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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GAGE12J Gene

protein-coding   GIFtS: 29
GCID: GC0XP049182

G Antigen 12J

(Previous name: G antigen 11)
(Previous symbol: GAGE11)
  Search for GAGE12J
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Antigen 12J1 2
GAGE111 2
G Antigen 111 2
GAGE-12J2 3

External Ids:    HGNC: 177781   Entrez Gene: 7293962   Ensembl: ENSG000002246597   OMIM: 3007335   UniProtKB: A6NER33   

Export aliases for GAGE12J gene to outside databases

Previous GC identifers: GC0XP049071 GC0XP049072 GC0XP049074 GC0XP049180 GC0XP049181


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GAGE12J Gene: 
GAGE12J (G antigen 12J) is a protein-coding gene. An important paralog of this gene is GAGE2D.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for GAGE12J
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for GAGE12J

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAGE12J


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

GAGE12J Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAGE12J gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP049182:  view genomic region     (about GC identifiers)

Start:
49,178,516 bp from pter      End:
49,185,866 bp from pter
Size:
7,351 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GG12J_HUMAN, A6NER3 (See protein sequence)
Recommended Name: G antigen 12J  
Size: 117 amino acids; 12896 Da
Miscellaneous: This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal
tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree
of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain
either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells
Caution: The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE
members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644
presented a new GAGE gene nomenclature based on the identified genes and their products

Explore the universe of human proteins at neXtProt for GAGE12J: NX_A6NER3

Explore proteomics data for GAGE12J at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NER3

  • GAGE12J Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GAGE12J Protein Expression
    REFSEQ proteins: NP_001091876.1  
    ENSEMBL proteins: 
     ENSP00000409832  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008625 GAGE

    Graphical View of Domain Structure for InterPro Entry A6NER3

    ProtoNet protein and cluster: A6NER3

    UniProtKB/Swiss-Prot: GG12J_HUMAN, A6NER3
    Similarity: Belongs to the GAGE family


    GAGE12J for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GAGE12J

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GAGE12J (GG12J)

    Search CenterWatch for drugs/clinical trials and news about GAGE12J / GG12J

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for GAGE12J gene: 
    NM_001098406.1  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000442437(uc010nit.3 uc004dnk.4 uc004dnl.4)
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GAGE12J expression in normal human tissues (normalized intensities)      GAGE12J embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GAGE12J Expression
    About this image


    GAGE12J expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Mesoderm (Gastrulation Derivatives)
             Mesoderm-like cells ( Derivation of cardiomyocytes from pluripotent stem cells and...
     
     Prostate (Endocrine System)

    See GAGE12J Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GAGE12J
        SABiosciences Custom PCR Arrays for GAGE12J
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAGE12J

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for GAGE12J gene from 1/2 species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    --
    --
    34(a)
    32(a)
    possible ortholog
    1 ↔ many
    X(42409468-42417781)
    X(44845511-44852279)


    ENSEMBL Gene Tree for GAGE12J (if available)
    TreeFam Gene Tree for GAGE12J (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GAGE12J gene
    GAGE12I1 2  GAGE12G1 2  GAGE12F1 2  GAGE11 2  GAGE2E1 2  GAGE12C1 2  GAGE12D1 2  GAGE12E1 2  
    GAGE131 2  GAGE2D1 2  GAGE12H1 2  GAGE2C1 2  GAGE2B1 2  GAGE2A1 2  XAGE32  GAGE102  
    XAGE52  XAGE2B2  PAGE12  XAGE22  
    18/26 SIMAP similar genes for GAGE12J using alignment to 1 protein entry:     GG12J_HUMAN(see all similar genes):
    GAGE3    GAGE5    GAGE6    GAGE12F    GAGE12G    GAGE12I
    GAGE7    GAGE4    GAGE1    GAGE12B    GAGE12C    GAGE12D
    GAGE12E    GAGE12H    GAGE13    GAGE2A    GAGE2B    GAGE2C

    GAGE12J for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/14 SNPs in GAGE12J are shown (see all 14)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0373874
    ----see VAR_0373872 P R mis40--------
    VAR_0439794
    ----see VAR_0439792 R Q mis40--------
    VAR_0373854
    ----see VAR_0373852 Y C mis40--------
    VAR_0373864
    ----see VAR_0373862 R S mis40--------
    rs1485739741,2
    ----49183641(+) AGCATC/TATATT 1 -- int10--------
    rs2011056221,2
    ----49177332(+) TCATGG/TGTTAA 1 -- us2k10--------
    rs3730948211,2
    ----49177668(+) ACAGGC/TTGAGC 1 -- us2k10--------
    rs2021930111,2
    ----49177569(+) TTTTTG/TGTAGT 1 -- us2k10--------
    rs2010027301,2
    ----49176907(+) CTTTTC/TCCTTT 1 -- us2k10--------
    rs3701650921,2
    ----49177503(+) CTGAGG/TGCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GAGE12J (49178516 - 49185866 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GAGE12J:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv821250CNV Deletion20802225
    nsv6897CNV Insertion18451855
    nsv6896CNV Insertion18451855
    esv24944CNV Gain+Loss19812545
    nsv515201CNV Complex21397061

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GAGE12J for disorders           About MalaCards
    OMIM gene information: 300733    OMIM disorders: --


    GAGE12J for disorders           About GeneDecksing


    Export disorders for GAGE12J gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GAGE12J gene integrated from 9 sources:
    (articles sorted by number of sources associating them with GAGE12J)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PubMed id 18179644)1, 2 Gjerstorff M.F. and Ditzel H.J. (2008)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 729396 HGNC: 17778 Ensembl:ENSG00000224659 euGenes: HUgn729396 ECgene: GAGE12J
    H-InvDB: GAGE12J

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GAGE12J Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GAGE12J gene:
    Search GeneIP for patents involving GAGE12J

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Search LifeMap BioReagents cell lines for GAGE12J
     Gene Synthesis
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     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAGE12J
     Browse SwitchGear 3'UTR luciferase reporter plasmids for GAGE12J
     Browse SwitchGear Promoter luciferase reporter plasmids for GAGE12J
     Search ThermoFisher Antibodies for GAGE12J
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat GAGE12J
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GAGE12J
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GAGE12J
    Customized:
     lentivirus for stable overexpression of GAGE12J
     lentivirus expression plasmids for stable overexpression of GAGE12J
     adenovirus for overexpression of GAGE12J
     Search LSBio for Antibodies for GAGE12J
    Customized transgenic rodents for:
     Humanization
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    transforming growth factor, beta 1
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