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Aliases for GAGE12E Gene

Aliases for GAGE12E Gene

  • G Antigen 12E 2 3
  • GAGE-12B 3 4
  • GAGE-12E 3 4
  • G Antigen 12C/D/E 3
  • GAGE-12C 4
  • GAGE-12D 4

External Ids for GAGE12E Gene

Previous GeneCards Identifiers for GAGE12E Gene

  • GC0XU900714
  • GC0XP049114
  • GC0XP049195
  • GC0XP049204
  • GC0XP049319
  • GC0XP049320
  • GC0XP049321

Summaries for GAGE12E Gene

GeneCards Summary for GAGE12E Gene

GAGE12E (G Antigen 12E) is a Protein Coding gene. An important paralog of this gene is XAGE2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE12E Gene

Genomics for GAGE12E Gene

Genomic Location for GAGE12E Gene

49,551,289 bp from pter
49,558,649 bp from pter
7,361 bases
Plus strand

Genomic View for GAGE12E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GAGE12E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAGE12E Gene

No data available for Regulatory Elements for GAGE12E Gene

Proteins for GAGE12E Gene

  • Protein details for GAGE12E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G antigen 12B/C/D/E
    Protein Accession:
    Secondary Accessions:
    • A6NHF1
    • B7ZL74

    Protein attributes for GAGE12E Gene

    117 amino acids
    Molecular mass:
    12925 Da
    Quaternary structure:
    No Data Available
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells

neXtProt entry for GAGE12E Gene

Proteomics data for GAGE12E Gene at MOPED

Post-translational modifications for GAGE12E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE12E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAGE12E Gene

Domains & Families for GAGE12E Gene

Protein Domains for GAGE12E Gene


Suggested Antigen Peptide Sequences for GAGE12E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE12E: view

No data available for Gene Families for GAGE12E Gene

Function for GAGE12E Gene

Gene Ontology (GO) - Molecular Function for GAGE12E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GAGE12E: view

Animal Model Products

CRISPR Products

miRNA for GAGE12E Gene

miRTarBase miRNAs that target GAGE12E

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAGE12E

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for GAGE12E Gene

Localization for GAGE12E Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GAGE12E Gene

Pathways & Interactions for GAGE12E Gene

SuperPathways for GAGE12E Gene

No Data Available

Interacting Proteins for GAGE12E Gene

Selected Interacting proteins: A1L429-GG12C_HUMAN for GAGE12E Gene via UniProtKB

Gene Ontology (GO) - Biological Process for GAGE12E Gene


No data available for Pathways by source and SIGNOR curated interactions for GAGE12E Gene

Drugs & Compounds for GAGE12E Gene

No Compound Related Data Available

Transcripts for GAGE12E Gene

mRNA/cDNA for GAGE12E Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAGE12E

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE12E Gene

No ASD Table

Relevant External Links for GAGE12E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GAGE12E Gene

mRNA expression in normal human tissues for GAGE12E Gene

genes like me logo Genes that share expression patterns with GAGE12E: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GAGE12E Gene

Orthologs for GAGE12E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAGE12E Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 93 (a)
Species with no ortholog for GAGE12E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAGE12E Gene

Gene Tree for GAGE12E (if available)
Gene Tree for GAGE12E (if available)

Paralogs for GAGE12E Gene

(23) SIMAP similar genes for GAGE12E Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GAGE12E: view

Variants for GAGE12E Gene

Sequence variations from dbSNP and Humsavar for GAGE12E Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1064628 -- 49,558,562(+) AGAAG(A/G)CACGT utr-variant-3-prime
rs2869196 -- 49,551,790(-) CGCTG(A/G)GGGGG intron-variant
rs5906794 -- 49,557,929(+) TTAAA(A/T)CTTTC intron-variant
rs6608869 -- 49,557,640(+) cttgc(A/G)atagt intron-variant
rs6608870 -- 49,557,685(+) tccct(A/G)caaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAGE12E Gene

Variant ID Type Subtype PubMed ID
nsv820429 CNV Deletion 20802225
esv28941 CNV Gain+Loss 19812545
nsv6899 CNV Insertion 18451855
nsv6900 CNV Loss 18451855
nsv515203 CNV Complex 21397061

Relevant External Links for GAGE12E Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GAGE12E Gene

Disorders for GAGE12E Gene

Relevant External Links for GAGE12E

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GAGE12E: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE12E Gene

Publications for GAGE12E Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  2. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff M.F. … Ditzel H.J. (Tissue Antigens 2008) 67
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 67

Products for GAGE12E Gene

Sources for GAGE12E Gene

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