GAGE2C Gene
protein-coding GIFtS: 38
GCID: GC0XP049226
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G antigen 2C
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Aliases
for GAGE2C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| G Antigen 2C1 2 3 | | GAGE-22 | | GAGE22 3 5 | | G Antigen 22 | | Cancer/Testis Antigen 4.22 3 | | G Antigen 2B/2C2 | | CT4.22 3 | | GAGE-2B3 | | GAGE-2C2 3 | | |
Export aliases for GAGE2C gene to outside databasesPrevious GC identifers: GC0XU900879 GC0XP049118 GC0XP049090 GC0XP049119 GC0XP049218 |
Summaries
for GAGE2C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GAGE2C:
This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except forthe testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions.The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologouscytolytic T lymphocytes. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: GAG2B_HUMAN, Q13066Function: Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes
|
Genomic Views
for GAGE2C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for GAGE2C
Other transcription factors
Search SABiosciences Chromatin IP Primers for GAGE2C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAGE2C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23GAGE2C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP049226: view genomic region
(about GC identifiers)
Start:
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49,226,171 bp from pter |
End:
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49,233,491 bp from pter |
Size:
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7,321 bases |
Orientation:
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plus strand |
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Proteins
for GAGE2C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GAG2B_HUMAN, Q13066 (See
protein sequence)Recommended Name: G antigen 2B/2C Size: 116 amino acids; 12786 Da
Miscellaneous: This gene belongs to a family of genes organized in clustered repeats. They have a high degree ofpredicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain eitherthe antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells
Caution: The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE membersmade impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGEgene nomenclature based on the identified genes and their products
Secondary accessions: C9K0W9 Q4V322Explore the universe of human proteins at neXtProt for GAGE2C: NX_Q13066
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13066
GAGE2C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001463.1
ENSEMBL proteins: ENSP00000371127 ENSP00000454300
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
-- | -- |
GAGE2C for ontologies About GeneDecksing
GAGE2C Antibody Products:
Assay Products for GAGE2C: |
Protein
Domains /
Families
for GAGE2C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GAGE2C for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q13066ProtoNet protein and cluster: Q13066 1 Blocks protein family: IPB008625 GAGE
UniProtKB/Swiss-Prot: GAG2B_HUMAN, Q13066Similarity: Belongs to the GAGE family |
Function
for GAGE2C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GAG2B_HUMAN, Q13066Function: Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE2C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE2C
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
-- | -- |
GAGE2C for ontologies About GeneDecksing
|
Pathways & Interactions
for GAGE2C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GAGE2C
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
-- | -- |
GAGE2C for ontologies About GeneDecksing
|
Drugs & Compounds
for GAGE2C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GAGE2C
Search CenterWatch for drugs/clinical trials and news about GAGE2C / GAG2B
|
Transcripts
for GAGE2C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GAGE2C gene: NM_001472.2 Unigene Cluster for GAGE2C: G antigen 2C Hs.460641 [show with all ESTs]Unigene Representative Sequence: BG2509532 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381708(uc004doa.3 uc004dob.4) ENST00000569168
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE2C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE2C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GAGE2C (NM_001472) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GAGE2C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAGE2C |
Additional cDNA sequence: AF058988.1 BC024914.1 BC069309.1 BC069558.1 BC113926.1 BC121182.1 BC121183.1 BC144193.1 U19143.1 U19145.1 U19146.1 1 DOTS entry: DT.444944 24/29 AceView cDNA sequences (see all 29): BM832793 BC024914 U19145 NM_001474 BC018052 BC005363 BC069309 BX108227 AW016546 NM_012196 AA447559 AW510753 CF780547 NM_001472 BX283580 BM836228 AF055473 U19143 BP431265 AW102587 AA738037 BG206349 BG208433 BG120838
GeneLoc Exon Structure
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Expression
for GAGE2C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GAGE2C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See GAGE2C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GAGE2C
SOURCE GeneReport for Unigene cluster: Hs.460641
UniProtKB/Swiss-Prot: GAG2B_HUMAN, Q13066Tissue specificity: Expressed in a variety of tumor tissues but not in normal tissues, except testis
SABiosciences Custom PCR Arrays for GAGE2C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAGE2C
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat GAGE2C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAGE2C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAGE2C |
Orthologs
for GAGE2C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for GAGE2C (if available)
TreeFam Gene Tree for GAGE2C (if available) |
Paralogs
for GAGE2C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GAGE2C gene
- GAGE2B1 2 GAGE2D1 2 GAGE2A1 2 GAGE2E1 2 GAGE12I1 2 GAGE12G1 2 GAGE12F1 2 GAGE131 2
- GAGE12C1 2 GAGE12D1 2 GAGE12E1 2 GAGE12H1 2 GAGE11 2 GAGE12J1 2 PAGE22 GAGE42
- XAGE32 GAGE102 PAGE32 XAGE52 XAGE2B2 PAGE52 PAGE2B2 PAGE12
- XAGE22 PAGE42
18/25 SIMAP similar genes for GAGE2C using alignment to 1 protein entry: GAG2B_HUMAN(see all similar genes):GAGE2A GAGE2D GAGE2E GAGE8 GAGE12F GAGE12G
GAGE12I GAGE7 GAGE12B GAGE12C GAGE12D GAGE12E
GAGE12H GAGE12J GAGE13 GAGE3 GAGE4 GAGE5
GAGE2C for paralogs About GeneDecksing
|
Genomic Variants
for GAGE2C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GAGE2C (49226171 - 49233491 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for GAGE2C
6 CNVs: 33164 73975 96665 83510 73974 31551 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for GAGE2C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GAGE2C for disorders About GeneDecksing
OMIM gene information: 300595
OMIM disorders: --
5  diseases for GAGE2C: About MalaCardsprostate cancer, progression of prostate cancer prostatitis breast cancer
melanoma
Export disorders for GAGE2C gene to outside databases
|
Publications
for GAGE2C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GAGE2C gene integrated from 9 sources:
(articles sorted by number of sources associating them with GAGE2C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PubMed id 18179644)1, 2 Gjerstorff M.F. and Ditzel H.J. (2008)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PubMed id 7544395)1, 2 van den Eynde B....Boon T. (1995)
- Combinatorial pharmacologic approaches target EZH2-me diated gene repression in breast cancer cells. (PubMed id 19934278)1 Sun F....Yu Q. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Expression of MAGE and GAGE in high-grade brain tumors: a potential target for specific immunotherapy and diagnostic markers. (PubMed id 10037183)1 Scarcella D.L....Ashley D.M. (1999)
- Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PubMed id 10397259)1 De Backer O.... van der Bruggen P. (1999)
- Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. (PubMed id 9651357)1 Chen M.E.... Sikes R.A. (1998)
- [Cockroach allergen Bla g 2 levels in houses in Lodz] (PubMed id 12362661)9 Stelmach I....Kuna P. (2002)
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External Searches for GAGE2C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing GAGE2C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GAGE2C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GAGE2C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GAGE2C | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for GAGE2C gene:
Search GeneIP for patents involving GAGE2C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GAGE2C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GAGE2C | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAGE2C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAGE2C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAGE2C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAGE2C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAGE2C |
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 | | | GAGE2C Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for GAGE2C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAGE2C |
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