Aliases for GAL Gene
External Ids for GAL Gene
Previous HGNC Symbols for GAL Gene
Previous GeneCards Identifiers for GAL Gene
This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Galanin has diverse physiological functions including nociception, feeding and energy homeostasis, osmotic regulation and water balance. GMAP has been demonstrated to possess antifungal activity and hypothesized to be part of the innate immune system. [provided by RefSeq, Jul 2015]
GeneCards Summary for GAL Gene
GAL (Galanin/GMAP Prepropeptide) is a Protein Coding gene. Diseases associated with GAL include epilepsy, familial temporal lobe, 8 and adjustment disorder. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include hormone activity and type 2 galanin receptor binding.
UniProtKB/Swiss-Prot for GAL Gene
Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion
Galanin is widely distributed in the central and peripheral nervous systems and the endocrine system. Three different galanin receptors (GAL1-3) have been identified. Disruption of galanin expression or galanin receptor signaling is seen in many multifactoral conditions.