GAGE8 Gene
protein-coding GIFtS: 35
GCID: GC0XU990292
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G antigen 8
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Aliases
for GAGE8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
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| G Antigen 81 2 3 | | Cancer/Testis Antigen Family 4, Member 82 | | CT4.81 2 3 | | G Antigen 2D2 | | Cancer/Testis Antigen 4.82 3 | | GAGE-2D3 | | GAGE-82 3 | | |
Export aliases for GAGE8 gene to outside databasesPrevious GC identifers: GC0XP047423 GC0XP048217 GC0XP048273 GC0XP049059 GC0XP049060 GC0XP049047 GC0XP049066 GC0XP049097 GC0XP049189 GC0XP049190 GC0XP049201 GC0XP049220 |
Summaries
for GAGE8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GAGE8:
This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except forthe testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions.The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologouscytolytic T lymphocytes. (provided by RefSeq, Jul 2008)
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Genomic Views
for GAGE8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NT_079573.4
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for GAGE8
Other transcription factors
Search SABiosciences Chromatin IP Primers for GAGE8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAGE8 |
Genomic Location:
Chromosome:X
Entrez Gene cytogenetic band: Xp11 HGNC cytogenetic band: Xp11GeneLoc information about chromosome X |
Proteins
for GAGE8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GGE2D_HUMAN, Q9UEU5 (See
protein sequence)Recommended Name: G antigen 2D Size: 116 amino acids; 12764 Da
Miscellaneous: This gene belongs to a family of genes organized in clustered repeats. They have a high degree ofpredicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain eitherthe antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells
Caution: The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE membersmade impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGEgene nomenclature based on the identified genes and their products
Secondary accessions: A6NG46 A6NNR8 B7ZL76 Q4V325Explore the universe of human proteins at neXtProt for GAGE8: NX_Q9UEU5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UEU5
GAGE8 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_036328.1
Human Recombinant Protein Products:
GAGE8 Antibody Products:
Assay Products for GAGE8: |
Protein
Domains /
Families
for GAGE8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GAGE8 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UEU5ProtoNet protein and cluster: Q9UEU5 1 Blocks protein family: IPB008625 GAGE
UniProtKB/Swiss-Prot: GGE2D_HUMAN, Q9UEU5Similarity: Belongs to the GAGE family |
Function
for GAGE8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
Genatlas biochemistry entry for GAGE8:G antigen 8,expressed in testis and in several tumors
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for GAGE8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAGE8 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
GAGE8 for ontologies About GeneDecksing
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Pathways & Interactions
for GAGE8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GAGE8
2 Interacting proteins for GAGE8 (Q9UEU51, 2, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
GAGE8 for ontologies About GeneDecksing
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Drugs & Compounds
for GAGE8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GAGE8
Search CenterWatch for drugs/clinical trials and news about GAGE8 / GGE2D
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Transcripts
for GAGE8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for GAGE8 gene: NM_012196.1 Unigene Cluster for GAGE8: G antigen 8 Hs.743690 [show with all ESTs]Unigene Representative Sequence: BG700165
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GAGE8 (NM_012196) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GAGE8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAGE8 |
Additional cDNA sequence: AF055473.1 BC018052.1 BC143620.1 BC171769.1 4 DOTS entries: DT.444944 DT.92427997 DT.121292581 DT.95197148
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Expression
for GAGE8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
Genevestigator expression for GAGE8
SOURCE GeneReport for Unigene cluster: Hs.743690
UniProtKB/Swiss-Prot: GGE2D_HUMAN, Q9UEU5Tissue specificity: Not expressed in normal tissues, except in testis, but expressed by a large proportion of tumors ofvarious histological origins
SABiosciences Custom PCR Arrays for GAGE8
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GAGE8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAGE8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAGE8 |
Orthologs
for GAGE8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
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Paralogs
for GAGE8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for GAGE8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for GAGE8
7 CNVs: 33164 73975 96665 83510 73974 37039 31551 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for GAGE8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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GAGE8 for disorders About GeneDecksing
OMIM gene information: 300638
OMIM disorders: --
4  diseases for GAGE8: About MalaCardsprostate cancer, progression of prostate cancer prostatitis melanoma
Export disorders for GAGE8 gene to outside databases
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Publications
for GAGE8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for GAGE8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with GAGE8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PubMed id 10397259)1, 2, 3 De Backer O.... van der Bruggen P. (1999)
- An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PubMed id 18179644)1, 2 Gjerstorff M.F. and Ditzel H.J. (2008)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. (PubMed id 9651357)1 Chen M.E.... Sikes R.A. (1998)
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External Searches for GAGE8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing GAGE8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing GAGE8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GAGE8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for GAGE8 gene:
Search GeneIP for patents involving GAGE8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for GAGE8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GAGE8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GAGE8 | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for GAGE8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GAGE8 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GAGE8 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAGE8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAGE8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAGE8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAGE8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAGE8 |
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 | | | GAGE8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for GAGE8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAGE8 |
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