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Aliases for GAK Gene

Aliases for GAK Gene

  • Cyclin G Associated Kinase 2 3
  • EC 2.7.11.1 4 63
  • Auxilin-2 2 3
  • Cyclin-G-Associated Kinase 3
  • DNAJC26 3
  • DNAJ26 3

External Ids for GAK Gene

Previous GeneCards Identifiers for GAK Gene

  • GC04M000847
  • GC04P000873

Summaries for GAK Gene

Entrez Gene Summary for GAK Gene

  • In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for GAK Gene

GAK (Cyclin G Associated Kinase) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Clathrin derived vesicle budding. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is TNS1.

UniProtKB/Swiss-Prot for GAK Gene

  • Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.

Gene Wiki entry for GAK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAK Gene

Genomics for GAK Gene

Regulatory Elements for GAK Gene

Genomic Location for GAK Gene

Start:
849,276 bp from pter
End:
932,390 bp from pter
Size:
83,115 bases
Orientation:
Minus strand

Genomic View for GAK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GAK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAK Gene

Proteins for GAK Gene

  • Protein details for GAK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14976-GAK_HUMAN
    Recommended name:
    Cyclin-G-associated kinase
    Protein Accession:
    O14976
    Secondary Accessions:
    • Q5U4P5
    • Q9BVY6

    Protein attributes for GAK Gene

    Size:
    1311 amino acids
    Molecular mass:
    143191 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GAK Gene

    Alternative splice isoforms for GAK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAK Gene

Proteomics data for GAK Gene at MOPED

Selected DME Specific Peptides for GAK Gene

Post-translational modifications for GAK Gene

  • Ubiquitination at Lys325
  • Modification sites at PhosphoSitePlus

Domains for GAK Gene

Gene Families for GAK Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)
IUPHAR :

Suggested Antigen Peptide Sequences for GAK Gene

Graphical View of Domain Structure for InterPro Entry

O14976

UniProtKB/Swiss-Prot:

GAK_HUMAN :
  • O14976
Domain:
  • Contains 1 C2 tensin-type domain.
  • Contains 1 J domain.
  • Contains 1 phosphatase tensin-type domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with GAK: view

Function for GAK Gene

Molecular function for GAK Gene

GENATLAS Biochemistry: cyclin G-associated kinase,ubiquitously expressed
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.

Enzyme Numbers (IUBMB) for GAK Gene

Gene Ontology (GO) - Molecular Function for GAK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 22645275
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with GAK: view
genes like me logo Genes that share phenotypes with GAK: view

Animal Models for GAK Gene

MGI Knock Outs for GAK:

miRNA for GAK Gene

No data available for Transcription Factor Targeting and HOMER Transcription for GAK Gene

Localization for GAK Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAK Gene

Cytoplasm, perinuclear region. Golgi apparatus, trans-Golgi network. Cell junction, focal adhesion. Note=Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAK Gene COMPARTMENTS Subcellular localization image for GAK gene
Compartment Confidence
golgi apparatus 4
cytosol 3
plasma membrane 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GAK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA --
GO:0005925 focal adhesion IEA --
GO:0016020 membrane IDA 19946888
GO:0030054 cell junction --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with GAK: view

Pathways for GAK Gene

genes like me logo Genes that share pathways with GAK: view

Gene Ontology (GO) - Biological Process for GAK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007029 endoplasmic reticulum organization IEA --
GO:0007030 Golgi organization IEA --
GO:0007049 cell cycle IEA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with GAK: view

Compounds for GAK Gene

(2) HMDB Compounds for GAK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(1) Novoseek inferred chemical compound relationships for GAK Gene

Compound -log(P) Hits PubMed IDs
tyrosine 17.8 1
genes like me logo Genes that share compounds with GAK: view

Transcripts for GAK Gene

Unigene Clusters for GAK Gene

Cyclin G associated kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GAK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^
SP1: - - - - - -
SP2:
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5:
SP6:
SP7:
SP8: - - - -
SP9: - - - -
SP10: - - - - - - - - - - - - - -
SP11: - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - -
SP13:
SP14:
SP15:
SP16: - - -
SP17: - -
SP18: - - - - - - - - - - - - - - - -
SP19: - - - -
SP20:
SP21: - - -
SP22:

ExUns: 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b · 25c ^ 26a · 26b ^ 27 ^ 28a · 28b ^
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - - - - - - - - - - - - - -
SP5: -
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

ExUns: 29 ^ 30a · 30b · 30c ^ 31a · 31b · 31c ^ 32a · 32b · 32c ^ 33
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - - -
SP15: - - -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for GAK Gene

GeneLoc Exon Structure for
GAK
ECgene alternative splicing isoforms for
GAK

Expression for GAK Gene

mRNA expression in normal human tissues for GAK Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GAK Gene

SOURCE GeneReport for Unigene cluster for GAK Gene Hs.369607

mRNA Expression by UniProt/SwissProt for GAK Gene

O14976-GAK_HUMAN
Tissue specificity: Ubiquitous. Highest in testis
genes like me logo Genes that share expressions with GAK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GAK Gene

Orthologs for GAK Gene

This gene was present in the common ancestor of animals.

Orthologs for GAK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GAK 35
  • 99.14 (n)
  • 99.62 (a)
GAK 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GAK 35
  • 81.83 (n)
  • 82.54 (a)
GAK 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAK 35
  • 83.01 (n)
  • 84.55 (a)
GAK 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gak 35
  • 81.03 (n)
  • 83.21 (a)
Gak 16
Gak 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GAK 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GAK 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gak 35
  • 80.73 (n)
  • 82.9 (a)
chicken
(Gallus gallus)
Aves GAK 35
  • 68.64 (n)
  • 72.36 (a)
GAK 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAK 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7462 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gak 35
  • 64.05 (n)
  • 69.23 (a)
Str.9982 35
zebrafish
(Danio rerio)
Actinopterygii gak 35
  • 69.36 (n)
  • 73.81 (a)
gak 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003715 35
  • 52.47 (n)
  • 44.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta aux 35
  • 49.94 (n)
  • 42.34 (a)
aux 36
  • 38 (a)
OneToMany
auxillin 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea tag-83 36
  • 25 (a)
OneToMany
F46G11.3 37
  • 36 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4547 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10856 36
  • 45 (a)
OneToMany
Species with no ortholog for GAK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GAK Gene

ENSEMBL:
Gene Tree for GAK (if available)
TreeFam:
Gene Tree for GAK (if available)

Paralogs for GAK Gene

Paralogs for GAK Gene

genes like me logo Genes that share paralogs with GAK: view

Variants for GAK Gene

Sequence variations from dbSNP and Humsavar for GAK Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs6964 -- 849,396(-) CGTGG(C/T)CTCTG utr-variant-3-prime
rs8093 -- 849,907(-) CTGGC(C/T)GTGCA synonymous-codon, reference
rs751091 -- 872,381(-) TCGGG(C/T)GCAGG intron-variant
rs755447 -- 871,439(+) ATGAC(A/G)ACGTC intron-variant
rs764324 -- 874,078(-) GCTCC(A/G)TCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAK Gene

Variant ID Type Subtype PubMed ID
nsv822425 CNV Loss 20364138
dgv1564e1 CNV Complex 17122850
nsv878247 CNV Loss 21882294
dgv5389n71 CNV Loss 21882294
dgv5390n71 CNV Loss 21882294
dgv5391n71 CNV Loss 21882294
nsv878262 CNV Loss 21882294
nsv878267 CNV Loss 21882294
dgv5392n71 CNV Loss 21882294
nsv461147 CNV Loss 19166990
nsv469998 CNV Loss 18288195
esv32803 CNV Gain 17666407
dgv5393n71 CNV Loss 21882294
nsv461148 CNV Loss 19166990
nsv878278 CNV Loss 21882294
nsv508987 CNV Insertion 20534489
esv2726715 CNV Deletion 23290073
nsv291489 CNV Loss 16902084
esv2726716 CNV Deletion 23290073
esv2726717 CNV Deletion 23290073
esv2726719 CNV Deletion 23290073
esv29984 CNV Loss 17803354
esv2726720 CNV Deletion 23290073
dgv5394n71 CNV Loss 21882294
esv2726721 CNV Deletion 23290073
dgv5395n71 CNV Loss 21882294
esv2726722 CNV Deletion 23290073
esv2726723 CNV Deletion 23290073
esv2726724 CNV Deletion 23290073
dgv847e201 CNV Deletion 23290073
esv2726726 CNV Deletion 23290073
esv2726727 CNV Deletion 23290073
esv2726730 CNV Deletion 23290073
esv2726731 CNV Deletion 23290073
esv2726732 CNV Deletion 23290073
esv2726733 CNV Deletion 23290073
esv2726734 CNV Deletion 23290073
esv2726735 CNV Deletion 23290073
esv2726736 CNV Deletion 23290073
esv2726737 CNV Deletion 23290073
nsv292455 CNV Loss 16902084
esv2726738 CNV Deletion 23290073
esv22328 CNV Gain 19812545
esv1655240 CNV Deletion 17803354

Relevant External Links for GAK Gene

HapMap Linkage Disequilibrium report
GAK
Human Gene Mutation Database (HGMD)
GAK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAK Gene

Disorders for GAK Gene

(1) University of Copenhagen DISEASES for GAK Gene

Relevant External Links for GAK

Genetic Association Database (GAD)
GAK
Human Genome Epidemiology (HuGE) Navigator
GAK
genes like me logo Genes that share disorders with GAK: view

No data available for UniProtKB/Swiss-Prot for GAK Gene

Publications for GAK Gene

  1. Structure, expression, and chromosomal localization of human GAK. (PMID: 9299234) Kimura S.H. … Nojima H. (Genomics 1997) 2 3 4 23
  2. Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation. (PMID: 10887964) Umeda A. … Ungewickell E. (Eur. J. Cell Biol. 2000) 3 23
  3. Expression of auxilin or AP180 inhibits endocytosis by mislocalizing clathrin: evidence for formation of nascent pits containing AP1 or AP2 but not clathrin. (PMID: 11148137) Zhao X. … Greene L.E. (J. Cell. Sci. 2001) 3 23
  4. Identification of NPM-ALK interacting proteins by tandem mass spectrometry. (PMID: 14968112) Crockett D.K. … Lim M.S. (Oncogene 2004) 3 23
  5. The serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling. (PMID: 15240878) Zhang L. … Roberts T.M. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 23

Products for GAK Gene

  • Addgene plasmids for GAK

Sources for GAK Gene

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