Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GALK2 Gene

protein-coding   GIFtS: 63
GCID: GC15P049447

Galactokinase 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Galactokinase 21 2 3
GK22 3 5
GalNAc Kinase2 3
EC 2.7.1.1573 8
N-Acetylgalactosamine Kinase2
EC 2.7.18

External Ids:    HGNC: 41191   Entrez Gene: 25852   Ensembl: ENSG000001569587   OMIM: 1370285   UniProtKB: Q014153   

Export aliases for GALK2 gene to outside databases

Previous GC identifers: GC15P045019 GC15P042493 GC15P047027 GC15P047164 GC15P047235 GC15P026280


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GALK2 Gene:
This gene encodes a highly efficient N-acetylgalactosamine (GalNAc) kinase, which has galactokinase activity when
galactose is present at high concentrations. Two alternatively spliced transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for GALK2 Gene: 
GALK2 (galactokinase 2) is a protein-coding gene. Diseases associated with GALK2 include galactokinase deficiency, and ocular hypotension, and among its related super-pathways are Galactose metabolism and Metabolism. GO annotations related to this gene include N-acetylgalactosamine kinase activity and galactokinase activity. An important paralog of this gene is GALK1.

UniProtKB/Swiss-Prot: GALK2_HUMAN, Q01415
Function: Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be
involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex
carbohydrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GALK2 gene promoter:
         Nkx6-1   AML1a   FOXO4   FOXJ2 (long isoform)   FOXJ2   C/EBPalpha   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGALK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GALK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GALK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.1-q21.2   Ensembl cytogenetic band:  15q21.1   HGNC cytogenetic band: 15q21.1-q21.2

GALK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GALK2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P049447:  view genomic region     (about GC identifiers)

Start:
49,447,853 bp from pter      End:
49,660,066 bp from pter
Size:
212,214 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GALK2_HUMAN, Q01415 (See protein sequence)
Recommended Name: N-acetylgalactosamine kinase  
Size: 458 amino acids; 50378 Da
Subunit: Monomer
2 PDB 3D structures from and Proteopedia for GALK2:
2A2C (3D)        2A2D (3D)    
Secondary accessions: Q7Z4Q4
Alternative splicing: 2 isoforms:  Q01415-1   Q01415-2   

Explore the universe of human proteins at neXtProt for GALK2: NX_Q01415

Explore proteomics data for GALK2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q01415

  • 4/9 DME Specific Peptides for GALK2 (Q01415) (see all 9)
     YECSCPE  GYSVLPMA  SGLSSSSA  RATDVKLP 

    GALK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GALK2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001001556.1  NP_002035.1  

    ENSEMBL proteins: 
     ENSP00000453193   ENSP00000453457   ENSP00000316632   ENSP00000453961   ENSP00000453849  
     ENSP00000453241   ENSP00000453129   ENSP00000379766   ENSP00000452679   ENSP00000453844  
     ENSP00000454123   ENSP00000453909   ENSP00000440312   ENSP00000452614   ENSP00000453652  
     ENSP00000453133   ENSP00000453252   ENSP00000453257   ENSP00000452637   ENSP00000443220  

    Human Recombinant Protein Products for GALK2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for GALK2
    OriGene Protein Over-expression Lysate for GALK2
    OriGene MassSpec for GALK2 
    OriGene Custom Protein Services for GALK2
    GenScript Custom Purified and Recombinant Proteins Services for GALK2
    Novus Biologicals GALK2 Proteins
    Novus Biologicals GALK2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GALK2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    GALK2 for ontologies           About GeneDecksing



    GALK2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GALK2
    GenScript Custom Superior Antibodies Services for GALK2
    Novus Biologicals GALK2 Antibodies
    Abcam antibodies for GALK2
    Cloud-Clone Corp. Antibodies for GALK2 
    ThermoFisher Antibody for GALK2
    LSBio Antibodies in human, mouse, rat for GALK2 

    Assay Products for GALK2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GALK2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GALK2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GALK2 
    Cloud-Clone Corp. CLIAs for GALK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/9 InterPro protein domains (see all 9):
     IPR000705 Galactokinase
     IPR006206 Mevalonate/galactokinase
     IPR019741 Galactokinase_CS
     IPR019539 GalKase_gal-bd
     IPR020568 Ribosomal_S5_D2-typ_fold

    Graphical View of Domain Structure for InterPro Entry Q01415

    ProtoNet protein and cluster: Q01415

    3 Blocks protein domains:
    IPB000705 Galactokinase
    IPB006203 GHMP kinase
    IPB013750 GHMP kinase


    UniProtKB/Swiss-Prot: GALK2_HUMAN, Q01415
    Similarity: Belongs to the GHMP kinase family. GalK subfamily


    GALK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GALK2_HUMAN, Q01415
    Function: Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be
    involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex
    carbohydrates
    Catalytic activity: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate

         Genatlas biochemistry entry for GALK2:
    galactokinase 2

         Enzyme Numbers (IUBMB): EC 2.7.1.1571 2 EC 2.7.12

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004335galactokinase activity IDA7542884
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:0016773phosphotransferase activity, alcohol group as acceptor ----
    GO:0033858N-acetylgalactosamine kinase activity IEA--
         
    GALK2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for GALK2:
     Decreased mitotic index  Increased cell death in breast  Large nuclei 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GALK2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GALK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GALK2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GALK2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GALK2
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate GALK2 (see all 24):
    hsa-miR-181c hsa-miR-4318 hsa-miR-16-1* hsa-miR-374c hsa-miR-183* hsa-miR-3658 hsa-miR-186 hsa-miR-18b*
    SwitchGear 3'UTR luciferase reporter plasmidGALK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GALK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GALK2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GALK2
    Sirion Biotech Customized adenovirus for overexpression of GALK2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GALK2 (see all 14)
    OriGene ORF clones in mouse, rat for GALK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GALK2 (NM_002044)
    Sino Biological Human cDNA Clone for GALK2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GALK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GALK2
    Sirion Biotech Customized lentivirus for stable overexpression of GALK2 
                         Customized lentivirus expression plasmids for stable overexpression of GALK2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GALK2
    Search LifeMap BioReagents cell lines for GALK2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALK2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GALK2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Galactose metabolism
    Galactose metabolism0.46
    Galactose metabolism0.46
    2Metabolism
    Metabolic pathways0.40
    3Amino sugar and nucleotide sugar metabolism
    Amino sugar and nucleotide sugar metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for GALK2
        Galactose metabolism


    1 GeneGo (Thomson Reuters) Pathway for GALK2
        Galactose metabolism



    3         Kegg Pathways  (Kegg details for GALK2):
        Galactose metabolism
    Amino sugar and nucleotide sugar metabolism
    Metabolic pathways


    GALK2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GALK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/30 Interacting proteins for GALK2 (Q014153 ENSP000003797664) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BLMHQ138673, ENSP000002617144I2D: score=1 STRING: ENSP00000261714
    ELP3Q9H9T33, ENSP000002563984I2D: score=1 STRING: ENSP00000256398
    H3F3AP842433I2D: score=1 
    H3F3BP842433I2D: score=1 
    WDR82Q6UXN93, ENSP000002964904I2D: score=1 STRING: ENSP00000296490
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS8798585
    GO:0006012galactose metabolic process IEA--
    GO:0046835carbohydrate phosphorylation ----

    GALK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GALK2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GALK2

    1 HMDB Compound for GALK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    N-Acetylgalactosamine2-Acetamido-2-desoxy-b-D-talofuranose (see all 113)1811-31-0--

    1 Novoseek inferred chemical compound relationship for GALK2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    galactose 64.2 5 8798585 (2), 7542884 (1), 16006554 (1)

    Search CenterWatch for drugs/clinical trials and news about GALK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GALK2 gene (2 alternative transcripts): 
    NM_001001556.1  NM_002044.2  

    Unigene Cluster for GALK2:

    Galactokinase 2
    Hs.122006  [show with all ESTs]
    Unigene Representative Sequence: NM_001001556
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000559883 ENST00000559963 ENST00000327171(uc001zxi.1 uc001zxj.1 uc010ufb.1 uc001zxk.2 uc010ufc.1)
    ENST00000560654 ENST00000558775 ENST00000561074 ENST00000559040 ENST00000560031
    ENST00000396509 ENST00000558956 ENST00000559208 ENST00000559095 ENST00000558145
    ENST00000560119 ENST00000544523 ENST00000560138 ENST00000559423 ENST00000559454

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GALK2
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate GALK2 (see all 24):
    hsa-miR-181c hsa-miR-4318 hsa-miR-16-1* hsa-miR-374c hsa-miR-183* hsa-miR-3658 hsa-miR-186 hsa-miR-18b*
    SwitchGear 3'UTR luciferase reporter plasmidGALK2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GALK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GALK2
    Clone
    Products:
         
    OriGene clones in human, mouse for GALK2 (see all 14)
    OriGene ORF clones in mouse, rat for GALK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GALK2 (NM_002044)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GALK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GALK2
    Sirion Biotech Customized lentivirus for stable overexpression of GALK2 
                         Customized lentivirus expression plasmids for stable overexpression of GALK2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GALK2
    OriGene qSTAR qPCR primer pairs in human, mouse for GALK2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GALK2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GALK2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GALK2

    Additional mRNA sequence: 

    AF461816.1 AK098049.1 AK301361.1 AK316440.1 AL832745.1 BC005141.2 BT006901.1 M84443.1 

    21 DOTS entries:

    DT.92429030  DT.100799639  DT.97819487  DT.309627  DT.121049838  DT.309626  DT.91708976  DT.121049747 
    DT.100818971  DT.95143967  DT.121049753  DT.100818969  DT.100818974  DT.100818975  DT.99980651  DT.100028538 
    DT.121049779  DT.97826656  DT.100028539  DT.100823423  DT.121049827 

    24/75 AceView cDNA sequences (see all 75):

    BF172544 AL601229 BP375931 BM148141 BI916238 AL709949 BI766538 BX393766 
    BX344863 AL601274 BP373724 AU118231 BX506742 BI768827 BI760818 CD700990 
    CA777641 BI548614 BQ674663 BG427583 BI464839 BU186028 BG401819 BM804902 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GALK2 expression in normal human tissues (normalized intensities)      GALK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTGGACTT
    GALK2 Expression
    About this image


    GALK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/atrium   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
             brain/forebrain/telencephalon   
     
     Lower Urinary Tract (Urinary System)
             visceral organ   
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Blood (Cardiovascular System)
             mouse/organ system/cardiovascular system   

    See GALK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GALK2

    SOURCE GeneReport for Unigene cluster: Hs.122006
        SABiosciences Custom PCR Arrays for GALK2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GALK2
    OriGene qSTAR qPCR primer pairs in human, mouse for GALK2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GALK2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GALK2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GALK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GALK2 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Galk21 , 5 galactokinase 21, 5 85.53(n)1
    89.09(a)1
      2 (61.76 cM)5
    699761  NM_175154.21  NP_780363.11 
     1258591095 
    chicken
    (Gallus gallus)
    Aves GALK21 galactokinase 2 77.44(n)
    79.04(a)
      415596  NM_001030557.1  NP_001025728.1 
    lizard
    (Anolis carolinensis)
    Reptilia GALK26
    Uncharacterized protein
    72(a)
    1 ↔ 1
    GL343506.1(235905-253476)
    African clawed frog
    (Xenopus laevis)
    Amphibia galk2-prov2 galactokinase 2 75.39(n)    BC044977.1 
    zebrafish
    (Danio rerio)
    Actinopterygii galk21 galactokinase 2 63.6(n)
    65.35(a)
      792268  NM_001007432.2  NP_001007433.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG52883
    Galk1
    galactokinase3
    Galactokinase1
    43(a)3
    51.33(n)1
    45.79(a)1
      66E63
    390311  NM_168308.21  NP_729439.11 
    worm
    (Caenorhabditis elegans)
    Secernentea M01D7.43
    tag-961
    galactokinase3
    Protein TAG-961
    39(a)3
    48.44(n)1
    44.09(a)1
      I(1845222-1850403)3
    1717551  NM_058508.21  NP_490909.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GAL1(YBR020W)4
    GAL11
    Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p less4
    Gal1p1
    48.98(n)1
    40.8(a)1
      2(279021-280607)4
    8523081, 4  NP_009576.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GALK1 Galactokinase 53.12(n)
    46.96(a)
      819837  NM_111534.3  NP_187310.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g08326001 hypothetical protein 52.23(n)
    45.85(a)
      4334679  NM_001058338.1  NP_001051803.1 


    ENSEMBL Gene Tree for GALK2 (if available)
    TreeFam Gene Tree for GALK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GALK2 gene
    GALK12  
    18/114 SIMAP similar genes for GALK2 using alignment to 15 protein entries:     GALK2_HUMAN (see all proteins) (see all similar genes):
    BUB1B    C12orf23    TAF2    TGFBR3    ARL6IP5    NLE1
    BIRC3    EIF3K    LRTOMT    NDUFS3    TCTEX1D2    ZNF554
    SLC24A1    BEAN1    PPIL6    SIPA1L3    ARIH1    MUC20

    GALK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2855 SNPs in GALK2 are shown (see all 2855)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438416111,2
    C--49451347(+) TGGCT-/GGG   
       
    /GGGG
    GTGTA
    2 -- int1 cds10--------
    rs116322111,2
    C,F,H--49451375(+) GTACCA/C/TGTGCA 1 -- int114NA EA WA CSA 856
    rs1431649651,2
    --49451458(+) TGAATA/GTCTTT 1 -- int10--------
    rs1509176341,2
    --49451647(+) GTGGCA/GGGTGC 1 -- int10--------
    rs1394059801,2
    C--49451765(+) AAGACC/TCTGTC 1 -- int10--------
    rs31058601,2
    C,A--49451785(+) AAAAAA/TAAAAT 1 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs1139461011,2
    C,F--49451925(+) TACATG/ACAAAT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs745236671,2
    C--49452116(+) CAGCTG/ATGTCT 1 -- int14Minor allele frequency- A:0.08CSA WA NA EA 360
    rs1442453161,2
    C--49452198(+) AGGCAC/TGGTGG 1 -- int10--------
    rs1149126451,2
    F--49452210(+) TCGTGC/TTTGTA 1 -- int11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for GALK2 (49447853 - 49660066 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for GALK2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672599CNV Deletion23128226
    esv2749671CNV Deletion23290073
    esv269481CNV Insertion20981092
    esv272719CNV Insertion20981092
    nsv827332CNV Loss20364138
    esv22168CNV Loss19812545
    nsv833002CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GALK2
    DNA2.0 Custom Variant and Variant Library Synthesis for GALK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 137028    OMIM disorders: --

    6 diseases for GALK2:    About MalaCards
    galactokinase deficiency    ocular hypotension    cryoglobulinemia    pneumonia
    alcoholism    tuberculosis

    1 disease from the University of Copenhagen DISEASES database for GALK2:
    Galactokinase deficiency

    GALK2 for disorders           About GeneDecksing


    Export disorders for GALK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GALK2 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with GALK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The molecular architecture of human N-acetylgalactosamine kinase. (PubMed id 16006554)1, 2, 9 Thoden J.B. and Holden H.M. (2005)
    2. Comparison of the enzymatic activities of human galactokinase GALK1 and a related human galactokinase protein GK2. (PubMed id 7542884)1, 2, 9 Ai Y.... Stambolian D. (1995)
    3. Identification of the GalNAc kinase amino acid sequence. (PubMed id 8798585)1, 2, 9 Pastuszak I.... Elbein A.D. (1996)
    4. Cloning of a human galactokinase gene (GK2) on chromosome 15 by complementation in yeast. (PubMed id 1438294)1, 2, 9 Lee R.T.... O'Donnell J.J. (1992)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Mechanistic studies on human N-acetylgalactosamine ki nase. (PubMed id 19874134)1, 9 Agnew A. and Timson D. (2010)
    7. Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation. (PubMed id 8702831)1, 9 Pastuszak I....Elbein A.D. (1996)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2585 HGNC: 4119 AceView: GALK2 Ensembl:ENSG00000156958 euGenes: HUgn2585
    ECgene: GALK2 Kegg: 2585 H-InvDB: GALK2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GALK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GALK2 gene:
    Search GeneIP for patents involving GALK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GALK2  
     OriGene qPCR primer pairs and template standards for GALK2   OriGene Protein Over-expression Lysate for GALK2  
     OriGene MassSpec something-or-other for GALK2   OriGene clones in human, mouse for GALK2  
     OriGene qSTAR qPCR primer pairs in human, mouse for GALK2   OriGene Purified Protein for GALK2  
     OriGene ORF clones in mouse, rat for GALK2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GALK2   OriGene Custom Protein Services for GALK2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GALK2
     QIAGEN SeqTarget long-range PCR primers for resequencing GALK2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GALK2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GALK2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GALK2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GALK2
     GenScript Custom Purified and Recombinant Proteins Services for GALK2 GenScript cDNA clones with any tag delivered in your preferred vector for GALK2
     GenScript Custom Assay Services for GALK2 GenScript Custom Superior Antibodies Services for GALK2
     GenScript Custom overexpressing Cell Line Services for GALK2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GALK2 promoter
     Search Chromatin IP Primers for GALK2
     RT2 qPCR Primer Assay in human, mouse, rat GALK2
     Search GNC Networks for GALK2
     SABiosciences Custom PCR Arrays for GALK2
     Search Tocris compounds for GALK2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for GALK2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GALK2 antibodies
     GALK2 proteins
     GALK2 lysates
     Antibodies for GALK2
     See all of Abcam's Antibodies, Kits and Proteins for GALK2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for GALK2
     Antibodies for GALK2
     ELISAs for GALK2
     CLIAs for GALK2
     Search LifeMap BioReagents cell lines for GALK2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GALK2
     SwitchGear 3'UTR luciferase reporter plasmids for GALK2
     SwitchGear Promoter luciferase reporter plasmids for GALK2
     ThermoFisher Antibody for GALK2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GALK2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GALK2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GALK2
    Customized:
     lentivirus for stable overexpression of GALK2
     lentivirus expression plasmids for stable overexpression of GALK2
     adenovirus for overexpression of GALK2
     LSBio Antibodies in human, mouse, rat for GALK2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GALK2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4