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Aliases for GAGE12I Gene

Aliases for GAGE12I Gene

  • G Antigen 12I 2 3
  • G Antigen 7B 2 3
  • Cancer/Testis Antigen 4.7 3
  • G Antigen 12F/G/I 3
  • GAGE-12I 4
  • GAGE-7B 3
  • GAGE7B 3
  • CT4.7 3
  • AL4 3

External Ids for GAGE12I Gene

Previous HGNC Symbols for GAGE12I Gene

  • GAGE7B

Previous GeneCards Identifiers for GAGE12I Gene

  • GC0XP049085
  • GC0XP049110
  • GC0XP049179
  • GC0XP049223
  • GC0XP049228
  • GC0XP049237
  • GC0XP049247
  • GC0XP049253
  • GC0XP049258
  • GC0XP049263
  • GC0XP049341

Summaries for GAGE12I Gene

Entrez Gene Summary for GAGE12I Gene

  • This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YYWPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAGE12I Gene

GAGE12I (G Antigen 12I) is a Protein Coding gene. An important paralog of this gene is GAGE12G.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE12I Gene

Genomics for GAGE12I Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GAGE12I Gene

Chromosome:
X
Orientation:
Unknown strand

Genomic View for GAGE12I Gene

Cytogenetic band:
  • Xp11.23 not on reference assembly by Entrez Gene
  • Xp11.23 not on reference assembly by HGNC
GeneLoc Logo Gene Density

RefSeq DNA sequence for GAGE12I Gene

No data available for Regulatory Elements for GAGE12I Gene

Proteins for GAGE12I Gene

  • Protein details for GAGE12I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CL82-GG12I_HUMAN
    Recommended name:
    G antigen 12I
    Protein Accession:
    P0CL82
    Secondary Accessions:
    • Q66I50

    Protein attributes for GAGE12I Gene

    Size:
    117 amino acids
    Molecular mass:
    12978 Da
    Quaternary structure:
    • Forms tetramers.
    Miscellaneous:
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells

neXtProt entry for GAGE12I Gene

Proteomics data for GAGE12I Gene at MOPED

Post-translational modifications for GAGE12I Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE12I Gene

REFSEQ proteins:

No data available for DME Specific Peptides for GAGE12I Gene

Domains & Families for GAGE12I Gene

Protein Domains for GAGE12I Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GAGE12I Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CL82

UniProtKB/Swiss-Prot:

GG12I_HUMAN :
  • Belongs to the GAGE family.
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE12I: view

No data available for Gene Families for GAGE12I Gene

Function for GAGE12I Gene

Gene Ontology (GO) - Molecular Function for GAGE12I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GAGE12I: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAGE12I

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAGE12I Gene

Localization for GAGE12I Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GAGE12I Gene

Pathways & Interactions for GAGE12I Gene

SuperPathways for GAGE12I Gene

No Data Available

Interacting Proteins for GAGE12I Gene

Selected Interacting proteins: P0CL82-GG12I_HUMAN for GAGE12I Gene via UniProtKB

Gene Ontology (GO) - Biological Process for GAGE12I Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GAGE12I Gene

Drugs & Compounds for GAGE12I Gene

No Compound Related Data Available

Transcripts for GAGE12I Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAGE12I

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE12I Gene

No ASD Table

Relevant External Links for GAGE12I Gene

ECgene alternative splicing isoforms for
GAGE12I

Expression for GAGE12I Gene

mRNA expression in normal human tissues for GAGE12I Gene

mRNA differential expression in normal tissues according to GTEx for GAGE12I Gene

This gene is overexpressed in Testis (x50.6).
genes like me logo Genes that share expression patterns with GAGE12I: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GAGE12I Gene

Orthologs for GAGE12I Gene

No data available for Orthologs and Evolution for GAGE12I Gene

Paralogs for GAGE12I Gene

Paralogs for GAGE12I Gene

genes like me logo Genes that share paralogs with GAGE12I: view

Variants for GAGE12I Gene

Structural Variations from Database of Genomic Variants (DGV) for GAGE12I Gene

Variant ID Type Subtype PubMed ID
esv24944 CNV Gain+Loss 19812545
nsv821250 CNV Deletion 20802225
nsv820429 CNV Deletion 20802225
esv28941 CNV Gain+Loss 19812545

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Variation tolerance and Relevant External Links for GAGE12I Gene

Disorders for GAGE12I Gene

Relevant External Links for GAGE12I

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAGE12I
genes like me logo Genes that share disorders with GAGE12I: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE12I Gene

Publications for GAGE12I Gene

  1. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PMID: 10397259) De Backer O. … van der Bruggen P. (Cancer Res. 1999) 2 23 67
  2. GAGE cancer-germline antigens are recruited to the nuclear envelope by germ cell-less (GCL). (PMID: 23029259) Gjerstorff M.F. … Ditzel H.J. (PLoS ONE 2012) 2 67
  3. Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. (PMID: 9651357) Chen M.E. … Sikes R.A. (J. Biol. Chem. 1998) 23 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. Expression, purification and characterization of the cancer-germline antigen GAGE12I: a candidate for cancer immunotherapy. (PMID: 20546897) Gjerstorff M.F. … Ditzel H.J. (Protein Expr. Purif. 2010) 67

Products for GAGE12I Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GAGE12I
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GAGE12I
    • Block miRNA regulation of GAGE12I using miScript Target Protectors

    Sources for GAGE12I Gene

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