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GAGE5 Gene

protein-coding   GIFtS: 30
GCID: GC0XU990068

G Antigen 5

  Search for GAGE5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Antigen 51 2     Cancer/Testis Antigen Family 41
Cancer/Testis Antigen 4.52 3     Member 51
CT4.52 3     Cancer/Testis Antigen Family 4, Member 52
GAGE-52 3     

External Ids:    HGNC: 41021   Entrez Gene: 25772   OMIM: 3005985   UniProtKB: Q130693   

Export aliases for GAGE5 gene to outside databases

Previous GC identifers: GC0XP048025 GC0XP048253 GC0XP048258 GC0XP049029 GC0XP049034 GC0XP049105 GC0XP049089 GC0XP049215 GC0XP049354 GC0XP049364


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GAGE5 Gene:
This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except
for the testis. The sequences of the family members are highly related but differ by scattered nucleotide
substitutions. The antigenic peptide YYWPRPRRY, which is also encoded by several other family members, is
recognized by autologous cytolytic T lymphocytes. (provided by RefSeq, Jul 2008)

GeneCards Summary for GAGE5 Gene:
GAGE5 (G antigen 5) is a protein-coding gene.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for GAGE5
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for GAGE5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GAGE5


Genomic Location:
Chromosome:X   

Entrez Gene cytogenetic band: Xp11.4-p11.2   HGNC cytogenetic band: Xp11.4-p11.2

GeneLoc information about chromosome X        


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GAGE5_HUMAN, Q13069 (See protein sequence)
Recommended Name: G antigen 5  
Size: 117 amino acids; 12924 Da
Miscellaneous: This gene belongs to a family of genes organized in clustered repeats. They have a high degree of
predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain
either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells
Caution: The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE
members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644
presented a new GAGE gene nomenclature based on the identified genes and their products
Secondary accessions: Q6FG72

Explore the universe of human proteins at neXtProt for GAGE5: NX_Q13069

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_001466.1  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008625 GAGE

    Graphical View of Domain Structure for InterPro Entry Q13069

    ProtoNet protein and cluster: Q13069

    1 Blocks protein domain: IPB008625 GAGE

    UniProtKB/Swiss-Prot: GAGE5_HUMAN, Q13069
    Similarity: Belongs to the GAGE family


    Find genes that share domains with GAGE5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GAGE5
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GAGE5
    Interactions:

        Search GeneGlobe Interaction Network for GAGE5

    3 Interacting proteins for GAGE5 (Q130692, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GMCL1P1Q8NEA92, 3MINT-66709 I2D: score=2 
    KIAA1524Q8TCG13I2D: score=2 
    GMCL1Q96IK53I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GAGE5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GAGE5 gene: 
    NM_001475.1  

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    Selected AceView cDNA sequences (see all 29):

    NM_001474 U19145 BM832793 BC024914 BC018052 CF780547 AW016546 U19143 
    BX283580 AF055473 NM_012196 AW510753 BC005363 BM836228 BC069309 BX108227 
    NM_001472 AA447559 AW102587 BG208433 BG120838 BP431265 AA738037 BG206349 

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GAGE5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GAGE5 Expression
    About this image

    GAGE5 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    UniProtKB/Swiss-Prot: GAGE5_HUMAN, Q13069
    Tissue specificity: Expressed in a variety of tumor tissues but not in normal tissues, except testis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAGE5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GAGE5 gene
    Selected SIMAP similar genes for GAGE5 using alignment to 1 protein entry:     GAGE5_HUMAN(see all similar genes):
    GAGE3    GAGE6    GAGE12F    GAGE12G    GAGE12I    GAGE12J
    GAGE7    GAGE4    GAGE1    GAGE12B    GAGE12C    GAGE12D
    GAGE12E    GAGE12H    GAGE13    GAGE2D    GAGE2E    GAGE8

    Find genes that share paralogs with GAGE5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GAGE5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821250CNV Deletion20802225
    esv24944CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing GAGE5
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300598    OMIM disorders: --


    Find genes that share disorders with GAGE5           About GenesLikeMe


    Export disorders for GAGE5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GAGE5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with GAGE5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PubMed id 7544395)1, 2, 3 van den Eynde B....Boon T. (J. Exp. Med. 1995)
    2. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PubMed id 18179644)1, 2 Gjerstorff M.F. and Ditzel H.J. (Tissue Antigens 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PubMed id 10397259)1, 2 De Backer O.... van der Bruggen P. (Cancer Res. 1999)
    5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
    6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. (PubMed id 9651357)1 Chen M.E.... Sikes R.A. (J. Biol. Chem. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2577 HGNC: 4102 AceView: GAGE2 euGenes: HUgn2577 ECgene: GAGE5
    H-InvDB: GAGE5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GAGE5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GAGE5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GAGE5 gene:
    Search GeneIP for patents involving GAGE5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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