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Aliases for GAGE2A Gene

Aliases for GAGE2A Gene

  • G Antigen 2A 2 3 5
  • Cancer/Testis Antigen Family 4, Member 2 2 3
  • G Antigen 2 2 3
  • GAGE-2A 3 4
  • GAGE2 3 4
  • Cancer/Testis Antigen 4.2 3
  • G Antigen 2A/2B 3
  • GAGE-2 3
  • CT4.2 3

External Ids for GAGE2A Gene

Previous HGNC Symbols for GAGE2A Gene

  • GAGE2

Previous GeneCards Identifiers for GAGE2A Gene

  • GC0XP049117
  • GC0XP049186
  • GC0XP049243
  • GC0XP049244
  • GC0XP049358
  • GC0XP049360

Summaries for GAGE2A Gene

GeneCards Summary for GAGE2A Gene

GAGE2A (G Antigen 2A) is a Protein Coding gene. An important paralog of this gene is GAGE13.

Additional gene information for GAGE2A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE2A Gene

Genomics for GAGE2A Gene

Regulatory Elements for GAGE2A Gene

Enhancers for GAGE2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH048910 1.3 ENCODE dbSUPER 14.6 -677.3 -677343 3 PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ETS1 TCF12 ENSG00000204620 GAGE12J SSXP9 GAGE12G PAGE1 SSX9 GAGE1 GAGE2A GAGE12H ENSG00000270747
GH0XH048589 1.2 Ensembl ENCODE 14.6 -998.3 -998285 3 ELF3 ARNT NFRKB RAD21 ZNF2 SCRT2 FOS ATF7 YY2 CEBPB ENSG00000204620 ENSG00000270747 SSXP9 SSX9 GAGE12H GAGE12G GAGE12C GAGE1 GAGE2A GAGE12J
GH0XH049610 0.9 ENCODE 0.3 +21.3 21274 0 PKNOX1 FOXA2 MLX ARNT INSM2 FEZF1 THRB RARA ZNF350 ZNF488 GAGE13 ENSG00000270012 WDR45 GAGE2A VDAC1P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GAGE2A on UCSC Golden Path with GeneCards custom track

Genomic Location for GAGE2A Gene

Chromosome:
X
Start:
49,589,515 bp from pter
End:
49,596,827 bp from pter
Size:
7,313 bases
Orientation:
Plus strand

Genomic View for GAGE2A Gene

Genes around GAGE2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAGE2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAGE2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAGE2A Gene

Proteins for GAGE2A Gene

  • Protein details for GAGE2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NT46-GAG2A_HUMAN
    Recommended name:
    G antigen 2A
    Protein Accession:
    Q6NT46

    Protein attributes for GAGE2A Gene

    Size:
    116 amino acids
    Molecular mass:
    12785 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for GAGE2A Gene

Post-translational modifications for GAGE2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAGE2A Gene

Domains & Families for GAGE2A Gene

Gene Families for GAGE2A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GAGE2A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GAGE2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NT46

UniProtKB/Swiss-Prot:

GAG2A_HUMAN :
  • Belongs to the GAGE family.
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE2A: view

Function for GAGE2A Gene

Gene Ontology (GO) - Molecular Function for GAGE2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with GAGE2A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GAGE2A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAGE2A Gene

Localization for GAGE2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAGE2A gene
Compartment Confidence
nucleus 3
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Golgi apparatus (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GAGE2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with GAGE2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GAGE2A Gene

Pathways & Interactions for GAGE2A Gene

SuperPathways for GAGE2A Gene

No Data Available

Interacting Proteins for GAGE2A Gene

Gene Ontology (GO) - Biological Process for GAGE2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GAGE2A: view

No data available for Pathways by source and SIGNOR curated interactions for GAGE2A Gene

Drugs & Compounds for GAGE2A Gene

No Compound Related Data Available

Transcripts for GAGE2A Gene

mRNA/cDNA for GAGE2A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GAGE2A Gene

G antigen 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GAGE2A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE2A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - - - -
SP2:
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - - - -
SP13: -
SP14: - - - - - -
SP15:
SP16: - - - - - - - - - - - - - - - -
SP17: - -

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b
SP1: - - -
SP2:
SP3:
SP4: - - -
SP5:
SP6: - - -
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - -
SP15:
SP16: - - - -
SP17:

Relevant External Links for GAGE2A Gene

GeneLoc Exon Structure for
GAGE2A
ECgene alternative splicing isoforms for
GAGE2A

Expression for GAGE2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAGE2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAGE2A Gene

This gene is overexpressed in Testis (x51.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GAGE2A Gene



NURSA nuclear receptor signaling pathways regulating expression of GAGE2A Gene:

GAGE2A

SOURCE GeneReport for Unigene cluster for GAGE2A Gene:

Hs.722100
genes like me logo Genes that share expression patterns with GAGE2A: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAGE2A Gene

Orthologs for GAGE2A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAGE2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 95 (a)
ManyToMany
-- 34
  • 95 (a)
ManyToMany
Species where no ortholog for GAGE2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAGE2A Gene

ENSEMBL:
Gene Tree for GAGE2A (if available)
TreeFam:
Gene Tree for GAGE2A (if available)

Paralogs for GAGE2A Gene

genes like me logo Genes that share paralogs with GAGE2A: view

Variants for GAGE2A Gene

Sequence variations from dbSNP and Humsavar for GAGE2A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs111841783 -- 49,589,961(+) GGCCT(A/G)GCACC intron-variant
rs112425647 -- 49,591,401(+) GTGTG(C/T)GTGTT intron-variant
rs112466482 -- 49,592,320(+) AGAAA(A/C)TGACA intron-variant
rs112597632 -- 49,591,627(+) TGTTC(C/T)AAGGT intron-variant
rs113157222 -- 49,591,438(+) AGGAA(A/G)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAGE2A Gene

Variant ID Type Subtype PubMed ID
dgv4237n106 CNV duplication 24896259
esv28941 CNV gain+loss 19812545
esv3327960 CNV duplication 20981092
esv3364710 CNV duplication 20981092
esv3392575 CNV duplication 20981092
esv3407218 CNV duplication 20981092
nsv1075727 CNV deletion 25765185
nsv1153207 CNV duplication 26484159
nsv515203 CNV gain 21397061
nsv6899 CNV insertion 18451855
nsv6900 CNV deletion 18451855
nsv820429 CNV deletion 20802225
nsv953412 CNV duplication 24416366

Relevant External Links for GAGE2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAGE2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GAGE2A Gene

Disorders for GAGE2A Gene

Relevant External Links for GAGE2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAGE2A

No disorders were found for GAGE2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE2A Gene

Publications for GAGE2A Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PMID: 7544395) Van den Eynde B … Boon T (The Journal of experimental medicine 1995) 2 3 60
  4. Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells. (PMID: 19934278) Sun F … Yu Q (Molecular cancer therapeutics 2009) 3 60
  5. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff MF … Ditzel HJ (Tissue antigens 2008) 4 60

Products for GAGE2A Gene

Sources for GAGE2A Gene

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