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Aliases for GAGE10 Gene

Aliases for GAGE10 Gene

  • G Antigen 10 2 3
  • GAGE-10 3 4

External Ids for GAGE10 Gene

Previous GeneCards Identifiers for GAGE10 Gene

  • GC0XP049048
  • GC0XP049063
  • GC0XP049064
  • GC0XP049160
  • GC0XP046817

Summaries for GAGE10 Gene

GeneCards Summary for GAGE10 Gene

GAGE10 (G Antigen 10) is a Protein Coding gene. An important paralog of this gene is XAGE2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE10 Gene

Genomics for GAGE10 Gene

Regulatory Elements for GAGE10 Gene

Genomic Location for GAGE10 Gene

Start:
49,303,669 bp from pter
End:
49,322,086 bp from pter
Size:
18,418 bases
Orientation:
Plus strand

Genomic View for GAGE10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GAGE10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAGE10 Gene

Proteins for GAGE10 Gene

  • Protein details for GAGE10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGK3-GAG10_HUMAN
    Recommended name:
    G antigen 10
    Protein Accession:
    A6NGK3
    Secondary Accessions:

    Protein attributes for GAGE10 Gene

    Size:
    116 amino acids
    Molecular mass:
    12651 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells

neXtProt entry for GAGE10 Gene

Proteomics data for GAGE10 Gene at MOPED

Post-translational modifications for GAGE10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAGE10 Gene

Domains for GAGE10 Gene

Protein Domains for GAGE10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GAGE10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NGK3

UniProtKB/Swiss-Prot:

GAG10_HUMAN :
  • A6NGK3
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE10: view

No data available for Gene Families for GAGE10 Gene

Function for GAGE10 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GAGE10 Gene

Localization for GAGE10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAGE10 Gene COMPARTMENTS Subcellular localization image for GAGE10 gene
Compartment Confidence
extracellular 2
mitochondrion 2
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GAGE10 Gene

Pathways for GAGE10 Gene

SuperPathways for GAGE10 Gene

No Data Available

Interacting Proteins for GAGE10 Gene

Gene Ontology (GO) - Biological Process for GAGE10 Gene

None

No data available for Pathways by source for GAGE10 Gene

Transcripts for GAGE10 Gene

mRNA/cDNA for GAGE10 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE10 Gene

No ASD Table

Relevant External Links for GAGE10 Gene

GeneLoc Exon Structure for
GAGE10
ECgene alternative splicing isoforms for
GAGE10

Expression for GAGE10 Gene

mRNA expression in normal human tissues for GAGE10 Gene

mRNA differential expression in normal tissues according to GTEx for GAGE10 Gene

This gene is overexpressed in Testis (7.9) and Pituitary (7.1).
genes like me logo Genes that share expressions with GAGE10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for GAGE10 Gene

Orthologs for GAGE10 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAGE10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GAGE10 35
  • 96.26 (n)
  • 90.65 (a)
-- 36
  • 91 (a)
ManyToMany
Species with no ortholog for GAGE10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAGE10 Gene

ENSEMBL:
Gene Tree for GAGE10 (if available)
TreeFam:
Gene Tree for GAGE10 (if available)

Paralogs for GAGE10 Gene

genes like me logo Genes that share paralogs with GAGE10: view

Variants for GAGE10 Gene

Sequence variations from dbSNP and Humsavar for GAGE10 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1984695 -- 49,305,188(+) AACAC(A/G/T)GAGTA intron-variant
rs1988075 -- 49,313,056(+) ttctc(A/T)gggta intron-variant
rs1988213 -- 49,317,880(+) TCAAT(A/G)CATAA intron-variant
rs2015487 -- 49,317,625(+) TTACA(G/T)GCGAG intron-variant
rs2091976 -- 49,305,763(+) TGAGA(A/G)AATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAGE10 Gene

Variant ID Type Subtype PubMed ID
nsv469734 CNV Complex 16826518
nsv471602 CNV Gain 15918152
esv24944 CNV Gain+Loss 19812545
nsv821250 CNV Deletion 20802225
nsv6896 CNV Insertion 18451855
nsv515201 CNV Complex 21397061

Relevant External Links for GAGE10 Gene

HapMap Linkage Disequilibrium report
GAGE10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAGE10 Gene

Disorders for GAGE10 Gene

No disorders were found for GAGE10 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for GAGE10 Gene

Publications for GAGE10 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  2. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff M.F. … Ditzel H.J. (Tissue Antigens 2008) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for GAGE10 Gene

Sources for GAGE10 Gene

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