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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GAL3ST1 Gene

protein-coding GIFtS: 54
GCID: GC22M030950

galactose-3-O-sulfotransferase 1

Explore 14 diseases affiliated with
GAL3ST1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Galactose-3-O-Sulfotransferase 1¹ ²		GalCer Sulfotransferase² ³
CST¹ ² ³ ⁵		Cerebroside (3'-Phosphoadenylylsulfate:Galactosylceramide 3') Sulfotransferase²
Cerebroside Sulfotransferase² ³		Galactosylceramide Sulfotransferase²
3'-Phosphoadenosine-5'-Phosphosulfate:GalCer Sulfotransferase² ³		EC 2.8.2.11³
3'-Phosphoadenylylsulfate:Galactosylceramide 3'-Sulfotransferase² ³

External Ids:	HGNC: 24240¹	Entrez Gene: 9514²	Ensembl: ENSG00000128242⁷	OMIM: 602300⁵	UniProtKB: Q99999³

Export aliases for GAL3ST1 gene to outside databases

Previous GC identifers: GC22M029276 GC22M029277 GC22M013912

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GAL3ST1:

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is

catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the

conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate +

galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: G3ST1_HUMAN, Q99999

Function: Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini

of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major

lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in

spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl

diacylglycerol (in vitro)

Gene Wiki entry for GAL3ST1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GAL3ST1 gene promoter:
Tal-1 ATF-2 Egr-1 E47 CREB Max PPAR-alpha CRE-BP1 ITF-2 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GAL3ST1 promoter sequence

Search SABiosciences Chromatin IP Primers for GAL3ST1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAL3ST1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2 Ensembl cytogenetic band: 22q12.2 HGNC cytogenetic band: 22q12.2

GAL3ST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAL3ST1 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M030950: view genomic region (about GC identifiers)

Start:	30,950,622 bp from pter	End:	30,970,574 bp from pter
Size:	19,953 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: G3ST1_HUMAN, Q99999 (See protein sequence)

Recommended Name: Galactosylceramide sulfotransferase

Size: 423 amino acids; 48764 Da

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)

Secondary accessions: Q96C63

Explore the universe of human proteins at neXtProt for GAL3ST1: NX_Q99999

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99999

GAL3ST1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004852.1

ENSEMBL proteins:

ENSP00000385825 ENSP00000385735 ENSP00000384122 ENSP00000384388 ENSP00000385207

ENSP00000390545 ENSP00000395080 ENSP00000405017 ENSP00000401426 ENSP00000391485

ENSP00000397092 ENSP00000391996 ENSP00000405381 ENSP00000401074 ENSP00000389876

ENSP00000398380 ENSP00000414542 ENSP00000412995 ENSP00000394912 ENSP00000399649

ENSP00000390068 ENSP00000343234 ENSP00000402587

Reactome Protein details: Q99999
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	Uscn Proteins for GAL3ST1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0005624	membrane fraction	--	--
GO:0005794	Golgi apparatus	--	--
GO:0005887	integral to plasma membrane	TAS	9030544
GO:0016020	membrane	TAS	9030544

GAL3ST1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GAL3ST1 for domains About GeneDecksing

1 InterPro domain/family:

IPR009729 Gal-3-0_sulfotransfrase

Graphical View of Domain Structure for InterPro Entry Q99999

ProtoNet protein and cluster: Q99999

1 Blocks protein family: IPB009729 Galactose-3-O-sulfotransferase

UniProtKB/Swiss-Prot: G3ST1_HUMAN, Q99999

Similarity: Belongs to the galactose-3-O-sulfotransferase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: G3ST1_HUMAN, Q99999

Function: Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini

of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major

lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in

spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl

diacylglycerol (in vitro)

Catalytic activity: 3'-phosphoadenylyl sulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a

galactosylceramidesulfate

Catalytic activity: 3'-phosphoadenylyl sulfate + monogalactosylalkylacylglycerol = adenosine 3',5'-bisphosphate +

monogalactosylalkylacylglycerol sulfate

Enzyme Number (IUBMB): EC 2.8.2.11¹

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAL3ST1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001733	galactosylceramide sulfotransferase activity	IEA	--
GO:0008146	sulfotransferase activity	TAS	9030544

GAL3ST1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Gal3st1^tm1Kho for GAL3ST1
     5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Gal3st1):

behavior/neurological

cellular

endocrine/exocrine gland

nervous system

reproductive system

GAL3ST1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Sphingolipid metabolism

	Sphingolipid metabolism	1.00			Sphingolipid metabolism	0.54
	Glycosphingolipid metabolism	0.54

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Biological oxidations

metapathway biotransformation

0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for GAL3ST1

metapathway biotransformation

4 Reactome Pathways for GAL3ST1

	Sphingolipid metabolism
	Glycosphingolipid metabolism
	Metabolism
	Metabolism of lipids and lipoproteins

2 Kegg Pathways (Kegg details for GAL3ST1):

	Sphingolipid metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: G3ST1_HUMAN, Q99999

Pathway: Lipid metabolism; sphingolipid metabolism

GAL3ST1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GAL3ST1

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/8 Interacting proteins for GAL3ST1 (ENSP00000343234⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GALC	ENSP00000261304⁴	STRING: ENSP00000261304
GLA	ENSP00000218516⁴	STRING: ENSP00000218516
UGT8	ENSP00000311648⁴	STRING: ENSP00000311648
NEU2	ENSP00000233840⁴	STRING: ENSP00000233840
NEU3	ENSP00000294064⁴	STRING: ENSP00000294064

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006487	protein N-linked glycosylation	TAS	9030544
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006665	sphingolipid metabolic process	TAS	--
GO:0006682	galactosylceramide biosynthetic process	IEA	--
GO:0006687	glycosphingolipid metabolic process	TAS	--

GAL3ST1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GAL3ST1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GAL3ST1

10/876 HMDB Compounds for GAL3ST1 (see all 876) About this table

Compound	Synonyms	CAS #	PubMed Ids
3-O-Sulfogalactosylceramide (d18:1/12:0)	Sulfatide (d18:1/12:0) (see all 13)	852100-88-0	--
3-O-Sulfogalactosylceramide (d18:1/14:0)	Sulfatide (d18:1/14:0) (see all 13)	--	--
3-O-Sulfogalactosylceramide (d18:1/16:0)	Sulfatide (d18:1/16:0) (see all 13)	862509-48-6	--
3-O-Sulfogalactosylceramide (d18:1/18:0)	Sulfatide (d18:1/18:0) (see all 13)	244215-65-4	--
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))	Sulfatide (d18:1/18:1(9Z)) (see all 13)	--	--
3-O-Sulfogalactosylceramide (d18:1/20:0)	Sulfatide (d18:1/20:0) (see all 13)	265096-81-9	--
3-O-Sulfogalactosylceramide (d18:1/22:0)	Sulfatide (d18:1/22:0) (see all 13)	265096-83-1	--
3-O-Sulfogalactosylceramide (d18:1/24:0)	Sulfatide (d18:1/24:0) (see all 16)	151122-71-3	--
3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))	Sulfatide (d18:1/24:1(15Z)) (see all 13)	151057-28-2	--
3-O-Sulfogalactosylceramide (d18:1/26:1(17Z))	Sulfatide (d18:1/26:1(17Z)) (see all 13)	928346-40-1	--

8 Novoseek chemical compound relationships for GAL3ST1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cerebroside	95.6	22	10727929 (2), 1715232 (1), 10378772 (1), 17715338 (1) (see all 13)
galactosylceramide	89.9	11	18097285 (2), 9030544 (1), 12175333 (1), 1330860 (1) (see all 7)
sulfatide	82.6	10	19895791 (2), 9030544 (1), 10378772 (1), 17715338 (1) (see all 5)
psychosine	79.7	1	8830034 (1)
lactosylceramide	70.6	1	12626418 (1)
glycolipid	65.3	5	1715232 (1), 10378772 (1), 9731487 (1)
galactose	43.5	1	11333265 (1)
lactose	35.1	1	11029462 (1)

Search CenterWatch for drugs/clinical trials and news about GAL3ST1 / G3ST1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GAL3ST1 gene:

NM_004861.1

Unigene Cluster for GAL3ST1:

Galactose-3-O-sulfotransferase 1

Hs.17958 [show with all ESTs]

Unigene Representative Sequence: NM_004861

18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):

ENST00000406955(uc003aih.1 uc010gvz.1) ENST00000402321 ENST00000402369

ENST00000401975(uc003aii.1) ENST00000406361 ENST00000441967 ENST00000431313

ENST00000452827 ENST00000437282 ENST00000416358 ENST00000427899 ENST00000423299

ENST00000443136 ENST00000423371 ENST00000428682 ENST00000453479 ENST00000426220

ENST00000447224

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Additional cDNA sequence:

AK313097.1 BC014649.1 BC019077.2 CR456350.1 D88667.1

9 DOTS entries:

DT.111025 DT.100699387 DT.91759420 DT.91759424 DT.120634337 DT.120634354 DT.120634341 DT.120634353

DT.95162593

24/68 AceView cDNA sequences (see all 68):

AW137588 D88667 AW473494 BE018867 NM_004861 CR595763 CR456350 AI052490

BI760652 BC014649 BC019077 BI753118 AA004502 AW270838 BG251254 AW294989

BG423020 BX410867 BX410865 AI077359 BM794092 BM807579 BG327446 BG419785

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for GAL3ST1 (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f	·	7g	·	7h	·	7i	·	7j	·	7k	·	7l
SP1:							-		-		-		-		-		-				-		-
SP2:																	-				-		-
SP3:																	-						-
SP4:																					-		-
SP5:							-		-		-		-		-		-		-		-		-

ECgene alternative splicing isoforms for GAL3ST1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GAL3ST1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

GAL3ST1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GAL3ST1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GAL3ST1

SOURCE GeneReport for Unigene cluster: Hs.17958

UniProtKB/Swiss-Prot: G3ST1_HUMAN, Q99999

Tissue specificity: Expressed in kidney proximal tubule, gastric mucosa and adenocarcinoma. Highly expressed in renal

cell carcinoma cell lines

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GAL3ST1 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gal3st1^{1 , 5}	galactose-3-O-sulfotransferase 1^{1, 5}	83.49(n)¹ 84.69(a)¹		11 (2.81 cM)⁵ 53897¹ NM_001177691.1¹ NP_001171162.1¹ 3983636⁵
chicken (Gallus gallus)	Aves	GAL3ST1¹	galactose-3-O-sulfotransferase 1	77.06(n) 70.71(a)		417006 XM_415296.3 XP_415296.2
lizard (Anolis carolinensis)	Reptilia	-- --	--	70(a) 69(a)	many → 1 many → 1	AAWZ02039048(5938-7651) GL343417.1(166392-168467)
African clawed frog (Xenopus laevis)	Amphibia	BC045120.1²	--	76.59(n)		BC045120.1
zebrafish (Danio rerio)	Actinopterygii	gal3st1¹	galactose-3-O-sulfotransferase 1	62.98(n) 58.41(a)		793735 NM_001126452.1 NP_001119924.1

ENSEMBL Gene Tree for GAL3ST1 (if available)
TreeFam Gene Tree for GAL3ST1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for GAL3ST1 gene

GAL3ST4² GAL3ST2² GAL3ST3²

2 SIMAP similar genes for GAL3ST1 using alignment to 17 protein entries: G3ST1_HUMAN (see all proteins):

GAL3ST2 GAL3ST3

GAL3ST1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for GAL3ST1
PGOHUM00000241156

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189402119^1,2		--	30950217(+)	`AGTGAC/TTGTCC`	1	--	ds500¹		0	--	--	--	--
rs145093090^1,2		--	30950277(+)	`AGGTCA/GCTGAG`	1	--	ds500¹		0	--	--	--	--
rs2267158^1,2	C,F,A,H,	--	30950360(+)	`TACTCT/CGTTGT`	1	--	ds500¹		27		NS EA NA WA CSA	2772
rs147171642^1,2		--	30950398(+)	`CACACA/GTGCAC`	1	--	ds500¹		0	--	--	--	--
rs73168694^1,2	C,	--	30950436(+)	`CACGCA/G/TCTTTT`	1	--	ds500¹		0	--	--	--	--
rs5997684^1,2	F,	--	30950514(+)	`CAAATC/TCCTGC`	1	--	ds500¹		1		WA	118
rs117382470^1,2	F,	--	30950549(+)	`ACTCAC/TCCAGG`	1	--	ds500¹		1		NA	120
rs76876427^1,2	C,F,	--	30950754(+)	`TGATCT/GCGGTT`	1	--	ut3¹		1		WA	118
rs75344364^1,2	F,	--	30950775(+)	`TGTGTT/GCATGG`	1	--	ut3¹		1		WA	118
rs115774030^1,2	F,	--	30950801(+)	`GCTGCC/GTCCCC`	1	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for GAL3ST1 (30950622 - 30970574 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GAL3ST1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAL3ST1

DNA2.0 Custom Variant and Variant Library Synthesis for GAL3ST1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GAL3ST1 for disorders           About GeneDecksing

OMIM gene information: 602300    OMIM disorders: --

14 diseases for GAL3ST1:    About MalaCards

renal cell carcinoma carcinoma metachromatic leukodystrophy leukodystrophy

insulin resistance hepatocellular carcinoma gastritis liver cancer

lung carcinoma cholesterol melanoma adenocarcinoma

hepatitis neuronitis

3 Novoseek disease relationships for GAL3ST1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma renal cell	54.6	7	8830034 (2), 10785389 (1), 9731487 (1)
hepatocellular carcinoma	25.5	1	1715232 (1)
cancer	0	1	10378772 (1)

Export disorders for GAL3ST1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GAL3ST1 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with GAL3ST1)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and expression of cDNA encoding human 3'- phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase. (PubMed id 9030544)^{1, 2, 3, 9} Honke K.... Wada Y. (1997)
Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene. (PubMed id 10785389)^{1, 2, 9} Tsuda M.... Honke K. (2000)
Purification and characterization of 3'-phosphoadenosine-5'- phosphosulfate:GalCer sulfotransferase from human renal cancer cells. (PubMed id 8830034)^{1, 2, 9} Honke K.... Makita A. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
Toward a complete human genome sequence. (PubMed id 9847074)^{1, 3} Wilson R. (1998)
N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase. (PubMed id 12175333)^{1, 9} Eckhardt M....Gieselmann V. (2002)
A variation in the cerebroside sulfotransferase gene is linked to exercise-modified insulin resistance and to type 2 diabetes. (PubMed id 19587831)^{1, 9} Roeske-Nielsen A....Lindblad U. (2009)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9514	HGNC: 24240	AceView: GAL3ST1	Ensembl:ENSG00000128242	euGenes: HUgn9514
ECgene: GAL3ST1	Kegg: 9514	H-InvDB: GAL3ST1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GAL3ST1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GAL3ST1	Genetics and Cytogenetics in Oncology and Haematology
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/

Intellectual Property for GAL3ST1 gene
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Patent Information for GAL3ST1 gene:
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galactose-3-O-sulfotransferase 1

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galactose-3-O-sulfotransferase 1

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