GAGE1 Gene
protein-coding GIFtS: 48
GCID: GC0XP049361
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G antigen 1
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Aliases
for GAGE1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| G Antigen 11 2 | | Cancer/Testis Antigen Family 4, Member 12 | | CT4.11 2 3 | | MZ2-F Antigen2 | | Cancer/Testis Antigen 4.12 3 | | Antigen MZ2-F3 | | GAGE-12 3 | | |
| External Ids: | HGNC: 40981 | Entrez Gene: 25432 | Ensembl: ENSG000002057777 | OMIM: 3005945 | UniProtKB: Q130653 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n333387 | |
Export aliases for GAGE1 gene to outside databasesPrevious GC identifers: GC0XP047961 GC0XP047425 GC0XP048004 GC0XP048215 GC0XP048271 GC0XP049057 GC0XP049061 GC0XP049049 GC0XP049070 GC0XP049242 GC0XP049250 GC0XP049359
Summaries
for GAGE1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GAGE1:
This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except forthe testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions.The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologouscytolytic T lymphocytes. Nothing is presently known about the function of this protein. Alternative splicing resultsin multiple transcript variants. (provided by RefSeq, Jun 2010)
UniProtKB/Swiss-Prot: GAGE1_HUMAN, Q13065Function: Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. Completely silent in normal adulttissues, except testis
|
Genomic Views
for GAGE1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_086939.3
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for GAGE1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GAGE1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAGE1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23GAGE1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP049361: view genomic region
(about GC identifiers)
Start:
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49,363,616 bp from pter |
End:
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49,373,139 bp from pter |
Size:
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9,524 bases |
Orientation:
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plus strand |
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Proteins
for GAGE1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GAGE1_HUMAN, Q13065 (See
protein sequence)Recommended Name: G antigen 1 Size: 139 amino acids; 15610 Da
Miscellaneous: This gene belongs to a family of genes organized in clustered repeats. They have a high degree ofpredicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain eitherthe antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells
Caution: The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE membersmade impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGEgene nomenclature based on the identified genes and their productsExplore the universe of human proteins at neXtProt for GAGE1: NX_Q13065
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13065
GAGE1 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins (2 alternative transcripts):
NP_001035753.1 NP_001459.2
ENSEMBL proteins: ENSP00000371128 ENSP00000455294
Human Recombinant Protein Products:
GAGE1 Antibody Products:
Assay Products for GAGE1: |
Protein
Domains /
Families
for GAGE1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GAGE1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q13065ProtoNet protein and cluster: Q13065 1 Blocks protein family: IPB008625 GAGE
UniProtKB/Swiss-Prot: GAGE1_HUMAN, Q13065Similarity: Belongs to the GAGE family |
Function
for GAGE1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GAGE1_HUMAN, Q13065Function: Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. Completely silent in normal adulttissues, except testis
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE1 (see all 4)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAGE1 |
|
Pathways & Interactions
for GAGE1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GAGE1
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006968 | cellular defense response |
TAS | 7544395 |
GAGE1 for ontologies About GeneDecksing
|
Drugs & Compounds
for GAGE1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GAGE1
Search CenterWatch for drugs/clinical trials and news about GAGE1
|
Transcripts
for GAGE1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GAGE1 gene (2 alternative transcripts): NM_001040663.2 NM_001468.4 Unigene Cluster for GAGE1: G antigen 1 Hs.278606 [show with all ESTs]Unigene Representative Sequence: NM_0014682 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381709(uc004doj.3 uc004dok.2 uc004dol.2) ENST00000565630
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GAGE1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): GAGE1 (NM_001468) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GAGE1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAGE1 |
Additional cDNA sequence: BC005363.1 BC036094.1 BC069470.1 3 DOTS entries: DT.444944 DT.75114676 DT.99995700 24/50 AceView cDNA sequences (see all 50): BI868671 U19145 NM_001476 BX111134 NM_001477 NM_001474 BM832793 BI826605 AF055474 BC024914 BM836021 BC036094 BC031628 BG773070 U19147 AI126437 BX283580 BC069470 NM_012196 U19143 BC069397 BX108227 NM_001475 BM836228
GeneLoc Exon Structure
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Expression
for GAGE1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GAGE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACATTCTTGT
About this image
Genevestigator expression for GAGE1
SOURCE GeneReport for Unigene cluster: Hs.278606
UniProtKB/Swiss-Prot: GAGE1_HUMAN, Q13065Tissue specificity: Expressed in a variety of tumor tissues but not in normal tissues, except testis
SABiosciences Custom PCR Arrays for GAGE1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GAGE1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat GAGE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAGE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAGE1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAGE1 |
Orthologs
for GAGE1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for GAGE1 (if available)
TreeFam Gene Tree for GAGE1 (if available) |
Paralogs
for GAGE1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GAGE1 gene
- GAGE12I1 2 GAGE12G1 2 GAGE12F1 2 GAGE12C1 2 GAGE12D1 2 GAGE12E1 2 GAGE12J1 2 GAGE2D1 2
- GAGE12H1 2 GAGE2C1 2 GAGE2E1 2 GAGE2B1 2 GAGE131 2 GAGE2A1 2 PAGE22 GAGE42
- XAGE32 GAGE102 PAGE32 XAGE52 XAGE2B2 PAGE52 PAGE2B2 PAGE12
- XAGE22 PAGE42
18/27 SIMAP similar genes for GAGE1 using alignment to 2 protein entries: GAGE1_HUMAN (see all proteins)
(see all similar genes):GAGE3 GAGE4 GAGE5 GAGE6 GAGE12F GAGE12G
GAGE12I GAGE12J GAGE7 GAGE2D GAGE2E GAGE8
GAGE12B GAGE12C GAGE12D GAGE12E GAGE12H GAGE13
GAGE1 for paralogs About GeneDecksing
|
Genomic Variants
for GAGE1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GAGE1 (49363616 - 49373139 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for GAGE1
9 CNVs: 96665 83510 37043 37041 31551 33164 73975 37044 37045 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAGE1 |
|
Disorders
/ Diseases
for GAGE1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GAGE1 for disorders About GeneDecksing
OMIM gene information: 300594
OMIM disorders: --
14  diseases for GAGE1: About MalaCardsadult astrocytic tumour juvenile astrocytoma squamous cell carcinoma stomach cancer
prostate cancer, progression of prostate cancer hepatocellular carcinoma ovarian cancer
pancreatic cancer prostatitis pancreatitis carcinoma
neuroblastoma melanoma
1 disease from the University of Copenhagen DISEASES database for GAGE1:Adult glioblastoma multiforme Export disorders for GAGE1 gene to outside databases
|
Publications
for GAGE1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GAGE1 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with GAGE1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PubMed id 7544395)1, 2, 3 van den Eynde B....Boon T. (1995)
- Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PubMed id 10397259)1, 2, 9 De Backer O.... van der Bruggen P. (1999)
- An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PubMed id 18179644)1, 2 Gjerstorff M.F. and Ditzel H.J. (2008)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Expression of tumor-specific antigen MAGE, GAGE and B AGE in ovarian cancer tissues and cell lines. (PubMed id 20423514)1 Zhang S....Yu Y. (2010)
- Global methylation pattern of genes in androgen-sensi tive and androgen-independent prostate cancer cells. (PubMed id 20053773)1 Mishra D.K....Vadgama J.V. (2010)
- Acetylation-induced transcription is required for act ive DNA demethylation in methylation-silenced genes. (PubMed id 17709385)1 D'Alessio A.C....Szyf M. (2007)
- MAGE-A1, GAGE and NY-ESO-1 cancer/testis antigen expression during human gonadal development. (PubMed id 17208940)1 Gjerstorff M.F....Ditzel H.J. (2007)
- Expression of cancer-testis (CT) antigens in placenta . (PubMed id 17715884)1 Jungbluth A.A....Vogel M. (2007)
- Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma. (PubMed id 16929165)1 Atanackovic D....Leuwer R. (2006)
|
External Searches for GAGE1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GAGE1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GAGE1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GAGE1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for GAGE1 gene:
Search GeneIP for patents involving GAGE1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GAGE1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GAGE1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GAGE1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAGE1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAGE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAGE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAGE1 |
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 |  |  |  | |
| | | | Search Tocris compounds for GAGE1 |
| |  |  |  |  | | | | |
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 | | | GAGE1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAGE1 |
|  |  |  | | | | Search ThermoFisher Antibodies for GAGE1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAGE1 |
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