Aliases for GAL3ST3 Gene
External Ids for GAL3ST3 Gene
Previous GeneCards Identifiers for GAL3ST3 Gene
This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3. [provided by RefSeq, Jul 2008]
GeneCards Summary for GAL3ST3 Gene
GAL3ST3 (Galactose-3-O-Sulfotransferase 3) is a Protein Coding gene. Among its related pathways are Phase II conjugation. GO annotations related to this gene include carbohydrate binding and 3-phosphoadenosine 5-phosphosulfate binding. An important paralog of this gene is GAL3ST2.
UniProtKB/Swiss-Prot for GAL3ST3 Gene
Transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc.