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GAGE12I Gene

protein-coding   GIFtS: 32

GC0XP049085
G antigen 12I
(Previous name: G antigen 7B )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GAGE7B)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
AL4 2
CT4.7 2
GAGE-12F 3
GAGE-12G 3
GAGE-12I 3
GAGE7B 2
OTTHUMG00000067390 1
OTTHUMP00000070307 2
Descriptions
G antigen 12I 2
G antigen 7B 1, 2
cancer/testis antigen 4.7 2
External Ids
HGNC: 41051
Entrez Gene: 267482
UniProtKB: Q66I503
Ensembl: ENSG000002057757
Search outside databases for aliases for GAGE12I gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GAGE12I:
This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal
tissues, except for the testis. The sequences of the family members are highly related but differ
by scattered nucleotide substitutions. The antigenic peptide YYWPRPRRY, which is also encoded by
several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by
RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.4-p11.2   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

GAGE12I Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP049085:     (about GC identifiers)

Start:
49,084,570 bp from pter
End:
49,120,425 bp from pter
Size:
35,856 bases
Orientation:
plus strand
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GG12F_HUMAN, Q66I50 (See protein sequence)
Recommended Name: G antigen 12F/G/I  
Size: 75 amino acids; 8454 Da

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001468.1  

    ENSEMBL proteins: 
    ENSP00000371136 ENSP00000371127 ENSP00000371124 ENSP00000371123 ENSP00000386110 ENSP00000384742 
    ENSP00000365346 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for GAGE12I: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for GAGE12I

    Assays for GAGE12I: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR008625 GAGE


       GeneDecks  GAGE12I for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q66I50

    ProtoNet protein and cluster: Q66I50

    1 Blocks protein family: IPB008625 GAGE

    UniProtKB/Swiss-Prot: GG12F_HUMAN, Q66I50
    Similarity: Belongs to the GAGE family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001477

                  Applied Biosystems Silencer® siRNAs for GAGE12I

                  Sigma-Aldrich siRNA for GAGE12I  
                         Sigma-Aldrich shRNA for GAGE12I  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for GAGE12I
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001477
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001477
                                     untagged cDNA clone in CMV expression vector: NM_001477 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001477

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for GAGE12I

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001477

                  Sigma-Aldrich siRNA for GAGE12I  
                         Sigma-Aldrich shRNA for GAGE12I  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001477  

    REFSEQ mRNAs for GAGE12I gene: 

    NM_001477.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001477  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001477
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001477
                                     untagged cDNA clone in CMV expression vector: NM_001477 

    24/50 AceView cDNA sequences (see all 50 ):

    BC036094 BI826605 NM_001476 U19145 BC024914 BG773070 BM836021 BM832793 
    U19147 NM_001474 NM_001477 BX111134 AF055474 BI868671 BC031628 AI126437 
    BC005363 NM_001468 U19143 BX108227 AF055473 NM_012196 BC069309 NM_001475 


    GeneLoc Exon Structure

    7 Ensembl transcripts including schematic representations:
    ENST00000381717  ENST00000381708  ENST00000381705  ENST00000381704  ENST00000404720  ENST00000402590  
    ENST00000376176  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    GAGE12I expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for GAGE12I

    1 / 2

    16 probe-sets matching GAGE12I gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    31954_f_at2 U95-A 23 1.00 0.05 0.58 0.44 -- -- -- -- --

    37065_f_at2 U95-A 24 1.00 0.05 0.63 1.19 -- -- -- -- --

    31498_f_at2 U95-A 24 1.00 0.05 0.82 1.25 -- -- -- -- --

    33671_f_at2 U95-A 24 1.00 0.04 0.88 0.81 -- -- -- -- --

    31960_f_at2 U95-A 24 1.00 0.04 0.66 0.89 -- -- -- -- --

    33680_f_at2 U95-A 24 1.00 0.04 0.49 0.75 -- -- -- -- --

    208235_x_at2 U133-A 23 1.00 0.05 -- -- -- -- -- -- --

    206640_x_at2 U133-A 23 1.00 0.05 -- -- -- -- -- -- --

    207739_s_at2 U133-A 23 1.00 0.04 -- -- -- -- -- -- --

    208155_x_at2 U133-A 23 0.91 0.05 -- -- -- -- -- -- --

    207086_x_at2 U133-A 23 0.91 0.05 -- -- -- -- -- -- --

    208235_x_at2 U133Plus2 23 1.00 0.05 -- -- -- -- -- -- --

    206640_x_at2 U133Plus2 23 1.00 0.05 -- -- -- -- -- -- --

    207739_s_at2 U133Plus2 23 1.00 0.04 -- -- -- -- -- -- --

    208155_x_at2 U133Plus2 23 0.91 0.05 -- -- -- -- -- -- --

    207086_x_at2 U133Plus2 23 0.91 0.05 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    ENSEMBL Gene Tree for GAGE12I
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for GAGE12I gene
    GAGE12G1 2  GAGE12F1 2  GAGE12D1  GAGE12C1 2  GAGE12E1 2  GAGE12H1 2  GAGE11 2  GAGE2C1  
    GAGE2B1 2  GAGE12J1 2  GAGE2D1 2  GAGE2E1 2  GAGE2A1 2  GAGE131 2  XAGE32  GAGE102  
    ENSG000001691642  XAGE52  XAGE2B2  PAGE12  XAGE22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    3 NCBI SNPs in GAGE12I are shown
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs59024451,2
    --49102258(+) ttatc-/Tagagt 1 -- ng510--------
    --
    rs712284671,2
    --49108711(+) ATAACA/GGAGAG 1 -- int10--------
    --
    rs712284661,2
    --49108587(+) GTTTCC/GTTATG 1 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for GAGE12I (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 300637

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    7 PubMed articles for GAGE12I gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 26748 HGNC: 4105 AceView: GAGE1 Ensembl:ENSG00000205775 euGenes: HUgn26748
    ECgene: GAGE12I H-InvDB: GAGE12I
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for GAGE12I:
     TaqMan ® Gene Expression Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for GAGE12I-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for GAGE12I Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for GAGE12I Browse small molecules at Sigma-Aldrich
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     Search Novus for antibodies for GAGE12I

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