Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GAL3ST1 Gene

Aliases for GAL3ST1 Gene

  • Galactose-3-O-Sulfotransferase 1 2 3 5
  • 3-Phosphoadenosine-5-Phosphosulfate:GalCer Sulfotransferase 3 4
  • CST 3 4
  • Cerebroside (3 Phosphoadenylylsulfate:Galactosylceramide 3) Sulfotransferase 2
  • Cerebroside (3-Phosphoadenylylsulfate:Galactosylceramide 3) Sulfotransferase 3
  • 3-Phosphoadenylylsulfate:Galactosylceramide 3-Sulfotransferase 4
  • Cerebroside Sulfotransferase 4
  • GalCer Sulfotransferase 4
  • EC 2.8.2.11 4

External Ids for GAL3ST1 Gene

Previous GeneCards Identifiers for GAL3ST1 Gene

  • GC22M029276
  • GC22M029277
  • GC22M030950
  • GC22M013912

Summaries for GAL3ST1 Gene

Entrez Gene Summary for GAL3ST1 Gene

  • Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. This gene encodes galactosylceramide sulfotransferase, which catalyzes the sulfation of membrane glycolipids including the final step in the synthesis of sulfatide, a major lipid component of the myelin sheath. This gene exhibits elevated expression in ovarian epithelial carcinoma and the encoded enzyme exhibits elevated activity in renal cell carcinoma. Mutations in this gene may be associated with reduced insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for GAL3ST1 Gene

GAL3ST1 (Galactose-3-O-Sulfotransferase 1) is a Protein Coding gene. Diseases associated with GAL3ST1 include congenital disorder of glycosylation, type iif and renal cell carcinoma. Among its related pathways are Metabolism and Sphingolipid metabolism. GO annotations related to this gene include sulfotransferase activity and galactosylceramide sulfotransferase activity. An important paralog of this gene is GAL3ST3.

UniProtKB/Swiss-Prot for GAL3ST1 Gene

  • Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro).

Gene Wiki entry for GAL3ST1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAL3ST1 Gene

Genomics for GAL3ST1 Gene

Regulatory Elements for GAL3ST1 Gene

Promoters for GAL3ST1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GAL3ST1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GAL3ST1 Gene

Chromosome:
22
Start:
30,554,635 bp from pter
End:
30,574,588 bp from pter
Size:
19,954 bases
Orientation:
Minus strand

Genomic View for GAL3ST1 Gene

Genes around GAL3ST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAL3ST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAL3ST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAL3ST1 Gene

Proteins for GAL3ST1 Gene

  • Protein details for GAL3ST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99999-G3ST1_HUMAN
    Recommended name:
    Galactosylceramide sulfotransferase
    Protein Accession:
    Q99999
    Secondary Accessions:
    • Q96C63

    Protein attributes for GAL3ST1 Gene

    Size:
    423 amino acids
    Molecular mass:
    48764 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GAL3ST1 Gene

Proteomics data for GAL3ST1 Gene at MOPED

Post-translational modifications for GAL3ST1 Gene

  • Glycosylation at Asn 66 and Asn 312
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for GAL3ST1
  • Santa Cruz Biotechnology (SCBT) Antibodies for GAL3ST1

No data available for DME Specific Peptides for GAL3ST1 Gene

Domains & Families for GAL3ST1 Gene

Gene Families for GAL3ST1 Gene

Protein Domains for GAL3ST1 Gene

Suggested Antigen Peptide Sequences for GAL3ST1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99999

UniProtKB/Swiss-Prot:

G3ST1_HUMAN :
  • Belongs to the galactose-3-O-sulfotransferase family.
Family:
  • Belongs to the galactose-3-O-sulfotransferase family.
genes like me logo Genes that share domains with GAL3ST1: view

Function for GAL3ST1 Gene

Molecular function for GAL3ST1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + a galactosylceramide = adenosine 3,5-bisphosphate + a galactosylceramidesulfate.
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + monogalactosylalkylacylglycerol = adenosine 3,5-bisphosphate + monogalactosylalkylacylglycerol sulfate.
UniProtKB/Swiss-Prot Function:
Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro).

Enzyme Numbers (IUBMB) for GAL3ST1 Gene

Gene Ontology (GO) - Molecular Function for GAL3ST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001733 galactosylceramide sulfotransferase activity IEA --
genes like me logo Genes that share ontologies with GAL3ST1: view
genes like me logo Genes that share phenotypes with GAL3ST1: view

Animal Models for GAL3ST1 Gene

MGI Knock Outs for GAL3ST1:

Animal Model Products

CRISPR Products

miRNA for GAL3ST1 Gene

miRTarBase miRNAs that target GAL3ST1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GAL3ST1 Gene

Localization for GAL3ST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAL3ST1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAL3ST1 Gene COMPARTMENTS Subcellular localization image for GAL3ST1 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
extracellular 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GAL3ST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GAL3ST1: view

Pathways & Interactions for GAL3ST1 Gene

genes like me logo Genes that share pathways with GAL3ST1: view

Pathways by source for GAL3ST1 Gene

2 BioSystems pathways for GAL3ST1 Gene

UniProtKB/Swiss-Prot Q99999-G3ST1_HUMAN

  • Pathway: Lipid metabolism; sphingolipid metabolism.

Interacting Proteins for GAL3ST1 Gene

Gene Ontology (GO) - Biological Process for GAL3ST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006487 protein N-linked glycosylation TAS 9030544
GO:0042552 myelination IEA --
genes like me logo Genes that share ontologies with GAL3ST1: view

No data available for SIGNOR curated interactions for GAL3ST1 Gene

Drugs & Compounds for GAL3ST1 Gene

(2) Drugs for GAL3ST1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(37) Additional Compounds for GAL3ST1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
genes like me logo Genes that share compounds with GAL3ST1: view

Transcripts for GAL3ST1 Gene

Unigene Clusters for GAL3ST1 Gene

Galactose-3-O-sulfotransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GAL3ST1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i · 7j · 7k · 7l
SP1: - - - - - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - - - -
SP10: - - -
SP11: - - -
SP12:

Relevant External Links for GAL3ST1 Gene

GeneLoc Exon Structure for
GAL3ST1
ECgene alternative splicing isoforms for
GAL3ST1

Expression for GAL3ST1 Gene

mRNA expression in normal human tissues for GAL3ST1 Gene

mRNA differential expression in normal tissues according to GTEx for GAL3ST1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.4), Brain - Substantia nigra (x4.4), and Nerve - Tibial (x4.3).

Protein differential expression in normal tissues from HIPED for GAL3ST1 Gene

This gene is overexpressed in Gallbladder (35.0), Urine (18.6), and Testis (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GAL3ST1 Gene



SOURCE GeneReport for Unigene cluster for GAL3ST1 Gene Hs.17958

mRNA Expression by UniProt/SwissProt for GAL3ST1 Gene

Q99999-G3ST1_HUMAN
Tissue specificity: Expressed in kidney proximal tubule, gastric mucosa and adenocarcinoma. Highly expressed in renal cell carcinoma cell lines.
genes like me logo Genes that share expression patterns with GAL3ST1: view

Protein tissue co-expression partners for GAL3ST1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GAL3ST1 Gene

Orthologs for GAL3ST1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAL3ST1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GAL3ST1 35
  • 90.56 (n)
  • 89.52 (a)
GAL3ST1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAL3ST1 35
  • 91.19 (n)
  • 90 (a)
CST 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gal3st1 35
  • 83.49 (n)
  • 84.69 (a)
Gal3st1 16
Gal3st1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GAL3ST1 35
  • 99.53 (n)
  • 99.53 (a)
GAL3ST1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gal3st1 35
  • 83.97 (n)
  • 84.45 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GAL3ST1 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves GAL3ST1 35
  • 77.06 (n)
  • 70.71 (a)
GAL3ST1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gal3st1 35
  • 57.43 (n)
  • 58.31 (a)
zebrafish
(Danio rerio)
Actinopterygii gal3st1 35
  • 62.98 (n)
  • 58.41 (a)
gal3st1 36
  • 57 (a)
OneToMany
GAL3ST1 (2 of 2) 36
  • 50 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
Species with no ortholog for GAL3ST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAL3ST1 Gene

ENSEMBL:
Gene Tree for GAL3ST1 (if available)
TreeFam:
Gene Tree for GAL3ST1 (if available)

Paralogs for GAL3ST1 Gene

Paralogs for GAL3ST1 Gene

Pseudogenes.org Pseudogenes for GAL3ST1 Gene

genes like me logo Genes that share paralogs with GAL3ST1: view

Variants for GAL3ST1 Gene

Sequence variations from dbSNP and Humsavar for GAL3ST1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2267161 - 30,557,308(+) GTACA(C/T)CAGCA reference, missense
rs42926 -- 30,556,789(+) gagta(C/T)agtgg intron-variant
rs42927 -- 30,557,637(+) ATGGG(A/G)CAGGG intron-variant
rs42928 -- 30,559,334(+) ctccc(C/T)ggttc intron-variant, upstream-variant-2KB
rs42929 -- 30,560,432(+) GCAAC(C/T)AGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAL3ST1 Gene

Variant ID Type Subtype PubMed ID
nsv829171 CNV Loss 20364138

Variation tolerance for GAL3ST1 Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.20; 87.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAL3ST1 Gene

HapMap Linkage Disequilibrium report
GAL3ST1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAL3ST1 Gene

Disorders for GAL3ST1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GAL3ST1 Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
congenital disorder of glycosylation, type iif
  • congenital disorder of glycosylation 2f
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GAL3ST1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAL3ST1
genes like me logo Genes that share disorders with GAL3ST1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAL3ST1 Gene

Publications for GAL3ST1 Gene

  1. Molecular cloning and expression of cDNA encoding human 3'- phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase. (PMID: 9030544) Honke K. … Wada Y. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. A variation in the cerebroside sulfotransferase gene is linked to exercise-modified insulin resistance and to type 2 diabetes. (PMID: 19587831) Roeske-Nielsen A. … Lindblad U. (Exp Diabetes Res 2009) 3 23
  3. N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase. (PMID: 12175333) Eckhardt M. … Gieselmann V. (Biochem. J. 2002) 3 23
  4. Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene. (PMID: 10785389) Tsuda M. … Honke K. (Eur. J. Biochem. 2000) 3 23
  5. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 2 3

Products for GAL3ST1 Gene

Sources for GAL3ST1 Gene

Back to Top

Content