GAGE2E Gene
protein-coding GIFtS: 37
GCID: GC0XP049254
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G antigen 2E
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Aliases
for GAGE2E gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| G Antigen 2E1 2 | | GAGE81 2 | | GAGE-2E2 3 |
Export aliases for GAGE2E gene to outside databasesPrevious GC identifers: GC0XU900863 GC0XP049087 GC0XP049091 GC0XP049199 GC0XP049207 GC0XP049210 GC0XP049224 GC0XP049227 GC0XP049238 GC0XP049248 |
Summaries
for GAGE2E gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for GAGE2E gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NT_079573.4
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for GAGE2E
Other transcription factors
Search SABiosciences Chromatin IP Primers for GAGE2E
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAGE2E |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23GAGE2E Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP049254: view genomic region
(about GC identifiers)
Start:
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49,197,607 bp from pter |
End:
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49,204,923 bp from pter |
Size:
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7,317 bases |
Orientation:
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plus strand |
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Proteins
for GAGE2E gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GAG2E_HUMAN, Q4V326 (See
protein sequence)Recommended Name: G antigen 2E Size: 116 amino acids; 12763 Da
Miscellaneous: This gene belongs to a multigene family expressed in a large variety of tumors whereas in normaltissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree ofpredicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain eitherthe antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells
Caution: The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE membersmade impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGEgene nomenclature based on the identified genes and their products
Secondary accessions: A6NFB1Explore the universe of human proteins at neXtProt for GAGE2E: NX_Q4V326
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q4V326
GAGE2E Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001120672.1
ENSEMBL proteins: ENSP00000384742
Human Recombinant Protein Products:
GAGE2E Antibody Products:
Assay Products for GAGE2E: |
Protein
Domains /
Families
for GAGE2E gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GAGE2E for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q4V326ProtoNet protein and cluster: Q4V326 1 Blocks protein family: IPB008625 GAGE
UniProtKB/Swiss-Prot: GAG2E_HUMAN, Q4V326Similarity: Belongs to the GAGE family |
Function
for GAGE2E gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE2E
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE2E (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GAGE2E (NM_001127200) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GAGE2E | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAGE2E |
|
Pathways & Interactions
for GAGE2E gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GAGE2E
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for GAGE2E (Q4V3263 ENSP000003847424) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for GAGE2E gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GAGE2E
Search CenterWatch for drugs/clinical trials and news about GAGE2E / GAG2E
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Transcripts
for GAGE2E gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GAGE2E gene: NM_001127200.1 Unigene Cluster for GAGE2E: G antigen 2E Hs.695911 [show with all ESTs]Unigene Representative Sequence: NM_0011272001 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000402590(uc010njb.3 uc004dno.4 uc004dnp.4 uc004dnq.4 uc004dnr.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE2E
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE2E (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GAGE2E (NM_001127200) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GAGE2E | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAGE2E |
1 DOTS entry: DT.444944 24/29 AceView cDNA sequences (see all 29): BC024914 NM_001474 U19145 BM832793 BC005363 BC069309 AA447559 BC018052 CF780547 NM_001472 AW510753 BM836228 BX283580 AF055473 U19143 NM_012196 AW016546 BX108227 BG206349 AW102587 AA738037 BG208433 BP431265 BG120838
GeneLoc Exon Structure
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Expression
for GAGE2E gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GAGE2E expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See GAGE2E Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GAGE2E
SOURCE GeneReport for Unigene cluster: Hs.695911
SABiosciences Custom PCR Arrays for GAGE2E
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAGE2E
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GAGE2E | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAGE2E | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAGE2E |
Orthologs
for GAGE2E gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for GAGE2E (if available)
TreeFam Gene Tree for GAGE2E (if available) |
Paralogs
for GAGE2E gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GAGE2E gene
- GAGE2D1 2 GAGE131 2 GAGE2C1 2 GAGE2B1 2 GAGE2A1 2 GAGE12J1 2 GAGE12I1 2 GAGE12G1 2
- GAGE12F1 2 GAGE11 2 GAGE12C1 2 GAGE12D1 2 GAGE12E1 2 GAGE12H1 2 PAGE22 GAGE42
- XAGE32 GAGE102 PAGE32 XAGE52 XAGE2B2 PAGE52 PAGE2B2 PAGE12
- XAGE22 PAGE42
18/26 SIMAP similar genes for GAGE2E using alignment to 1 protein entry: GAG2E_HUMAN(see all similar genes):GAGE2D GAGE8 GAGE2A GAGE2B GAGE2C GAGE13
GAGE3 GAGE5 GAGE6 GAGE12B GAGE12C GAGE12D
GAGE12E GAGE12F GAGE12G GAGE12H GAGE12I GAGE12J
GAGE2E for paralogs About GeneDecksing
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Genomic Variants
for GAGE2E gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for GAGE2E (49197607 - 49204923 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for GAGE2E
7 CNVs: 33164 73975 96665 83510 73974 37039 31551 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for GAGE2E gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GAGE2E for disorders About GeneDecksing
OMIM gene information: 300736
OMIM disorders: --
4  diseases for GAGE2E: About MalaCardsprostate cancer, progression of prostate cancer prostatitis melanoma
Export disorders for GAGE2E gene to outside databases
|
Publications
for GAGE2E gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GAGE2E gene integrated from 9 sources:
(articles sorted by number of sources associating them with GAGE2E) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PubMed id 18179644)1, 2 Gjerstorff M.F. and Ditzel H.J. (2008)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PubMed id 10397259)1 De Backer O.... van der Bruggen P. (1999)
- Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. (PubMed id 9651357)1 Chen M.E.... Sikes R.A. (1998)
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External Searches for GAGE2E gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing GAGE2E gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing GAGE2E gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GAGE2E gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GAGE2E | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for GAGE2E gene:
Search GeneIP for patents involving GAGE2E
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GAGE2E gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GAGE2E | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GAGE2E | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAGE2E | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GAGE2E | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE2E | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE2E | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GAGE2E | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAGE2E | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAGE2E | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAGE2E | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAGE2E | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAGE2E |
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| | | | Search Tocris compounds for GAGE2E |
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 | | | GAGE2E Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for GAGE2E |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAGE2E |
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