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Aliases for GAL3ST1 Gene

Aliases for GAL3ST1 Gene

  • Galactose-3-O-Sulfotransferase 1 2 3
  • CST 3 4 6
  • 3-Phosphoadenylylsulfate:Galactosylceramide 3-Sulfotransferase 3 4
  • 3-Phosphoadenosine-5-Phosphosulfate:GalCer Sulfotransferase 3 4
  • Cerebroside Sulfotransferase 3 4
  • GalCer Sulfotransferase 3 4
  • Cerebroside (3 Phosphoadenylylsulfate:Galactosylceramide 3) Sulfotransferase 2
  • Cerebroside (3-Phosphoadenylylsulfate:Galactosylceramide 3) Sulfotransferase 3
  • Galactosylceramide Sulfotransferase 3
  • EC 2.8.2.11 4

External Ids for GAL3ST1 Gene

Summaries for GAL3ST1 Gene

Entrez Gene Summary for GAL3ST1 Gene

  • Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAL3ST1 Gene

GAL3ST1 (Galactose-3-O-Sulfotransferase 1) is a Protein Coding gene. Diseases associated with GAL3ST1 include metachromatic leukodystrophy and renal cell carcinoma. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. GO annotations related to this gene include sulfotransferase activity and galactosylceramide sulfotransferase activity. An important paralog of this gene is GAL3ST3.

UniProtKB/Swiss-Prot for GAL3ST1 Gene

  • Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro).

Gene Wiki entry for GAL3ST1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAL3ST1 Gene

Genomics for GAL3ST1 Gene

Genomic Location for GAL3ST1 Gene

Start:
30,554,635 bp from pter
End:
30,574,587 bp from pter
Size:
19,953 bases
Orientation:
Minus strand

Genomic View for GAL3ST1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GAL3ST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAL3ST1 Gene

Regulatory Elements for GAL3ST1 Gene

Proteins for GAL3ST1 Gene

  • Protein details for GAL3ST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99999-G3ST1_HUMAN
    Recommended name:
    Galactosylceramide sulfotransferase
    Protein Accession:
    Q99999
    Secondary Accessions:
    • Q96C63

    Protein attributes for GAL3ST1 Gene

    Size:
    423 amino acids
    Molecular mass:
    48764 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GAL3ST1 Gene

Proteomics data for GAL3ST1 Gene at MOPED

Post-translational modifications for GAL3ST1 Gene

  • Glycosylation at Asn66 and Asn312

No data available for DME Specific Peptides for GAL3ST1 Gene

Domains for GAL3ST1 Gene

Gene Families for GAL3ST1 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for GAL3ST1 Gene

Suggested Antigen Peptide Sequences for GAL3ST1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99999

UniProtKB/Swiss-Prot:

G3ST1_HUMAN
Family:
  • Belongs to the galactose-3-O-sulfotransferase family.:
    • Q99999
genes like me logo Genes that share domains with GAL3ST1: view

Function for GAL3ST1 Gene

Molecular function for GAL3ST1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + a galactosylceramide = adenosine 3,5-bisphosphate + a galactosylceramidesulfate
UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + monogalactosylalkylacylglycerol = adenosine 3,5-bisphosphate + monogalactosylalkylacylglycerol sulfate
UniProtKB/Swiss-Prot Function: Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro).

Enzyme Numbers (IUBMB) for GAL3ST1 Gene

Gene Ontology (GO) - Molecular Function for GAL3ST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001733 galactosylceramide sulfotransferase activity IEA --
GO:0008146 sulfotransferase activity TAS 9030544
genes like me logo Genes that share ontologies with GAL3ST1: view
genes like me logo Genes that share phenotypes with GAL3ST1: view

Animal Models for GAL3ST1 Gene

MGI Knock Outs for GAL3ST1:

miRNA for GAL3ST1 Gene

miRTarBase miRNAs that target GAL3ST1

No data available for Transcription Factor Targeting and HOMER Transcription for GAL3ST1 Gene

Localization for GAL3ST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAL3ST1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAL3ST1 Gene COMPARTMENTS Subcellular localization image for GAL3ST1 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
extracellular 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GAL3ST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus --
GO:0005887 integral component of plasma membrane TAS 9030544
GO:0016020 membrane TAS 9030544
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GAL3ST1: view

Pathways for GAL3ST1 Gene

genes like me logo Genes that share pathways with GAL3ST1: view

Pathways by source for GAL3ST1 Gene

UniProtKB/Swiss-Prot Q99999-G3ST1_HUMAN

  • Pathway: Lipid metabolism; sphingolipid metabolism

Interacting Proteins for GAL3ST1 Gene

Gene Ontology (GO) - Biological Process for GAL3ST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006487 protein N-linked glycosylation TAS 9030544
GO:0006665 sphingolipid metabolic process --
GO:0006682 galactosylceramide biosynthetic process IEA --
GO:0006687 glycosphingolipid metabolic process --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with GAL3ST1: view

Compounds for GAL3ST1 Gene

(876) HMDB Compounds for GAL3ST1 Gene

Compound Synonyms Cas Number PubMed IDs
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • Sulfatide (d18:1/12:0)
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • Sulfatide (d18:1/14:0)
Not Available
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • Sulfatide (d18:1/16:0)
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • Sulfatide (d18:1/18:0)
244215-65-4
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))
  • Sulfatide (d18:1/18:1(9Z))
Not Available

(8) Novoseek inferred chemical compound relationships for GAL3ST1 Gene

Compound -log(P) Hits PubMed IDs
cerebroside 95.6 14
galactosylceramide 89.9 8
sulfatide 82.6 6
psychosine 79.7 1
lactosylceramide 70.6 1
genes like me logo Genes that share compounds with GAL3ST1: view

Transcripts for GAL3ST1 Gene

Unigene Clusters for GAL3ST1 Gene

Galactose-3-O-sulfotransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GAL3ST1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i · 7j · 7k · 7l
SP1: - - - - - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - - - -
SP10: - - -
SP11: - - -
SP12:

Relevant External Links for GAL3ST1 Gene

GeneLoc Exon Structure for
GAL3ST1
ECgene alternative splicing isoforms for
GAL3ST1

Expression for GAL3ST1 Gene

mRNA expression in normal human tissues for GAL3ST1 Gene

mRNA differential expression in normal tissues according to GTEx for GAL3ST1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (7.4), Brain - Substantia nigra (4.4), and Nerve - Tibial (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GAL3ST1 Gene

SOURCE GeneReport for Unigene cluster for GAL3ST1 Gene Hs.17958

mRNA Expression by UniProt/SwissProt for GAL3ST1 Gene

Q99999-G3ST1_HUMAN
Tissue specificity: Expressed in kidney proximal tubule, gastric mucosa and adenocarcinoma. Highly expressed in renal cell carcinoma cell lines
genes like me logo Genes that share expressions with GAL3ST1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GAL3ST1 Gene

Orthologs for GAL3ST1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAL3ST1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GAL3ST1 35
  • 99.53 (n)
  • 99.53 (a)
GAL3ST1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GAL3ST1 35
  • 90.56 (n)
  • 89.52 (a)
GAL3ST1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CST 36
  • 89 (a)
OneToOne
GAL3ST1 35
  • 91.19 (n)
  • 90 (a)
mouse
(Mus musculus)
Mammalia Gal3st1 35
  • 83.49 (n)
  • 84.69 (a)
Gal3st1 16
Gal3st1 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GAL3ST1 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gal3st1 35
  • 83.97 (n)
  • 84.45 (a)
chicken
(Gallus gallus)
Aves GAL3ST1 35
  • 77.06 (n)
  • 70.71 (a)
GAL3ST1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gal3st1 35
  • 57.43 (n)
  • 58.31 (a)
zebrafish
(Danio rerio)
Actinopterygii gal3st1 35
  • 62.98 (n)
  • 58.41 (a)
gal3st1 36
  • 57 (a)
OneToMany
GAL3ST1 (2 of 2) 36
  • 50 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
Species with no ortholog for GAL3ST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAL3ST1 Gene

ENSEMBL:
Gene Tree for GAL3ST1 (if available)
TreeFam:
Gene Tree for GAL3ST1 (if available)

Paralogs for GAL3ST1 Gene

Paralogs for GAL3ST1 Gene

Pseudogenes.org Pseudogenes for GAL3ST1 Gene

genes like me logo Genes that share paralogs with GAL3ST1: view

Variants for GAL3ST1 Gene

Sequence variations from dbSNP and Humsavar for GAL3ST1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs42926 -- 30,556,789(+) gagta(C/T)agtgg intron-variant
rs42927 -- 30,557,637(+) ATGGG(A/G)CAGGG intron-variant
rs42928 -- 30,559,334(+) ctccc(C/T)ggttc intron-variant
rs42929 -- 30,560,432(+) GCAAC(C/T)AGCAC intron-variant
rs42930 -- 30,563,527(+) ggaag(G/T)atcac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAL3ST1 Gene

Variant ID Type Subtype PubMed ID
nsv829171 CNV Loss 20364138

Relevant External Links for GAL3ST1 Gene

HapMap Linkage Disequilibrium report
GAL3ST1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAL3ST1 Gene

Disorders for GAL3ST1 Gene

(1) University of Copenhagen DISEASES for GAL3ST1 Gene

(3) Novoseek inferred disease relationships for GAL3ST1 Gene

Disease -log(P) Hits PubMed IDs
carcinoma renal cell 54.6 4
hepatocellular carcinoma 25.5 1
cancer 0 1
genes like me logo Genes that share disorders with GAL3ST1: view

No data available for UniProtKB/Swiss-Prot for GAL3ST1 Gene

Publications for GAL3ST1 Gene

  1. Molecular cloning and expression of cDNA encoding human 3'- phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase. (PMID: 9030544) Honke K. … Wada Y. (J. Biol. Chem. 1997) 2 3 4 23
  2. Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene. (PMID: 10785389) Tsuda M. … Honke K. (Eur. J. Biochem. 2000) 3 4 23
  3. Purification and characterization of 3'-phosphoadenosine-5'- phosphosulfate:GalCer sulfotransferase from human renal cancer cells. (PMID: 8830034) Honke K. … Makita A. (J. Biochem. 1996) 3 4 23
  4. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 2 3
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4

Products for GAL3ST1 Gene

Sources for GAL3ST1 Gene

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