GAGE12J Gene
protein-coding GIFtS: 31
GCID: GC0XP049182
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G antigen 12J(Previous name: G antigen 11 )
(Previous symbol: GAGE11)
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Aliases
for GAGE12J gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
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| G Antigen 12J1 2 | | GAGE111 2 | | G Antigen 111 2 | | GAGE-12J2 3 | | OTTHUMG000000241371 |
Export aliases for GAGE12J gene to outside databasesPrevious GC identifers: GC0XP049071 GC0XP049072 GC0XP049074 GC0XP049180 GC0XP049181 |
Summaries
for GAGE12J gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Genomic Views
for GAGE12J gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NT_079573.4
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for GAGE12J
Other transcription factors
Search SABiosciences Chromatin IP Primers for GAGE12J
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAGE12J |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23GAGE12J Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP049182: view genomic region
(about GC identifiers)
Start:
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49,178,516 bp from pter |
End:
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49,185,866 bp from pter |
Size:
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7,351 bases |
Orientation:
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plus strand |
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Proteins
for GAGE12J gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GG12J_HUMAN, A6NER3 (See
protein sequence)Recommended Name: G antigen 12J Size: 117 amino acids; 12896 Da
Miscellaneous: This gene belongs to a multigene family expressed in a large variety of tumors whereas in normaltissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree ofpredicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain eitherthe antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells
Caution: The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE membersmade impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGEgene nomenclature based on the identified genes and their productsExplore the universe of human proteins at neXtProt for GAGE12J: NX_A6NER3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NER3
GAGE12J Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001091876.1
ENSEMBL proteins: ENSP00000409832
Human Recombinant Protein Products:
GAGE12J Antibody Products:
Assay Products for GAGE12J: |
Protein
Domains /
Families
for GAGE12J gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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GAGE12J for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A6NER3ProtoNet protein and cluster: A6NER3 UniProtKB/Swiss-Prot: GG12J_HUMAN, A6NER3Similarity: Belongs to the GAGE family |
Function
for GAGE12J gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE12J
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE12J
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GAGE12J (NM_001098406) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GAGE12J | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat GAGE12J |
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Pathways & Interactions
for GAGE12J gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GAGE12J
|
Drugs & Compounds
for GAGE12J gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GAGE12J
Search CenterWatch for drugs/clinical trials and news about GAGE12J / GG12J
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Transcripts
for GAGE12J gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for GAGE12J gene: NM_001098406.1 Unigene Cluster for GAGE12J: G antigen 12J Hs.695912 [show with all ESTs]Unigene Representative Sequence: BE7776981 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000442437(uc010nit.3 uc004dnk.4 uc004dnl.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE12J
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE12J
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GAGE12J (NM_001098406) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GAGE12J | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat GAGE12J |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAGE12J
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GAGE12J | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAGE12J | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAGE12J |
4 DOTS entries: DT.444944 DT.121292581 DT.75114676 DT.95283004
GeneLoc Exon Structure
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Expression
for GAGE12J gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GAGE12J expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See GAGE12J Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GAGE12J
SOURCE GeneReport for Unigene cluster: Hs.695912
SABiosciences Custom PCR Arrays for GAGE12J
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAGE12J
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GAGE12J | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAGE12J | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAGE12J |
Orthologs
for GAGE12J gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for GAGE12J (if available)
TreeFam Gene Tree for GAGE12J (if available) |
Paralogs
for GAGE12J gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GAGE12J gene
- GAGE12I1 2 GAGE12G1 2 GAGE12F1 2 GAGE11 2 GAGE2E1 2 GAGE12C1 2 GAGE12D1 2 GAGE12E1 2
- GAGE131 2 GAGE2D1 2 GAGE12H1 2 GAGE2C1 2 GAGE2B1 2 GAGE2A1 2 PAGE22 GAGE42
- XAGE32 GAGE102 PAGE32 XAGE52 XAGE2B2 PAGE52 PAGE2B2 PAGE12
- XAGE22 PAGE42
18/26 SIMAP similar genes for GAGE12J using alignment to 1 protein entry: GG12J_HUMAN(see all similar genes):GAGE3 GAGE5 GAGE6 GAGE12F GAGE12G GAGE12I
GAGE7 GAGE4 GAGE1 GAGE12B GAGE12C GAGE12D
GAGE12E GAGE12H GAGE13 GAGE2A GAGE2B GAGE2C
GAGE12J for paralogs About GeneDecksing
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Genomic Variants
for GAGE12J gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for GAGE12J (49178516 - 49185866 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for GAGE12J
13 CNVs: 37037 96665 83510 73974 37038 31551 37034 33164 37033 37032 37035 37039 37036 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for GAGE12J gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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 GAGE12J for disorders About MalaCards
GAGE12J for disorders About GeneDecksing
OMIM gene information: 300733
OMIM disorders: --
Export disorders for GAGE12J gene to outside databases
|
Publications
for GAGE12J gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for GAGE12J gene integrated from 9 sources:
(articles sorted by number of sources associating them with GAGE12J) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PubMed id 18179644)1, 2 Gjerstorff M.F. and Ditzel H.J. (2008)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for GAGE12J gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing GAGE12J gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing GAGE12J gene
(According to HUGE)
About This Section
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Specialized Databases showing GAGE12J gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for GAGE12J | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for GAGE12J gene:
Search GeneIP for patents involving GAGE12J
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for GAGE12J gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GAGE12J | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GAGE12J | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAGE12J | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GAGE12J | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE12J | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE12J | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GAGE12J | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAGE12J | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAGE12J | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAGE12J | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAGE12J | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAGE12J |
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 | | | GAGE12J Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for GAGE12J |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat GAGE12J |
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