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Aliases for GAGE10 Gene

Aliases for GAGE10 Gene

  • G Antigen 10 2 3 5
  • GAGE-10 3 4

External Ids for GAGE10 Gene

Previous GeneCards Identifiers for GAGE10 Gene

  • GC0XP049048
  • GC0XP049063
  • GC0XP049064
  • GC0XP049160
  • GC0XP046817

Summaries for GAGE10 Gene

GeneCards Summary for GAGE10 Gene

GAGE10 (G Antigen 10) is a Protein Coding gene. An important paralog of this gene is GAGE13.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE10 Gene

Genomics for GAGE10 Gene

Regulatory Elements for GAGE10 Gene

Enhancers for GAGE10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF049307 1.3 Ensembl ENCODE 0.4 +5.6 5568 2.8 HDGF ATF1 ZNF121 GLIS2 ZNF143 ZNF207 KLF7 ZNF263 SP3 REST GAGE13 GAGE10 GAGE12J
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GAGE10 on UCSC Golden Path with GeneCards custom track

Genomic Location for GAGE10 Gene

49,303,646 bp from pter
49,319,844 bp from pter
16,199 bases
Plus strand

Genomic View for GAGE10 Gene

Genes around GAGE10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAGE10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAGE10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAGE10 Gene

Proteins for GAGE10 Gene

  • Protein details for GAGE10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G antigen 10
    Protein Accession:

    Protein attributes for GAGE10 Gene

    116 amino acids
    Molecular mass:
    12651 Da
    Quaternary structure:
    No Data Available
    • This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for GAGE10 Gene

Post-translational modifications for GAGE10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAGE10 Gene

Domains & Families for GAGE10 Gene

Protein Domains for GAGE10 Gene


Suggested Antigen Peptide Sequences for GAGE10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE10: view

No data available for Gene Families for GAGE10 Gene

Function for GAGE10 Gene

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAGE10 Gene

Localization for GAGE10 Gene

Subcellular locations from

Jensen Localization Image for GAGE10 Gene COMPARTMENTS Subcellular localization image for GAGE10 gene
Compartment Confidence
extracellular 2
mitochondrion 2
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GAGE10 Gene

Pathways & Interactions for GAGE10 Gene

SuperPathways for GAGE10 Gene

No Data Available

Interacting Proteins for GAGE10 Gene

Selected Interacting proteins: A6NGK3-GAG10_HUMAN for GAGE10 Gene via UniProtKB

Gene Ontology (GO) - Biological Process for GAGE10 Gene


No data available for Pathways by source and SIGNOR curated interactions for GAGE10 Gene

Transcripts for GAGE10 Gene

mRNA/cDNA for GAGE10 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE10 Gene

No ASD Table

Relevant External Links for GAGE10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GAGE10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GAGE10 Gene

mRNA differential expression in normal tissues according to GTEx for GAGE10 Gene

This gene is overexpressed in Testis (x7.9) and Pituitary (x7.1).

NURSA nuclear receptor signaling pathways regulating expression of GAGE10 Gene:

genes like me logo Genes that share expression patterns with GAGE10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GAGE10 Gene

Orthologs for GAGE10 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAGE10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GAGE10 34
  • 96.26 (n)
-- 35
  • 91 (a)
Species where no ortholog for GAGE10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAGE10 Gene

Gene Tree for GAGE10 (if available)
Gene Tree for GAGE10 (if available)

Paralogs for GAGE10 Gene

genes like me logo Genes that share paralogs with GAGE10: view

Variants for GAGE10 Gene

Sequence variations from dbSNP and Humsavar for GAGE10 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10580626 -- 49,306,848(+) ACAAA(-/CAAA)CAAAC intron-variant
rs111602038 -- 49,315,479(+) ACTGC(A/G)TCATA intron-variant
rs111622823 -- 49,315,072(+) CAAAC(A/C)CTTTC intron-variant
rs111674184 -- 49,315,529(+) TCAAG(A/G)GCACT intron-variant
rs111851556 -- 49,304,192(+) GACTG(C/T)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAGE10 Gene

Variant ID Type Subtype PubMed ID
esv3392254 CNV duplication 20981092
esv3451555 CNV duplication 20981092
esv3573952 CNV loss 25503493
nsv469734 CNV gain+loss 16826518
nsv471602 CNV gain 15918152
nsv6896 CNV insertion 18451855

Variation tolerance for GAGE10 Gene

Residual Variation Intolerance Score: 68.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAGE10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAGE10 Gene

Disorders for GAGE10 Gene

Relevant External Links for GAGE10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GAGE10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE10 Gene

Publications for GAGE10 Gene

  1. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff M.F. … Ditzel H.J. (Tissue Antigens 2008) 3 4 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for GAGE10 Gene

Sources for GAGE10 Gene

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