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Aliases for GAGE8 Gene

Aliases for GAGE8 Gene

  • G Antigen 8 4 2 3
  • Cancer/Testis Antigen 4.8 3 4
  • GAGE-8 3 4
  • CT4.8 3 4
  • Cancer/Testis Antigen Family 4, Member 8 3
  • Cancer/Testis Antigen Family 4 2
  • G Antigen 2D 3
  • GAGE2D GAGE8 4
  • Member 8 2
  • GAGE-2D 4

External Ids for GAGE8 Gene

Previous GeneCards Identifiers for GAGE8 Gene

  • GC0XP047423
  • GC0XP048217
  • GC0XP048273
  • GC0XP049059
  • GC0XP049060
  • GC0XP049047
  • GC0XP049066
  • GC0XP049097
  • GC0XP049189
  • GC0XP049190
  • GC0XP049201
  • GC0XP049220

Summaries for GAGE8 Gene

Entrez Gene Summary for GAGE8 Gene

  • This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAGE8 Gene

GAGE8 (G Antigen 8) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE8 Gene

Genomics for GAGE8 Gene

Genomic Location for GAGE8 Gene

Orientation:
Unknown strand

Genomic View for GAGE8 Gene

Cytogenetic band:
  • Xp11 not on reference assembly by Entrez Gene
  • Xp11 not on reference assembly by HGNC

RefSeq DNA sequence for GAGE8 Gene

No data available for Regulatory Elements for GAGE8 Gene

Proteins for GAGE8 Gene

  • Protein details for GAGE8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UEU5-GGE2D_HUMAN
    Recommended name:
    G antigen 2D
    Protein Accession:
    Q9UEU5
    Secondary Accessions:
    • A6NG46
    • A6NNR8
    • B7ZL76
    • Q4V325

    Protein attributes for GAGE8 Gene

    Size:
    116 amino acids
    Molecular mass:
    12764 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells

neXtProt entry for GAGE8 Gene

Proteomics data for GAGE8 Gene at MOPED

Post-translational modifications for GAGE8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE8 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for GAGE8 Gene

Domains for GAGE8 Gene

Protein Domains for GAGE8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GAGE8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UEU5

UniProtKB/Swiss-Prot:

GGE2D_HUMAN :
  • Q9UEU5
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE8: view

No data available for Gene Families for GAGE8 Gene

Function for GAGE8 Gene

Molecular function for GAGE8 Gene

GENATLAS Biochemistry: G antigen 8,expressed in testis and in several tumors

Gene Ontology (GO) - Molecular Function for GAGE8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with GAGE8: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GAGE8 Gene

Localization for GAGE8 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GAGE8 Gene

Pathways for GAGE8 Gene

SuperPathways for GAGE8 Gene

No Data Available

Interacting Proteins for GAGE8 Gene

Gene Ontology (GO) - Biological Process for GAGE8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 10397259
genes like me logo Genes that share ontologies with GAGE8: view

No data available for Pathways by source for GAGE8 Gene

Transcripts for GAGE8 Gene

mRNA/cDNA for GAGE8 Gene

(1) REFSEQ mRNAs :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAGE8

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE8 Gene

No ASD Table

Relevant External Links for GAGE8 Gene

ECgene alternative splicing isoforms for
GAGE8

Expression for GAGE8 Gene

mRNA expression in normal human tissues for GAGE8 Gene

mRNA Expression by UniProt/SwissProt for GAGE8 Gene

Q9UEU5-GGE2D_HUMAN
Tissue specificity: Not expressed in normal tissues, except in testis, but expressed by a large proportion of tumors of various histological origins
genes like me logo Genes that share expressions with GAGE8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for GAGE8 Gene

Orthologs for GAGE8 Gene

No data available for Orthologs and Evolution for GAGE8 Gene

Paralogs for GAGE8 Gene

genes like me logo Genes that share paralogs with GAGE8: view

No data available for Paralogs for GAGE8 Gene

Variants for GAGE8 Gene

Structural Variations from Database of Genomic Variants (DGV) for GAGE8 Gene

Variant ID Type Subtype PubMed ID
esv24944 CNV Gain+Loss 19812545
nsv821250 CNV Deletion 20802225
nsv6897 CNV Insertion 18451855
nsv515202 CNV Complex 21397061
nsv820429 CNV Deletion 20802225
esv28941 CNV Gain+Loss 19812545

Relevant External Links for GAGE8 Gene

Human Gene Mutation Database (HGMD)
GAGE8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GAGE8 Gene

Disorders for GAGE8 Gene

No disorders were found for GAGE8 Gene.

No data available for UniProtKB/Swiss-Prot for GAGE8 Gene

Publications for GAGE8 Gene

  1. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PMID: 10397259) De Backer O. … van der Bruggen P. (Cancer Res. 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff M.F. … Ditzel H.J. (Tissue Antigens 2008) 3 4
  5. Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. (PMID: 9651357) Chen M.E. … Sikes R.A. (J. Biol. Chem. 1998) 3

Products for GAGE8 Gene

Sources for GAGE8 Gene

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