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Aliases for GALNT1 Gene

Aliases for GALNT1 Gene

  • Polypeptide N-Acetylgalactosaminyltransferase 1 2 3
  • Protein-UDP Acetylgalactosaminyltransferase 1 2 3 4
  • Polypeptide GalNAc Transferase 1 2 3 4
  • UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 1 (GalNAc-T1) 2 3
  • UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 1 3 4
  • Pp-GaNTase 1 3 4
  • EC 2.4.1.41 4 63
  • GALNAC-T1 3 4
  • GalNAc Transferase 1 3

External Ids for GALNT1 Gene

Summaries for GALNT1 Gene

Entrez Gene Summary for GALNT1 Gene

  • This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the literature. [provided by RefSeq, Jul 2008]

GeneCards Summary for GALNT1 Gene

GALNT1 (Polypeptide N-Acetylgalactosaminyltransferase 1) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include manganese ion binding and polypeptide N-acetylgalactosaminyltransferase activity. An important paralog of this gene is GALNT4.

UniProtKB/Swiss-Prot for GALNT1 Gene

  • Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7.

Gene Wiki entry for GALNT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALNT1 Gene

Genomics for GALNT1 Gene

Genomic Location for GALNT1 Gene

Start:
35,581,117 bp from pter
End:
35,711,834 bp from pter
Size:
130,718 bases
Orientation:
Plus strand

Genomic View for GALNT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GALNT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALNT1 Gene

Regulatory Elements for GALNT1 Gene

Proteins for GALNT1 Gene

  • Protein details for GALNT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10472-GALT1_HUMAN
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 1
    Protein Accession:
    Q10472
    Secondary Accessions:
    • Q86TJ7
    • Q9UM86

    Protein attributes for GALNT1 Gene

    Size:
    559 amino acids
    Molecular mass:
    64219 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GALNT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALNT1 Gene

Proteomics data for GALNT1 Gene at MOPED

Post-translational modifications for GALNT1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn95 and Asn552

Other Protein References for GALNT1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GALNT1 Gene

Gene Families for GALNT1 Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

Graphical View of Domain Structure for InterPro Entry

Q10472

UniProtKB/Swiss-Prot:

GALT1_HUMAN
Domain:
  • There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.:
    • Q10472
  • The ricin B-type lectin domain directs the glycopeptide specificity. It is required in the glycopeptide specificity of enzyme activity but not for activity with naked peptide substrates, suggesting that it triggers the catalytic domain to act on GalNAc-glycopeptide substrates (By similarity).:
    • Q10472
  • Contains 1 ricin B-type lectin domain.:
    • Q10472
Family:
  • Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.:
    • Q10472
genes like me logo Genes that share domains with GALNT1: view

Function for GALNT1 Gene

Molecular function for GALNT1 Gene

GENATLAS Biochemistry: galactosamine
UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide
UniProtKB/Swiss-Prot Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7.

Enzyme Numbers (IUBMB) for GALNT1 Gene

Gene Ontology (GO) - Molecular Function for GALNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity IDA 9295285
GO:0030145 manganese ion binding IDA 9295285
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with GALNT1: view
genes like me logo Genes that share phenotypes with GALNT1: view

Animal Models for GALNT1 Gene

MGI Knock Outs for GALNT1:

miRNA for GALNT1 Gene

miRTarBase miRNAs that target GALNT1

No data available for Transcription Factor Targeting and HOMER Transcription for GALNT1 Gene

Localization for GALNT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GALNT1 Gene

Polypeptide N-acetylgalactosaminyltransferase 1: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Polypeptide N-acetylgalactosaminyltransferase 1 soluble form: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GALNT1 Gene COMPARTMENTS Subcellular localization image for GALNT1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GALNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region IEA --
GO:0005794 colocalizes_with Golgi apparatus IDA 12506059
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GALNT1: view

Pathways for GALNT1 Gene

genes like me logo Genes that share pathways with GALNT1: view

Pathways by source for GALNT1 Gene

UniProtKB/Swiss-Prot Q10472-GALT1_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for GALNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0018242 protein O-linked glycosylation via serine IDA 9295285
GO:0018243 protein O-linked glycosylation via threonine IDA 9295285
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with GALNT1: view

Compounds for GALNT1 Gene

(5) HMDB Compounds for GALNT1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Lactosamine
  • beta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
13000-25-4
Manganese
  • manganese
7439-96-5
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-acetyl-D-galactosamine
7277-98-7

(1) Drugbank Compounds for GALNT1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-D-Mannose
3458-28-4 target
genes like me logo Genes that share compounds with GALNT1: view

Transcripts for GALNT1 Gene

Unigene Clusters for GALNT1 Gene

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GALNT1 Gene

No ASD Table

Relevant External Links for GALNT1 Gene

GeneLoc Exon Structure for
GALNT1
ECgene alternative splicing isoforms for
GALNT1

Expression for GALNT1 Gene

mRNA expression in normal human tissues for GALNT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GALNT1 Gene

SOURCE GeneReport for Unigene cluster for GALNT1 Gene Hs.514806

mRNA Expression by UniProt/SwissProt for GALNT1 Gene

Q10472-GALT1_HUMAN
Tissue specificity: Widely expressed. Expressed in all tissues tested.
genes like me logo Genes that share expressions with GALNT1: view

No data available for mRNA differential expression in normal tissues for GALNT1 Gene

Orthologs for GALNT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GALNT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALNT1 35
  • 99.82 (n)
  • 100 (a)
GALNT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GALNT1 35
  • 95.05 (n)
  • 98.93 (a)
GALNT1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GALNT1 35
  • 96.06 (n)
  • 99.46 (a)
GALNT1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Galnt1 35
  • 93.62 (n)
  • 98.39 (a)
Galnt1 16
Galnt1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GALNT1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GALNT1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Galnt1 35
  • 92.31 (n)
  • 98.93 (a)
chicken
(Gallus gallus)
Aves GALNT1 35
  • 86.29 (n)
  • 97.67 (a)
GALNT1 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GALNT1 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68664 35
tropical clawed frog
(Silurana tropicalis)
Amphibia galnt1 35
  • 80.64 (n)
  • 91.7 (a)
zebrafish
(Danio rerio)
Actinopterygii galnt1 35
  • 77.74 (n)
  • 91.38 (a)
galnt1 36
  • 91 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008613 35
  • 59.12 (n)
  • 67.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta pgant5 35
  • 59.95 (n)
  • 63.55 (a)
pgant5 36
  • 55 (a)
OneToMany
CG10000 37
  • 30 (a)
CG7579 37
  • 30 (a)
BcDNA:GH09147 37
  • 56 (a)
CG7297 37
  • 34 (a)
CG9152 37
  • 65 (a)
CG7304 37
  • 30 (a)
CG2103 37
  • 38 (a)
GalNAc-T1 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea gly-3 35
  • 55.82 (n)
  • 53.02 (a)
gly-3 36
  • 46 (a)
OneToMany
Y45F10D.3 37
  • 41 (a)
gly-7 37
  • 42 (a)
Y39E4B.12a 37
  • 51 (a)
Y47D3A.23 37
  • 41 (a)
H38K22.5b 37
  • 45 (a)
H38K22.5c 37
  • 53 (a)
Y39E4B.12b 37
  • 50 (a)
gly-3 37
  • 47 (a)
Y39E4B.12c 37
  • 51 (a)
Species with no ortholog for GALNT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALNT1 Gene

ENSEMBL:
Gene Tree for GALNT1 (if available)
TreeFam:
Gene Tree for GALNT1 (if available)

Paralogs for GALNT1 Gene

Pseudogenes.org Pseudogenes for GALNT1 Gene

genes like me logo Genes that share paralogs with GALNT1: view

Variants for GALNT1 Gene

Sequence variations from dbSNP and Humsavar for GALNT1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs472312 -- 35,685,383(+) TAGAT(A/T)ATGAA intron-variant
rs475231 -- 35,696,416(+) TTTAG(A/G)GCATC intron-variant
rs475663 -- 35,650,571(+) caacc(A/G)taaaa intron-variant
rs476409 -- 35,650,621(+) ggaaa(C/G)cattc intron-variant
rs487599 -- 35,661,432(+) gagac(A/C)aaggt intron-variant

Relevant External Links for GALNT1 Gene

HapMap Linkage Disequilibrium report
GALNT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GALNT1 Gene

Disorders for GALNT1 Gene

Relevant External Links for GALNT1

Genetic Association Database (GAD)
GALNT1
Human Genome Epidemiology (HuGE) Navigator
GALNT1
genes like me logo Genes that share disorders with GALNT1: view

No data available for UniProtKB/Swiss-Prot for GALNT1 Gene

Publications for GALNT1 Gene

  1. Identification of two cysteine residues involved in the binding of UDP-GalNAc to UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1). (PMID: 12199709) Tenno M. … Kurosaka A. (Eur. J. Biochem. 2002) 2 3 23
  2. Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium. (PMID: 20142253) Phelan C.M. … . (Cancer Epidemiol. Biomarkers Prev. 2010) 3 23 48
  3. Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D- galactosamine:polypeptide N-acetylgalactosaminyltransferase. (PMID: 7592619) White T. … Clausen H. (J. Biol. Chem. 1995) 2 3 4
  4. cDNA cloning, expression, and chromosomal localization of a human UDP-GalNAc:polypeptide, N-acetylgalactosaminyltransferase. (PMID: 8690719) Meurer J.A. … Elhammer A.P. (J. Biochem. 1995) 3 4
  5. Organization of a human UDP-GalNAc:polypeptide, N- acetylgalactosaminyltransferase gene and a related processed pseudogene. (PMID: 8727794) Meurer J.A. … Elhammer A.P. (Glycobiology 1996) 3 4

Products for GALNT1 Gene

Sources for GALNT1 Gene

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