Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GAL3ST3 Gene

Aliases for GAL3ST3 Gene

  • Galactose-3-O-Sulfotransferase 3 2 3 5
  • Gal-Beta-1, 3-GalNAc 3-Sulfotransferase 3 3 4
  • Beta-Galactose-3-O-Sulfotransferase 3 3 4
  • GAL3ST-3 3 4
  • Galbeta1-3GalNAc 3-Sulfotransferase 3 3
  • Galactose 3-Sulfotransferase 3
  • EC 2.8.2.- 4
  • GAL3ST2 3
  • Gal3ST3 4

External Ids for GAL3ST3 Gene

Previous GeneCards Identifiers for GAL3ST3 Gene

  • GC11M065587
  • GC11M065566
  • GC11M065810
  • GC11M062134

Summaries for GAL3ST3 Gene

Entrez Gene Summary for GAL3ST3 Gene

  • This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAL3ST3 Gene

GAL3ST3 (Galactose-3-O-Sulfotransferase 3) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include carbohydrate binding and 3-phosphoadenosine 5-phosphosulfate binding. An important paralog of this gene is GAL3ST2.

UniProtKB/Swiss-Prot for GAL3ST3 Gene

  • Transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc.

Gene Wiki entry for GAL3ST3 Gene

Additional gene information for GAL3ST3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAL3ST3 Gene

Genomics for GAL3ST3 Gene

Regulatory Elements for GAL3ST3 Gene

Enhancers for GAL3ST3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H066111 1.5 Ensembl ENCODE dbSUPER 12 -67.0 -66986 10 HNRNPUL1 HDGF PKNOX1 FOXA2 ATF1 ARID4B SIN3A ATF7 FOS RUNX3 ENSG00000255320 SF3B2 SART1 EIF1AD ENSG00000258297 ENSG00000255038 PACS1 KAT5 RBM14 CD248
GH11H065650 2 FANTOM5 Ensembl ENCODE dbSUPER 4.1 +396.5 396469 5 HDGF PKNOX1 FOXA2 ARID4B SIN3A ZBTB7B YY1 ZNF766 ZNF143 ZNF207 KAT5 SF1 SART1 MAP3K11 EHBP1L1 EIF1AD SF3B2 PCNX3 SIPA1 RNASEH2C
GH11H066044 1.2 Ensembl ENCODE 0.7 +3.9 3915 1 HDAC1 RB1 ARID4B SIN3A ZNF2 RAD21 GLIS2 SCRT2 ZNF143 RCOR1 SF3B2 ENSG00000255038 PACS1 ENSG00000255320 GAL3ST3 CATSPER1
GH11H066048 0.8 Ensembl ENCODE 0.7 +0.2 189 1 ZFHX2 POLR2A EZH2 EGR2 PACS1 GAL3ST3 CATSPER1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GAL3ST3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GAL3ST3 Gene

Chromosome:
11
Start:
66,040,765 bp from pter
End:
66,049,180 bp from pter
Size:
8,416 bases
Orientation:
Minus strand

Genomic View for GAL3ST3 Gene

Genes around GAL3ST3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAL3ST3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAL3ST3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAL3ST3 Gene

Proteins for GAL3ST3 Gene

  • Protein details for GAL3ST3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A11-G3ST3_HUMAN
    Recommended name:
    Galactose-3-O-sulfotransferase 3
    Protein Accession:
    Q96A11
    Secondary Accessions:
    • Q14D05

    Protein attributes for GAL3ST3 Gene

    Size:
    431 amino acids
    Molecular mass:
    48956 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for GAL3ST3 Gene

Post-translational modifications for GAL3ST3 Gene

  • Glycosylation at posLast=9191, isoforms=110, posLast=177177, and posLast=302302
  • Modification sites at PhosphoSitePlus

Other Protein References for GAL3ST3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAL3ST3 Gene

Domains & Families for GAL3ST3 Gene

Gene Families for GAL3ST3 Gene

Protein Domains for GAL3ST3 Gene

Suggested Antigen Peptide Sequences for GAL3ST3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A11

UniProtKB/Swiss-Prot:

G3ST3_HUMAN :
  • Belongs to the galactose-3-O-sulfotransferase family.
Family:
  • Belongs to the galactose-3-O-sulfotransferase family.
genes like me logo Genes that share domains with GAL3ST3: view

Function for GAL3ST3 Gene

Molecular function for GAL3ST3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.0-8.0.;
UniProtKB/Swiss-Prot Function:
Transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc.

Enzyme Numbers (IUBMB) for GAL3ST3 Gene

Phenotypes From GWAS Catalog for GAL3ST3 Gene

Gene Ontology (GO) - Molecular Function for GAL3ST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001733 galactosylceramide sulfotransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0030246 carbohydrate binding NAS 11323440
GO:0050656 3-phosphoadenosine 5-phosphosulfate binding NAS 11323440
GO:0050694 galactose 3-O-sulfotransferase activity IMP 11356829
genes like me logo Genes that share ontologies with GAL3ST3: view
genes like me logo Genes that share phenotypes with GAL3ST3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GAL3ST3

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GAL3ST3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAL3ST3 Gene

Localization for GAL3ST3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAL3ST3 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAL3ST3 gene
Compartment Confidence
golgi apparatus 4
extracellular 2
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GAL3ST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11323440
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with GAL3ST3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GAL3ST3 Gene

Pathways & Interactions for GAL3ST3 Gene

genes like me logo Genes that share pathways with GAL3ST3: view

Pathways by source for GAL3ST3 Gene

1 BioSystems pathway for GAL3ST3 Gene

UniProtKB/Swiss-Prot Q96A11-G3ST3_HUMAN

  • Pathway: Protein modification; carbohydrate sulfation.

Interacting Proteins for GAL3ST3 Gene

Selected Interacting proteins: Q96A11-G3ST3_HUMAN for GAL3ST3 Gene via IID

Symbol External ID(s) Details
GPC2
SPN

Gene Ontology (GO) - Biological Process for GAL3ST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005996 monosaccharide metabolic process NAS 11323440
GO:0006790 sulfur compound metabolic process NAS 11323440
GO:0009247 glycolipid biosynthetic process IEA --
GO:0009311 oligosaccharide metabolic process NAS 11323440
GO:0030166 proteoglycan biosynthetic process NAS 11356829
genes like me logo Genes that share ontologies with GAL3ST3: view

No data available for SIGNOR curated interactions for GAL3ST3 Gene

Drugs & Compounds for GAL3ST3 Gene

(1) Drugs for GAL3ST3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0

(1) Additional Compounds for GAL3ST3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Poly-N-acetyllactosamine
  • 2-(Acetylamino)-2-deoxy-4-O-beta-D-galactopyranosyl-D-Glucose
  • 2-(Acetylamino)-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose homopolymer
  • N-Acetyl-4-O-beta-D-galactopyranosyl-D-glucosamine
  • N-Acetyl-lactosamine
  • O-beta-D-Galactopyranosyl-(14)-2-deoxy-2-acetamido-D-glucose
82441-98-3
genes like me logo Genes that share compounds with GAL3ST3: view

Transcripts for GAL3ST3 Gene

mRNA/cDNA for GAL3ST3 Gene

Unigene Clusters for GAL3ST3 Gene

Galactose-3-O-sulfotransferase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GAL3ST3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GAL3ST3 Gene

No ASD Table

Relevant External Links for GAL3ST3 Gene

GeneLoc Exon Structure for
GAL3ST3
ECgene alternative splicing isoforms for
GAL3ST3

Expression for GAL3ST3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAL3ST3 Gene

mRNA differential expression in normal tissues according to GTEx for GAL3ST3 Gene

This gene is overexpressed in Thyroid (x5.6), Brain - Putamen (basal ganglia) (x5.2), and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for GAL3ST3 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GAL3ST3 Gene



Protein tissue co-expression partners for GAL3ST3 Gene

NURSA nuclear receptor signaling pathways regulating expression of GAL3ST3 Gene:

GAL3ST3

SOURCE GeneReport for Unigene cluster for GAL3ST3 Gene:

Hs.208343

mRNA Expression by UniProt/SwissProt for GAL3ST3 Gene:

Q96A11-G3ST3_HUMAN
Tissue specificity: Highly expressed in thyroid, brain, kidney, heart and spinal cord.

Evidence on tissue expression from TISSUES for GAL3ST3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with GAL3ST3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAL3ST3 Gene

Orthologs for GAL3ST3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAL3ST3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GAL3ST3 33 34
  • 99.07 (n)
cow
(Bos Taurus)
Mammalia GAL3ST3 33 34
  • 92.25 (n)
dog
(Canis familiaris)
Mammalia GAL3ST3 33 34
  • 91.94 (n)
rat
(Rattus norvegicus)
Mammalia Gal3st3 33
  • 88.06 (n)
mouse
(Mus musculus)
Mammalia Gal3st3 33 16 34
  • 87.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GAL3ST3 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GAL3ST3 34
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAL3ST3 34
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100330824 33
  • 59.22 (n)
CABZ01088238.1 34
  • 55 (a)
OneToOne
Species where no ortholog for GAL3ST3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAL3ST3 Gene

ENSEMBL:
Gene Tree for GAL3ST3 (if available)
TreeFam:
Gene Tree for GAL3ST3 (if available)

Paralogs for GAL3ST3 Gene

Paralogs for GAL3ST3 Gene

(2) SIMAP similar genes for GAL3ST3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GAL3ST3: view

Variants for GAL3ST3 Gene

Sequence variations from dbSNP and Humsavar for GAL3ST3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000647311 -- 66,048,036(+) GGGCT(A/G)GGTTT intron-variant
rs1000995568 -- 66,044,864(+) GTTCA(C/T)ACAGT intron-variant
rs1001045099 -- 66,044,500(+) TTCTC(A/G)TTTTT intron-variant
rs1001128804 -- 66,046,075(+) ATTTA(G/T)TCCTC intron-variant, upstream-variant-2KB
rs1001190855 -- 66,044,463(+) GGAGA(C/T)GACTC intron-variant

Variation tolerance for GAL3ST3 Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.23; 76.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAL3ST3 Gene

Human Gene Mutation Database (HGMD)
GAL3ST3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAL3ST3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GAL3ST3 Gene

Disorders for GAL3ST3 Gene

Relevant External Links for GAL3ST3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAL3ST3

No disorders were found for GAL3ST3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAL3ST3 Gene

Publications for GAL3ST3 Gene

  1. Molecular cloning and expression of a novel human beta-Gal-3-O-sulfotransferase that acts preferentially on N-acetyllactosamine in N- and O-glycans. (PMID: 11323440) Suzuki A … Fukuda M (The Journal of biological chemistry 2001) 2 3 4 22 60
  2. A novel human Gal-3-O-sulfotransferase: molecular cloning, characterization, and its implications in biosynthesis of (SO(4)-3)Galbeta1-4(Fucalpha1-3)GlcNAc. (PMID: 11356829) El-Fasakhany FM … Muramatsu T (The Journal of biological chemistry 2001) 2 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Molecular cloning and characterization of a novel human galactose 3-O-sulfotransferase that transfers sulfate to gal beta 1-->3galNAc residue in O-glycans. (PMID: 11333265) Seko A … Yamashita K (The Journal of biological chemistry 2001) 3 22 60
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 60

Products for GAL3ST3 Gene

Sources for GAL3ST3 Gene

Content
Loading form....