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Aliases for GAL3ST4 Gene

Aliases for GAL3ST4 Gene

  • Galactose-3-O-Sulfotransferase 4 2 3 5
  • Gal-Beta-1,3-GalNAc 3-Sulfotransferase 3 4
  • Beta-Galactose-3-O-Sulfotransferase 4 3 4
  • GAL3ST-4 3 4
  • Beta-Galactose-3-O-Sulfotransferase, 4 3
  • Galbeta1-3GalNAc 3-Sulfotransferase 3
  • EC 2.8.2.- 4

External Ids for GAL3ST4 Gene

Previous GeneCards Identifiers for GAL3ST4 Gene

  • GC07M099369
  • GC07M099401
  • GC07M099594
  • GC07M099757
  • GC07M094391
  • GC07M099758
  • GC07M099760
  • GC07M099770
  • GC07M099790

Summaries for GAL3ST4 Gene

Entrez Gene Summary for GAL3ST4 Gene

  • This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate to the C-3' position of galactose residues in O-linked glycoproteins. This enzyme is highly specific for core 1 structures, with asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being good substrates. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAL3ST4 Gene

GAL3ST4 (Galactose-3-O-Sulfotransferase 4) is a Protein Coding gene. Among its related pathways are Phase II conjugation. GO annotations related to this gene include galactosylceramide sulfotransferase activity and proteoglycan sulfotransferase activity. An important paralog of this gene is GAL3ST1.

UniProtKB/Swiss-Prot for GAL3ST4 Gene

  • Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc.

Gene Wiki entry for GAL3ST4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAL3ST4 Gene

Genomics for GAL3ST4 Gene

Regulatory Elements for GAL3ST4 Gene

Promoters for GAL3ST4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GAL3ST4 on UCSC Golden Path with GeneCards custom track

Genomic Location for GAL3ST4 Gene

Chromosome:
7
Start:
100,159,242 bp from pter
End:
100,168,750 bp from pter
Size:
9,509 bases
Orientation:
Minus strand

Genomic View for GAL3ST4 Gene

Genes around GAL3ST4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAL3ST4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAL3ST4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAL3ST4 Gene

Proteins for GAL3ST4 Gene

  • Protein details for GAL3ST4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RP7-G3ST4_HUMAN
    Recommended name:
    Galactose-3-O-sulfotransferase 4
    Protein Accession:
    Q96RP7
    Secondary Accessions:
    • A4D2A8
    • B4DWL8
    • D6W5U5
    • Q8N3P7
    • Q8WZ17
    • Q96E33
    • Q9HA78

    Protein attributes for GAL3ST4 Gene

    Size:
    486 amino acids
    Molecular mass:
    54166 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GAL3ST4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAL3ST4 Gene

Proteomics data for GAL3ST4 Gene at MOPED

Post-translational modifications for GAL3ST4 Gene

  • Glycosylation at Asn 374
  • Modification sites at PhosphoSitePlus

Other Protein References for GAL3ST4 Gene

No data available for DME Specific Peptides for GAL3ST4 Gene

Domains & Families for GAL3ST4 Gene

Gene Families for GAL3ST4 Gene

Protein Domains for GAL3ST4 Gene

Suggested Antigen Peptide Sequences for GAL3ST4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96RP7

UniProtKB/Swiss-Prot:

G3ST4_HUMAN :
  • Belongs to the galactose-3-O-sulfotransferase family.
Family:
  • Belongs to the galactose-3-O-sulfotransferase family.
genes like me logo Genes that share domains with GAL3ST4: view

Function for GAL3ST4 Gene

Molecular function for GAL3ST4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6-7.;
UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc.

Enzyme Numbers (IUBMB) for GAL3ST4 Gene

genes like me logo Genes that share phenotypes with GAL3ST4: view

Animal Model Products

CRISPR Products

miRNA for GAL3ST4 Gene

miRTarBase miRNAs that target GAL3ST4

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAL3ST4 Gene

Localization for GAL3ST4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAL3ST4 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAL3ST4 Gene COMPARTMENTS Subcellular localization image for GAL3ST4 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GAL3ST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,NAS 11333265
genes like me logo Genes that share ontologies with GAL3ST4: view

Pathways & Interactions for GAL3ST4 Gene

SuperPathways for GAL3ST4 Gene

Superpath Contained pathways
1 Phase II conjugation
genes like me logo Genes that share pathways with GAL3ST4: view

Pathways by source for GAL3ST4 Gene

1 BioSystems pathway for GAL3ST4 Gene

UniProtKB/Swiss-Prot Q96RP7-G3ST4_HUMAN

  • Pathway: Protein modification; carbohydrate sulfation.

Interacting Proteins for GAL3ST4 Gene

Selected Interacting proteins: Q96RP7-G3ST4_HUMAN for GAL3ST4 Gene via I2D

Symbol External ID(s) Details
XRCC6

Gene Ontology (GO) - Biological Process for GAL3ST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009058 biosynthetic process IEA --
GO:0009100 glycoprotein metabolic process NAS 11333265
genes like me logo Genes that share ontologies with GAL3ST4: view

No data available for SIGNOR curated interactions for GAL3ST4 Gene

Drugs & Compounds for GAL3ST4 Gene

(1) Drugs for GAL3ST4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Pharma 32
genes like me logo Genes that share compounds with GAL3ST4: view

Transcripts for GAL3ST4 Gene

Unigene Clusters for GAL3ST4 Gene

Galactose-3-O-sulfotransferase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GAL3ST4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3:

Relevant External Links for GAL3ST4 Gene

GeneLoc Exon Structure for
GAL3ST4
ECgene alternative splicing isoforms for
GAL3ST4

Expression for GAL3ST4 Gene

mRNA expression in normal human tissues for GAL3ST4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAL3ST4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.6) and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for GAL3ST4 Gene

This gene is overexpressed in Heart (47.4), Placenta (9.7), and Pancreas (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GAL3ST4 Gene



SOURCE GeneReport for Unigene cluster for GAL3ST4 Gene Hs.44856

mRNA Expression by UniProt/SwissProt for GAL3ST4 Gene

Q96RP7-G3ST4_HUMAN
Tissue specificity: Expressed mainly in placenta, thymus, testis, ovary, spinal cord, trachea and adrenal gland and at low levels in brain, lung, spleen, prostate, small intestine, colon, stomach thyroid and lymph node.
genes like me logo Genes that share expression patterns with GAL3ST4: view

Protein tissue co-expression partners for GAL3ST4 Gene

Primer Products

In Situ Assay Products

Orthologs for GAL3ST4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAL3ST4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GAL3ST4 35
  • 87.58 (n)
  • 88.61 (a)
GAL3ST4 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAL3ST4 35
  • 87.72 (n)
  • 87.86 (a)
GAL3ST4 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gal3st4 35
  • 80.65 (n)
  • 79.33 (a)
Gal3st4 16
Gal3st4 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GAL3ST4 35
  • 99.59 (n)
  • 99.17 (a)
GAL3ST4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gal3st4 35
  • 81.35 (n)
  • 80.38 (a)
oppossum
(Monodelphis domestica)
Mammalia GAL3ST4 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves GAL3ST4 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAL3ST4 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gal3st4 35
  • 56.88 (n)
  • 51.95 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC565556 35
  • 51.01 (n)
  • 45.73 (a)
GAL3ST4 36
  • 40 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
Species with no ortholog for GAL3ST4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAL3ST4 Gene

ENSEMBL:
Gene Tree for GAL3ST4 (if available)
TreeFam:
Gene Tree for GAL3ST4 (if available)

Paralogs for GAL3ST4 Gene

Paralogs for GAL3ST4 Gene

Pseudogenes.org Pseudogenes for GAL3ST4 Gene

genes like me logo Genes that share paralogs with GAL3ST4: view

Variants for GAL3ST4 Gene

Sequence variations from dbSNP and Humsavar for GAL3ST4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_021989 -
VAR_033736 -
rs1918352 -- 100,165,816(+) accct(A/G)tctca intron-variant
rs2405440 -- 100,163,350(+) CTCCT(A/G)GTCTC intron-variant
rs2405441 -- 100,168,005(+) AGAGA(C/G)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAL3ST4 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv428180 CNV Gain 18775914
nsv888773 CNV Loss 21882294

Variation tolerance for GAL3ST4 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAL3ST4 Gene

HapMap Linkage Disequilibrium report
GAL3ST4
Human Gene Mutation Database (HGMD)
GAL3ST4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAL3ST4 Gene

Disorders for GAL3ST4 Gene

Relevant External Links for GAL3ST4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAL3ST4

No disorders were found for GAL3ST4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAL3ST4 Gene

Publications for GAL3ST4 Gene

  1. Molecular cloning and characterization of a novel human galactose 3- O-sulfotransferase that transfers sulfate to Galbeta1->3GalNAc residue in O-glycans. (PMID: 11333265) Seko A. … Yamashita K. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Evidence for GAL3ST4 mutation as the potential cause of pectus excavatum. (PMID: 23147795) Wu S. … Wang D. (Cell Res. 2012) 3
  3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 3
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Identification of physiologically relevant substrates for cloned Gal: 3-O-sulfotransferases (Gal3STs): distinct high affinity of Gal3ST-2 and LS180 sulfotransferase for the globo H backbone, Gal3ST-3 for N-glycan multiterminal Galbeta1, 4GlcNAcbeta units and 6-sulfoGalbeta1, 4GlcNAcbeta, and Gal3ST-4 for the mucin core-2 trisaccharide. (PMID: 14701868) Chandrasekaran E.V. … Matta K.L. (J. Biol. Chem. 2004) 3

Products for GAL3ST4 Gene

Sources for GAL3ST4 Gene

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