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Aliases for GAGE12F Gene

Aliases for GAGE12F Gene

  • G Antigen 12F 2 3 5
  • GAGE-12F 3 4
  • G Antigen 12F/G/I 3

External Ids for GAGE12F Gene

Previous GeneCards Identifiers for GAGE12F Gene

  • GC00U922120
  • GC0XP049051
  • GC0XP049194
  • GC0XP049203
  • GC0XP049217
  • GC0XP049205
  • GC0XP049298
  • GC0XP049299
  • GC0XP049307
  • GC0XP049326

Summaries for GAGE12F Gene

GeneCards Summary for GAGE12F Gene

GAGE12F (G Antigen 12F) is a Protein Coding gene. An important paralog of this gene is XAGE5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE12F Gene

Genomics for GAGE12F Gene

Genomic Location for GAGE12F Gene

Chromosome:
X
Start:
49,560,876 bp from pter
End:
49,568,205 bp from pter
Size:
7,330 bases
Orientation:
Plus strand

Genomic View for GAGE12F Gene

Genes around GAGE12F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAGE12F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAGE12F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for Regulatory Elements and RefSeq DNA sequence for GAGE12F Gene

Proteins for GAGE12F Gene

  • Protein details for GAGE12F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CL80-GG12F_HUMAN
    Recommended name:
    G antigen 12F
    Protein Accession:
    P0CL80
    Secondary Accessions:
    • Q66I50

    Protein attributes for GAGE12F Gene

    Size:
    117 amino acids
    Molecular mass:
    12978 Da
    Quaternary structure:
    • Forms tetramers.
    Miscellaneous:
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

    Alternative splice isoforms for GAGE12F Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAGE12F Gene

Proteomics data for GAGE12F Gene at MOPED

Post-translational modifications for GAGE12F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE12F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAGE12F Gene

Domains & Families for GAGE12F Gene

Protein Domains for GAGE12F Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GAGE12F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CL80

UniProtKB/Swiss-Prot:

GG12F_HUMAN :
  • Belongs to the GAGE family.
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE12F: view

No data available for Gene Families for GAGE12F Gene

Function for GAGE12F Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAGE12F Gene

Localization for GAGE12F Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GAGE12F Gene

Pathways & Interactions for GAGE12F Gene

SuperPathways for GAGE12F Gene

No Data Available

Interacting Proteins for GAGE12F Gene

Gene Ontology (GO) - Biological Process for GAGE12F Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GAGE12F Gene

Drugs & Compounds for GAGE12F Gene

No Compound Related Data Available

Transcripts for GAGE12F Gene

mRNA/cDNA for GAGE12F Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GAGE12F Gene

G antigen 12F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE12F Gene

No ASD Table

Relevant External Links for GAGE12F Gene

GeneLoc Exon Structure for
GAGE12F
ECgene alternative splicing isoforms for
GAGE12F

Expression for GAGE12F Gene

mRNA expression in normal human tissues for GAGE12F Gene

SOURCE GeneReport for Unigene cluster for GAGE12F Gene Hs.695912

genes like me logo Genes that share expression patterns with GAGE12F: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GAGE12F Gene

Orthologs for GAGE12F Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAGE12F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 94 (a)
OneToMany
Species with no ortholog for GAGE12F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAGE12F Gene

ENSEMBL:
Gene Tree for GAGE12F (if available)
TreeFam:
Gene Tree for GAGE12F (if available)

Paralogs for GAGE12F Gene

genes like me logo Genes that share paralogs with GAGE12F: view

Variants for GAGE12F Gene

Sequence variations from dbSNP and Humsavar for GAGE12F Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2001221 -- 49,562,999(+) CATGT(A/G)TGTTG intron-variant
rs2005560 -- 49,562,966(+) TTGTA(C/T)TGTGT intron-variant
rs2008500 -- 49,562,450(+) AGTTA(G/T)GACCA intron-variant
rs2869201 -- 49,559,803(-) ggcgc(C/G)cttga upstream-variant-2KB
rs2869203 -- 49,559,372(-) GGCAA(C/T)GACGg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GAGE12F Gene

Variant ID Type Subtype PubMed ID
esv24944 CNV Gain+Loss 19812545
nsv821250 CNV Deletion 20802225
nsv820429 CNV Deletion 20802225
esv28941 CNV Gain+Loss 19812545

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for GAGE12F Gene

Disorders for GAGE12F Gene

Relevant External Links for GAGE12F

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAGE12F

No disorders were found for GAGE12F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE12F Gene

Publications for GAGE12F Gene

  1. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff M.F. … Ditzel H.J. (Tissue Antigens 2008) 3 4 67

Products for GAGE12F Gene

Sources for GAGE12F Gene

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