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Aliases for GAL3ST2 Gene

Aliases for GAL3ST2 Gene

  • Galactose-3-O-Sulfotransferase 2 2 3 5
  • Glycoprotein Beta-Gal 3-Sulfotransferase 2 3 4
  • Gal-Beta-1, 3-GalNAc 3-Sulfotransferase 2 3 4
  • Beta-Galactose-3-O-Sulfotransferase 2 3 4
  • GAL3ST-2 3 4
  • GP3ST 3 4
  • Galbeta1-3GalNAc 3-Sulfotransferase 2 3
  • Gal 3-O-Sulphotransferase 3
  • EC 2.8.2.- 4

External Ids for GAL3ST2 Gene

Previous GeneCards Identifiers for GAL3ST2 Gene

  • GC11M068343
  • GC11M067490
  • GC11M066059
  • GC11M065585
  • GC02P243038
  • GC02P242436
  • GC02P242364
  • GC02P242716
  • GC02P234469

Summaries for GAL3ST2 Gene

Entrez Gene Summary for GAL3ST2 Gene

  • This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. This enzyme has been implicated in tumor metastasis processes. This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAL3ST2 Gene

GAL3ST2 (Galactose-3-O-Sulfotransferase 2) is a Protein Coding gene. Diseases associated with GAL3ST2 include Mucinous Adenocarcinoma. Among its related pathways are Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include sulfotransferase activity and galactosylceramide sulfotransferase activity. An important paralog of this gene is GAL3ST4.

UniProtKB/Swiss-Prot for GAL3ST2 Gene

  • Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency.

Gene Wiki entry for GAL3ST2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAL3ST2 Gene

Genomics for GAL3ST2 Gene

Regulatory Elements for GAL3ST2 Gene

Enhancers for GAL3ST2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F241769 1.4 FANTOM5 Ensembl ENCODE 13.1 -4.0 -4004 6.3 HDGF PKNOX1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 PAF1 SP5 D2HGDH GAL3ST2 ENSG00000223374 NEU4 GC02P241774 LOC105373976
GH02F241739 1.4 FANTOM5 Ensembl ENCODE 11.6 -36.2 -36225 2.0 GATA3 NR2F1 RARA NFE2L2 D2HGDH NEU4 ENSG00000215023 ING5 GAL3ST2 RTP5 ATG4B ENSG00000215692 GC02P241747
GH02F241762 1.1 FANTOM5 Ensembl ENCODE 6.8 -13.6 -13559 2.1 KLF1 PKNOX1 MAX EBF1 ZNF316 GATA3 POLR2A EED ZNF207 RCOR1 D2HGDH GAL3ST2 ENSG00000224272 ATG4B PDCD1 PIR37451 LOC105373976
GH02F241733 0.6 ENCODE 6.4 -41.8 -41815 2.1 HDGF MLX ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF121 GLIS2 SP5 D2HGDH GAL3ST2 GC02P241738 PIR35530
GH02F241802 1 Ensembl ENCODE 5.6 +31.1 31130 10.3 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 ZNF263 SP5 ZHX2 ENSG00000224272 NEU4 D2HGDH RTP5 ENSG00000234793 ENSG00000235151 PDCD1 GAL3ST2 LINC01237 PIR47886
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GAL3ST2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GAL3ST2 Gene

241,776,825 bp from pter
241,804,287 bp from pter
27,463 bases
Plus strand

Genomic View for GAL3ST2 Gene

Genes around GAL3ST2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAL3ST2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAL3ST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAL3ST2 Gene

Proteins for GAL3ST2 Gene

  • Protein details for GAL3ST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Galactose-3-O-sulfotransferase 2
    Protein Accession:
    Secondary Accessions:
    • Q17RK0
    • Q57Z52

    Protein attributes for GAL3ST2 Gene

    398 amino acids
    Molecular mass:
    46110 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GAL3ST2 Gene

Post-translational modifications for GAL3ST2 Gene

  • Glycosylation at Asn 79, Asn 132, Asn 179, Asn 287, Asn 330, and Asn 360
  • Modification sites at PhosphoSitePlus

Other Protein References for GAL3ST2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAL3ST2 Gene

Domains & Families for GAL3ST2 Gene

Gene Families for GAL3ST2 Gene

Protein Domains for GAL3ST2 Gene

Suggested Antigen Peptide Sequences for GAL3ST2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the galactose-3-O-sulfotransferase family.
  • Belongs to the galactose-3-O-sulfotransferase family.
genes like me logo Genes that share domains with GAL3ST2: view

Function for GAL3ST2 Gene

Molecular function for GAL3ST2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.0-6.5.;
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by Cu(2+) and Zn(2+).
UniProtKB/Swiss-Prot Function:
Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency.

Enzyme Numbers (IUBMB) for GAL3ST2 Gene

Gene Ontology (GO) - Molecular Function for GAL3ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001733 galactosylceramide sulfotransferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008146 sulfotransferase activity IDA 11029462
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with GAL3ST2: view
genes like me logo Genes that share phenotypes with GAL3ST2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAL3ST2 Gene

Localization for GAL3ST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAL3ST2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for GAL3ST2 Gene COMPARTMENTS Subcellular localization image for GAL3ST2 gene
Compartment Confidence
golgi apparatus 4
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GAL3ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane TAS 11029462
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with GAL3ST2: view

Pathways & Interactions for GAL3ST2 Gene

genes like me logo Genes that share pathways with GAL3ST2: view

Pathways by source for GAL3ST2 Gene

1 BioSystems pathway for GAL3ST2 Gene

UniProtKB/Swiss-Prot Q9H3Q3-G3ST2_HUMAN

  • Pathway: Protein modification; carbohydrate sulfation.

Interacting Proteins for GAL3ST2 Gene

Selected Interacting proteins: Q9H3Q3-G3ST2_HUMAN for GAL3ST2 Gene via UniProtKB IID

Gene Ontology (GO) - Biological Process for GAL3ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0009247 glycolipid biosynthetic process IEA --
genes like me logo Genes that share ontologies with GAL3ST2: view

No data available for SIGNOR curated interactions for GAL3ST2 Gene

Transcripts for GAL3ST2 Gene

mRNA/cDNA for GAL3ST2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(38) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GAL3ST2 Gene

Galactose-3-O-sulfotransferase 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAL3ST2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12a · 12b
SP1: - - - - - - - -
SP2: - -
SP4: - - - - - - -
SP5: - - -
SP6: -
SP7: - - - -
SP8: - - -
SP9: - - - - - - - -
SP10: - - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - -

Relevant External Links for GAL3ST2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GAL3ST2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GAL3ST2 Gene

mRNA differential expression in normal tissues according to GTEx for GAL3ST2 Gene

This gene is overexpressed in Colon - Transverse (x21.4).

Protein differential expression in normal tissues from HIPED for GAL3ST2 Gene

This gene is overexpressed in Oral epithelium (63.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GAL3ST2 Gene

Protein tissue co-expression partners for GAL3ST2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GAL3ST2 Gene:


SOURCE GeneReport for Unigene cluster for GAL3ST2 Gene:


mRNA Expression by UniProt/SwissProt for GAL3ST2 Gene:

Tissue specificity: Ubiquitous. Detected in heart, stomach, colon, liver and spleen, in epithelial cells lining the lower to middle layer of the crypts in colonic mucosa, hepatocytes surrounding the central vein of the liver, extravillous cytotrophoblasts in the basal plate of the septum of the placenta, renal tubules of the kidney, and neuronal cells of the cerebral cortex.
genes like me logo Genes that share expression patterns with GAL3ST2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GAL3ST2 Gene

Orthologs for GAL3ST2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAL3ST2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GAL3ST2 34 35
  • 99.03 (n)
(Canis familiaris)
Mammalia GAL3ST2 34 35
  • 83.8 (n)
(Bos Taurus)
Mammalia GAL3ST2 34 35
  • 82.24 (n)
(Mus musculus)
Mammalia Gm9994 34 16 35
  • 73.63 (n)
Gal3st2 35
  • 68 (a)
Gm6086 35
  • 67 (a)
(Rattus norvegicus)
Mammalia Gal3st2 34
  • 73.43 (n)
(Monodelphis domestica)
Mammalia GAL3ST2 35
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 60 (a)
-- 35
  • 43 (a)
(Gallus gallus)
Aves GAL3ST2 34 35
  • 62.67 (n)
(Anolis carolinensis)
Reptilia GAL3ST2 35
  • 50 (a)
(Danio rerio)
Actinopterygii LOC556126 34
  • 56.63 (n)
CABZ01079005.1 35
  • 33 (a)
si:dkey-246m18.2 35
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
-- 35
  • 33 (a)
-- 35
  • 25 (a)
Species where no ortholog for GAL3ST2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAL3ST2 Gene

Gene Tree for GAL3ST2 (if available)
Gene Tree for GAL3ST2 (if available)

Paralogs for GAL3ST2 Gene

Paralogs for GAL3ST2 Gene

(2) SIMAP similar genes for GAL3ST2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GAL3ST2: view

Variants for GAL3ST2 Gene

Sequence variations from dbSNP and Humsavar for GAL3ST2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs372108744 Likely pathogenic 241,801,858(+) CAGCA(C/T)GGTGC reference, missense
rs78620448 Uncertain significance 241,776,985(+) CAGAG(A/G)TAAGG splice-donor-variant
rs10171845 -- 241,784,101(+) caatc(G/T)cagct intron-variant
rs10184669 -- 241,787,595(+) gttct(A/C)ctgct intron-variant
rs10208011 -- 241,783,655(+) tttat(C/T)ctaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAL3ST2 Gene

Variant ID Type Subtype PubMed ID
dgv165e55 CNV loss 17911159
dgv4200n100 CNV loss 25217958
dgv4201n100 CNV gain 25217958
esv3594840 CNV loss 21293372
esv3594841 CNV loss 21293372
esv3594842 CNV gain 21293372
esv3893578 CNV loss 25118596
nsv1002941 CNV gain 25217958
nsv1006733 CNV gain 25217958
nsv10232 CNV gain+loss 18304495
nsv584982 CNV loss 21841781
nsv955300 CNV deletion 24416366
nsv955301 CNV deletion 24416366
nsv997984 CNV gain 25217958

Variation tolerance for GAL3ST2 Gene

Residual Variation Intolerance Score: 90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.73; 73.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAL3ST2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAL3ST2 Gene

Disorders for GAL3ST2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GAL3ST2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mucinous adenocarcinoma
  • mucin-producing adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GAL3ST2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GAL3ST2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAL3ST2 Gene

Publications for GAL3ST2 Gene

  1. Molecular cloning and characterization of a human beta-Gal-3'- sulfotransferase that acts on both type 1 and type 2 (Galbeta 1-3/1- 4GlcNAc-R) oligosaccharides. (PMID: 11029462) Honke K. … Taniguchi N. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. Gal3ST-2 involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrins. (PMID: 15921657) Shi B.Z. … Wu X.Z. (Biochem. Biophys. Res. Commun. 2005) 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. GAL3ST2 from mammary gland epithelial cells affects differentiation of 3T3-L1 preadipocytes. (PMID: 25532485) Guerra L.N. … Calvo J.C. (Clin Transl Oncol 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for GAL3ST2 Gene

Sources for GAL3ST2 Gene

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