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Aliases for GAGE4 Gene

Aliases for GAGE4 Gene

  • G Antigen 4 2 3
  • Cancer/Testis Antigen Family 4, Member 4 2 3
  • Cancer/Testis Antigen 4.4 3 4
  • GAGE-4 3 4
  • CT4.4 3 4

External Ids for GAGE4 Gene

Previous GeneCards Identifiers for GAGE4 Gene

  • GC0XP047420
  • GC0XP048024
  • GC0XP048252
  • GC0XP049028
  • GC0XP049103
  • GC0XP049056
  • GC0XP049069
  • GC0XP049088
  • GC0XP049213
  • GC0XP049357
  • GC0XP049366

Summaries for GAGE4 Gene

Entrez Gene Summary for GAGE4 Gene

  • This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YYWPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAGE4 Gene

GAGE4 (G Antigen 4) is a Protein Coding gene.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE4 Gene

Genomics for GAGE4 Gene

Genomic Location for GAGE4 Gene

Chromosome:
X
Orientation:
Unknown strand

Genomic View for GAGE4 Gene


Cytogenetic band:
  • Xp11.4-p11.2 by Entrez Gene
  • Xp11.4-p11.2 not on reference assembly by HGNC
GeneLoc Logo Gene Density

No data available for Regulatory Elements and RefSeq DNA sequence for GAGE4 Gene

Proteins for GAGE4 Gene

  • Protein details for GAGE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13068-GAGE4_HUMAN
    Recommended name:
    G antigen 4
    Protein Accession:
    Q13068
    Secondary Accessions:
    • A8MU85
    • Q6NT33

    Protein attributes for GAGE4 Gene

    Size:
    117 amino acids
    Molecular mass:
    12885 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for GAGE4 Gene

Post-translational modifications for GAGE4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE4 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for GAGE4 Gene

Domains & Families for GAGE4 Gene

Protein Domains for GAGE4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GAGE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13068

UniProtKB/Swiss-Prot:

GAGE4_HUMAN :
  • Belongs to the GAGE family.
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE4: view

No data available for Gene Families for GAGE4 Gene

Function for GAGE4 Gene

Phenotypes for GAGE4 Gene

GenomeRNAi human phenotypes for GAGE4:
genes like me logo Genes that share phenotypes with GAGE4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAGE4 Gene

Localization for GAGE4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GAGE4 Gene

Pathways & Interactions for GAGE4 Gene

SuperPathways for GAGE4 Gene

No Data Available

Interacting Proteins for GAGE4 Gene

Selected Interacting proteins: Q13068-GAGE4_HUMAN for GAGE4 Gene via IID

Gene Ontology (GO) - Biological Process for GAGE4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GAGE4 Gene

Drugs & Compounds for GAGE4 Gene

No Compound Related Data Available

Transcripts for GAGE4 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE4 Gene

No ASD Table

Relevant External Links for GAGE4 Gene

ECgene alternative splicing isoforms for
GAGE4

Expression for GAGE4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAGE4 Gene

NURSA nuclear receptor signaling pathways regulating expression of GAGE4 Gene:

GAGE4

mRNA Expression by UniProt/SwissProt for GAGE4 Gene:

Q13068-GAGE4_HUMAN
Tissue specificity: Expressed in a variety of tumor tissues but not in normal tissues, except testis.
genes like me logo Genes that share expression patterns with GAGE4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAGE4 Gene

Orthologs for GAGE4 Gene

No data available for Orthologs and Evolution for GAGE4 Gene

Paralogs for GAGE4 Gene

genes like me logo Genes that share paralogs with GAGE4: view

No data available for Paralogs for GAGE4 Gene

Variants for GAGE4 Gene

Structural Variations from Database of Genomic Variants (DGV) for GAGE4 Gene

Variant ID Type Subtype PubMed ID
dgv4237n106 CNV duplication 24896259
esv28941 CNV gain+loss 19812545
esv3364710 CNV duplication 20981092
esv3380090 CNV duplication 20981092
esv3435089 CNV duplication 20981092
esv3449504 CNV duplication 20981092
nsv1077583 CNV duplication 25765185
nsv1077584 CNV duplication 25765185
nsv1129078 CNV duplication 24896259
nsv1147303 CNV duplication 26484159
nsv1152758 CNV duplication 26484159
nsv820429 CNV deletion 20802225
nsv953412 CNV duplication 24416366

Relevant External Links for GAGE4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAGE4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for GAGE4 Gene

Disorders for GAGE4 Gene

Relevant External Links for GAGE4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAGE4

No disorders were found for GAGE4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE4 Gene

Publications for GAGE4 Gene

  1. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PMID: 7544395) van den Eynde B. … Boon T. (J. Exp. Med. 1995) 2 3 4 64
  2. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff M.F. … Ditzel H.J. (Tissue Antigens 2008) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PMID: 10397259) De Backer O. … van der Bruggen P. (Cancer Res. 1999) 3 4 64
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4 64

Products for GAGE4 Gene

Sources for GAGE4 Gene

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