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GAGE2A Gene

protein-coding GIFtS: 34

GC0XP049243

G antigen 2A
(Previous name: G antigen 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GAGE2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CT4.2 ^¹, ², ³
GAGE-2 ^³
GAGE2 ^², ³
MGC96883 ^²
MGC96930 ^²
MGC96942 ^²
OTTHUMP00000025841 ^²

Descriptions
Cancer/testis antigen 4.2 ^³
G antigen 2 ^¹
G antigen 2A ^²
cancer/testis antigen family 4, member 2 ^²

External Ids
HGNC: 4099¹
Entrez Gene: 729447²
UniProtKB: Q13066³
Ensembl: ENSG00000189064⁷

Search outside databases for aliases for GAGE2A gene

Previous GC identifers: GC0XP049117 GC0XP049186

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: GAGE2_HUMAN, Q13066

Function: Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23

GAGE2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP049243: (about GC identifiers)

Start:	49,241,032 bp from pter
End:	49,248,384 bp from pter
Size:	7,353 bases
Orientation:	plus strand

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GAGE2_HUMAN, Q13066 (See protein sequence)

Recommended Name: G antigen 2A/2B

Size: 116 amino acids; 12786 Da

Secondary accessions: Q4V322

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001120684.1

ENSEMBL proteins:

ENSP00000355421 ENSP00000384805

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

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Antibodies for GAGE2A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for GAGE2A

Assays for GAGE2A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q13066

ProtoNet protein and cluster: Q13066

1 Blocks protein family: IPB008625 GAGE

UniProtKB/Swiss-Prot: GAGE2_HUMAN, Q13066

Similarity: Belongs to the GAGE family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Applied Biosystems Silencer® siRNAs for GAGE2A

Sigma-Aldrich siRNA for GAGE2A

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GAGE2A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001127212
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001127212
untagged cDNA clone in CMV expression vector: NM_001127212

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001127212

UniProtKB/Swiss-Prot: GAGE2_HUMAN, Q13066

Function: Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GAGE2A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Sigma-Aldrich siRNA for GAGE2A

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001127212

REFSEQ mRNAs for GAGE2A gene:

NM_001127212.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001127212

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001127212
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001127212
                                 untagged cDNA clone in CMV expression vector: NM_001127212

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for GAGE2A (see all 17 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	^	14	^	15	^	16	^	17	^	18	^	19	^
SP1:																																					-		-		-		-		-		-				-
SP2:
SP3:																	-		-		-				-		-		-		-		-		-		-
SP4:																							-		-		-		-		-						-		-		-		-		-		-				-
SP5:																																					-				-		-		-		-		-

ExUns:	20	^	21	^	22	^	23	^	24a	·	24b
SP1:	-		-		-
SP2:
SP3:
SP4:	-		-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for GAGE2A

2 Ensembl transcripts including schematic representations:

ENST00000362097 ENST00000403072

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GAGE2A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GAGE2A

¹ / ²

15 probe-sets matching GAGE2A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31497_at²	U95-A	23	1.00	0.10	0.39	2.10	--	--	--	--	--
33671_f_at²	U95-A	24	1.00	0.04	0.86	0.60	--	--	--	--	--
31960_f_at²	U95-A	24	1.00	0.04	0.72	0.66	--	--	--	--	--
33680_f_at²	U95-A	24	1.00	0.04	0.50	0.55	--	--	--	--	--
37065_f_at²	U95-A	24	0.94	0.04	0.61	0.88	--	--	--	--	--
31498_f_at²	U95-A	24	0.94	0.04	0.73	0.92	--	--	--	--	--
31954_f_at²	U95-A	23	0.94	0.04	0.62	0.32	--	--	--	--	--
207739_s_at²	U133-A	23	1.00	0.04	--	--	--	--	--	--	--
208235_x_at²	U133-A	23	0.82	0.04	--	--	--	--	--	--	--
207086_x_at²	U133-A	23	0.82	0.04	--	--	--	--	--	--	--
206640_x_at²	U133-A	23	0.82	0.04	--	--	--	--	--	--	--
207739_s_at²	U133Plus2	23	1.00	0.04	--	--	--	--	--	--	--
208235_x_at²	U133Plus2	23	0.82	0.04	--	--	--	--	--	--	--
207086_x_at²	U133Plus2	23	0.82	0.04	--	--	--	--	--	--	--
206640_x_at²	U133Plus2	23	0.82	0.04	--	--	--	--	--	--	--

GeneDecks GAGE2A for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --
UniProtKB/Swiss-Prot: GAGE2_HUMAN, Q13066
Tissue specificity: Expressed in a variety of tumor tissues but not in normal tissues, except
testis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

ENSEMBL Gene Tree for GAGE2A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GAGE2A gene

GAGE2C¹ ² GAGE2B¹ ² GAGE2D¹ ² GAGE2E¹ ² GAGE12I¹ GAGE12G¹ ² GAGE12F¹ ² GAGE13¹ ²

GAGE12D¹ GAGE12C¹ ² GAGE12E¹ ² GAGE12H¹ ² GAGE1¹ ² GAGE12J¹ ² XAGE3² GAGE10²

ENSG00000169164² XAGE5² XAGE2B² PAGE1² XAGE2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

6 NCBI SNPs in GAGE2A are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs71263998^1,2	--	49242225(-)	`AGGCCAATA/G ATAGG`	1	R/YW	fra¹		0	--	--	--	--
--	rs71766261^1,2	--	49242946(+)	`TGTGT-/TGGTGTG`	1	--	int¹		0	--	--	--	--
--	rs57514394^1,2	--	49243016(+)	`ATTGAC/GTGGAA`	1	--	int¹		0	--	--	--	--
--	rs60862992^1,2	--	49242952(+)	`TGTGT-/GTAGGC`	1	--	int¹		0	--	--	--	--
--	rs59427157^1,2	--	49242953(+)	`GTGTT-/GAGGCA`	1	--	int¹		0	--	--	--	--
--	rs71801636^1,2	--	49247080(+)	`TATTT-/TAT TTATTATTTA`	1	--	int¹		0	--	--	--	--

About this table
The following additional 3 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs3747320

rs3747318

rs12834696

HapMap Linkage Disequilibrium images for GAGE2A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300720

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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6 PubMed articles for GAGE2A gene:

A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PubMed id 7544395)^{2, 3, 4} van den Eynde B....Boon T. (1995)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)³ Harrington J.J....Ducar M. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 729447	HGNC: 4099	Ensembl:ENSG00000189064	euGenes: HUgn729447	ECgene: GAGE2A
H-InvDB: GAGE2A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for GAGE2A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GAGE2A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GAGE2A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GAGE2A		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
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	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for GAGE2A

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for GAGE2A

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GAGE2A Gene

protein-coding GIFtS: 34

Aliases &
Descriptions
for GAGE2A

Summaries
for GAGE2A

Genomic Location
for GAGE2A

Proteins
for GAGE2A

Protein Domains/
Families
for GAGE2A

Gene Function
for GAGE2A

Pathways & Interactions
for GAGE2A

Drugs & Compounds
for GAGE2A

Transcripts
for GAGE2A

Expression
for GAGE2A

Orthologs
for GAGE2A

Paralogs
for GAGE2A

SNPs/Variants
for GAGE2A

Disorders & Mutations
for GAGE2A

Medical News
for GAGE2A

Publications
for GAGE2A

Search for GAGE2A

Genome Databases showing GAGE2A

Other Databases showing GAGE2A

Specialized Databases showing GAGE2A

Licensable Technologies
for GAGE2A

Services
for GAGE2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GAGE2A Gene

protein-coding GIFtS: 34

Aliases & Descriptionsfor GAGE2A

Summariesfor GAGE2A

Genomic Locationfor GAGE2A

Proteinsfor GAGE2A

Protein Domains/Familiesfor GAGE2A

Gene Functionfor GAGE2A

Pathways & Interactionsfor GAGE2A

Drugs & Compoundsfor GAGE2A

Transcriptsfor GAGE2A

Expression for GAGE2A

Orthologsfor GAGE2A

Paralogsfor GAGE2A

SNPs/Variantsfor GAGE2A

Disorders & Mutationsfor GAGE2A

Medical Newsfor GAGE2A

Publicationsfor GAGE2A

Search for GAGE2A

Genome Databases showing GAGE2A

Other Databases showing GAGE2A

Specialized Databases showing GAGE2A

Licensable Technologiesfor GAGE2A

Servicesfor GAGE2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GAGE2A

Summaries
for GAGE2A

Genomic Location
for GAGE2A

Proteins
for GAGE2A

Protein Domains/
Families
for GAGE2A

Gene Function
for GAGE2A

Pathways & Interactions
for GAGE2A

Drugs & Compounds
for GAGE2A

Transcripts
for GAGE2A

Expression
for GAGE2A

Orthologs
for GAGE2A

Paralogs
for GAGE2A

SNPs/Variants
for GAGE2A

Disorders & Mutations
for GAGE2A

Medical News
for GAGE2A

Publications
for GAGE2A

Licensable Technologies
for GAGE2A

Services
for GAGE2A