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Aliases for GAGE1 Gene

Aliases for GAGE1 Gene

  • G Antigen 1 2 3 5
  • Cancer/Testis Antigen Family 4, Member 1 2 3
  • Cancer/Testis Antigen 4.1 3 4
  • GAGE-1 3 4
  • CT4.1 3 4
  • MZ2-F Antigen 3
  • Antigen MZ2-F 4

External Ids for GAGE1 Gene

Previous GeneCards Identifiers for GAGE1 Gene

  • GC0XP047961
  • GC0XP047425
  • GC0XP048004
  • GC0XP048215
  • GC0XP048271
  • GC0XP049057
  • GC0XP049061
  • GC0XP049049
  • GC0XP049070
  • GC0XP049242
  • GC0XP049250
  • GC0XP049359
  • GC0XP049361

Summaries for GAGE1 Gene

Entrez Gene Summary for GAGE1 Gene

  • This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. Nothing is presently known about the function of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

GeneCards Summary for GAGE1 Gene

GAGE1 (G Antigen 1) is a Protein Coding gene. An important paralog of this gene is GAGE13.

UniProtKB/Swiss-Prot for GAGE1 Gene

  • Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. Completely silent in normal adult tissues, except testis.

Additional gene information for GAGE1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE1 Gene

Genomics for GAGE1 Gene

GeneHancer (GH) Regulatory Elements for GAGE1 Gene

Promoters and enhancers for GAGE1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI049590 Promoter 0.5 EPDnew 550.8 +1.1 1128 0.1 GAGE1 GAGE2A VDAC1P2
GH0XI049600 Promoter 0.5 EPDnew 550.4 +10.7 10706 0.1 GAGE1 GAGE2A VDAC1P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GAGE1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GAGE1 Gene

Genomic Locations for GAGE1 Gene
19,041 bases
Plus strand

Genomic View for GAGE1 Gene

Genes around GAGE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAGE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAGE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAGE1 Gene

Proteins for GAGE1 Gene

  • Protein details for GAGE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G antigen 1
    Protein Accession:

    Protein attributes for GAGE1 Gene

    139 amino acids
    Molecular mass:
    15610 Da
    Quaternary structure:
    No Data Available
    • This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for GAGE1 Gene

Post-translational modifications for GAGE1 Gene

No Post-translational modifications

Other Protein References for GAGE1 Gene

No data available for DME Specific Peptides for GAGE1 Gene

Domains & Families for GAGE1 Gene

Gene Families for GAGE1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GAGE1 Gene


Suggested Antigen Peptide Sequences for GAGE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE1: view

Function for GAGE1 Gene

Molecular function for GAGE1 Gene

UniProtKB/Swiss-Prot Function:
Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. Completely silent in normal adult tissues, except testis.

Phenotypes From GWAS Catalog for GAGE1 Gene

Gene Ontology (GO) - Molecular Function for GAGE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GAGE1: view

Phenotypes for GAGE1 Gene

GenomeRNAi human phenotypes for GAGE1:
genes like me logo Genes that share phenotypes with GAGE1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAGE1 Gene

Localization for GAGE1 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Golgi apparatus (1)
  • Plasma membrane (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GAGE1 Gene

Pathways & Interactions for GAGE1 Gene

SuperPathways for GAGE1 Gene

No Data Available

Interacting Proteins for GAGE1 Gene

Gene Ontology (GO) - Biological Process for GAGE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 7544395
genes like me logo Genes that share ontologies with GAGE1: view

No data available for Pathways by source and SIGNOR curated interactions for GAGE1 Gene

Drugs & Compounds for GAGE1 Gene

No Compound Related Data Available

Transcripts for GAGE1 Gene

Unigene Clusters for GAGE1 Gene

G antigen 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE1 Gene

No ASD Table

Relevant External Links for GAGE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GAGE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GAGE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAGE1 Gene

This gene is overexpressed in Testis (x50.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GAGE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GAGE1 Gene:


SOURCE GeneReport for Unigene cluster for GAGE1 Gene:


mRNA Expression by UniProt/SwissProt for GAGE1 Gene:

Tissue specificity: Expressed in a variety of tumor tissues but not in normal tissues, except testis.
genes like me logo Genes that share expression patterns with GAGE1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAGE1 Gene

Orthologs for GAGE1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAGE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 94 (a)
Species where no ortholog for GAGE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAGE1 Gene

Gene Tree for GAGE1 (if available)
Gene Tree for GAGE1 (if available)

Paralogs for GAGE1 Gene

Variants for GAGE1 Gene

Sequence variations from dbSNP and Humsavar for GAGE1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1002859072 -- 49,607,746(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1016723267 -- 49,608,643(+) G/A downstream_transcript_variant
rs1016733137 -- 49,608,234(+) G/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1020740167 -- 49,607,486(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1025156111 -- 49,607,361(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GAGE1 Gene

Variant ID Type Subtype PubMed ID
dgv4237n106 CNV duplication 24896259
esv28941 CNV gain+loss 19812545
esv3364710 CNV duplication 20981092
esv3392575 CNV duplication 20981092
esv3407218 CNV duplication 20981092
nsv1153207 CNV duplication 26484159
nsv515203 CNV gain 21397061
nsv6899 CNV insertion 18451855
nsv6900 CNV deletion 18451855
nsv820429 CNV deletion 20802225
nsv953412 CNV duplication 24416366

Variation tolerance for GAGE1 Gene

Gene Damage Index Score: 2.53; 44.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAGE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAGE1 Gene

Disorders for GAGE1 Gene

Additional Disease Information for GAGE1

No disorders were found for GAGE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE1 Gene

Publications for GAGE1 Gene

  1. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PMID: 10397259) De Backer O … van der Bruggen P (Cancer research 1999) 3 4 22 58
  2. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PMID: 7544395) Van den Eynde B … Boon T (The Journal of experimental medicine 1995) 2 3 4 58
  3. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. (PMID: 18179644) Gjerstorff MF … Ditzel HJ (Tissue antigens 2008) 3 4 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58

Products for GAGE1 Gene

Sources for GAGE1 Gene

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