GAGE10 Gene
protein-coding GIFtS: 32
GCID: GC0XP049160
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G antigen 10
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Aliases
for GAGE10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| G Antigen 101 2 | | GAGE-102 3 | | OTTHUMG000000241361 |
Export aliases for GAGE10 gene to outside databasesPrevious GC identifers: GC0XP049048 GC0XP049063 GC0XP049064 GC0XP046817 |
Summaries
for GAGE10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for GAGE10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GAGE10 gene promoter:
GR TBP GR-beta HNF-4alpha1 Egr-4 Arnt MZF-1 PPAR-gamma1 GR-alpha PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for GAGE10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAGE10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23GAGE10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP049160: view genomic region
(about GC identifiers)
Start:
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49,160,125 bp from pter |
End:
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49,176,323 bp from pter |
Size:
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16,199 bases |
Orientation:
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plus strand |
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Proteins
for GAGE10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GAG10_HUMAN, A6NGK3 (See
protein sequence)Recommended Name: G antigen 10 Size: 116 amino acids; 12651 Da
Miscellaneous: This gene belongs to a multigene family expressed in a large variety of tumors whereas in normaltissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree ofpredicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain eitherthe antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells
Caution: The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE membersmade impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGEgene nomenclature based on the identified genes and their productsExplore the universe of human proteins at neXtProt for GAGE10: NX_A6NGK3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NGK3
GAGE10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001091883.2
ENSEMBL proteins: ENSP00000385415
Human Recombinant Protein Products:
GAGE10 Antibody Products:
Assay Products for GAGE10: |
Protein
Domains /
Families
for GAGE10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GAGE10 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A6NGK3ProtoNet protein and cluster: A6NGK3 UniProtKB/Swiss-Prot: GAG10_HUMAN, A6NGK3Similarity: Belongs to the GAGE family |
Function
for GAGE10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE10
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GAGE10 (NM_001098413) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GAGE10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAGE10 |
|
Pathways & Interactions
for GAGE10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GAGE10
|
Drugs & Compounds
for GAGE10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GAGE10
Search CenterWatch for drugs/clinical trials and news about GAGE10 / GAG10
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Transcripts
for GAGE10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GAGE10 gene: NM_001098413.2 Unigene Cluster for GAGE10: G antigen 10 Hs.562044 [show with all ESTs]Unigene Representative Sequence: NM_0010984131 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000407599(uc010nir.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE10
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GAGE10 (NM_001098413) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GAGE10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAGE10 |
2 DOTS entries: DT.121292581 DT.444944
GeneLoc Exon Structure
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Expression
for GAGE10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GAGE10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See GAGE10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GAGE10
SOURCE GeneReport for Unigene cluster: Hs.562044
SABiosciences Custom PCR Arrays for GAGE10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAGE10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GAGE10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAGE10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAGE10 |
Orthologs
for GAGE10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for GAGE10 (if available)
TreeFam Gene Tree for GAGE10 (if available) |
Paralogs
for GAGE10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GAGE10 gene
- PAGE22 GAGE2D2 GAGE42 XAGE32 GAGE12H2 GAGE12I2 PAGE32 XAGE52
- XAGE2B2 PAGE52 GAGE12C2 GAGE12E2 GAGE12D2 PAGE2B2 GAGE12 GAGE2E2
- GAGE2C2 GAGE12F2 PAGE12 GAGE132 XAGE22 GAGE12G2 GAGE2A2 GAGE2B2
- GAGE12J2 PAGE42
18/27 SIMAP similar genes for GAGE10 using alignment to 1 protein entry: GAG10_HUMAN(see all similar genes):GAGE2D GAGE2E GAGE8 GAGE12J GAGE13 GAGE2A
GAGE2B GAGE2C GAGE5 GAGE6 GAGE12F GAGE12G
GAGE12I GAGE3 GAGE4 GAGE7 GAGE1 GAGE12B
GAGE10 for paralogs About GeneDecksing
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Genomic Variants
for GAGE10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for GAGE10 (49160125 - 49176323 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for GAGE10
8 CNVs: 33164 0824 96665 83510 73974 37032 2278 31551 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAGE10 |
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Disorders
/ Diseases
for GAGE10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 GAGE10 for disorders About MalaCards
GAGE10 for disorders About GeneDecksing
OMIM gene information: 300737
OMIM disorders: --
Export disorders for GAGE10 gene to outside databases
|
Publications
for GAGE10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GAGE10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with GAGE10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PubMed id 18179644)1, 2 Gjerstorff M.F. and Ditzel H.J. (2008)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (2001)
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External Searches for GAGE10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing GAGE10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing GAGE10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GAGE10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GAGE10 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for GAGE10 gene:
Search GeneIP for patents involving GAGE10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GAGE10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GAGE10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GAGE10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAGE10 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GAGE10 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GAGE10 | | OriGene Custom Protein Services for GAGE10 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GAGE10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAGE10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAGE10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAGE10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAGE10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAGE10 |
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 | | | GAGE10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for GAGE10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAGE10 |
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