Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GAL3ST4 Gene

Aliases for GAL3ST4 Gene

  • Galactose-3-O-Sulfotransferase 4 2 3
  • Gal-Beta-1,3-GalNAc 3-Sulfotransferase 3 4
  • Beta-Galactose-3-O-Sulfotransferase 4 3 4
  • GAL3ST-4 3 4
  • Beta-Galactose-3-O-Sulfotransferase, 4 3
  • Galbeta1-3GalNAc 3-Sulfotransferase 3
  • EC 2.8.2.- 4

External Ids for GAL3ST4 Gene

Previous GeneCards Identifiers for GAL3ST4 Gene

  • GC07M099369
  • GC07M099401
  • GC07M099594
  • GC07M099757
  • GC07M094391
  • GC07M099758
  • GC07M099760
  • GC07M099770
  • GC07M099790

Summaries for GAL3ST4 Gene

Entrez Gene Summary for GAL3ST4 Gene

  • This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate to the C-3' position of galactose residues in O-linked glycoproteins. This enzyme is highly specific for core 1 structures, with asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being good substrates. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAL3ST4 Gene

GAL3ST4 (Galactose-3-O-Sulfotransferase 4) is a Protein Coding gene. Among its related pathways are Biological oxidations. GO annotations related to this gene include 3-phosphoadenosine 5-phosphosulfate binding and proteoglycan sulfotransferase activity. An important paralog of this gene is GAL3ST1.

UniProtKB/Swiss-Prot for GAL3ST4 Gene

  • Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc.

Gene Wiki entry for GAL3ST4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAL3ST4 Gene

Genomics for GAL3ST4 Gene

Regulatory Elements for GAL3ST4 Gene

Genomic Location for GAL3ST4 Gene

Start:
100,159,242 bp from pter
End:
100,168,750 bp from pter
Size:
9,509 bases
Orientation:
Minus strand

Genomic View for GAL3ST4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GAL3ST4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAL3ST4 Gene

Proteins for GAL3ST4 Gene

  • Protein details for GAL3ST4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RP7-G3ST4_HUMAN
    Recommended name:
    Galactose-3-O-sulfotransferase 4
    Protein Accession:
    Q96RP7
    Secondary Accessions:
    • A4D2A8
    • B4DWL8
    • D6W5U5
    • Q8N3P7
    • Q8WZ17
    • Q96E33
    • Q9HA78

    Protein attributes for GAL3ST4 Gene

    Size:
    486 amino acids
    Molecular mass:
    54166 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GAL3ST4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAL3ST4 Gene

Proteomics data for GAL3ST4 Gene at MOPED

Post-translational modifications for GAL3ST4 Gene

  • Glycosylation at Asn374
  • Modification sites at PhosphoSitePlus

Other Protein References for GAL3ST4 Gene

No data available for DME Specific Peptides for GAL3ST4 Gene

Domains for GAL3ST4 Gene

Gene Families for GAL3ST4 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for GAL3ST4 Gene

Suggested Antigen Peptide Sequences for GAL3ST4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96RP7

UniProtKB/Swiss-Prot:

G3ST4_HUMAN :
  • Q96RP7
Family:
  • Belongs to the galactose-3-O-sulfotransferase family.
genes like me logo Genes that share domains with GAL3ST4: view

Function for GAL3ST4 Gene

Molecular function for GAL3ST4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is 6-7.;
UniProtKB/Swiss-Prot Function: Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc.

Enzyme Numbers (IUBMB) for GAL3ST4 Gene

Gene Ontology (GO) - Molecular Function for GAL3ST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001733 galactosylceramide sulfotransferase activity IEA --
GO:0050656 3-phosphoadenosine 5-phosphosulfate binding NAS 11333265
GO:0050694 galactose 3-O-sulfotransferase activity IDA 11333265
GO:0050698 proteoglycan sulfotransferase activity NAS 11333265
genes like me logo Genes that share ontologies with GAL3ST4: view

Phenotypes for GAL3ST4 Gene

GenomeRNAi human phenotypes for GAL3ST4:
genes like me logo Genes that share phenotypes with GAL3ST4: view

Animal Model Products

CRISPR Products

miRNA for GAL3ST4 Gene

miRTarBase miRNAs that target GAL3ST4

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GAL3ST4 Gene

Localization for GAL3ST4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAL3ST4 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAL3ST4 Gene COMPARTMENTS Subcellular localization image for GAL3ST4 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GAL3ST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus --
GO:0016020 membrane IDA 11333265
GO:0016021 integral component of membrane NAS 11333265
GO:0032580 Golgi cisterna membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with GAL3ST4: view

Pathways for GAL3ST4 Gene

SuperPathways for GAL3ST4 Gene

Superpath Contained pathways
1 Biological oxidations
genes like me logo Genes that share pathways with GAL3ST4: view

Pathways by source for GAL3ST4 Gene

1 BioSystems pathway for GAL3ST4 Gene

UniProtKB/Swiss-Prot Q96RP7-G3ST4_HUMAN

  • Pathway: Protein modification; carbohydrate sulfation

Interacting Proteins for GAL3ST4 Gene

Selected Interacting proteins: Q96RP7-G3ST4_HUMAN for GAL3ST4 Gene via I2D

Symbol External ID(s) Details
XRCC6

Gene Ontology (GO) - Biological Process for GAL3ST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006790 sulfur compound metabolic process NAS 11333265
GO:0007267 cell-cell signaling NAS 11333265
GO:0009058 biosynthetic process --
GO:0009100 glycoprotein metabolic process NAS 11333265
GO:0009311 oligosaccharide metabolic process NAS 11333265
genes like me logo Genes that share ontologies with GAL3ST4: view

Compounds for GAL3ST4 Gene

(1) HMDB Compounds for GAL3ST4 Gene

Compound Synonyms Cas Number PubMed IDs
Manganese
  • manganese
7439-96-5
genes like me logo Genes that share compounds with GAL3ST4: view

Transcripts for GAL3ST4 Gene

Unigene Clusters for GAL3ST4 Gene

Galactose-3-O-sulfotransferase 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAL3ST4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAL3ST4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3:

Relevant External Links for GAL3ST4 Gene

GeneLoc Exon Structure for
GAL3ST4
ECgene alternative splicing isoforms for
GAL3ST4

Expression for GAL3ST4 Gene

mRNA expression in normal human tissues for GAL3ST4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAL3ST4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (4.6) and Skin - Sun Exposed (Lower leg) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GAL3ST4 Gene

SOURCE GeneReport for Unigene cluster for GAL3ST4 Gene Hs.44856

mRNA Expression by UniProt/SwissProt for GAL3ST4 Gene

Q96RP7-G3ST4_HUMAN
Tissue specificity: Expressed mainly in placenta, thymus, testis, ovary, spinal cord, trachea and adrenal gland and at low levels in brain, lung, spleen, prostate, small intestine, colon, stomach thyroid and lymph node.
genes like me logo Genes that share expressions with GAL3ST4: view

In Situ Assay Products

Orthologs for GAL3ST4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAL3ST4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GAL3ST4 35
  • 99.59 (n)
  • 99.17 (a)
GAL3ST4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GAL3ST4 35
  • 87.58 (n)
  • 88.61 (a)
GAL3ST4 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAL3ST4 35
  • 87.72 (n)
  • 87.86 (a)
GAL3ST4 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gal3st4 35
  • 80.65 (n)
  • 79.33 (a)
Gal3st4 16
Gal3st4 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GAL3ST4 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gal3st4 35
  • 81.35 (n)
  • 80.38 (a)
chicken
(Gallus gallus)
Aves GAL3ST4 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAL3ST4 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gal3st4 35
  • 56.88 (n)
  • 51.95 (a)
zebrafish
(Danio rerio)
Actinopterygii GAL3ST4 36
  • 40 (a)
OneToOne
LOC565556 35
  • 51.01 (n)
  • 45.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
Species with no ortholog for GAL3ST4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAL3ST4 Gene

ENSEMBL:
Gene Tree for GAL3ST4 (if available)
TreeFam:
Gene Tree for GAL3ST4 (if available)

Paralogs for GAL3ST4 Gene

Paralogs for GAL3ST4 Gene

Pseudogenes.org Pseudogenes for GAL3ST4 Gene

genes like me logo Genes that share paralogs with GAL3ST4: view

Variants for GAL3ST4 Gene

Sequence variations from dbSNP and Humsavar for GAL3ST4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1918352 -- 100,165,816(+) accct(A/G)tctca intron-variant
rs2405440 -- 100,163,350(+) CTCCT(A/G)GTCTC intron-variant
rs2405441 -- 100,168,005(+) AGAGA(C/G)ACACA intron-variant
rs7787294 -- 100,162,014(+) aatgc(A/C)tgcag intron-variant
rs7787492 -- 100,162,205(+) tgctt(A/G)agccc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAL3ST4 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv428180 CNV Gain 18775914
nsv888773 CNV Loss 21882294

Relevant External Links for GAL3ST4 Gene

HapMap Linkage Disequilibrium report
GAL3ST4
Human Gene Mutation Database (HGMD)
GAL3ST4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAL3ST4 Gene

Disorders for GAL3ST4 Gene

No disorders were found for GAL3ST4 Gene.

No data available for UniProtKB/Swiss-Prot for GAL3ST4 Gene

Publications for GAL3ST4 Gene

  1. Molecular cloning and characterization of a novel human galactose 3- O-sulfotransferase that transfers sulfate to Galbeta1->3GalNAc residue in O-glycans. (PMID: 11333265) Seko A. … Yamashita K. (J. Biol. Chem. 2001) 2 3 4 23
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4

Products for GAL3ST4 Gene

Sources for GAL3ST4 Gene

Back to Top

Content