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GAGE12J Gene

protein-coding   GIFtS: 29

GC0XP049072
G antigen 12J
(Previous name: G antigen 11 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GAGE11)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
GAGE-12J 3
GAGE11 2
OTTHUMG00000024137 1
OTTHUMP00000025835 2
Descriptions
G antigen 11 1, 2
G antigen 12J 2
External Ids
HGNC: 177781
Entrez Gene: 7293962
UniProtKB: A6NER33
Ensembl: ENSG000002152757
Search outside databases for aliases for GAGE12J gene

Previous GC identifer: GC0XP049071

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

GAGE12J Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP049072:     (about GC identifiers)

Start:
49,047,131 bp from pter
End:
49,072,810 bp from pter
Size:
25,680 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000023.9  NT_079573.3  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GG12J_HUMAN, A6NER3 (See protein sequence)
Recommended Name: G antigen 12J  
Size: 117 amino acids; 12896 Da

REFSEQ proteins: NP_001091876.1  

ENSEMBL proteins: 
ENSP00000385546 ENSP00000332419 


Human Recombinant Proteins 
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for GAGE12J: 
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Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for GAGE12J

Assays for GAGE12J: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR008625 GAGE


   GeneDecks  GAGE12J for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry A6NER3

ProtoNet protein and cluster: A6NER3

UniProtKB/Swiss-Prot: GG12J_HUMAN, A6NER3
Similarity: Belongs to the GAGE family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Applied Biosystems Silencer® siRNAs for GAGE12J

              Sigma-Aldrich siRNA for GAGE12J  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001098406
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001098406
                                 untagged cDNA clone in CMV expression vector: NM_001098406 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001098406

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GAGE12J

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Sigma-Aldrich siRNA for GAGE12J  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001098406  

REFSEQ mRNAs for GAGE12J gene: 

NM_001098406.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001098406  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001098406
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001098406
                                 untagged cDNA clone in CMV expression vector: NM_001098406 

4 DOTS entries:

DT.444944  DT.121292581  DT.75114676  DT.95283004 

Unigene Cluster for GAGE12J:

G antigen 12J
Hs.709908  [show with all ESTs]
Unigene Representative Sequence: BE777698


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000401963  ENST00000332114  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GAGE12J expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for GAGE12J

1 / 2

16 probe-sets matching GAGE12J gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

37065_f_at2 U95-A 24 1.00 0.05 0.63 1.19 -- -- -- -- --

33671_f_at2 U95-A 24 1.00 0.04 0.88 0.81 -- -- -- -- --

31960_f_at2 U95-A 24 1.00 0.04 0.66 0.89 -- -- -- -- --

33680_f_at2 U95-A 24 1.00 0.04 0.49 0.75 -- -- -- -- --

31498_f_at2 U95-A 24 0.94 0.04 0.82 1.25 -- -- -- -- --

31954_f_at2 U95-A 23 0.94 0.04 0.58 0.44 -- -- -- -- --

207739_s_at2 U133-A 23 1.00 0.04 -- -- -- -- -- -- --

208155_x_at2 U133-A 23 0.91 0.05 -- -- -- -- -- -- --

207086_x_at2 U133-A 23 0.91 0.04 -- -- -- -- -- -- --

208235_x_at2 U133-A 23 0.91 0.04 -- -- -- -- -- -- --

206640_x_at2 U133-A 23 0.91 0.04 -- -- -- -- -- -- --

207739_s_at2 U133Plus2 23 1.00 0.04 -- -- -- -- -- -- --

208155_x_at2 U133Plus2 23 0.91 0.05 -- -- -- -- -- -- --

207086_x_at2 U133Plus2 23 0.91 0.04 -- -- -- -- -- -- --

208235_x_at2 U133Plus2 23 0.91 0.04 -- -- -- -- -- -- --

206640_x_at2 U133Plus2 23 0.91 0.04 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.709908
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

ENSEMBL Gene Tree for GAGE12J
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for GAGE12J gene
GAGE12I1  GAGE12G1 2  GAGE12F1 2  GAGE11 2  GAGE12D1  GAGE12C1 2  GAGE12E1 2  GAGE131 2  
GAGE2D1 2  GAGE2E1 2  GAGE12H1 2  GAGE2C1 2  GAGE2B1 2  GAGE2A1 2  XAGE32  GAGE102  
ENSG000001691642  XAGE52  XAGE2B2  PAGE12  XAGE22  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/57 NCBI SNPs in GAGE12J are shown (see all 57 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 1)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs70640961,2
A,C,H49066642(+) GACCTA/GTTATT 1 Y/C mis14Minor allele frequency- G:0.00EU EA WA 416
--
rs65204181,2
A,C49066663(+) AAGACC/GCTATG 1 P/R mis10--------
--
rs66098801,2
C49070111(+) AAGCTC/GATAGC 1 D/H mis10--------
--
rs70641051,2
A49066655(+) CCTAGA/TCCAAG 1 R/S mis10--------
--
rs21789721,2
A49064118(+) atttcA/Gccatc 1 -- ng510--------
--
rs21789731,2
A49064173(+) tcattC/Gcattc 1 -- ng510--------
--
rs66098751,2
A,C49068823(+) ATCATA/GTATTC 1 -- int10--------
--
rs64178111,2
A,C49070425(+) aggcgG/Tgctcc 1 -- int10--------
--
rs70664001,2
A,C49068610(+) ataaaC/Tacata 1 -- int10--------
--
rs110912551,2
A,C49070341(+) tggtgC/Gcatct 1 -- int10--------
About this table

HapMap Linkage Disequilibrium images for GAGE12J (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300733

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

3 PubMed articles for GAGE12J gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 729396 HGNC: 17778 Ensembl:ENSG00000215275 euGenes: HUgn729396 ECgene: GAGE12J
H-InvDB: GAGE12J
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for GAGE12J:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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