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Aliases for GAGE2A Gene

Aliases for GAGE2A Gene

  • G Antigen 2A 2 3
  • G Antigen 2 2 3
  • GAGE-2A 3 4
  • GAGE2 3 4
  • Cancer/Testis Antigen Family 4, Member 2 3
  • Cancer/Testis Antigen Family 4 2
  • Cancer/Testis Antigen 4.2 3
  • G Antigen 2A/2B 3
  • Member 2 2
  • GAGE-2 3
  • CT4.2 3

External Ids for GAGE2A Gene

Previous HGNC Symbols for GAGE2A Gene

  • GAGE2

Previous GeneCards Identifiers for GAGE2A Gene

  • GC0XP049117
  • GC0XP049186
  • GC0XP049243
  • GC0XP049244
  • GC0XP049358
  • GC0XP049360

Summaries for GAGE2A Gene

GeneCards Summary for GAGE2A Gene

GAGE2A (G Antigen 2A) is a Protein Coding gene. An important paralog of this gene is XAGE2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE2A Gene

Genomics for GAGE2A Gene

Genomic Location for GAGE2A Gene

Start:
49,589,515 bp from pter
End:
49,596,827 bp from pter
Size:
7,313 bases
Orientation:
Plus strand

Genomic View for GAGE2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GAGE2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAGE2A Gene

No data available for Regulatory Elements for GAGE2A Gene

Proteins for GAGE2A Gene

  • Protein details for GAGE2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NT46-GAG2A_HUMAN
    Recommended name:
    G antigen 2A
    Protein Accession:
    Q6NT46
    Secondary Accessions:

    Protein attributes for GAGE2A Gene

    Size:
    116 amino acids
    Molecular mass:
    12785 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells

neXtProt entry for GAGE2A Gene

Proteomics data for GAGE2A Gene at MOPED

Post-translational modifications for GAGE2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAGE2A Gene

Domains for GAGE2A Gene

Protein Domains for GAGE2A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GAGE2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NT46

UniProtKB/Swiss-Prot:

GAG2A_HUMAN :
  • Q6NT46
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE2A: view

No data available for Gene Families for GAGE2A Gene

Function for GAGE2A Gene

Gene Ontology (GO) - Molecular Function for GAGE2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with GAGE2A: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAGE2A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GAGE2A Gene

Localization for GAGE2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAGE2A Gene COMPARTMENTS Subcellular localization image for GAGE2A gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GAGE2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with GAGE2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GAGE2A Gene

Pathways for GAGE2A Gene

SuperPathways for GAGE2A Gene

No Data Available

Interacting Proteins for GAGE2A Gene

Gene Ontology (GO) - Biological Process for GAGE2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GAGE2A: view

No data available for Pathways by source for GAGE2A Gene

Transcripts for GAGE2A Gene

mRNA/cDNA for GAGE2A Gene

(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GAGE2A Gene

G antigen 2A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAGE2A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GAGE2A
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE2A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - - - -
SP2:
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - - - -
SP13: -
SP14: - - - - - -
SP15:
SP16: - - - - - - - - - - - - - - - -
SP17: - -

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b
SP1: - - -
SP2:
SP3:
SP4: - - -
SP5:
SP6: - - -
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - -
SP15:
SP16: - - - -
SP17:

Relevant External Links for GAGE2A Gene

GeneLoc Exon Structure for
GAGE2A
ECgene alternative splicing isoforms for
GAGE2A

Expression for GAGE2A Gene

mRNA expression in normal human tissues for GAGE2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAGE2A Gene

This gene is overexpressed in Testis (51.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GAGE2A Gene

SOURCE GeneReport for Unigene cluster for GAGE2A Gene Hs.722100

genes like me logo Genes that share expressions with GAGE2A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GAGE2A Gene

Orthologs for GAGE2A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAGE2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
ManyToMany
-- 36
  • 95 (a)
ManyToMany
Species with no ortholog for GAGE2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAGE2A Gene

ENSEMBL:
Gene Tree for GAGE2A (if available)
TreeFam:
Gene Tree for GAGE2A (if available)

Paralogs for GAGE2A Gene

genes like me logo Genes that share paralogs with GAGE2A: view

Variants for GAGE2A Gene

Sequence variations from dbSNP and Humsavar for GAGE2A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2869195 -- 49,590,160(-) CTGCT(G/T)TGGGC intron-variant
rs2904020 -- 49,590,576(+) TTATC(C/G)ATGGA intron-variant
rs6608889 -- 49,595,132(+) TGAAA(A/G)TCTCT intron-variant
rs6608891 -- 49,596,387(+) GAAAG(A/G)CCATG intron-variant
rs6609974 -- 49,590,848(+) AATGA(G/T)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAGE2A Gene

Variant ID Type Subtype PubMed ID
esv24944 CNV Gain+Loss 19812545
nsv821250 CNV Deletion 20802225
nsv820429 CNV Deletion 20802225
esv28941 CNV Gain+Loss 19812545
nsv6899 CNV Insertion 18451855
nsv6900 CNV Loss 18451855
nsv515203 CNV Complex 21397061

Relevant External Links for GAGE2A Gene

HapMap Linkage Disequilibrium report
GAGE2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAGE2A Gene

Disorders for GAGE2A Gene

No disorders were found for GAGE2A Gene.

No data available for UniProtKB/Swiss-Prot for GAGE2A Gene

Publications for GAGE2A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  3. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PMID: 7544395) van den Eynde B. … Boon T. (J. Exp. Med. 1995) 2 3
  4. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for GAGE2A Gene

Sources for GAGE2A Gene

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