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GAGE2C Gene

protein-coding   GIFtS: 38
GCID: GC0XP049226

G Antigen 2C

  Search for GAGE2C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Antigen 2C1 2 3     GAGE-22
GAGE22 3 5     G Antigen 22
Cancer/Testis Antigen 4.22 3     G Antigen 2B/2C2
CT4.22 3     GAGE-2B3
GAGE-2C2 3     

External Ids:    HGNC: 319581   Entrez Gene: 25742   Ensembl: ENSG000002362497   OMIM: 3005955   UniProtKB: Q130663   

Export aliases for GAGE2C gene to outside databases

Previous GC identifers: GC0XU900879 GC0XP049118 GC0XP049090 GC0XP049119 GC0XP049218


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GAGE2C Gene:
This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except
for the testis. The sequences of the family members are highly related but differ by scattered nucleotide
substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is
recognized by autologous cytolytic T lymphocytes. (provided by RefSeq, Jul 2008)

GeneCards Summary for GAGE2C Gene:
GAGE2C (G antigen 2C) is a protein-coding gene. An important paralog of this gene is GAGE2D.

UniProtKB/Swiss-Prot: GAG2B_HUMAN, Q13066
Function: Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_079573.5  
Regulatory elements:
   Search for regulatory transcription factor binding sites for GAGE2C
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for GAGE2C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GAGE2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

GAGE2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAGE2C gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP049226:  view genomic region     (about GC identifiers)

Start:
49,226,171 bp from pter      End:
49,233,491 bp from pter
Size:
7,321 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GAG2B_HUMAN, Q13066 (See protein sequence)
Recommended Name: G antigen 2B/2C  
Size: 116 amino acids; 12786 Da
Miscellaneous: This gene belongs to a family of genes organized in clustered repeats. They have a high degree of
predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain
either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells
Caution: The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE
members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644
presented a new GAGE gene nomenclature based on the identified genes and their products
Secondary accessions: C9K0W9 Q4V322

Explore the universe of human proteins at neXtProt for GAGE2C: NX_Q13066

Explore proteomics data for GAGE2C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GAGE2C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001463.1  
    ENSEMBL proteins: 
     ENSP00000371127  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008625 GAGE

    Graphical View of Domain Structure for InterPro Entry Q13066

    ProtoNet protein and cluster: Q13066

    1 Blocks protein domain: IPB008625 GAGE

    UniProtKB/Swiss-Prot: GAG2B_HUMAN, Q13066
    Similarity: Belongs to the GAGE family


    Find genes that share domains with GAGE2C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GAG2B_HUMAN, Q13066
    Function: Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ----
         
    Find genes that share ontologies with GAGE2C           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ----

    Find genes that share ontologies with GAGE2C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GAGE2C
    Interactions:

        Search GeneGlobe Interaction Network for GAGE2C

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ----

    Find genes that share ontologies with GAGE2C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GAGE2C (GAG2B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GAGE2C gene: 
    NM_001472.2  

    Unigene Cluster for GAGE2C:

    G antigen 2C
    Hs.460641  [show with all ESTs]
    Unigene Representative Sequence: BG250953
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000381708(uc004doa.3 uc004dob.4)
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      QuantiTect SYBR Green Assays in human, mouse, rat GAGE2C
      QuantiFast Probe-based Assays in human, mouse, rat GAGE2C

    Additional mRNA sequence: 

    AF055474.1 BC024914.1 BC031628.1 BC069309.1 BC069558.1 BC113926.1 BC121182.1 BC121183.1 
    BC144193.1 U19143.1 U19145.1 U19146.1 

    1 DOTS entry:

    DT.444944 

    Selected AceView cDNA sequences (see all 29):

    BM832793 NM_001474 U19145 BC024914 BX283580 BC069309 NM_012196 CF780547 
    AW016546 BM836228 NM_001472 BX108227 AW510753 BC018052 AA447559 U19143 
    AF055473 BC005363 BG120838 AW102587 BG206349 AA738037 BP431265 BG208433 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GAGE2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GAGE2C Expression
    About this image

    GAGE2C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GAGE2C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.460641

    UniProtKB/Swiss-Prot: GAG2B_HUMAN, Q13066
    Tissue specificity: Expressed in a variety of tumor tissues but not in normal tissues, except testis

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for GAGE2C gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia --
    --
    Uncharacterized protein
    96(a)
    96(a)
    many ↔ many
    many ↔ many
    X(49680693-49686352)
    X(49654180-49660340)


    ENSEMBL Gene Tree for GAGE2C (if available)
    TreeFam Gene Tree for GAGE2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GAGE2C gene
    GAGE2A1 2  GAGE2E1 2  GAGE12I1 2  GAGE12G1 2  GAGE12D1 2  GAGE12C1 2  GAGE12E1 2  GAGE12H1 2  
    GAGE11 2  GAGE12J1 2  GAGE2D2  XAGE32  GAGE102  XAGE52  XAGE2B2  GAGE12F2  
    GAGE132  PAGE12  XAGE22  GAGE2B2  
    Selected SIMAP similar genes for GAGE2C using alignment to 1 protein entry:     GAG2B_HUMAN(see all similar genes):
    GAGE2A    GAGE2D    GAGE2E    GAGE8    GAGE12F    GAGE12G
    GAGE12I    GAGE7    GAGE12B    GAGE12C    GAGE12D    GAGE12E
    GAGE12H    GAGE12J    GAGE13    GAGE3    GAGE4    GAGE5

    Find genes that share paralogs with GAGE2C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GAGE2C (see all 26)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2013077421,2
    C--49227430(+) TTGTGA/CTAGCG 1 -- int10--------
    rs3773495061,2
    ----49231324(+) ACTGCC/GCTTTA 1 -- int10--------
    rs1467072331,2
    ----49228318(+) AAAGAA/CGGAAG 1 -- int10--------
    rs3682131531,2
    ----49227175(+) CTTATC/TTGAGA 1 -- int10--------
    rs1425371451,2
    ----49228270(+) TTGTAC/TTGTGT 1 -- int10--------
    rs1381854271,2
    ----49227630(+) GAGTAC/TAATAG 1 -- int10--------
    rs1433025331,2
    ----49228599(+) AAAACA/GGAATT 1 -- int10--------
    rs3712787831,2
    ----49227447(+) CATTAC/GGTGGA 1 -- int10--------
    rs1393632801,2
    ----49228332(+) TTTTGC/GTGAAA 1 -- int10--------
    rs1462331041,2
    ----49233309(+) TAGGGC/TCATCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for GAGE2C (49226171 - 49233491 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GAGE2C:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821250CNV Deletion20802225
    nsv820429CNV Deletion20802225
    esv24944CNV Gain+Loss19812545
    esv28941CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300595    OMIM disorders: --


    Find genes that share disorders with GAGE2C           About GenesLikeMe


    Export disorders for GAGE2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GAGE2C gene integrated from 10 sources:
    (articles sorted by number of sources associating them with GAGE2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PubMed id 18179644)1, 2 Gjerstorff M.F. and Ditzel H.J. (Tissue Antigens 2008)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PubMed id 7544395)1, 2 van den Eynde B....Boon T. (J. Exp. Med. 1995)
    5. Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells. (PubMed id 19934278)1 Sun F....Yu Q. (Mol. Cancer Ther. 2009)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Expression of MAGE and GAGE in high-grade brain tumors: a potential target for specific immunotherapy and diagnostic markers. (PubMed id 10037183)1 Scarcella D.L....Ashley D.M. (Clin. Cancer Res. 1999)
    8. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PubMed id 10397259)1 De Backer O.... van der Bruggen P. (Cancer Res. 1999)
    9. Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. (PubMed id 9651357)1 Chen M.E.... Sikes R.A. (J. Biol. Chem. 1998)
    10. [Cockroach allergen Bla g 2 levels in houses in Lodz]. (PubMed id 12362661)9 Stelmach I....Kuna P. (Pol. Merkur. Lekarski 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2574 HGNC: 31958 AceView: GAGE2 Ensembl:ENSG00000236249 euGenes: HUgn2574
    ECgene: GAGE2C H-InvDB: GAGE2C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GAGE2C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GAGE2C gene:
    Search GeneIP for patents involving GAGE2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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