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Aliases for GAGE4 Gene

Aliases for GAGE4 Gene

  • G Antigen 4 2 3
  • Cancer/Testis Antigen 4.4 3 4
  • GAGE-4 3 4
  • CT4.4 3 4
  • Cancer/Testis Antigen Family 4, Member 4 3
  • Cancer/Testis Antigen Family 4 2
  • Member 4 2

External Ids for GAGE4 Gene

Previous GeneCards Identifiers for GAGE4 Gene

  • GC0XP047420
  • GC0XP048024
  • GC0XP048252
  • GC0XP049028
  • GC0XP049103
  • GC0XP049056
  • GC0XP049069
  • GC0XP049088
  • GC0XP049213
  • GC0XP049357
  • GC0XP049366

Summaries for GAGE4 Gene

Entrez Gene Summary for GAGE4 Gene

  • This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YYWPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAGE4 Gene

GAGE4 (G Antigen 4) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE4 Gene

Genomics for GAGE4 Gene

Genomic Location for GAGE4 Gene

Orientation:
Unknown strand

Genomic View for GAGE4 Gene

Cytogenetic band:
  • Xp11.4-p11.2 by Entrez Gene
  • Xp11.4-p11.2 not on reference assembly by HGNC

RefSeq DNA sequence for GAGE4 Gene

No data available for Regulatory Elements for GAGE4 Gene

Proteins for GAGE4 Gene

  • Protein details for GAGE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13068-GAGE4_HUMAN
    Recommended name:
    G antigen 4
    Protein Accession:
    Q13068
    Secondary Accessions:
    • A8MU85
    • Q6NT33

    Protein attributes for GAGE4 Gene

    Size:
    117 amino acids
    Molecular mass:
    12885 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells

neXtProt entry for GAGE4 Gene

Proteomics data for GAGE4 Gene at MOPED

Post-translational modifications for GAGE4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE4 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for GAGE4 Gene

Domains for GAGE4 Gene

Protein Domains for GAGE4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GAGE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13068

UniProtKB/Swiss-Prot:

GAGE4_HUMAN :
  • Q13068
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE4: view

No data available for Gene Families for GAGE4 Gene

Function for GAGE4 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAGE4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GAGE4 Gene

Localization for GAGE4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GAGE4 Gene

Pathways for GAGE4 Gene

SuperPathways for GAGE4 Gene

No Data Available

Interacting Proteins for GAGE4 Gene

Gene Ontology (GO) - Biological Process for GAGE4 Gene

None

No data available for Pathways by source for GAGE4 Gene

Transcripts for GAGE4 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAGE4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE4 Gene

No ASD Table

Relevant External Links for GAGE4 Gene

ECgene alternative splicing isoforms for
GAGE4

Expression for GAGE4 Gene

mRNA expression in normal human tissues for GAGE4 Gene

mRNA Expression by UniProt/SwissProt for GAGE4 Gene

Q13068-GAGE4_HUMAN
Tissue specificity: Expressed in a variety of tumor tissues but not in normal tissues, except testis
genes like me logo Genes that share expressions with GAGE4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for GAGE4 Gene

Orthologs for GAGE4 Gene

No data available for Orthologs and Evolution for GAGE4 Gene

Paralogs for GAGE4 Gene

genes like me logo Genes that share paralogs with GAGE4: view

No data available for Paralogs for GAGE4 Gene

Variants for GAGE4 Gene

Structural Variations from Database of Genomic Variants (DGV) for GAGE4 Gene

Variant ID Type Subtype PubMed ID
esv24944 CNV Gain+Loss 19812545
nsv821250 CNV Deletion 20802225

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for GAGE4 Gene

Disorders for GAGE4 Gene

No disorders were found for GAGE4 Gene.

No data available for UniProtKB/Swiss-Prot for GAGE4 Gene

Publications for GAGE4 Gene

  1. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PMID: 7544395) van den Eynde B. … Boon T. (J. Exp. Med. 1995) 2 3 4
  2. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PMID: 10397259) De Backer O. … van der Bruggen P. (Cancer Res. 1999) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff M.F. … Ditzel H.J. (Tissue Antigens 2008) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4

Products for GAGE4 Gene

Sources for GAGE4 Gene

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