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Aliases for GAGE1 Gene

Aliases for GAGE1 Gene

  • G Antigen 1 2 3 5
  • Cancer/Testis Antigen 4.1 3 4
  • GAGE-1 3 4
  • CT4.1 3 4
  • Cancer/Testis Antigen Family 4, Member 1 3
  • Cancer/Testis Antigen Family 4 2
  • MZ2-F Antigen 3
  • Antigen MZ2-F 4
  • Member 1 2

External Ids for GAGE1 Gene

Previous GeneCards Identifiers for GAGE1 Gene

  • GC0XP047961
  • GC0XP047425
  • GC0XP048004
  • GC0XP048215
  • GC0XP048271
  • GC0XP049057
  • GC0XP049061
  • GC0XP049049
  • GC0XP049070
  • GC0XP049242
  • GC0XP049250
  • GC0XP049359
  • GC0XP049361

Summaries for GAGE1 Gene

Entrez Gene Summary for GAGE1 Gene

  • This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. Nothing is presently known about the function of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

GeneCards Summary for GAGE1 Gene

GAGE1 (G Antigen 1) is a Protein Coding gene. An important paralog of this gene is XAGE5.

UniProtKB/Swiss-Prot for GAGE1 Gene

  • Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. Completely silent in normal adult tissues, except testis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAGE1 Gene

Genomics for GAGE1 Gene

Genomic Location for GAGE1 Gene

49,589,496 bp from pter
49,608,536 bp from pter
19,041 bases
Plus strand

Genomic View for GAGE1 Gene

Genes around GAGE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAGE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAGE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAGE1 Gene

No data available for Regulatory Elements for GAGE1 Gene

Proteins for GAGE1 Gene

  • Protein details for GAGE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G antigen 1
    Protein Accession:

    Protein attributes for GAGE1 Gene

    139 amino acids
    Molecular mass:
    15610 Da
    Quaternary structure:
    No Data Available
    • This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

neXtProt entry for GAGE1 Gene

Proteomics data for GAGE1 Gene at MOPED

Post-translational modifications for GAGE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAGE1 Gene

No data available for DME Specific Peptides for GAGE1 Gene

Domains & Families for GAGE1 Gene

Protein Domains for GAGE1 Gene


Suggested Antigen Peptide Sequences for GAGE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with GAGE1: view

No data available for Gene Families for GAGE1 Gene

Function for GAGE1 Gene

Molecular function for GAGE1 Gene

UniProtKB/Swiss-Prot Function:
Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. Completely silent in normal adult tissues, except testis.

Phenotypes for GAGE1 Gene

GenomeRNAi human phenotypes for GAGE1:
genes like me logo Genes that share phenotypes with GAGE1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAGE1 Gene

Localization for GAGE1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GAGE1 Gene

Pathways & Interactions for GAGE1 Gene

SuperPathways for GAGE1 Gene

No Data Available

Interacting Proteins for GAGE1 Gene

Selected Interacting proteins: Q13065-GAGE1_HUMAN for GAGE1 Gene via UniProtKB

Gene Ontology (GO) - Biological Process for GAGE1 Gene


No data available for Pathways by source and SIGNOR curated interactions for GAGE1 Gene

Drugs & Compounds for GAGE1 Gene

No Compound Related Data Available

Transcripts for GAGE1 Gene

Unigene Clusters for GAGE1 Gene

G antigen 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GAGE1 Gene

No ASD Table

Relevant External Links for GAGE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GAGE1 Gene

mRNA expression in normal human tissues for GAGE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAGE1 Gene

This gene is overexpressed in Testis (x50.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GAGE1 Gene

SOURCE GeneReport for Unigene cluster for GAGE1 Gene Hs.278606

mRNA Expression by UniProt/SwissProt for GAGE1 Gene

Tissue specificity: Expressed in a variety of tumor tissues but not in normal tissues, except testis.
genes like me logo Genes that share expression patterns with GAGE1: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for GAGE1 Gene

Orthologs for GAGE1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAGE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 94 (a)
Species with no ortholog for GAGE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GAGE1 Gene

Gene Tree for GAGE1 (if available)
Gene Tree for GAGE1 (if available)

Paralogs for GAGE1 Gene

genes like me logo Genes that share paralogs with GAGE1: view

Variants for GAGE1 Gene

Sequence variations from dbSNP and Humsavar for GAGE1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1967646 -- 49,603,685(+) AAGCT(C/G)ATAGC nc-transcript-variant, reference, missense
rs1967647 -- 49,603,849(+) TCATA(C/T)TGTAA intron-variant
rs2142402 -- 49,598,007(+) ctgag(G/T)agctg upstream-variant-2KB
rs2142405 -- 49,602,162(+) AAATG(A/G)ATAAA intron-variant
rs2142406 -- 49,602,288(+) ctgta(A/C)cactt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAGE1 Gene

Variant ID Type Subtype PubMed ID
nsv820429 CNV Deletion 20802225
esv28941 CNV Gain+Loss 19812545
nsv6899 CNV Insertion 18451855
nsv6900 CNV Loss 18451855
nsv515203 CNV Complex 21397061

Variation tolerance for GAGE1 Gene

Gene Damage Index Score: 2.53; 44.09% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GAGE1 Gene

Disorders for GAGE1 Gene

Relevant External Links for GAGE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GAGE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAGE1 Gene

Publications for GAGE1 Gene

  1. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. (PMID: 7544395) van den Eynde B. … Boon T. (J. Exp. Med. 1995) 2 3 4 67
  2. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. (PMID: 10397259) De Backer O. … van der Bruggen P. (Cancer Res. 1999) 3 23
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells. (PMID: 20053773) Mishra D.K. … Vadgama J.V. (Mol. Cancer Ther. 2010) 3

Products for GAGE1 Gene

Sources for GAGE1 Gene