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Aliases for GAL3ST3 Gene

Aliases for GAL3ST3 Gene

  • Galactose-3-O-Sulfotransferase 3 2 3 5
  • Gal-Beta-1, 3-GalNAc 3-Sulfotransferase 3 3 4
  • Beta-Galactose-3-O-Sulfotransferase 3 3 4
  • GAL3ST-3 3 4
  • Galbeta1-3GalNAc 3-Sulfotransferase 3 3
  • Galactose 3-Sulfotransferase 3
  • EC 2.8.2.- 4
  • GAL3ST2 3
  • Gal3ST3 4

External Ids for GAL3ST3 Gene

Previous GeneCards Identifiers for GAL3ST3 Gene

  • GC11M065587
  • GC11M065566
  • GC11M065810
  • GC11M062134

Summaries for GAL3ST3 Gene

Entrez Gene Summary for GAL3ST3 Gene

  • This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAL3ST3 Gene

GAL3ST3 (Galactose-3-O-Sulfotransferase 3) is a Protein Coding gene. Among its related pathways are Phase II conjugation. GO annotations related to this gene include carbohydrate binding and 3-phosphoadenosine 5-phosphosulfate binding. An important paralog of this gene is GAL3ST1.

UniProtKB/Swiss-Prot for GAL3ST3 Gene

  • Transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc.

Gene Wiki entry for GAL3ST3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAL3ST3 Gene

Genomics for GAL3ST3 Gene

Regulatory Elements for GAL3ST3 Gene

Enhancers for GAL3ST3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GAL3ST3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GAL3ST3 Gene

Chromosome:
11
Start:
66,040,765 bp from pter
End:
66,049,180 bp from pter
Size:
8,416 bases
Orientation:
Minus strand

Genomic View for GAL3ST3 Gene

Genes around GAL3ST3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAL3ST3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAL3ST3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAL3ST3 Gene

Proteins for GAL3ST3 Gene

  • Protein details for GAL3ST3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A11-G3ST3_HUMAN
    Recommended name:
    Galactose-3-O-sulfotransferase 3
    Protein Accession:
    Q96A11
    Secondary Accessions:
    • Q14D05

    Protein attributes for GAL3ST3 Gene

    Size:
    431 amino acids
    Molecular mass:
    48956 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for GAL3ST3 Gene

Proteomics data for GAL3ST3 Gene at MOPED

Post-translational modifications for GAL3ST3 Gene

  • Glycosylation at Asn 91, Asn 110, Asn 177, and Asn 302
  • Modification sites at PhosphoSitePlus

Other Protein References for GAL3ST3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GAL3ST3 Gene

Domains & Families for GAL3ST3 Gene

Gene Families for GAL3ST3 Gene

Protein Domains for GAL3ST3 Gene

Suggested Antigen Peptide Sequences for GAL3ST3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A11

UniProtKB/Swiss-Prot:

G3ST3_HUMAN :
  • Belongs to the galactose-3-O-sulfotransferase family.
Family:
  • Belongs to the galactose-3-O-sulfotransferase family.
genes like me logo Genes that share domains with GAL3ST3: view

Function for GAL3ST3 Gene

Molecular function for GAL3ST3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.0-8.0.;
UniProtKB/Swiss-Prot Function:
Transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc.

Enzyme Numbers (IUBMB) for GAL3ST3 Gene

genes like me logo Genes that share phenotypes with GAL3ST3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GAL3ST3

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAL3ST3 Gene

Localization for GAL3ST3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAL3ST3 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAL3ST3 Gene COMPARTMENTS Subcellular localization image for GAL3ST3 gene
Compartment Confidence
golgi apparatus 4
extracellular 2
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for GAL3ST3 Gene

Pathways & Interactions for GAL3ST3 Gene

SuperPathways for GAL3ST3 Gene

Superpath Contained pathways
1 Phase II conjugation
genes like me logo Genes that share pathways with GAL3ST3: view

Pathways by source for GAL3ST3 Gene

1 BioSystems pathway for GAL3ST3 Gene

UniProtKB/Swiss-Prot Q96A11-G3ST3_HUMAN

  • Pathway: Protein modification; carbohydrate sulfation.

Interacting Proteins for GAL3ST3 Gene

Gene Ontology (GO) - Biological Process for GAL3ST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005996 monosaccharide metabolic process NAS 11323440
GO:0009058 biosynthetic process IEA --
GO:0009311 oligosaccharide metabolic process NAS 11323440
genes like me logo Genes that share ontologies with GAL3ST3: view

No data available for SIGNOR curated interactions for GAL3ST3 Gene

Drugs & Compounds for GAL3ST3 Gene

(1) Drugs for GAL3ST3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0

(1) Additional Compounds for GAL3ST3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Poly-N-acetyllactosamine
  • 2-(Acetylamino)-2-deoxy-4-O-beta-D-galactopyranosyl-D-Glucose
  • 2-(Acetylamino)-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose homopolymer
  • N-Acetyl-4-O-beta-D-galactopyranosyl-D-glucosamine
  • N-Acetyl-lactosamine
  • O-beta-D-Galactopyranosyl-(14)-2-deoxy-2-acetamido-D-glucose
82441-98-3
genes like me logo Genes that share compounds with GAL3ST3: view

Transcripts for GAL3ST3 Gene

mRNA/cDNA for GAL3ST3 Gene

Unigene Clusters for GAL3ST3 Gene

Galactose-3-O-sulfotransferase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GAL3ST3 Gene

No ASD Table

Relevant External Links for GAL3ST3 Gene

GeneLoc Exon Structure for
GAL3ST3
ECgene alternative splicing isoforms for
GAL3ST3

Expression for GAL3ST3 Gene

mRNA expression in normal human tissues for GAL3ST3 Gene

mRNA differential expression in normal tissues according to GTEx for GAL3ST3 Gene

This gene is overexpressed in Thyroid (x5.6), Brain - Putamen (basal ganglia) (x5.2), and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for GAL3ST3 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GAL3ST3 Gene



SOURCE GeneReport for Unigene cluster for GAL3ST3 Gene Hs.208343

mRNA Expression by UniProt/SwissProt for GAL3ST3 Gene

Q96A11-G3ST3_HUMAN
Tissue specificity: Highly expressed in thyroid, brain, kidney, heart and spinal cord.
genes like me logo Genes that share expression patterns with GAL3ST3: view

Protein tissue co-expression partners for GAL3ST3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GAL3ST3 Gene

Orthologs for GAL3ST3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAL3ST3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GAL3ST3 35
  • 92.25 (n)
  • 94.84 (a)
GAL3ST3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAL3ST3 35
  • 91.94 (n)
  • 96.28 (a)
GAL3ST3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gal3st3 35
  • 87.98 (n)
  • 94.88 (a)
Gal3st3 16
Gal3st3 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GAL3ST3 35
  • 99.07 (n)
  • 98.33 (a)
GAL3ST3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gal3st3 35
  • 88.06 (n)
  • 95.12 (a)
oppossum
(Monodelphis domestica)
Mammalia GAL3ST3 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GAL3ST3 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAL3ST3 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100330824 35
  • 59.22 (n)
  • 59.22 (a)
CABZ01088238.1 36
  • 55 (a)
OneToOne
Species with no ortholog for GAL3ST3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAL3ST3 Gene

ENSEMBL:
Gene Tree for GAL3ST3 (if available)
TreeFam:
Gene Tree for GAL3ST3 (if available)

Paralogs for GAL3ST3 Gene

Paralogs for GAL3ST3 Gene

(2) SIMAP similar genes for GAL3ST3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GAL3ST3: view

Variants for GAL3ST3 Gene

Sequence variations from dbSNP and Humsavar for GAL3ST3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs35285455 - 66,043,141(+) AGGCG(G/T)CGTCG reference, missense
rs4565902 - 66,042,574(+) CGGGC(G/T)CGGGC reference, missense
rs1125078 -- 66,042,404(+) AGCCC(A/C)TTGAA utr-variant-3-prime
rs2000672 -- 66,040,533(-) AATCT(C/T)GGCTC downstream-variant-500B
rs11600888 -- 66,049,103(+) GAGGG(G/T)GCCCG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GAL3ST3 Gene

Variant ID Type Subtype PubMed ID
dgv1186n71 CNV Loss 21882294
nsv897770 CNV Loss 21882294

Variation tolerance for GAL3ST3 Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.23; 76.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAL3ST3 Gene

HapMap Linkage Disequilibrium report
GAL3ST3
Human Gene Mutation Database (HGMD)
GAL3ST3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAL3ST3 Gene

Disorders for GAL3ST3 Gene

Relevant External Links for GAL3ST3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAL3ST3

No disorders were found for GAL3ST3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAL3ST3 Gene

Publications for GAL3ST3 Gene

  1. Molecular cloning and expression of a novel human beta-Gal-3-O- sulfotransferase that acts preferentially on N-acetyllactosamine in N- and O-glycans. (PMID: 11323440) Suzuki A. … Fukuda M. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. A novel human Gal-3-O-sulfotransferase: molecular cloning, characterization, and its implications in biosynthesis of (SO4- 3)Galbeta 1-4(Fucalpha 1-3)GlcNAc. (PMID: 11356829) El-Fasakhany F.M. … Muramatsu T. (J. Biol. Chem. 2001) 2 3
  3. Molecular cloning and characterization of a novel human galactose 3- O-sulfotransferase that transfers sulfate to Galbeta1->3GalNAc residue in O-glycans. (PMID: 11333265) Seko A. … Yamashita K. (J. Biol. Chem. 2001) 3 23
  4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  5. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3

Products for GAL3ST3 Gene

Sources for GAL3ST3 Gene

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