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GAGE2B Gene

protein-coding   GIFtS: 29

GC0XP049123
G antigen 2B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CT4.2 3
GAGE-2 3
GAGE2 3
OTTHUMP00000070308 2
Descriptions
Cancer/testis antigen 4.2 3
G antigen 2B 2
External Ids
HGNC: 319571
Entrez Gene: 6450372
UniProtKB: Q130663
Ensembl: ENSG000002152537
Search outside databases for aliases for GAGE2B gene

Previous GC identifer: GC0XU900862

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: GAGE2_HUMAN, Q13066
Function: Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

GAGE2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP049123:     (about GC identifiers)

Start:
49,122,652 bp from pter
End:
49,129,941 bp from pter
Size:
7,290 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000023.9  NT_079573.3  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GAGE2_HUMAN, Q13066 (See protein sequence)
Recommended Name: G antigen 2A/2B  
Size: 116 amino acids; 12786 Da
Secondary accessions: Q4V322

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001091881.1  

    ENSEMBL proteins: 
    ENSP00000371132 ENSP00000382766 ENSP00000371144 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
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    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for GAGE2B: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for GAGE2B

    Assays for GAGE2B: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR008625 GAGE


       GeneDecks  GAGE2B for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q13066

    ProtoNet protein and cluster: Q13066

    1 Blocks protein family: IPB008625 GAGE

    UniProtKB/Swiss-Prot: GAGE2_HUMAN, Q13066
    Similarity: Belongs to the GAGE family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                    Browse Origene for 29mer shRNA kit in GFP-retroviral vector

                  Applied Biosystems Silencer® siRNAs for GAGE2B

                  Browse siRNA at Sigma-Aldrich  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001098411
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001098411
                                     untagged cDNA clone in CMV expression vector: NM_001098411 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001098411

    UniProtKB/Swiss-Prot: GAGE2_HUMAN, Q13066
    Function: Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for GAGE2B

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                    Browse Origene for 29mer shRNA kit in GFP-retroviral vector

                  Browse siRNA at Sigma-Aldrich  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001098411  

    REFSEQ mRNAs for GAGE2B gene: 

    NM_001098411.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001098411  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001098411
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001098411
                                     untagged cDNA clone in CMV expression vector: NM_001098411 

    Unigene Cluster for GAGE2B:

    G antigen 2B
    Hs.714681
    Unigene Representative Sequence: NM_001098411


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000381713  ENST00000399877  ENST00000381725  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    GAGE2B expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for GAGE2B

    1 / 2

    9 probe-sets matching GAGE2B gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    31497_at2 U95-A 23 1.00 0.10 0.39 2.10 -- -- -- -- --

    33671_f_at2 U95-A 24 1.00 0.04 0.86 0.60 -- -- -- -- --

    31960_f_at2 U95-A 24 1.00 0.04 0.72 0.66 -- -- -- -- --

    33680_f_at2 U95-A 24 1.00 0.04 0.50 0.55 -- -- -- -- --

    37065_f_at2 U95-A 24 0.94 0.04 0.61 0.88 -- -- -- -- --

    31498_f_at2 U95-A 24 0.94 0.04 0.73 0.92 -- -- -- -- --

    31954_f_at2 U95-A 23 0.94 0.04 0.62 0.32 -- -- -- -- --

    207739_s_at2 U133-A 23 1.00 0.04 -- -- -- -- -- -- --

    207739_s_at2 U133Plus2 23 1.00 0.04 -- -- -- -- -- -- --
    GeneDecks  GAGE2B for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.714681

    UniProtKB/Swiss-Prot: GAGE2_HUMAN, Q13066
    Tissue specificity: Expressed in a variety of tumor tissues but not in normal tissues, except
    testis

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    ENSEMBL Gene Tree for GAGE2B
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for GAGE2B gene
    GAGE2C1 2  GAGE2D1 2  GAGE2E1 2  GAGE2A1 2  GAGE12I1  GAGE12G1 2  GAGE12F1 2  GAGE131 2  
    GAGE12D1  GAGE12C1 2  GAGE12E1 2  GAGE12H1 2  GAGE11 2  GAGE12J1 2  XAGE32  GAGE102  
    ENSG000001691642  XAGE52  XAGE2B2  PAGE12  XAGE22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

      --
    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 300726

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    5 PubMed articles for GAGE2B gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 645037 HGNC: 31957 Ensembl:ENSG00000215253 euGenes: HUgn645037 ECgene: GAGE2B
    H-InvDB: GAGE2B
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for GAGE2B:
     TaqMan ® Gene Expression Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for GAGE2B-related products

     Millipore Custom Antibody & Bulk Services
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     Millipore Immunoassay Services
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     Browse siRNAs at Sigma-Aldrich Browse antibodies at Sigma-Aldrich
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     Search Novus for antibodies for GAGE2B

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