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Aliases & Descriptions for GAL
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| GAL1 3 | | GALN 2, 3, 5 | | GLNN 1, 2, 3, 5 | | GMAP 1, 2 | | MGC40167 2 | | galanin 1, 2 |
| | | Descriptions |
|---|
| galanin prepropeptide 2 | | galanin-message-associated peptide 2 | | galanin-related peptide 2 |
|
| | Search outside databases for aliases for GAL genePrevious GC identifers: GC11P070974 GC11P070148 GC11P068701 GC11P068227 GC11P068206 |
Summaries for GAL(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for GAL: Galanin is small neuropeptide that functions as a cellular messenger within the central and peripheral nervous systems, modulating diverse physiologic functions (Mechenthaler, 2008 [PubMed 18500643]).[supplied by OMIM] UniProtKB/Swiss-Prot: GALA_HUMAN, P22466Function: Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretionGene Wiki entry for GAL (Galanin) |
Genomic Location for GAL
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the GAL gene 
Entrez Gene cytogenetic band: 11q13.2 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13.2GAL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P068208:
(about GC identifiers)
Start:
|
68,208,559 bp from pter |
End:
|
68,215,219 bp from pter |
Size:
|
6,661 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000011.8 NT_033903.7
| Proteins for GAL
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GALA_HUMAN, P22466 (See
protein sequence)Recommended Name: Galanin precursor Size: 123 amino acids; 13302 Da
Subcellular location: Secreted
Secondary accessions: Q14413Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_057057.2
ENSEMBL proteins: ENSP00000265643
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for GAL: Assays for GAL: | Protein
Domains/ Families for GAL(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P22466
ProtoNet protein and cluster: P22466 2 Blocks protein families: IPB008174 Galanin IPB013068 Galanin message associated peptide (GMAP)
UniProtKB/Swiss-Prot: GALA_HUMAN, P22466Similarity: Belongs to the galanin family | Gene Function for GAL
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015973
Applied Biosystems Silencer® siRNAs for GAL
Sigma-Aldrich siRNA for GAL  Sigma-Aldrich shRNA for GAL  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015973                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015973                                  untagged cDNA clone in CMV expression vector: NM_015973 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015973
UniProtKB/Swiss-Prot: GALA_HUMAN, P22466Function: Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretionGenatlas biochemistry entry for GAL:preprogalanin,including galanin and galanin message associated peptide,widely distributed in peripheral and central nervous system,eliciting numerous functions,including inhibition of neurotransmitter release,regulation of pituitary hormone secretion and possibly food intake; also coexpressed with GALNR1 in ciliary epithelium7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Gal):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005184 | neuropeptide hormone activity |
NAS | 1722333 | About this table | Pathways & Interactions for GAL
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for GAL 
5/58 Interacting proteins for GAL (ENSP000002656433) via UniProtKB, MINT, and/or STRING (see all 58
)About this table
5/15 Gene Ontology (GO) biological process terms (links to tree view) (see all 15
): About this table
|
Drugs & Compounds for GAL(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for GAL available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| M617 | Selective GAL1 agonist | [860790-38-1] | | Kainic acid | Potent excitant and neurotoxin | [487-79-6] | | Galnon | Selective, non-peptide GAL1 agonist | [475115-35-6] | | Galanin (1-30) (human) | Endogenous galanin receptor agonist | [119418-04-1] | | M871 | Selective GAL2 antagonist | [908844-75-7] | About this table
10/57 Novoseek chemical compound relationships for GAL gene (see all 57
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gal 1 |
92.92 |
176 |
9455920 (10), 10764829 (8), 19011096 (6), 10674999 (4) (see all 81) |
| (h,g)-a-l |
87.47 |
8 |
7686918 (1), 7534460 (1), 7539818 (1), 8930940 (1) (see all 7) |
| galantide |
84.76 |
21 |
18362840 (3), 17477304 (3), 7518053 (3), 11005758 (1) (see all 7) |
| enterostatin |
77.60 |
7 |
11732637 (1), 12612162 (1), 8221149 (1), 16149568 (1) (see all 7) |
| galp |
72.17 |
20 |
17604107 (2), 15099568 (2), 16787232 (2), 14988032 (2) (see all 9) |
| helospectin |
69.51 |
2 |
1335445 (1), 1605004 (1) |
| pgal |
63.67 |
1 |
9061507 (1) |
| hexarelin |
55.47 |
17 |
9854683 (6), 10754475 (1) |
| secretoneurin |
48.10 |
4 |
9751103 (2), 9655476 (1), 16872680 (1) |
| gal(beta1-3)galnac |
43.95 |
2 |
16607538 (1), 17664004 (1) |
About this table
|
Transcripts for GAL(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015973
Sigma-Aldrich siRNA for GAL  Sigma-Aldrich shRNA for GAL  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_015973 REFSEQ mRNAs for GAL gene: NM_015973.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015973               OriGene GFP tagged cDNA clone in CMV expression vector: NM_015973                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015973                                  untagged cDNA clone in CMV expression vector: NM_015973  Additional cDNA sequence: AF077047.1 BC030241.1 M77140.1 2 DOTS entries: DT.108209 DT.91765148 24/77 AceView cDNA sequences (see all 77
):BM129549 BE503279 AW590258 BF059503 BM764944 BM794204 BM841367 AV745385 AV745387 AL556409 BM740781 BM745398 BE672134 AV745443 BM846531 M77140 BG675116 BM764546 BC030241 AV745983 AI337122 NM_015973 AA760994 BU930913
highest scoring ESTs for GAL:M77140 AA492353 AA702835 AA760994 AF077047 AI337122 AI340259 AI623173 AI637899 AI825519 Unigene Cluster for GAL: Galanin prepropeptide Hs.278959 [show with all ESTs]Unigene Representative Sequence: BQ888773
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000265643
|
Expression for GAL
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GAL expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GAL
1 / 2 / 3 3 probe-sets matching GAL gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.278959
Expression variation in blood from EXPOLDB for GAL |
Orthologs for GAL
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GAL gene from 5 species
About this table Species with no ortholog for GAL
ENSEMBL Gene Tree for GAL | Paralogs for GAL(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for GAL(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for GAL (up to first 250kb)
|
Disorders & Mutations for GAL
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 137035
10/77 Novoseek disease relationships for GAL gene (see all 77
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| alzheimers disease |
41.13 |
56 |
7510783 (4), 9928179 (3), 11826038 (2), 14993421 (2) (see all 28) |
| trophoblastic tumor |
38.19 |
5 |
15221419 (2), 16607538 (1) |
| pituitary tumors |
37.52 |
4 |
10098517 (2), 7694774 (1), 10199778 (1) |
| acromegaly |
35.60 |
22 |
18617732 (5), 7536207 (4), 7680832 (4), 7508379 (3) (see all 7) |
| pituitary adenoma |
31.78 |
9 |
10199778 (2), 11940053 (2), 14700749 (2), 1719117 (1) (see all 5) |
| ganglioneuroma |
30.22 |
3 |
1718239 (1), 11857022 (1), 11867941 (1) |
| prolactinoma |
29.06 |
2 |
10686432 (1), 9928158 (1) |
| insulinoma |
28.48 |
6 |
1699538 (2), 7536469 (1), 1370155 (1) |
| neuroendocrine tumors |
25.44 |
9 |
1718239 (4), 12966352 (1), 18288336 (1), 15944034 (1) (see all 6) |
| pain disorder |
21.48 |
2 |
15615535 (1), 1380624 (1) |
About this table
Genetic Association Database: GAL Human Genome Epidemiology Navigator: GAL (33 documents)
|
Medical News for GAL(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications for GAL (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/728 PubMed articles for GAL gene (see all 728
):- Genomic organization and localization of the gene encoding human preprogalanin. (PubMed id 7508413)2, 3, 4 Evans H.... Herzog H. (1993)
- Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populations. (PubMed id 16314872)1, 3, 6 Belfer I....Enoch M.A. (2006)
- Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity. (PubMed id 15930442)1, 3, 6 Schauble N....Hinney A. (2005)
- Sequence of human galanin and its inhibition of glucose-stimulated insulin secretion from RIN cells. (PubMed id 1370155)1, 3, 4 McKnight G.L.... Taborsky G.L. (1992)
- Human galanin: primary structure and identification of two molecular forms. (PubMed id 1710578)1, 3, 4 Bersani M....Holst J.J. (1991)
- Isolation and primary structure of pituitary human galanin, a 30- residue nonamidated neuropeptide. (PubMed id 1722333)1, 3, 4 Schmidt W.E.... Creutzfeldt W. (1991)
- Identification and characterization of phosphorylated proteins in the human pituitary. (PubMed id 14997482)3, 4 Giorgianni F.... Desiderio D.M. (2004)
- Galanin in pituitary adenomas. (PubMed id 14700749)1, 3 Grenback E....Hulting A.L. (2004)
- Galanin: a biologically active peptide. (PubMed id 12769595)1, 3 Vrontakis M.E. (2002)
- Functional and immunocytochemical evidence that galanin is a physiological regulator of human jejunal motility. (PubMed id 11595426)1, 3 Balint A....Varga G. (2001)
|
Search for GAL
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GAL
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GAL
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GAL(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for GAL(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GAL:

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| | | | Tocris compounds for GAL |
|
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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