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Aliases for GALK2 Gene

Aliases for GALK2 Gene

  • Galactokinase 2 2 3 4
  • GK2 3 4 6
  • GalNAc Kinase 3 4
  • EC 2.7.1.157 4 63
  • N-Acetylgalactosamine Kinase 3
  • EC 2.7.1 63

External Ids for GALK2 Gene

Previous GeneCards Identifiers for GALK2 Gene

  • GC15P045019
  • GC15P042493
  • GC15P047027
  • GC15P047164
  • GC15P047235
  • GC15P049447
  • GC15P026280

Summaries for GALK2 Gene

Entrez Gene Summary for GALK2 Gene

  • This gene encodes a highly efficient N-acetylgalactosamine (GalNAc) kinase, which has galactokinase activity when galactose is present at high concentrations. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]

GeneCards Summary for GALK2 Gene

GALK2 (Galactokinase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include galactokinase activity and N-acetylgalactosamine kinase activity. An important paralog of this gene is GALK1.

UniProtKB/Swiss-Prot for GALK2 Gene

  • Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GALK2 Gene

Genomics for GALK2 Gene

Regulatory Elements for GALK2 Gene

Genomic Location for GALK2 Gene

Start:
49,155,656 bp from pter
End:
49,367,869 bp from pter
Size:
212,214 bases
Orientation:
Plus strand

Genomic View for GALK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GALK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GALK2 Gene

Proteins for GALK2 Gene

  • Protein details for GALK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01415-GALK2_HUMAN
    Recommended name:
    N-acetylgalactosamine kinase
    Protein Accession:
    Q01415
    Secondary Accessions:
    • Q7Z4Q4

    Protein attributes for GALK2 Gene

    Size:
    458 amino acids
    Molecular mass:
    50378 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for GALK2 Gene

    Alternative splice isoforms for GALK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GALK2 Gene

Proteomics data for GALK2 Gene at MOPED

Post-translational modifications for GALK2 Gene

  • Ubiquitination at Lys35 and Lys327
  • Modification sites at PhosphoSitePlus

Domains for GALK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q01415

UniProtKB/Swiss-Prot:

GALK2_HUMAN :
  • Q01415
Family:
  • Belongs to the GHMP kinase family. GalK subfamily.
genes like me logo Genes that share domains with GALK2: view

No data available for Gene Families for GALK2 Gene

Function for GALK2 Gene

Molecular function for GALK2 Gene

GENATLAS Biochemistry: galactokinase 2
UniProtKB/Swiss-Prot CatalyticActivity: ATP + N-acetyl-alpha-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
UniProtKB/Swiss-Prot Function: Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates.

Enzyme Numbers (IUBMB) for GALK2 Gene

Gene Ontology (GO) - Molecular Function for GALK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004335 galactokinase activity IDA 7542884
GO:0005524 ATP binding IEA --
GO:0033858 N-acetylgalactosamine kinase activity IEA --
genes like me logo Genes that share ontologies with GALK2: view
genes like me logo Genes that share phenotypes with GALK2: view

Animal Model Products

CRISPR Products

miRNA for GALK2 Gene

miRTarBase miRNAs that target GALK2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GALK2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GALK2 Gene

Localization for GALK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GALK2 Gene COMPARTMENTS Subcellular localization image for GALK2 gene
Compartment Confidence
cytosol 2
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GALK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GALK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GALK2 Gene

Pathways for GALK2 Gene

genes like me logo Genes that share pathways with GALK2: view

Gene Ontology (GO) - Biological Process for GALK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 8798585
GO:0006012 galactose metabolic process IEA --
GO:0046835 carbohydrate phosphorylation IEA --
genes like me logo Genes that share ontologies with GALK2: view

Compounds for GALK2 Gene

(1) HMDB Compounds for GALK2 Gene

Compound Synonyms Cas Number PubMed IDs
N-Acetylgalactosamine
  • 2-Acetamido-2-desoxy-b-D-talofuranose
1811-31-0

(1) Novoseek inferred chemical compound relationships for GALK2 Gene

Compound -log(P) Hits PubMed IDs
galactose 64.2 4
genes like me logo Genes that share compounds with GALK2: view

Transcripts for GALK2 Gene

Unigene Clusters for GALK2 Gene

Galactokinase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GALK2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GALK2 Gene

No ASD Table

Relevant External Links for GALK2 Gene

GeneLoc Exon Structure for
GALK2
ECgene alternative splicing isoforms for
GALK2

Expression for GALK2 Gene

mRNA expression in normal human tissues for GALK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GALK2 Gene

SOURCE GeneReport for Unigene cluster for GALK2 Gene Hs.122006

genes like me logo Genes that share expressions with GALK2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GALK2 Gene

Orthologs for GALK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GALK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GALK2 35
  • 99.64 (n)
  • 99.56 (a)
GALK2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GALK2 35
  • 91.61 (n)
  • 93.65 (a)
GALK2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GALK2 35
  • 90.39 (n)
  • 92.58 (a)
GALK2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Galk2 35
  • 85.53 (n)
  • 89.09 (a)
Galk2 16
Galk2 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GALK2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Galk2 35
  • 85.01 (n)
  • 89.08 (a)
chicken
(Gallus gallus)
Aves GALK2 35
  • 77.44 (n)
  • 79.04 (a)
GALK2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GALK2 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia galk2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia galk2 35
  • 70.97 (n)
  • 73.09 (a)
Str.4096 35
zebrafish
(Danio rerio)
Actinopterygii galk2 35
  • 63.6 (n)
  • 65.35 (a)
galk2 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012568 35
  • 51.19 (n)
  • 46.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta Galk 35
  • 51.17 (n)
  • 45.58 (a)
Galk 36
  • 41 (a)
OneToOne
CG5288 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea tag-96 35
  • 48.48 (n)
  • 44.2 (a)
tag-96 36
  • 41 (a)
OneToOne
M01D7.4 37
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GAL1 36
  • 32 (a)
ManyToMany
GAL1 38
GAL3 35
  • 47.92 (n)
  • 42 (a)
GAL3 36
  • 32 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08393g 35
  • 46.73 (n)
  • 40.64 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3036 35
thale cress
(Arabidopsis thaliana)
eudicotyledons GALK 35
  • 52.58 (n)
  • 46.65 (a)
rice
(Oryza sativa)
Liliopsida Os03g0832600 35
  • 52.34 (n)
  • 45.75 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08687 35
  • 46.25 (n)
  • 41.43 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gal1 35
  • 46.99 (n)
  • 39.13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToOne
Species with no ortholog for GALK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GALK2 Gene

ENSEMBL:
Gene Tree for GALK2 (if available)
TreeFam:
Gene Tree for GALK2 (if available)

Paralogs for GALK2 Gene

Paralogs for GALK2 Gene

genes like me logo Genes that share paralogs with GALK2: view

Variants for GALK2 Gene

Sequence variations from dbSNP and Humsavar for GALK2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs478500 -- 49,205,652(+) ataga(C/T)tgtga intron-variant
rs481466 -- 49,212,584(+) aagat(G/T)catct intron-variant
rs485182 -- 49,165,622(-) tattG(A/G)CATTT intron-variant
rs496645 -- 49,185,575(-) gatgg(A/G)aatgt intron-variant
rs500122 -- 49,202,829(+) TAGAA(A/G)AATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GALK2 Gene

Variant ID Type Subtype PubMed ID
nsv827332 CNV Loss 20364138
esv22168 CNV Loss 19812545
esv2749671 CNV Deletion 23290073
esv2672599 CNV Deletion 23128226
esv269481 CNV Insertion 20981092
esv272719 CNV Insertion 20981092
nsv833002 CNV Gain 17160897

Relevant External Links for GALK2 Gene

HapMap Linkage Disequilibrium report
GALK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GALK2 Gene

Disorders for GALK2 Gene

(1) University of Copenhagen DISEASES for GALK2 Gene

genes like me logo Genes that share disorders with GALK2: view

No data available for UniProtKB/Swiss-Prot for GALK2 Gene

Publications for GALK2 Gene

  1. Identification of the GalNAc kinase amino acid sequence. (PMID: 8798585) Pastuszak I. … Elbein A.D. (J. Biol. Chem. 1996) 3 4 23
  2. The molecular architecture of human N-acetylgalactosamine kinase. (PMID: 16006554) Thoden J.B. … Holden H.M. (J. Biol. Chem. 2005) 3 4 23
  3. Cloning of a human galactokinase gene (GK2) on chromosome 15 by complementation in yeast. (PMID: 1438294) Lee R.T. … O'Donnell J.J. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23
  4. Comparison of the enzymatic activities of human galactokinase GALK1 and a related human galactokinase protein GK2. (PMID: 7542884) Ai Y. … Stambolian D. (Biochem. Biophys. Res. Commun. 1995) 3 4 23
  5. Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation. (PMID: 8702831) Pastuszak I. … Elbein A.D. (J. Biol. Chem. 1996) 3 23

Products for GALK2 Gene

  • Addgene plasmids for GALK2

Sources for GALK2 Gene

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