALNT10
      QuantiTect SYBR Green Assays in human, mouse, rat GALNT10
      QuantiFast Probe-based Assays in human, mouse, rat GALNT10

    Additional mRNA sequence: 

    AB078145.1 AF086521.1 AJ505950.1 AK023782.1 AK023815.1 AK074132.1 AK127135.1 AL096739.1 
    BC007224.1 BC050333.1 BC072450.1 BC098444.1 

    10 DOTS entries:

    DT.91756427  DT.100815179  DT.455010  DT.207887  DT.207888  DT.429265  DT.99950840  DT.120855848 
    DT.95326329  DT.100815178 

    Selected AceView cDNA sequences (see all 292):

    BQ430127 BQ549377 BX092156 AI056422 NM_017540 D45606 AI810607 AI923899 
    BU193910 CN480265 BF115390 AI765120 AI146361 AL713447 BQ227630 BF058164 
    AI393316 BF195398 NM_198321 AI049804 BE550908 BQ581613 BQ212113 AI280602 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GALNT10    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                        -     -                                       
    SP2:                                      -                 -     -                                       
    SP3:                                                                                                      
    SP4:                                                                                                      


    ECgene alternative splicing isoforms for GALNT10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GALNT10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGACTCCT
    GALNT10 Expression
    About this image


    GALNT10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Brain (Nervous System)
             Midbrain tegmentum
     
     Epidermis (Integumentary System)
     
     Dermis (Integumentary System)
    GALNT10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GALNT10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631797

    UniProtKB/Swiss-Prot: GLT10_HUMAN, Q86SR1
    Tissue specificity: Widely expressed. Expressed at high level in small intestine, and at intermediate levels in
    stomach, pancreas, ovary, thyroid gland and spleen. Weakly expressed in other tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including GALNT10: 
              Glycosylation in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GALNT10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GALNT10
    QuantiTect SYBR Green Assays in human, mouse, rat GALNT10
    QuantiFast Probe-based Assays in human, mouse, rat GALNT10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALNT10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for GALNT10 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Galnt101 , 5 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more1, 5 88.67(n)1
    95.36(a)1
      11 (35.27 cM)5
    1712121  NM_134189.21  NP_598950.21 
     576454425 
    chicken
    (Gallus gallus)
    Aves GALNT101 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase more 80.1(n)
    89.22(a)
      416260  XM_004944936.1  XP_004944993.1 
    lizard
    (Anolis carolinensis)
    Reptilia GALNT106
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-a...
    85(a)
    1 ↔ 1
    GL343205.1(275420-354425)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL878409.22   -- 76.69(n)    AL878409.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.125402 Transcribed sequence with weak similarity to protein more 74.66(n)    BI472749.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pgant61 polypeptide GalNAc transferase 6 56.59(n)
    52.09(a)
      38346  NM_001274413.1  NP_001261342.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gly-101 gly-10 54.61(n)
    51.33(a)
      178343  NM_001047572.2  NP_001041037.1 


    ENSEMBL Gene Tree for GALNT10 (if available)
    TreeFam Gene Tree for GALNT10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GALNT10 gene
    GALNT122  GALNT12  GALNTL62  GALNT32  GALNT22  GALNT132  GALNT62  POC1B-GALNT42  
    GALNT152  GALNT72  GALNT52  GALNT142  GALNTL52  GALNT42  GALNT162  GALNT112  
    Selected SIMAP similar genes for GALNT10 using alignment to 5 protein entries:     GLT10_HUMAN (see all proteins) (see all similar genes):
    GALNTL6    GALNTL5    GALNT6    GALNT1    GALNT12    GALNT4
    GalNAc-T10    GALNT15    GALNT16    GALNT5    GALNT13    GalNAc-T16
    GALNT3    GALNT14    GALNT2    WBSCR17    POC1B-GALNT4    GALNT7

    Find genes that share paralogs with GALNT10           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for GALNT10
    PGOHUM00000262872


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GALNT10 (see all 3892)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1380070011,2
    Cuntested1153709279(+) CTGGTC/TGACGA 2 V syn11Minor allele frequency- T:0.00NA 4552
    rs1136276681,2
    C--148711814(+) TCCCACCCCC/
            
    CCCCC
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs613901211,2
    C--148838843(+) ATATA-/TAAAAGA 1 -- int11Minor allele frequency- TA:0.00NA 2
    rs1850885751,2
    --153568338(+) CGCCAC/TCACGC 1 -- us2k10--------
    rs1899461061,2
    --153568381(+) GGTTTC/TGCCAT 1 -- us2k10--------
    rs1825770341,2
    --153568485(+) TCATTC/TGCCAA 1 -- us2k10--------
    rs1872726431,2
    --153568640(+) CCTGAC/GGAGGA 1 -- us2k10--------
    rs1919824561,2
    C--153568652(+) TTTTAA/GAAGGC 1 -- us2k10--------
    rs1171821941,2
    F--153568905(+) GGTGAT/CGGAAG 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1838009281,2
    --153568998(+) AGAACC/TTGGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GALNT10 (153570290 - 153800544 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GALNT10 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730935CNV Deletion23290073
    esv2662546CNV Deletion23128226
    esv2730934CNV Deletion23290073
    nsv5080CNV Insertion18451855
    nsv5079CNV Insertion18451855
    esv2582402CNV Insertion19546169
    esv23918CNV Loss19812545
    nsv524343CNV Loss19592680
    nsv883057CNV Loss21882294
    nsv521696CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GALNT10
    DNA2.0 Custom Variant and Variant Library Synthesis for GALNT10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608043    OMIM disorders: --


    Find genes that share disorders with GALNT10           About GenesLikeMe

    Genetic Association Database (GAD): GALNT10
    Human Genome Epidemiology (HuGE) Navigator: GALNT10 (1 document)

    Export disorders for GALNT10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GALNT10 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with GALNT10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc- T10. (PubMed id 12417297)1, 2, 3 Cheng L....Narimatsu H. (FEBS Lett. 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. A genome-wide association study of behavioral disinhibition. (PubMed id 23942779)1 McGue M....Iacono W.G. (Behav. Genet. 2013)
    6. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. (PubMed id 23583978)1 Monda K.L....Haiman C.A. (Nat. Genet. 2013)
    7. Genome-wide association of BMI in African Americans. (PubMed id 21701570)1 Ng M.C....Bowden D.W. (Obesity (Silver Spring) 2012)
    8. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    9. Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2. (PubMed id 19460755)1 Perrine C.L....Gerken T.A. (J. Biol. Chem. 2009)
    10. The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection. (PubMed id 18562306)1 Raman J....Tabak L.A. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55568 HGNC: 19873 AceView: GALNT10 Ensembl:ENSG00000164574 euGenes: HUgn55568
    ECgene: GALNT10 Kegg: 55568 H-InvDB: GALNT10

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GALNT10 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=GALNT10
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_492
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_493

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GALNT10 gene:
    Search GeneIP for patents involving GALNT10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for GALNT10 (Polypeptide GalNac Transferase 10/GALNT10)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for GALNT10 (Polypeptide GalNac Transferase 10/GALNT10)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GALNT10   OriGene RNAi products in human, mouse, rat for GALNT10  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for GALNT10  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GALNT10  
     OriGene qSTAR qPCR primer pairs in human, mouse for GALNT10   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GALNT10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GALNT10   OriGene Custom Protein Services for GALNT10  

     
     
     Block miRNA regulation of human, mouse, rat GALNT10 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GALNT10
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GALNT10 Predesigned siRNA for gene silencing in human, mouse, rat GALNT10
     QuantiFast Probe-based Assays in human, mouse, rat GALNT10 QuantiTect SYBR Green Assays in human, mouse, rat GALNT10
     PCR Arrays including human, mouse, rat GALNT10 Search Chromatin IP Primers for GALNT10
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GALNT10  Search GeneGlobe Interaction Network for GALNT10
     Regulatory tfbs in GALNT10 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GALNT10 GenScript cDNA clones with any tag delivered in your preferred vector for GALNT10
     GenScript Custom Assay Services for GALNT10 GenScript Custom overexpressing Cell Line Services for GALNT10
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for GALNT10 (GLT10)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GALNT10 antibodies
     GALNT10 proteins
     GALNT10 lysates
     Antibodies for GALNT10
     See all of Abcam's Antibodies, Kits and Proteins for GALNT10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for GALNT10
     Antibodies for GALNT10
     ELISAs for GALNT10
     CLIAs for GALNT10



     Browse ESI BIO Cell Lines and PureStem Progenitors for GALNT10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALNT10
     Browse SwitchGear 3'UTR luciferase reporter plasmids for GALNT10
     SwitchGear Promoter luciferase reporter plasmids for GALNT10
     ThermoFisher Antibodies for GALNT10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GALNT10
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GALNT10
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GALNT10
     LSBio Antibodies in human, mouse, rat for GALNT10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for GALNT10
      Search eBioscience for proteins for GALNT10
      Search eBioscience for elisas for GALNT10
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GALNT10 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4