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Aliases for GAGE2D Gene

Aliases for GAGE2D Gene

  • G Antigen 2D 2 3
  • Cancer/Testis Antigen 4.8 3 4
  • GAGE-2D 3 4
  • GAGE-8 3 4
  • CT4.8 3 4
  • G Antigen 12F 5
  • GAGE2D GAGE8 4
  • G Antigen 8 4
  • GAGE12F 5
  • GAGE8 3

External Ids for GAGE2D Gene

Previous GeneCards Identifiers for GAGE2D Gene

  • GC0XU900855
  • GC0XP049096
  • GC0XP049098
  • GC0XP049099
  • GC0XP049191
  • GC0XP049206
  • GC0XP049209
  • GC0XP049219
  • GC0XP049229
  • GC0XP049236
  • GC0XP049246
  • GC0XP049252
  • GC0XP049257
  • GC0XP049262

Summaries for GAGE2D Gene

GeneCards Summary for GAGE2D Gene

GAGE2D (G Antigen 2D) is a Protein Coding gene. An important paralog of this gene is XAGE5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE2D Gene

Genomics for GAGE2D Gene

Genomic Location for GAGE2D Gene

49,560,844 bp from pter
49,568,208 bp from pter
7,365 bases
Plus strand

Genomic View for GAGE2D Gene

Genes around GAGE2D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAGE2D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAGE2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAGE2D Gene

No data available for Regulatory Elements for GAGE2D Gene

Proteins for GAGE2D Gene

  • Protein details for GAGE2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G antigen 2D
    Protein Accession:
    Secondary Accessions:
    • A6NG46
    • A6NNR8
    • B7ZL76
    • Q4V325

    Protein attributes for GAGE2D Gene

    116 amino acids
    Molecular mass:
    12764 Da
    Quaternary structure:
    No Data Available
    • This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for GAGE2D Gene

Proteomics data for GAGE2D Gene at MOPED

Post-translational modifications for GAGE2D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE2D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAGE2D Gene

Domains & Families for GAGE2D Gene

Protein Domains for GAGE2D Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE2D: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for GAGE2D Gene

Function for GAGE2D Gene

Animal Model Products

miRNA for GAGE2D Gene

miRTarBase miRNAs that target GAGE2D

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAGE2D Gene

Localization for GAGE2D Gene

Subcellular locations from

Jensen Localization Image for GAGE2D Gene COMPARTMENTS Subcellular localization image for GAGE2D gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GAGE2D Gene

Pathways & Interactions for GAGE2D Gene

SuperPathways for GAGE2D Gene

No Data Available

Interacting Proteins for GAGE2D Gene

Gene Ontology (GO) - Biological Process for GAGE2D Gene


No data available for Pathways by source and SIGNOR curated interactions for GAGE2D Gene

Drugs & Compounds for GAGE2D Gene

No Compound Related Data Available

Transcripts for GAGE2D Gene

mRNA/cDNA for GAGE2D Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE2D Gene

No ASD Table

Relevant External Links for GAGE2D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GAGE2D Gene

mRNA expression in normal human tissues for GAGE2D Gene

mRNA differential expression in normal tissues according to GTEx for GAGE2D Gene

This gene is overexpressed in Testis (x49.5).

mRNA Expression by UniProt/SwissProt for GAGE2D Gene

Tissue specificity: Not expressed in normal tissues, except in testis, but expressed by a large proportion of tumors of various histological origins.
genes like me logo Genes that share expression patterns with GAGE2D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GAGE2D Gene

Orthologs for GAGE2D Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAGE2D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 94 (a)
Species with no ortholog for GAGE2D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAGE2D Gene

Gene Tree for GAGE2D (if available)
Gene Tree for GAGE2D (if available)

Paralogs for GAGE2D Gene

genes like me logo Genes that share paralogs with GAGE2D: view

Variants for GAGE2D Gene

Structural Variations from Database of Genomic Variants (DGV) for GAGE2D Gene

Variant ID Type Subtype PubMed ID
esv24944 CNV Gain+Loss 19812545
nsv821250 CNV Deletion 20802225

Variation tolerance for GAGE2D Gene

Gene Damage Index Score: 5.67; 72.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for GAGE2D Gene

Disorders for GAGE2D Gene

Relevant External Links for GAGE2D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GAGE2D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE2D Gene

Publications for GAGE2D Gene

  1. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff M.F. … Ditzel H.J. (Tissue Antigens 2008) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PMID: 10397259) De Backer O. … van der Bruggen P. (Cancer Res. 1999) 3

Products for GAGE2D Gene

Sources for GAGE2D Gene