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Aliases for GAGE2A Gene

Aliases for GAGE2A Gene

  • G Antigen 2A 2 3 5
  • G Antigen 2 2 3
  • GAGE-2A 3 4
  • GAGE2 3 4
  • Cancer/Testis Antigen Family 4, Member 2 3
  • Cancer/Testis Antigen Family 4 2
  • Cancer/Testis Antigen 4.2 3
  • Member 2 2
  • GAGE-2 3
  • CT4.2 3

External Ids for GAGE2A Gene

Previous HGNC Symbols for GAGE2A Gene

  • GAGE2

Previous GeneCards Identifiers for GAGE2A Gene

  • GC0XP049117
  • GC0XP049186
  • GC0XP049243
  • GC0XP049244
  • GC0XP049358
  • GC0XP049360

Summaries for GAGE2A Gene

GeneCards Summary for GAGE2A Gene

GAGE2A (G Antigen 2A) is a Protein Coding gene. An important paralog of this gene is XAGE5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE2A Gene

Genomics for GAGE2A Gene

Genomic Location for GAGE2A Gene

Chromosome:
X
Start:
49,589,515 bp from pter
End:
49,596,827 bp from pter
Size:
7,313 bases
Orientation:
Plus strand

Genomic View for GAGE2A Gene

Genes around GAGE2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAGE2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAGE2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAGE2A Gene

No data available for Regulatory Elements for GAGE2A Gene

Proteins for GAGE2A Gene

  • Protein details for GAGE2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NT46-GAG2A_HUMAN
    Recommended name:
    G antigen 2A
    Protein Accession:
    Q6NT46

    Protein attributes for GAGE2A Gene

    Size:
    116 amino acids
    Molecular mass:
    12785 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for GAGE2A Gene

Proteomics data for GAGE2A Gene at MOPED

Post-translational modifications for GAGE2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAGE2A Gene

Domains & Families for GAGE2A Gene

Protein Domains for GAGE2A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GAGE2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NT46

UniProtKB/Swiss-Prot:

GAG2A_HUMAN :
  • Belongs to the GAGE family.
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE2A: view

No data available for Gene Families for GAGE2A Gene

Function for GAGE2A Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAGE2A Gene

Localization for GAGE2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAGE2A Gene COMPARTMENTS Subcellular localization image for GAGE2A gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GAGE2A Gene

Pathways & Interactions for GAGE2A Gene

SuperPathways for GAGE2A Gene

No Data Available

Interacting Proteins for GAGE2A Gene

Gene Ontology (GO) - Biological Process for GAGE2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GAGE2A Gene

Drugs & Compounds for GAGE2A Gene

No Compound Related Data Available

Transcripts for GAGE2A Gene

mRNA/cDNA for GAGE2A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GAGE2A Gene

G antigen 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE2A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - - - -
SP2:
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - - - -
SP13: -
SP14: - - - - - -
SP15:
SP16: - - - - - - - - - - - - - - - -
SP17: - -

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b
SP1: - - -
SP2:
SP3:
SP4: - - -
SP5:
SP6: - - -
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - -
SP15:
SP16: - - - -
SP17:

Relevant External Links for GAGE2A Gene

GeneLoc Exon Structure for
GAGE2A
ECgene alternative splicing isoforms for
GAGE2A

Expression for GAGE2A Gene

mRNA expression in normal human tissues for GAGE2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAGE2A Gene

This gene is overexpressed in Testis (x51.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GAGE2A Gene



SOURCE GeneReport for Unigene cluster for GAGE2A Gene Hs.722100

genes like me logo Genes that share expression patterns with GAGE2A: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GAGE2A Gene

Orthologs for GAGE2A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAGE2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
ManyToMany
-- 36
  • 95 (a)
ManyToMany
Species with no ortholog for GAGE2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAGE2A Gene

ENSEMBL:
Gene Tree for GAGE2A (if available)
TreeFam:
Gene Tree for GAGE2A (if available)

Paralogs for GAGE2A Gene

genes like me logo Genes that share paralogs with GAGE2A: view

Variants for GAGE2A Gene

Sequence variations from dbSNP and Humsavar for GAGE2A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2008737 -- 49,591,866(-) CCGCT(A/G)AGAAA intron-variant
rs1810400 -- 49,591,960(+) TCTCC(C/G)AGATA intron-variant
rs2142397 -- 49,590,289(+) ttact(C/G)gggac intron-variant
rs2904020 -- 49,590,576(+) TTATC(C/G)ATGGA intron-variant
rs2869195 -- 49,590,160(-) CTGCT(G/T)TGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAGE2A Gene

Variant ID Type Subtype PubMed ID
esv24944 CNV Gain+Loss 19812545
nsv821250 CNV Deletion 20802225
nsv820429 CNV Deletion 20802225
esv28941 CNV Gain+Loss 19812545
nsv6899 CNV Insertion 18451855
nsv6900 CNV Loss 18451855
nsv515203 CNV Complex 21397061

Relevant External Links for GAGE2A Gene

HapMap Linkage Disequilibrium report
GAGE2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GAGE2A Gene

Disorders for GAGE2A Gene

Relevant External Links for GAGE2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAGE2A

No disorders were found for GAGE2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE2A Gene

Publications for GAGE2A Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
  2. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PMID: 7544395) van den Eynde B. … Boon T. (J. Exp. Med. 1995) 2 3
  3. Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells. (PMID: 19934278) Sun F. … Yu Q. (Mol. Cancer Ther. 2009) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for GAGE2A Gene

Sources for GAGE2A Gene

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