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Aliases for GAGE1 Gene

Aliases for GAGE1 Gene

  • G Antigen 1 2 3
  • Cancer/Testis Antigen 4.1 3 4
  • GAGE-1 3 4
  • CT4.1 3 4
  • Cancer/Testis Antigen Family 4, Member 1 3
  • Cancer/Testis Antigen Family 4 2
  • MZ2-F Antigen 3
  • Antigen MZ2-F 4
  • Member 1 2

External Ids for GAGE1 Gene

Previous GeneCards Identifiers for GAGE1 Gene

  • GC0XP047961
  • GC0XP047425
  • GC0XP048004
  • GC0XP048215
  • GC0XP048271
  • GC0XP049057
  • GC0XP049061
  • GC0XP049049
  • GC0XP049070
  • GC0XP049242
  • GC0XP049250
  • GC0XP049359
  • GC0XP049361

Summaries for GAGE1 Gene

Entrez Gene Summary for GAGE1 Gene

  • This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. Nothing is presently known about the function of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

GeneCards Summary for GAGE1 Gene

GAGE1 (G Antigen 1) is a Protein Coding gene. Diseases associated with GAGE1 include glioblastoma multiforme and stomach cancer. An important paralog of this gene is XAGE2.

UniProtKB/Swiss-Prot for GAGE1 Gene

  • Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. Completely silent in normal adult tissues, except testis

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE1 Gene

Genomics for GAGE1 Gene

Genomic Location for GAGE1 Gene

Start:
49,589,496 bp from pter
End:
49,608,536 bp from pter
Size:
19,041 bases
Orientation:
Plus strand

Genomic View for GAGE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GAGE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAGE1 Gene

No data available for Regulatory Elements for GAGE1 Gene

Proteins for GAGE1 Gene

  • Protein details for GAGE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13065-GAGE1_HUMAN
    Recommended name:
    G antigen 1
    Protein Accession:
    Q13065
    Secondary Accessions:

    Protein attributes for GAGE1 Gene

    Size:
    139 amino acids
    Molecular mass:
    15610 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells

neXtProt entry for GAGE1 Gene

Proteomics data for GAGE1 Gene at MOPED

Post-translational modifications for GAGE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE1 Gene

No data available for DME Specific Peptides for GAGE1 Gene

Domains for GAGE1 Gene

Protein Domains for GAGE1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GAGE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13065

UniProtKB/Swiss-Prot:

GAGE1_HUMAN :
  • Q13065
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE1: view

No data available for Gene Families for GAGE1 Gene

Function for GAGE1 Gene

Molecular function for GAGE1 Gene

UniProtKB/Swiss-Prot Function: Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. Completely silent in normal adult tissues, except testis

Gene Ontology (GO) - Molecular Function for GAGE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GAGE1: view

Animal Model Products

CRISPR Products

miRNA for GAGE1 Gene

miRTarBase miRNAs that target GAGE1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GAGE1 Gene

Localization for GAGE1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAGE1 Gene COMPARTMENTS Subcellular localization image for GAGE1 gene
Compartment Confidence
nucleus 3
cytosol 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GAGE1 Gene

Pathways for GAGE1 Gene

SuperPathways for GAGE1 Gene

No Data Available

Interacting Proteins for GAGE1 Gene

Selected Interacting proteins: Q13065-GAGE1_HUMAN for GAGE1 Gene via UniProtKB

Gene Ontology (GO) - Biological Process for GAGE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 7544395
genes like me logo Genes that share ontologies with GAGE1: view

No data available for Pathways by source for GAGE1 Gene

Transcripts for GAGE1 Gene

Unigene Clusters for GAGE1 Gene

G antigen 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAGE1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GAGE1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE1 Gene

No ASD Table

Relevant External Links for GAGE1 Gene

GeneLoc Exon Structure for
GAGE1
ECgene alternative splicing isoforms for
GAGE1

Expression for GAGE1 Gene

mRNA expression in normal human tissues for GAGE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAGE1 Gene

This gene is overexpressed in Testis (50.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for GAGE1 Gene

SOURCE GeneReport for Unigene cluster for GAGE1 Gene Hs.278606

mRNA Expression by UniProt/SwissProt for GAGE1 Gene

Q13065-GAGE1_HUMAN
Tissue specificity: Expressed in a variety of tumor tissues but not in normal tissues, except testis
genes like me logo Genes that share expressions with GAGE1: view

In Situ Assay Products

Orthologs for GAGE1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAGE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 94 (a)
OneToMany
Species with no ortholog for GAGE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAGE1 Gene

ENSEMBL:
Gene Tree for GAGE1 (if available)
TreeFam:
Gene Tree for GAGE1 (if available)

Paralogs for GAGE1 Gene

genes like me logo Genes that share paralogs with GAGE1: view

Variants for GAGE1 Gene

Sequence variations from dbSNP and Humsavar for GAGE1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2142406 -- 49,602,288(+) ctgta(A/C)cactt intron-variant
rs2178978 -- 49,602,335(+) ATTTT(G/T)TACCA intron-variant
rs3747318 -- 49,605,108(-) TCTCT(C/T)GCCAT intron-variant, nc-transcript-variant
rs3747319 -- 49,604,782(-) TTTCA(A/C)AAGAT intron-variant
rs3747320 -- 49,604,771(-) CTTAC(A/G)CTACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAGE1 Gene

Variant ID Type Subtype PubMed ID
nsv820429 CNV Deletion 20802225
esv28941 CNV Gain+Loss 19812545
nsv6899 CNV Insertion 18451855
nsv6900 CNV Loss 18451855
nsv515203 CNV Complex 21397061

Relevant External Links for GAGE1 Gene

HapMap Linkage Disequilibrium report
GAGE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAGE1 Gene

Disorders for GAGE1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for GAGE1 Gene including...

Search for GAGE1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for GAGE1 Gene

genes like me logo Genes that share disorders with GAGE1: view

No data available for UniProtKB/Swiss-Prot for GAGE1 Gene

Publications for GAGE1 Gene

  1. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PMID: 7544395) van den Eynde B. … Boon T. (J. Exp. Med. 1995) 2 3 4
  2. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PMID: 10397259) De Backer O. … van der Bruggen P. (Cancer Res. 1999) 3 4 23
  3. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff M.F. … Ditzel H.J. (Tissue Antigens 2008) 3 4
  4. Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells. (PMID: 20053773) Mishra D.K. … Vadgama J.V. (Mol. Cancer Ther. 2010) 3
  5. Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian cancer tissues and cell lines. (PMID: 20423514) Zhang S. … Yu Y. (BMC Cancer 2010) 3

Products for GAGE1 Gene

Sources for GAGE1 Gene

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