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Aliases for GAGE12J Gene

Aliases for GAGE12J Gene

  • G Antigen 12J 2 3
  • G Antigen 11 2 3
  • GAGE-12J 4
  • GAGE11 3

External Ids for GAGE12J Gene

Previous HGNC Symbols for GAGE12J Gene

  • GAGE11

Previous GeneCards Identifiers for GAGE12J Gene

  • GC0XP049071
  • GC0XP049072
  • GC0XP049074
  • GC0XP049180
  • GC0XP049181
  • GC0XP049182

Summaries for GAGE12J Gene

GeneCards Summary for GAGE12J Gene

GAGE12J (G Antigen 12J) is a Protein Coding gene. An important paralog of this gene is XAGE2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE12J Gene

Genomics for GAGE12J Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GAGE12J Gene

Start:
49,322,037 bp from pter
End:
49,329,387 bp from pter
Size:
7,351 bases
Orientation:
Plus strand

Genomic View for GAGE12J Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GAGE12J Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAGE12J Gene

No data available for Regulatory Elements for GAGE12J Gene

Proteins for GAGE12J Gene

  • Protein details for GAGE12J Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NER3-GG12J_HUMAN
    Recommended name:
    G antigen 12J
    Protein Accession:
    A6NER3
    Secondary Accessions:

    Protein attributes for GAGE12J Gene

    Size:
    117 amino acids
    Molecular mass:
    12896 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells

neXtProt entry for GAGE12J Gene

Proteomics data for GAGE12J Gene at MOPED

Post-translational modifications for GAGE12J Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE12J Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAGE12J Gene

Domains for GAGE12J Gene

Protein Domains for GAGE12J Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GAGE12J Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NER3

UniProtKB/Swiss-Prot:

GG12J_HUMAN :
  • A6NER3
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE12J: view

No data available for Gene Families for GAGE12J Gene

Function for GAGE12J Gene

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAGE12J

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GAGE12J Gene

Localization for GAGE12J Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAGE12J Gene COMPARTMENTS Subcellular localization image for GAGE12J gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GAGE12J Gene

Pathways for GAGE12J Gene

SuperPathways for GAGE12J Gene

No Data Available

Interacting Proteins for GAGE12J Gene

Gene Ontology (GO) - Biological Process for GAGE12J Gene

None

No data available for Pathways by source for GAGE12J Gene

Transcripts for GAGE12J Gene

mRNA/cDNA for GAGE12J Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAGE12J

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE12J Gene

No ASD Table

Relevant External Links for GAGE12J Gene

GeneLoc Exon Structure for
GAGE12J
ECgene alternative splicing isoforms for
GAGE12J

Expression for GAGE12J Gene

mRNA expression in normal human tissues for GAGE12J Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAGE12J Gene

This gene is overexpressed in Testis (50.6).
genes like me logo Genes that share expressions with GAGE12J: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for GAGE12J Gene

Orthologs for GAGE12J Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAGE12J Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 93 (a)
OneToMany
Species with no ortholog for GAGE12J:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAGE12J Gene

ENSEMBL:
Gene Tree for GAGE12J (if available)
TreeFam:
Gene Tree for GAGE12J (if available)

Paralogs for GAGE12J Gene

genes like me logo Genes that share paralogs with GAGE12J: view

Variants for GAGE12J Gene

Sequence variations from dbSNP and Humsavar for GAGE12J Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1137130 -- 49,326,707(+) AAGCT(C/G)ATAGC missense, reference
rs6417807 -- 49,323,647(+) AGTTA(G/T)GACCA intron-variant
rs6520418 - 49,323,240(+) AAGAC(C/G)CTATG reference, missense
rs6520419 -- 49,323,714(+) ATTTT(C/T)TATTT intron-variant
rs6520420 -- 49,323,806(+) CTCAA(A/C)GTCAG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for GAGE12J Gene

Variant ID Type Subtype PubMed ID
esv24944 CNV Gain+Loss 19812545
nsv821250 CNV Deletion 20802225
nsv6896 CNV Insertion 18451855
nsv515201 CNV Complex 21397061
nsv6897 CNV Insertion 18451855

Relevant External Links for GAGE12J Gene

HapMap Linkage Disequilibrium report
GAGE12J

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAGE12J Gene

Disorders for GAGE12J Gene

No disorders were found for GAGE12J Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for GAGE12J Gene

Publications for GAGE12J Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  2. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff M.F. … Ditzel H.J. (Tissue Antigens 2008) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for GAGE12J Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GAGE12J
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GAGE12J
    • Block miRNA regulation of GAGE12J using miScript Target Protectors

    Sources for GAGE12J Gene

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