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Aliases for GAGE12E Gene

Aliases for GAGE12E Gene

  • G Antigen 12E 2 3 5
  • GAGE-12B 3 4
  • GAGE-12E 3 4
  • GAGE12B GAGE12C GAGE12D GAGE12E 4
  • G Antigen 12B/C/D/E 3
  • G Antigen 12C/D/E 3
  • GAGE-12C 4
  • GAGE-12D 4

External Ids for GAGE12E Gene

Previous GeneCards Identifiers for GAGE12E Gene

  • GC0XU900714
  • GC0XP049114
  • GC0XP049195
  • GC0XP049204
  • GC0XP049319
  • GC0XP049320
  • GC0XP049321

Summaries for GAGE12E Gene

GeneCards Summary for GAGE12E Gene

GAGE12E (G Antigen 12E) is a Protein Coding gene. An important paralog of this gene is GAGE12D.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE12E Gene

Genomics for GAGE12E Gene

Genomic Location for GAGE12E Gene

Chromosome:
X
Start:
49,551,289 bp from pter
End:
49,558,649 bp from pter
Size:
7,361 bases
Orientation:
Plus strand

Genomic View for GAGE12E Gene

Genes around GAGE12E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAGE12E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAGE12E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAGE12E Gene

No data available for Regulatory Elements for GAGE12E Gene

Proteins for GAGE12E Gene

  • Protein details for GAGE12E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L429-GG12C_HUMAN
    Recommended name:
    G antigen 12B/C/D/E
    Protein Accession:
    A1L429
    Secondary Accessions:
    • A6NHF1
    • B7ZL74

    Protein attributes for GAGE12E Gene

    Size:
    117 amino acids
    Molecular mass:
    12925 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for GAGE12E Gene

Post-translational modifications for GAGE12E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE12E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAGE12E Gene

Domains & Families for GAGE12E Gene

Protein Domains for GAGE12E Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GAGE12E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1L429

UniProtKB/Swiss-Prot:

GG12C_HUMAN :
  • Belongs to the GAGE family.
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE12E: view

No data available for Gene Families for GAGE12E Gene

Function for GAGE12E Gene

Gene Ontology (GO) - Molecular Function for GAGE12E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GAGE12E: view

Animal Model Products

miRNA for GAGE12E Gene

miRTarBase miRNAs that target GAGE12E

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAGE12E Gene

Localization for GAGE12E Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GAGE12E Gene

Pathways & Interactions for GAGE12E Gene

SuperPathways for GAGE12E Gene

No Data Available

Gene Ontology (GO) - Biological Process for GAGE12E Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GAGE12E Gene

Transcripts for GAGE12E Gene

mRNA/cDNA for GAGE12E Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE12E Gene

No ASD Table

Relevant External Links for GAGE12E Gene

GeneLoc Exon Structure for
GAGE12E
ECgene alternative splicing isoforms for
GAGE12E

Expression for GAGE12E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GAGE12E Gene

NURSA nuclear receptor signaling pathways regulating expression of GAGE12E Gene:

GAGE12E
genes like me logo Genes that share expression patterns with GAGE12E: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GAGE12E Gene

Orthologs for GAGE12E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAGE12E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 93 (a)
OneToMany
Species where no ortholog for GAGE12E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAGE12E Gene

ENSEMBL:
Gene Tree for GAGE12E (if available)
TreeFam:
Gene Tree for GAGE12E (if available)

Paralogs for GAGE12E Gene

(23) SIMAP similar genes for GAGE12E Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GAGE12E: view

Variants for GAGE12E Gene

Sequence variations from dbSNP and Humsavar for GAGE12E Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1064628 -- 49,558,562(+) AGAAG(A/G)CACGT utr-variant-3-prime
rs113686575 -- 49,551,472(+) AGCGG(A/G)TCCCG intron-variant
rs11798010 -- 49,553,056(+) CTCAA(C/T)GTCAG reference, missense
rs137911653 -- 49,558,839(+) GTGGC(A/G)CGATC downstream-variant-500B, upstream-variant-2KB
rs138525902 -- 49,558,412(+) ACCCA(C/T)AGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAGE12E Gene

Variant ID Type Subtype PubMed ID
dgv4237n106 CNV duplication 24896259
esv28941 CNV gain+loss 19812545
esv3363500 CNV duplication 20981092
esv3364710 CNV duplication 20981092
esv3373509 CNV duplication 20981092
esv3374855 CNV duplication 20981092
esv3393529 CNV duplication 20981092
esv3407218 CNV duplication 20981092
esv3434123 CNV duplication 20981092
esv3435089 CNV duplication 20981092
esv3445396 CNV duplication 20981092
esv3446455 CNV duplication 20981092
esv3449504 CNV duplication 20981092
esv3450031 CNV duplication 20981092
esv3451132 CNV duplication 20981092
esv3451692 CNV duplication 20981092
nsv1075724 CNV deletion 25765185
nsv1075725 CNV deletion 25765185
nsv1075726 CNV deletion 25765185
nsv1076708 CNV duplication 25765185
nsv1077583 CNV duplication 25765185
nsv1077584 CNV duplication 25765185
nsv1129078 CNV duplication 24896259
nsv1141677 CNV duplication 24896259
nsv1147303 CNV duplication 26484159
nsv1151845 CNV duplication 26484159
nsv515203 CNV gain 21397061
nsv6899 CNV insertion 18451855
nsv6900 CNV deletion 18451855
nsv820429 CNV deletion 20802225
nsv953412 CNV duplication 24416366

Relevant External Links for GAGE12E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAGE12E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GAGE12E Gene

Disorders for GAGE12E Gene

Relevant External Links for GAGE12E

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAGE12E

No disorders were found for GAGE12E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE12E Gene

Publications for GAGE12E Gene

  1. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff M.F. … Ditzel H.J. (Tissue Antigens 2008) 3 4 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 3 64

Products for GAGE12E Gene

Sources for GAGE12E Gene

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