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Aliases for GADL1 Gene

Aliases for GADL1 Gene

  • Glutamate Decarboxylase Like 1 2 3 5
  • Glutamate Decarboxylase-Like Protein 1 3 4
  • Cysteine Sulfinic Acid Decarboxylase 3 4
  • Glutamate Decarboxylase-Like 1 2 3
  • Aspartate 1-Decarboxylase 3 4
  • EC 4.1.1.29 4 63
  • HuCSADC 3 4
  • CSADC 3 4
  • HuADC 3 4
  • ADC 3 4
  • EC 4.1.1.15 63
  • EC 4.1.1.11 4
  • EC 4.1.1 63

External Ids for GADL1 Gene

Summaries for GADL1 Gene

GeneCards Summary for GADL1 Gene

GADL1 (Glutamate Decarboxylase Like 1) is a Protein Coding gene. Diseases associated with GADL1 include Gadl1-Related Altered Drug Metabolism. Among its related pathways are Pantothenate and CoA biosynthesis and Taurine and hypotaurine metabolism. GO annotations related to this gene include pyridoxal phosphate binding and sulfinoalanine decarboxylase activity. An important paralog of this gene is DDC.

UniProtKB/Swiss-Prot for GADL1 Gene

  • May catalyze the decarboxylation of aspartate, cysteine sulfinic acid, and cysteic acid to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GADL1 Gene

Genomics for GADL1 Gene

Regulatory Elements for GADL1 Gene

Enhancers for GADL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GADL1 on UCSC Golden Path with GeneCards custom track

Promoters for GADL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GADL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GADL1 Gene

Chromosome:
3
Start:
30,726,200 bp from pter
End:
30,894,765 bp from pter
Size:
168,566 bases
Orientation:
Minus strand

Genomic View for GADL1 Gene

Genes around GADL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GADL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GADL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GADL1 Gene

Proteins for GADL1 Gene

  • Protein details for GADL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZQY3-GADL1_HUMAN
    Recommended name:
    Acidic amino acid decarboxylase GADL1
    Protein Accession:
    Q6ZQY3

    Protein attributes for GADL1 Gene

    Size:
    521 amino acids
    Molecular mass:
    59246 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH93701.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI11987.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC87546.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for GADL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GADL1 Gene

Proteomics data for GADL1 Gene at MOPED

Selected DME Specific Peptides for GADL1 Gene

Post-translational modifications for GADL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GADL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GADL1 Gene

Suggested Antigen Peptide Sequences for GADL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZQY3

UniProtKB/Swiss-Prot:

GADL1_HUMAN :
  • Belongs to the group II decarboxylase family.
Family:
  • Belongs to the group II decarboxylase family.
genes like me logo Genes that share domains with GADL1: view

No data available for Gene Families for GADL1 Gene

Function for GADL1 Gene

Molecular function for GADL1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.72 mM for aspartate {ECO:0000269 PubMed:23038267}; KM=1.14 mM for cysteine sulfinic acid {ECO:0000269 PubMed:23038267}; Vmax=1.56 umol/min/mg enzyme toward aspartate {ECO:0000269 PubMed:23038267}; Vmax=2.31 umol/min/mg enzyme toward cysteine sulfinic acid {ECO:0000269 PubMed:23038267};
UniProtKB/Swiss-Prot CatalyticActivity:
L-aspartate = beta-alanine + CO(2).
UniProtKB/Swiss-Prot CatalyticActivity:
3-sulfino-L-alanine = hypotaurine + CO(2).
UniProtKB/Swiss-Prot Function:
May catalyze the decarboxylation of aspartate, cysteine sulfinic acid, and cysteic acid to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate.

Enzyme Numbers (IUBMB) for GADL1 Gene

Gene Ontology (GO) - Molecular Function for GADL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004068 aspartate 1-decarboxylase activity IEA --
GO:0016831 carboxy-lyase activity IEA,TAS --
genes like me logo Genes that share ontologies with GADL1: view
genes like me logo Genes that share phenotypes with GADL1: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GADL1 Gene

Localization for GADL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GADL1 Gene COMPARTMENTS Subcellular localization image for GADL1 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GADL1 Gene

Pathways & Interactions for GADL1 Gene

genes like me logo Genes that share pathways with GADL1: view

Interacting Proteins for GADL1 Gene

Gene Ontology (GO) - Biological Process for GADL1 Gene

None

No data available for SIGNOR curated interactions for GADL1 Gene

Drugs & Compounds for GADL1 Gene

(1) Drugs for GADL1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyridoxal Phosphate Nutra Target, cofactor 14
genes like me logo Genes that share compounds with GADL1: view

Transcripts for GADL1 Gene

mRNA/cDNA for GADL1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GADL1 Gene

Glutamate decarboxylase-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GADL1 Gene

No ASD Table

Relevant External Links for GADL1 Gene

GeneLoc Exon Structure for
GADL1
ECgene alternative splicing isoforms for
GADL1

Expression for GADL1 Gene

mRNA expression in normal human tissues for GADL1 Gene

mRNA differential expression in normal tissues according to GTEx for GADL1 Gene

This gene is overexpressed in Muscle - Skeletal (x21.0), Esophagus - Gastroesophageal Junction (x13.7), and Esophagus - Muscularis (x8.5).

Protein differential expression in normal tissues from HIPED for GADL1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GADL1 Gene



SOURCE GeneReport for Unigene cluster for GADL1 Gene Hs.657052

genes like me logo Genes that share expression patterns with GADL1: view

Protein tissue co-expression partners for GADL1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GADL1 Gene

Orthologs for GADL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GADL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GADL1 35
  • 88.16 (n)
  • 91.36 (a)
GADL1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GADL1 35
  • 92.39 (n)
  • 94.05 (a)
GADL1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gadl1 35
  • 86.79 (n)
  • 90.24 (a)
Gadl1 16
Gadl1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GADL1 35
  • 99.35 (n)
  • 99.41 (a)
GADL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gadl1 35
  • 82.89 (n)
  • 83.38 (a)
oppossum
(Monodelphis domestica)
Mammalia GADL1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GADL1 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves GADL1 35
  • 80.07 (n)
  • 85.54 (a)
GADL1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GADL1 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gadl1 35
  • 74.1 (n)
  • 79.12 (a)
Str.2151 35
zebrafish
(Danio rerio)
Actinopterygii zgc:163121 36
  • 46 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008904 35
  • 56.63 (n)
  • 51.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta b 35
  • 56.56 (n)
  • 50.32 (a)
b 36
  • 42 (a)
ManyToMany
CG5618 36
  • 46 (a)
ManyToMany
Species with no ortholog for GADL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GADL1 Gene

ENSEMBL:
Gene Tree for GADL1 (if available)
TreeFam:
Gene Tree for GADL1 (if available)

Paralogs for GADL1 Gene

Paralogs for GADL1 Gene

(5) SIMAP similar genes for GADL1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for GADL1 Gene

genes like me logo Genes that share paralogs with GADL1: view

Variants for GADL1 Gene

Sequence variations from dbSNP and Humsavar for GADL1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs711681 -- 30,760,826(+) GATGG(A/G)CAGCC intron-variant
rs711682 -- 30,761,061(+) GTATA(C/T)TTTGA intron-variant
rs711683 -- 30,761,215(+) TTATA(C/T)ATTGA intron-variant
rs711684 -- 30,761,225(+) AGAGA(C/T)GTTCT intron-variant
rs1024083 -- 30,777,059(-) ACAAT(C/G)ACAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GADL1 Gene

Variant ID Type Subtype PubMed ID
nsv7352 OTHER Inversion 18451855
nsv876665 CNV Gain 21882294
nsv522284 CNV Loss 19592680
nsv522385 CNV Loss 19592680
esv2663822 CNV Deletion 23128226
esv2666210 CNV Deletion 23128226
nsv460484 CNV Gain 19166990
nsv876666 CNV Gain 21882294
esv2660444 CNV Deletion 23128226
nsv515560 CNV Loss 19592680
nsv514144 CNV Loss 21397061
nsv441818 CNV CNV 18776908

Variation tolerance for GADL1 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GADL1 Gene

Disorders for GADL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GADL1 Gene - From: GeneTests

Disorder Aliases PubMed IDs
gadl1-related altered drug metabolism
- elite association - COSMIC cancer census association via MalaCards
Search GADL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GADL1

Genetic Association Database (GAD)
GADL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GADL1
genes like me logo Genes that share disorders with GADL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GADL1 Gene

Publications for GADL1 Gene

  1. GADL1 gene polymorphisms and lithium response in bipolar I disorder: lack of association from an Indian population. (PMID: 25415457) Kotambail A. … Satyamoorthy K. (Psychiatr. Genet. 2015) 3 67
  2. Variant GADL1 and response to lithium therapy in bipolar I disorder. (PMID: 24369049) Chen C.H. … Cheng A.T. (N. Engl. J. Med. 2014) 3
  3. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3
  4. Genetic variants associated with disordered eating. (PMID: 23568457) Wade T.D. … Martin N.G. (Int J Eat Disord 2013) 3
  5. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25

Products for GADL1 Gene

Sources for GADL1 Gene

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