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Aliases & Descriptions for GAGE1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases CT4.1 1 , 2 , 3 GAGE-1 3 MGC33825 2 OTTHUMG00000024136 1 OTTHUMP00000025848 2
Descriptions Cancer/testis antigen 4.1 3 G antigen 1 2 MZ2-F antigen 2 , 3 cancer/testis antigen family 4, member 1 2
Search outside databases for aliases for GAGE1 genePrevious GC identifers: GC0XP047961 GC0XP047425 GC0XP048004 GC0XP048215 GC0XP048271 GC0XP049057 GC0XP049061 GC0XP049049 GC0XP049070
Summaries for GAGE1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for GAGE1 : This gene belongs to a family of genes that are expressed in a variety of tumors but not in normaltissues, except for the testis. The sequences of the family members are highly related but differby scattered nucleotide substitutions. The GAGE1 cDNA contains a 143-bp insertion, located in thecoding sequence near the termination codon, that is absent from the other cDNAs.The antigenicpeptide YRPRPRRY, which is also encoded by several other family members, is recognized byautologous cytolytic T lymphocytes. Nothing is presently known about the function of this protein.An alternatively spliced transcript variant has been found for this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: GAGE1_HUMAN, Q13065 Function : Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. Completely silentin normal adult tissues, except testis
Genomic Location for GAGE1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xp11.4-p11.2 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23 GAGE1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XP049242:
(about GC identifiers )
Start:
49,241,043 bp from pter
End:
49,260,086 bp from pter
Size:
19,044 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000023.9 NT_086939.2 Proteins for GAGE1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: GAGE1_HUMAN, Q13065 (See
protein sequence )Recommended Name: G antigen 1 Size : 138 amino acids; 15418 Da
REFSEQ proteins (2 alternative transcripts):
NP_001035753.1 NP_001459.2 ENSEMBL proteins: ENSP00000371128 ENSP00000347280 ENSP00000371119 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: GAGE1 Antibodies for GAGE1: Assays for GAGE1:
Protein
Domains/ Families for GAGE1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q13065 ProtoNet protein and cluster: Q13065
1 Blocks protein family : IPB008625 GAGE UniProtKB/Swiss-Prot: GAGE1_HUMAN, Q13065 Similarity : Belongs to the GAGE family
Gene Function for GAGE1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Sigma-Aldrich ,
RNAi Products ,
Clones , and
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Millipore ,
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Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001468 Applied Biosystems Silencer ® siRNAs for GAGE1 Sigma-Aldrich siRNA for GAGE1 Sigma-Aldrich shRNA for GAGE1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001040663                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001040663                                  untagged cDNA clones in CMV expression vector (see all 4 ): BC036094  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001468 UniProtKB/Swiss-Prot: GAGE1_HUMAN, Q13065 Function : Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. Completely silentin normal adult tissues, except testis
Pathways & Interactions for GAGE1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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--1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006968 cellular defense response
TAS 7544395
About this table
Drugs & Compounds for GAGE1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for GAGE1
Transcripts for GAGE1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001468 Sigma-Aldrich siRNA for GAGE1 Sigma-Aldrich shRNA for GAGE1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001040663 NM_001468
REFSEQ mRNAs for GAGE1 gene (2 alternative transcripts): NM_001040663.1 NM_001468.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001040663 NM_001468
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001040663                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001040663                                  untagged cDNA clones in CMV expression vector (see all 4 ): BC036094  
Additional cDNA sequence: BC005363.1 BC069397.1 BC069470.1
3 DOTS entries : DT.444944 DT.75114676 DT.99995700
24/50 AceView cDNA sequences (see all 50
):NM_001474 AF055474 BC031628 BX111134 BM832793 U19147 U19145 BC036094 BG773070 BI826605 NM_001477 BC024914 BI868671 BM836021 NM_001476 NM_012196 NM_001472 BX108227 U19143 BC069309 BC069397 NM_001468 BC018052 U19142
highest scoring ESTs for GAGE1 :BI560935 CV025032 EC474538 EC485731 EC487355 EC530904 NM_001040663 XM_001130982 XM_001130991 BC036094
Unigene Cluster for GAGE1: G antigen 1 Hs.632815 [show with all ESTs ] Unigene Representative Sequence: NM_001468 GeneLoc Exon Structure 3 Ensembl transcripts including schematic representations : ENST00000381709
ENST00000355154
ENST00000381700
Expression for GAGE1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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GAGE1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for GAGE1 1 / 2 / 3
19 probe-sets matching GAGE1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.632815 Expression variation in blood from EXPOLDB for GAGE1
UniProtKB/Swiss-Prot: GAGE1_HUMAN, Q13065 Tissue specificity : Expressed in a variety of tumor tissues but not in normal tissues, excepttestis
Orthologs for GAGE1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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ENSEMBL Gene Tree for GAGE1 Paralogs for GAGE1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for GAGE1 gene GAGE12I 1 GAGE12G 1 2 GAGE12F 1 2 GAGE12D 1 GAGE12C 1 2 GAGE12E 1 2 GAGE12J 1 2 GAGE2D 1 2 GAGE2E 1 2 GAGE12H 1 2 GAGE2C 1 2 GAGE2B 1 2 GAGE13 1 2 GAGE2A 1 2 XAGE3 2 GAGE10 2 ENSG00000169164 2 XAGE5 2 XAGE2B 2 PAGE1 2 XAGE2 2
SNPs/Variants for GAGE1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for GAGE1 (up to first 250kb)
Disorders & Mutations for GAGE1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 300594
Medical News for GAGE1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for GAGE1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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9 PubMed articles for GAGE1 gene :
Search for GAGE1
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing GAGE1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing GAGE1
(According to HUGE )
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--
Specialized Databases showing GAGE1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for GAGE1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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