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Aliases for GAGE2C Gene

Aliases for GAGE2C Gene

  • G Antigen 2C 2 3 4
  • GAGE2 3 4 6
  • Cancer/Testis Antigen 4.2 3 4
  • GAGE-2C 3 4
  • CT4.2 3 4
  • G Antigen 2B/2C 3
  • GAGE2B GAGE2C 4
  • G Antigen 2 3
  • GAGE-2B 4
  • GAGE-2 3

External Ids for GAGE2C Gene

Previous GeneCards Identifiers for GAGE2C Gene

  • GC0XU900879
  • GC0XP049118
  • GC0XP049090
  • GC0XP049119
  • GC0XP049218
  • GC0XP049226

Summaries for GAGE2C Gene

Entrez Gene Summary for GAGE2C Gene

  • This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAGE2C Gene

GAGE2C (G Antigen 2C) is a Protein Coding gene. An important paralog of this gene is GAGE2A.

UniProtKB/Swiss-Prot for GAGE2C Gene

  • Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE2C Gene

Genomics for GAGE2C Gene

Genomic Location for GAGE2C Gene

Start:
49,331,615 bp from pter
End:
49,338,962 bp from pter
Size:
7,348 bases
Orientation:
Plus strand

Genomic View for GAGE2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GAGE2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAGE2C Gene

No data available for Regulatory Elements for GAGE2C Gene

Proteins for GAGE2C Gene

  • Protein details for GAGE2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13066-GAG2B_HUMAN
    Recommended name:
    G antigen 2B/2C
    Protein Accession:
    Q13066
    Secondary Accessions:
    • C9K0W9
    • Q4V322

    Protein attributes for GAGE2C Gene

    Size:
    116 amino acids
    Molecular mass:
    12786 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells

neXtProt entry for GAGE2C Gene

Proteomics data for GAGE2C Gene at MOPED

Post-translational modifications for GAGE2C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE2C Gene

REFSEQ proteins:

No data available for DME Specific Peptides for GAGE2C Gene

Domains for GAGE2C Gene

Protein Domains for GAGE2C Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GAGE2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13066

UniProtKB/Swiss-Prot:

GAG2B_HUMAN :
  • Q13066
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE2C: view

No data available for Gene Families for GAGE2C Gene

Function for GAGE2C Gene

Molecular function for GAGE2C Gene

UniProtKB/Swiss-Prot Function: Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes

Gene Ontology (GO) - Molecular Function for GAGE2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with GAGE2C: view

Animal Model Products

CRISPR Products

miRNA for GAGE2C Gene

miRTarBase miRNAs that target GAGE2C

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAGE2C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GAGE2C Gene

Localization for GAGE2C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAGE2C Gene COMPARTMENTS Subcellular localization image for GAGE2C gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GAGE2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with GAGE2C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GAGE2C Gene

Pathways for GAGE2C Gene

SuperPathways for GAGE2C Gene

No Data Available

Interacting Proteins for GAGE2C Gene

Gene Ontology (GO) - Biological Process for GAGE2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GAGE2C: view

No data available for Pathways by source for GAGE2C Gene

Transcripts for GAGE2C Gene

Unigene Clusters for GAGE2C Gene

G antigen 2C:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAGE2C

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE2C Gene

No ASD Table

Relevant External Links for GAGE2C Gene

GeneLoc Exon Structure for
GAGE2C
ECgene alternative splicing isoforms for
GAGE2C

Expression for GAGE2C Gene

mRNA expression in normal human tissues for GAGE2C Gene

mRNA differential expression in normal tissues according to GTEx for GAGE2C Gene

This gene is overexpressed in Testis (51.7).

SOURCE GeneReport for Unigene cluster for GAGE2C Gene Hs.460641

mRNA Expression by UniProt/SwissProt for GAGE2C Gene

Q13066-GAG2B_HUMAN
Tissue specificity: Expressed in a variety of tumor tissues but not in normal tissues, except testis.
genes like me logo Genes that share expressions with GAGE2C: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for GAGE2C Gene

Orthologs for GAGE2C Gene

No data available for Orthologs and Evolution for GAGE2C Gene

Paralogs for GAGE2C Gene

Paralogs for GAGE2C Gene

genes like me logo Genes that share paralogs with GAGE2C: view

Variants for GAGE2C Gene

Structural Variations from Database of Genomic Variants (DGV) for GAGE2C Gene

Variant ID Type Subtype PubMed ID
esv24944 CNV Gain+Loss 19812545
nsv821250 CNV Deletion 20802225
nsv820429 CNV Deletion 20802225
esv28941 CNV Gain+Loss 19812545

Relevant External Links for GAGE2C Gene

HapMap Linkage Disequilibrium report
GAGE2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GAGE2C Gene

Disorders for GAGE2C Gene

No disorders were found for GAGE2C Gene.

No data available for UniProtKB/Swiss-Prot for GAGE2C Gene

Publications for GAGE2C Gene

  1. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PMID: 7544395) van den Eynde B. … Boon T. (J. Exp. Med. 1995) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff M.F. … Ditzel H.J. (Tissue Antigens 2008) 3 4
  5. Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells. (PMID: 19934278) Sun F. … Yu Q. (Mol. Cancer Ther. 2009) 3

Products for GAGE2C Gene

Sources for GAGE2C Gene

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