GAK Gene
protein-coding GIFtS: 66
GCID: GC04M000832
|
|
cyclin G associated kinase
| |
Aliases
for GAK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cyclin G Associated Kinase1 2 | | DNAJC261 2 | | EC 2.7.11.13 8 | | DNAJ262 | | Auxilin-21 | | Cyclin-G-Associated Kinase2 |
Export aliases for GAK gene to outside databasesPrevious GC identifers: GC04M000847 GC04P000873 |
Summaries
for GAK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GAK:
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities areregulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylationand dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A throughI. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstreamof p53. GAK is an association partner of cyclin G and CDK5. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: GAK_HUMAN, O14976Function: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating ofclathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peakingat G1
Gene Wiki entry for GAK
|
Genomic Views
for GAK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_037622.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GAK gene promoter:
MAZR AP-1 NRSF form 1 Egr-1 ATF-2 Nkx2-5 E4BP4 NRSF form 2 HFH-1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for GAK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16GAK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M000832: view genomic region
(about GC identifiers)
Start:
|
843,064 bp from pter |
End:
|
926,174 bp from pter |
Size:
|
83,111 bases |
Orientation:
|
minus strand |
|
Proteins
for GAK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GAK_HUMAN, O14976 (See
protein sequence)Recommended Name: Cyclin-G-associated kinase Size: 1311 amino acids; 143191 Da
Subcellular location: Cytoplasm, perinuclear region. Golgi apparatus, trans-Golgi network. Cell junction, focaladhesion (Probable). Note=Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasmamembrane, probably at focal adhesions
1 PDB 3D structure from  and Proteopedia  for GAK:3LL6 (3D)
Secondary accessions: Q9BVY6Explore the universe of human proteins at neXtProt for GAK: NX_O14976
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14976
3 DME Specific Peptides for GAK (O14976)
GAK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005246.2
ENSEMBL proteins: ENSP00000424553 ENSP00000421361 ENSP00000314499 ENSP00000421049 ENSP00000426062 ENSP00000426908 ENSP00000426728 ENSP00000424701 ENSP00000421814 ENSP00000422391 Reactome Protein details: O14976
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
GAK for ontologies About GeneDecksing
GAK Antibody Products:
Assay Products for GAK: |
Protein
Domains /
Families
for GAK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GAK for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry O14976ProtoNet protein and cluster: O14976 UniProtKB/Swiss-Prot: GAK_HUMAN, O14976Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase familySimilarity: Contains 1 C2 tensin-type domainSimilarity: Contains 1 J domainSimilarity: Contains 1 phosphatase tensin-type domainSimilarity: Contains 1 protein kinase domain |
Function
for GAK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GAK_HUMAN, O14976Function: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating ofclathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peakingat G1Catalytic activity: ATP + a protein = ADP + a phosphoprotein Genatlas biochemistry entry for GAK:cyclin G-associated kinase,ubiquitously expressed
Enzyme Number (IUBMB): EC 2.7.11.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAK (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAK (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GAK (NM_005255) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GAK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAK |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
GAK for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for GAK:
Animal Models:
Mouse knock-out Gaktm1Legr for GAK
11 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Gak):
GAK for phenotypes About GeneDecksing
|
Pathways & Interactions
for GAK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Clathrin derived vesicle budding | | | 2 | Membrane Trafficking | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for GAK
GAK for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GAK
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/18 Interacting proteins for GAK (O149761, 3 ENSP000003144994) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007049 | cell cycle |
IEA | -- |
GAK for ontologies About GeneDecksing
|
Drugs & Compounds
for GAK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GAK for compounds About GeneDecksing
 Browse Tocris compounds for GAK
2 HMDB Compounds for GAK About this table
1 Novoseek chemical compound relationship for GAK gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
17.8 |
1 |
15240878 (1) |
Search CenterWatch for drugs/clinical trials and news about GAK
|
Transcripts
for GAK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GAK gene: NM_005255.2 Unigene Cluster for GAK: Cyclin G associated kinase Hs.369607 [show with all ESTs]Unigene Representative Sequence: NM_00525518/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21): ENST00000502799 ENST00000504668 ENST00000511163(uc003gbn.4 uc010ibk.1)
ENST00000509566(uc010ibj.3) ENST00000515868 ENST00000511345 ENST00000314167(uc003gbl.4 uc003gbm.4)
ENST00000511980 ENST00000510799 ENST00000504947 ENST00000504435 ENST00000505819(uc003gbo.2)
ENST00000507580 ENST00000502656 ENST00000507991 ENST00000512325 ENST00000510022
ENST00000511229
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAK (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAK (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GAK (NM_005255) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GAK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAK |
Additional cDNA sequence: AB208854.1 AK092587.1 AK097714.1 AK126735.1 AK127351.1 AK299554.1 AK309413.1 BC000816.1 BC001290.1 BC008668.1 BC063606.1 BC085005.1 BC107076.1 BT007015.1 D88435.1 21 DOTS entries: DT.100820401 DT.85105285 DT.91646784 DT.97805260 DT.100820398 DT.40195532 DT.100731881 DT.100820407 DT.40273133 DT.95375046 DT.100820403 DT.95375051 DT.121268339 DT.92436107 DT.95375047 DT.121268463 DT.91735016 DT.100742954 DT.102829199 DT.95202658 DT.99985301 24/288 AceView cDNA sequences (see all 288): BU155663 AW205280 BU175868 BQ883480 AI738640 BE893662 BM856353 CA435606 BM470164 AA341485 AI805383 BQ937515 BM668589 BC001290 BU726628 AI273763 BU848980 BM693265 AI356308 AI218742 BM987018 BF063414 CR596345 BQ187701
GeneLoc Exon Structure
5/22 Alternative Splicing Database (ASD) splice patterns (SP) for GAK (see all 22) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | - | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | | | - | | | | - | | - | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25a | · | 25b | · | 25c | ^ | 26a | · | 26b | ^ | 27 | ^ | 28a | · | 28b | ^ |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | |
| ExUns: | 29 | ^ | 30a | · | 30b | · | 30c | ^ | 31a | · | 31b | · | 31c | ^ | 32a | · | 32b | · | 32c | ^ | 33 |
|---|
|
| SP1: | - | | | | | | | | - | | | | | | - | | | | | | | | |
| SP2: | - | | | | | | | | - | | | | | | - | | | | | | | | |
| SP3: | - | | | | | | | | - | | | | | | - | | | | | | | | |
| SP4: | - | | | | | | | | - | | | | | | - | | | | | | | | |
| SP5: | - | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for GAK
|
Expression
for GAK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GAK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCCTGGTG
About this image
See GAK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GAK
SOURCE GeneReport for Unigene cluster: Hs.369607
UniProtKB/Swiss-Prot: GAK_HUMAN, O14976Tissue specificity: Ubiquitous. Highest in testis
SABiosciences Custom PCR Arrays for GAK
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GAK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAK |
Orthologs
for GAK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for GAK gene from 8/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
GAK1 |
cyclin G associated kinase |
68.9(n)
73.23(a) |
|
427291 XM_424873.3 XP_424873.3 |
lizard
(Anolis carolinensis) |
Reptilia |
GAK6 |
-- |
71(a) |
1 ↔ 1 |
GL343201.1(538281-619235) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.74622 |
Xenopus laevis transcribed sequence with moderate similarity more |
76.41(n) |
|
BG813832.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1001511581 |
cyclin-G-associated kinase-like |
67.73(n)
69.64(a) |
|
100151158 XM_001919189.3 XP_001919224.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
auxillin3
aux1 |
protein amino acid phosphorylation protein
kinase3
auxillin1 |
41(a)3
47.04(n)1
38.92(a)1 |
|
82A13
405271 NM_141181.21 NP_649438.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
F46G11.33 |
serine/threonine-protein kinase |
36(a) |
|
X(5818674-5821419) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT2G328506 |
AP2-associated kinase |
22(a) |
1 ↔ 1 |
2(13935186-13938845) |
rice
(Oryza sativa) |
Liliopsida |
---- |
cyclin G-associated kinase, putative, expressed |
23(a)21(a) |
1 ↔ many1 ↔ many |
9(5846603-5850899) 2(22886399-22891575) |
ENSEMBL Gene Tree for GAK (if available)
TreeFam Gene Tree for GAK (if available) |
Paralogs
for GAK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GAK gene
- TNS12 DNAJC62 PTEN2 TPTE2 TNS32 TNS42 TENC12 TPTE22
8 SIMAP similar genes for GAK using alignment to 12 protein entries: GAK_HUMAN (see all proteins):TNS1 DNAJC6 BMP2K BRAF TNS3 PTEN
STK11 STK25
GAK for paralogs About GeneDecksing
|
Genomic Variants
for GAK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for GAK
4 CNVs: 3475 68594 30188 7453
1 Indel: 12377
Human Gene Mutation Database (HGMD): GAK
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAK |
|
Disorders
/ Diseases
for GAK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GAK for disorders About GeneDecksing
OMIM gene information: 602052
OMIM disorders: --
5  diseases for GAK: About MalaCardsparkinson's disease prostate cancer prostatitis malaria
neuronitis
1 disease from the University of Copenhagen DISEASES database for GAK:Parkinson's disease Human Genome Epidemiology (HuGE) Navigator: GAK (17 documents)
Export disorders for GAK gene to outside databases
|
Publications
for GAK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GAK gene, integrated from 9 sources (see all 50):
(articles sorted by number of sources associating them with GAK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structure, expression, and chromosomal localization of human GAK. (PubMed id 9299234)1, 2, 3, 9 Kimura S.H.... Nojima H. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells. (PubMed id 10625686)1, 2 Greener T.... Greene L.E. (2000)
- GAK, a regulator of clathrin-mediated membrane traffi cking, localizes not only in the cytoplasm but also in the nucleus. (PubMed id 19371378)1, 9 Sato J....Nojima H. (2009)
- Recruitment dynamics of GAK and auxilin to clathrin-coated pits during endocytosis. (PubMed id 16895969)1, 9 Lee D.W....Greene L.E. (2006)
- GAK, a regulator of clathrin-mediated membrane traffi c, also controls centrosome integrity and chromosome congression. (PubMed id 19654208)1, 9 Shimizu H....Nojima H. (2009)
- Canonical interaction of cyclin G associated kinase with adaptor protein 1 regulates lysosomal enzyme sorting. (PubMed id 17538018)1, 9 Kametaka S....Bonifacino J.S. (2007)
- The serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling. (PubMed id 15240878)1, 9 Zhang L....Roberts T.M. (2004)
- GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain. (PubMed id 9013862)1, 9 Kanaoka Y....Nojima H. (1997)
- Expression of auxilin or AP180 inhibits endocytosis by mislocalizing clathrin: evidence for formation of nascent pits containing AP1 or AP2 but not clathrin. (PubMed id 11148137)1, 9 Zhao X....Greene L.E. (2001)
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External Searches for GAK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing GAK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing GAK gene
(According to HUGE)
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Specialized Databases showing GAK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for GAK gene:
Search GeneIP for patents involving GAK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for GAK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GAK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GAK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAK | | | OriGene Protein Over-expression Lysate for GAK | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GAK | | OriGene 3'-UTR Clone for GAK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for GAK | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GAK | | OriGene Custom Protein Services for GAK | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GAK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAK |
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| | | | Search Tocris compounds for GAK |
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 | | | GAK Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAK |
|  |  |  | | | | ThermoFisher Antibodies for GAK |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAK |
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